Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 21

1.

De novo design of bioactive protein switches.

Langan RA, Boyken SE, Ng AH, Samson JA, Dods G, Westbrook AM, Nguyen TH, Lajoie MJ, Chen Z, Berger S, Mulligan VK, Dueber JE, Novak WRP, El-Samad H, Baker D.

Nature. 2019 Aug;572(7768):205-210. doi: 10.1038/s41586-019-1432-8. Epub 2019 Jul 24.

PMID:
31341284
2.

Programmable design of orthogonal protein heterodimers.

Chen Z, Boyken SE, Jia M, Busch F, Flores-Solis D, Bick MJ, Lu P, VanAernum ZL, Sahasrabuddhe A, Langan RA, Bermeo S, Brunette TJ, Mulligan VK, Carter LP, DiMaio F, Sgourakis NG, Wysocki VH, Baker D.

Nature. 2019 Jan;565(7737):106-111. doi: 10.1038/s41586-018-0802-y. Epub 2018 Dec 19.

3.

A systematic study of minima in alanine dipeptide.

Mironov V, Alexeev Y, Mulligan VK, Fedorov DG.

J Comput Chem. 2019 Jan 15;40(2):297-309. doi: 10.1002/jcc.25589. Epub 2018 Oct 23.

PMID:
30368851
4.

Accurate computational design of multipass transmembrane proteins.

Lu P, Min D, DiMaio F, Wei KY, Vahey MD, Boyken SE, Chen Z, Fallas JA, Ueda G, Sheffler W, Mulligan VK, Xu W, Bowie JU, Baker D.

Science. 2018 Mar 2;359(6379):1042-1046. doi: 10.1126/science.aaq1739.

PMID:
29496880
5.

A computational method for the design of nested proteins by loop-directed domain insertion.

Blacklock KM, Yang L, Mulligan VK, Khare SD.

Proteins. 2018 Mar;86(3):354-369. doi: 10.1002/prot.25445. Epub 2018 Jan 24.

PMID:
29250820
6.

Comprehensive computational design of ordered peptide macrocycles.

Hosseinzadeh P, Bhardwaj G, Mulligan VK, Shortridge MD, Craven TW, Pardo-Avila F, Rettie SA, Kim DE, Silva DA, Ibrahim YM, Webb IK, Cort JR, Adkins JN, Varani G, Baker D.

Science. 2017 Dec 15;358(6369):1461-1466. doi: 10.1126/science.aap7577.

7.

De novo design of covalently constrained mesosize protein scaffolds with unique tertiary structures.

Dang B, Wu H, Mulligan VK, Mravic M, Wu Y, Lemmin T, Ford A, Silva DA, Baker D, DeGrado WF.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):10852-10857. doi: 10.1073/pnas.1710695114. Epub 2017 Sep 25.

8.

Global analysis of protein folding using massively parallel design, synthesis, and testing.

Rocklin GJ, Chidyausiku TM, Goreshnik I, Ford A, Houliston S, Lemak A, Carter L, Ravichandran R, Mulligan VK, Chevalier A, Arrowsmith CH, Baker D.

Science. 2017 Jul 14;357(6347):168-175. doi: 10.1126/science.aan0693.

9.

The Rosetta All-Atom Energy Function for Macromolecular Modeling and Design.

Alford RF, Leaver-Fay A, Jeliazkov JR, O'Meara MJ, DiMaio FP, Park H, Shapovalov MV, Renfrew PD, Mulligan VK, Kappel K, Labonte JW, Pacella MS, Bonneau R, Bradley P, Dunbrack RL Jr, Das R, Baker D, Kuhlman B, Kortemme T, Gray JJ.

J Chem Theory Comput. 2017 Jun 13;13(6):3031-3048. doi: 10.1021/acs.jctc.7b00125. Epub 2017 May 12.

10.

Simultaneous Optimization of Biomolecular Energy Functions on Features from Small Molecules and Macromolecules.

Park H, Bradley P, Greisen P Jr, Liu Y, Mulligan VK, Kim DE, Baker D, DiMaio F.

J Chem Theory Comput. 2016 Dec 13;12(12):6201-6212. Epub 2016 Nov 7.

11.

Accurate de novo design of hyperstable constrained peptides.

