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c-Src regulates cargo transit via the Golgi in pancreatic acinar cells.

Kostenko S, Heu CC, Yaron JR, Singh G, de Oliveira C, Muller WJ, Singh VP.

Sci Rep. 2018 Aug 9;8(1):11903. doi: 10.1038/s41598-018-30370-4.


Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program.

Hirukawa A, Smith HW, Zuo D, Dufour CR, Savage P, Bertos N, Johnson RM, Bui T, Bourque G, Basik M, Giguère V, Park M, Muller WJ.

Nat Commun. 2018 Jun 29;9(1):2547. doi: 10.1038/s41467-018-04864-8.


The Receptor Tyrosine Kinase AXL Is Required at Multiple Steps of the Metastatic Cascade during HER2-Positive Breast Cancer Progression.

Goyette MA, Duhamel S, Aubert L, Pelletier A, Savage P, Thibault MP, Johnson RM, Carmeliet P, Basik M, Gaboury L, Muller WJ, Park M, Roux PP, Gratton JP, Côté JF.

Cell Rep. 2018 May 1;23(5):1476-1490. doi: 10.1016/j.celrep.2018.04.019.


Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance.

Ha JR, Ahn R, Smith HW, Sabourin V, Hébert S, Cepeda Cañedo E, Im YK, Kleinman CL, Muller WJ, Ursini-Siegel J.

Mol Cancer Res. 2018 May;16(5):894-908. doi: 10.1158/1541-7786.MCR-17-0623. Epub 2018 Feb 16.


Marine fish oil is more potent than plant-based n-3 polyunsaturated fatty acids in the prevention of mammary tumors.

Liu J, Abdelmagid SA, Pinelli CJ, Monk JM, Liddle DM, Hillyer LM, Hucik B, Silva A, Subedi S, Wood GA, Robinson LE, Muller WJ, Ma DWL.

J Nutr Biochem. 2018 May;55:41-52. doi: 10.1016/j.jnutbio.2017.12.011. Epub 2017 Dec 27.


Pediatric Considerations for Postexposure Human Immunodeficiency Virus Prophylaxis.

Muller WJ, Chadwick EG.

Infect Dis Clin North Am. 2018 Mar;32(1):91-101. doi: 10.1016/j.idc.2017.10.006. Review.


In vivo evidence supporting a metastasis suppressor role for Stard13 (Dlc2) in ErbB2 (Neu) oncogene induced mouse mammary tumors.

Basak P, Leslie H, Dillon RL, Muller WJ, Raouf A, Mowat MRA.

Genes Chromosomes Cancer. 2018 Apr;57(4):182-191. doi: 10.1002/gcc.22519. Epub 2017 Dec 29.


Progressive polarity loss and luminal collapse disrupt tissue organization in carcinoma.

Halaoui R, Rejon C, Chatterjee SJ, Szymborski J, Meterissian S, Muller WJ, Omeroglu A, McCaffrey L.

Genes Dev. 2017 Aug 1;31(15):1573-1587. doi: 10.1101/gad.300566.117. Epub 2017 Sep 8.


ErbB2-positive mammary tumors can escape PI3K-p110α loss through downregulation of the Pten tumor suppressor.

Simond AM, Rao T, Zuo D, Zhao JJ, Muller WJ.

Oncogene. 2017 Oct 26;36(43):6059-6066. doi: 10.1038/onc.2017.264. Epub 2017 Aug 7.


Two distinct mTORC2-dependent pathways converge on Rac1 to drive breast cancer metastasis.

Morrison Joly M, Williams MM, Hicks DJ, Jones B, Sanchez V, Young CD, Sarbassov DD, Muller WJ, Brantley-Sieders D, Cook RS.

Breast Cancer Res. 2017 Jun 30;19(1):74. doi: 10.1186/s13058-017-0868-8.


Stat3 regulates centrosome clustering in cancer cells via Stathmin/PLK1.

Morris EJ, Kawamura E, Gillespie JA, Balgi A, Kannan N, Muller WJ, Roberge M, Dedhar S.

Nat Commun. 2017 May 5;8:15289. doi: 10.1038/ncomms15289.


LPP is a Src substrate required for invadopodia formation and efficient breast cancer lung metastasis.

Ngan E, Stoletov K, Smith HW, Common J, Muller WJ, Lewis JD, Siegel PM.

Nat Commun. 2017 Apr 24;8:15059. doi: 10.1038/ncomms15059.


The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression.

Ahn R, Sabourin V, Bolt AM, Hébert S, Totten S, De Jay N, Festa MC, Young YK, Im YK, Pawson T, Koromilas AE, Muller WJ, Mann KK, Kleinman CL, Ursini-Siegel J.

Nat Commun. 2017 Mar 9;8:14638. doi: 10.1038/ncomms14638.


Mapping sites of herpes simplex virus type 1 glycoprotein D that permit insertions and impact gD and gB receptors usage.

Fan Q, Kopp S, Connolly SA, Muller WJ, Longnecker R.

Sci Rep. 2017 Mar 3;7:43712. doi: 10.1038/srep43712.


β-Catenin haploinsufficiency promotes mammary tumorigenesis in an ErbB2-positive basal breast cancer model.

Bui T, Schade B, Cardiff RD, Aina OH, Sanguin-Gendreau V, Muller WJ.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):E707-E716. doi: 10.1073/pnas.1610383114. Epub 2017 Jan 17. Erratum in: Proc Natl Acad Sci U S A. 2017 Mar 14;114(11):E2265. Tung, Bui [corrected to Bui, Tung].


The glucose transporter GLUT1 is required for ErbB2-induced mammary tumorigenesis.

Wellberg EA, Johnson S, Finlay-Schultz J, Lewis AS, Terrell KL, Sartorius CA, Abel ED, Muller WJ, Anderson SM.

Breast Cancer Res. 2016 Dec 20;18(1):131. doi: 10.1186/s13058-016-0795-0.


Preliminary Results From the US Zika Pregnancy Registry: Untangling Risks for Congenital Anomalies.

Muller WJ, Miller ES.

JAMA. 2017 Jan 3;317(1):35-36. doi: 10.1001/jama.2016.18632. No abstract available.


Ablation of miR-10b Suppresses Oncogene-Induced Mammary Tumorigenesis and Metastasis and Reactivates Tumor-Suppressive Pathways.

Kim J, Siverly AN, Chen D, Wang M, Yuan Y, Wang Y, Lee H, Zhang J, Muller WJ, Liang H, Gan B, Yang X, Sun Y, You MJ, Ma L.

Cancer Res. 2016 Nov 1;76(21):6424-6435. Epub 2016 Aug 28.


Treatment of perinatal viral infections to improve neurologic outcomes.

Muller WJ.

Pediatr Res. 2017 Jan;81(1-2):162-169. doi: 10.1038/pr.2016.191. Epub 2016 Sep 27. Review.


Whole Genome Comparison of Thermus sp. NMX2.A1 Reveals Principle Carbon Metabolism Differences with Closest Relation Thermus scotoductus SA-01.

Müller WJ, Tlalajoe N, Cason ED, Litthauer D, Reva O, Brzuszkiewicz E, van Heerden E.

G3 (Bethesda). 2016 Sep 8;6(9):2791-7. doi: 10.1534/g3.116.032953.


ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer.

Deblois G, Smith HW, Tam IS, Gravel SP, Caron M, Savage P, Labbé DP, Bégin LR, Tremblay ML, Park M, Bourque G, St-Pierre J, Muller WJ, Giguère V.

Nat Commun. 2016 Jul 12;7:12156. doi: 10.1038/ncomms12156.


IV pentamidine for Pneumocystis jiroveci pneumonia prophylaxis in pediatric allogeneic stem cell transplant patients.

Curi DA, Duerst RE, Badke C, Bell J, Chaudhury S, Kletzel M, Schneiderman J, Tse WT, Muller WJ, Hijiya N.

Bone Marrow Transplant. 2016 Oct;51(10):1394-1396. doi: 10.1038/bmt.2016.133. Epub 2016 May 23. No abstract available.


Rictor/mTORC2 Drives Progression and Therapeutic Resistance of HER2-Amplified Breast Cancers.

Morrison Joly M, Hicks DJ, Jones B, Sanchez V, Estrada MV, Young C, Williams M, Rexer BN, Sarbassov dos D, Muller WJ, Brantley-Sieders D, Cook RS.

Cancer Res. 2016 Aug 15;76(16):4752-64. doi: 10.1158/0008-5472.CAN-15-3393. Epub 2016 Apr 25.