Bhardwaj G, Mulligan VK, Bahl CD, Gilmore JM, Harvey PJ, Cheneval O, Buchko GW, Pulavarti SV, Kaas Q, Eletsky A, Huang PS, Johnsen WA, Greisen PJ, Rocklin GJ, Song Y, Linsky TW, Watkins A, Rettie SA, Xu X, Carter LP, Bonneau R, Olson JM, Coutsias E, Correnti CE, Szyperski T, Craik DJ, Baker D.

Nature. 2016 Oct 20;538(7625):329-335. doi: 10.1038/nature19791. Epub 2016 Sep 14.

12.

Computational design of an unnatural amino acid dependent metalloprotein with atomic level accuracy.

Mills JH, Khare SD, Bolduc JM, Forouhar F, Mulligan VK, Lew S, Seetharaman J, Tong L, Stoddard BL, Baker D.

J Am Chem Soc. 2013 Sep 11;135(36):13393-9. doi: 10.1021/ja403503m. Epub 2013 Aug 29.

13.

Protein misfolding in the late-onset neurodegenerative diseases: common themes and the unique case of amyotrophic lateral sclerosis.

Mulligan VK, Chakrabartty A.

Proteins. 2013 Aug;81(8):1285-303. doi: 10.1002/prot.24285. Epub 2013 Jul 2. Review.

PMID:
23508986
14.

Early steps in oxidation-induced SOD1 misfolding: implications for non-amyloid protein aggregation in familial ALS.

Mulligan VK, Kerman A, Laister RC, Sharda PR, Arslan PE, Chakrabartty A.

J Mol Biol. 2012 Aug 24;421(4-5):631-52. doi: 10.1016/j.jmb.2012.04.016. Epub 2012 Apr 24.

PMID:
22542526
15.

Analyzing complicated protein folding kinetics rapidly by analytical Laplace inversion using a Tikhonov regularization variant.

Mulligan VK, Hadley KC, Chakrabartty A.

Anal Biochem. 2012 Feb 1;421(1):181-90. doi: 10.1016/j.ab.2011.10.050. Epub 2011 Nov 4.

PMID:
22119751
16.

CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization.

Ceccarelli DF, Laister RC, Mulligan VK, Kean MJ, Goudreault M, Scott IC, Derry WB, Chakrabartty A, Gingras AC, Sicheri F.

J Biol Chem. 2011 Jul 15;286(28):25056-64. doi: 10.1074/jbc.M110.213777. Epub 2011 May 11.

17.

ALS-causing SOD1 mutations promote production of copper-deficient misfolded species.

Ip P, Mulligan VK, Chakrabartty A.

J Mol Biol. 2011 Jun 24;409(5):839-52. doi: 10.1016/j.jmb.2011.04.027. Epub 2011 Apr 27.

PMID:
21549128
18.

Prion disease susceptibility is affected by beta-structure folding propensity and local side-chain interactions in PrP.

Khan MQ, Sweeting B, Mulligan VK, Arslan PE, Cashman NR, Pai EF, Chakrabartty A.

Proc Natl Acad Sci U S A. 2010 Nov 16;107(46):19808-13. doi: 10.1073/pnas.1005267107. Epub 2010 Nov 1.

19.

Conversion of Abeta42 into a folded soluble native-like protein using a semi-random library of amphipathic helices.

Arslan PE, Mulligan VK, Ho S, Chakrabartty A.

J Mol Biol. 2010 Mar 12;396(5):1284-94. doi: 10.1016/j.jmb.2009.12.019. Epub 2009 Dec 21.

PMID:
20026077
20.

Denaturational stress induces formation of zinc-deficient monomers of Cu,Zn superoxide dismutase: implications for pathogenesis in amyotrophic lateral sclerosis.

Mulligan VK, Kerman A, Ho S, Chakrabartty A.

J Mol Biol. 2008 Nov 7;383(2):424-36. doi: 10.1016/j.jmb.2008.08.024. Epub 2008 Aug 22.

PMID:
18761352
21.

Drosophila melanogaster Cad99C, the orthologue of human Usher cadherin PCDH15, regulates the length of microvilli.

D'Alterio C, Tran DD, Yeung MW, Hwang MS, Li MA, Arana CJ, Mulligan VK, Kubesh M, Sharma P, Chase M, Tepass U, Godt D.

J Cell Biol. 2005 Nov 7;171(3):549-58. Epub 2005 Oct 31. Erratum in: J Cell Biol. 2005 Dec 19;171(6):1085.

Supplemental Content

Loading ...
Support Center