The ErbB2ΔEx16 splice variant is a major oncogenic driver in breast cancer that promotes a pro-metastatic tumor microenvironment.

Turpin J, Ling C, Crosby EJ, Hartman ZC, Simond AM, Chodosh LA, Rennhack JP, Andrechek ER, Ozcelik J, Hallett M, Mills GB, Cardiff RD, Gray JW, Griffith OL, Muller WJ.

Oncogene. 2016 Nov 24;35(47):6053-6064. doi: 10.1038/onc.2016.129. Epub 2016 May 9.


The Type I Interferon Response Determines Differences in Choroid Plexus Susceptibility between Newborns and Adults in Herpes Simplex Virus Encephalitis.

Wilcox DR, Folmsbee SS, Muller WJ, Longnecker R.

MBio. 2016 Apr 12;7(2):e00437-16. doi: 10.1128/mBio.00437-16.


Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression.

Boulay PL, Mitchell L, Turpin J, Huot-Marchand JÉ, Lavoie C, Sanguin-Gendreau V, Jones L, Mitra S, Livingstone JM, Campbell S, Hallett M, Mills GB, Park M, Chodosh L, Strathdee D, Norman JC, Muller WJ.

Cancer Res. 2016 May 1;76(9):2662-74. doi: 10.1158/0008-5472.CAN-15-2782. Epub 2016 Mar 1.


Use of a genetically engineered mouse model as a preclinical tool for HER2 breast cancer.

Creedon H, Balderstone LA, Muir M, Balla J, Gomez-Cuadrado L, Tracey N, Loane J, Klinowska T, Muller WJ, Brunton VG.

Dis Model Mech. 2016 Feb;9(2):131-40. doi: 10.1242/dmm.023143. Epub 2015 Dec 31.


STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis.

Jones LM, Broz ML, Ranger JJ, Ozcelik J, Ahn R, Zuo D, Ursini-Siegel J, Hallett MT, Krummel M, Muller WJ.

Cancer Res. 2016 Mar 15;76(6):1416-28. doi: 10.1158/0008-5472.CAN-15-2770. Epub 2015 Dec 30.


PIK3CA(H1047R)- and Her2-initiated mammary tumors escape PI3K dependency by compensatory activation of MEK-ERK signaling.

Cheng H, Liu P, Ohlson C, Xu E, Symonds L, Isabella A, Muller WJ, Lin NU, Krop IE, Roberts TM, Winer EP, Arteaga CL, Zhao JJ.

Oncogene. 2016 Jun 9;35(23):2961-70. doi: 10.1038/onc.2015.377. Epub 2015 Dec 7.


HSV targeting of the host phosphatase PP1α is required for disseminated disease in the neonate and contributes to pathogenesis in the brain.

Wilcox DR, Muller WJ, Longnecker R.

Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):E6937-44. doi: 10.1073/pnas.1513045112. Epub 2015 Nov 30.


What do metabolic rates tell us about thermal niches? Mechanisms driving crayfish distributions along an altitudinal gradient.

Stoffels RJ, Richardson AJ, Vogel MT, Coates SP, Müller WJ.

Oecologia. 2016 Jan;180(1):45-54. doi: 10.1007/s00442-015-3463-7. Epub 2015 Oct 6.


Loss of PTPN12 Stimulates Progression of ErbB2-Dependent Breast Cancer by Enhancing Cell Survival, Migration, and Epithelial-to-Mesenchymal Transition.

Li J, Davidson D, Martins Souza C, Zhong MC, Wu N, Park M, Muller WJ, Veillette A.

Mol Cell Biol. 2015 Dec;35(23):4069-82. doi: 10.1128/MCB.00741-15. Epub 2015 Sep 21.


Aspergillus thyroiditis: first antemortem case diagnosed by fine-needle aspiration culture in a pediatric stem cell transplant patient.

Badawy SM, Becktell KD, Muller WJ, Schneiderman J.

Transpl Infect Dis. 2015 Dec;17(6):868-71. doi: 10.1111/tid.12445. Epub 2015 Oct 7.


Early viral suppression improves neurocognitive outcomes in HIV-infected children.

Crowell CS, Huo Y, Tassiopoulos K, Malee KM, Yogev R, Hazra R, Rutstein RM, Nichols SL, Smith RA, Williams PL, Oleske J, Muller WJ; PACTG 219C Study Team and the Pediatric HIVAIDS Cohort Study (PHACS).

AIDS. 2015 Jan 28;29(3):295-304. doi: 10.1097/QAD.0000000000000528.


Loss of periostin/OSF-2 in ErbB2/Neu-driven tumors results in androgen receptor-positive molecular apocrine-like tumors with reduced Notch1 activity.

Sriram R, Lo V, Pryce B, Antonova L, Mears AJ, Daneshmand M, McKay B, Conway SJ, Muller WJ, Sabourin LA.

Breast Cancer Res. 2015 Jan 16;17:7. doi: 10.1186/s13058-014-0513-8.


Differential reliance on autophagy for protection from HSV encephalitis between newborns and adults.

Wilcox DR, Wadhwani NR, Longnecker R, Muller WJ.

PLoS Pathog. 2015 Jan 8;11(1):e1004580. doi: 10.1371/journal.ppat.1004580. eCollection 2015 Jan.


ERBB2 deficiency alters an E2F-1-dependent adaptive stress response and leads to cardiac dysfunction.

Perry MC, Dufour CR, Eichner LJ, Tsang DW, Deblois G, Muller WJ, Giguère V.

Mol Cell Biol. 2014 Dec 1;34(23):4232-43. doi: 10.1128/MCB.00895-14. Epub 2014 Sep 22.


Herpes simplex virus serotype and entry receptor availability alter CNS disease in a mouse model of neonatal HSV.

Kopp SJ, Ranaivo HR, Wilcox DR, Karaba AH, Wainwright MS, Muller WJ.

Pediatr Res. 2014 Dec;76(6):528-34. doi: 10.1038/pr.2014.135. Epub 2014 Sep 8.


Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling.

Bagci H, Laurin M, Huber J, Muller WJ, Côté JF.

Cell Death Dis. 2014 Aug 14;5:e1375. doi: 10.1038/cddis.2014.338.


Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model.

Roselli S, Kahl RG, Copeland BT, Naylor MJ, Weidenhofer J, Muller WJ, Ashman LK.

BMC Cancer. 2014 Jul 11;14:509. doi: 10.1186/1471-2407-14-509.


Herpesvirus entry mediator (HVEM) attenuates signals mediated by the lymphotoxin β receptor (LTβR) in human cells stimulated by the shared ligand LIGHT.

Bechill J, Muller WJ.

Mol Immunol. 2014 Nov;62(1):96-103. doi: 10.1016/j.molimm.2014.06.013. Epub 2014 Jun 28.


Mammary tumour development is dose-dependently inhibited by n-3 polyunsaturated fatty acids in the MMTV-neu(ndl)-YD5 transgenic mouse model.

Leslie MA, Abdelmagid SA, Perez K, Muller WJ, Ma DW.

Lipids Health Dis. 2014 Jun 11;13:96. doi: 10.1186/1476-511X-13-96.


Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3.

Robichaud N, del Rincon SV, Huor B, Alain T, Petruccelli LA, Hearnden J, Goncalves C, Grotegut S, Spruck CH, Furic L, Larsson O, Muller WJ, Miller WH, Sonenberg N.

Oncogene. 2015 Apr 16;34(16):2032-42. doi: 10.1038/onc.2014.146. Epub 2014 Jun 9.


Neurologic disease in HIV-infected children and the impact of combination antiretroviral therapy.

Crowell CS, Malee KM, Yogev R, Muller WJ.

Rev Med Virol. 2014 Sep;24(5):316-31. doi: 10.1002/rmv.1793. Epub 2014 May 8. Review.


c-Src drives intestinal regeneration and transformation.

Cordero JB, Ridgway RA, Valeri N, Nixon C, Frame MC, Muller WJ, Vidal M, Sansom OJ.

EMBO J. 2014 Jul 1;33(13):1474-91. doi: 10.1002/embj.201387454. Epub 2014 Apr 30.


Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors.

Sahin O, Wang Q, Brady SW, Ellis K, Wang H, Chang CC, Zhang Q, Priya P, Zhu R, Wong ST, Landis MD, Muller WJ, Esteva FJ, Chang J, Yu D.

Cell Res. 2014 May;24(5):542-59. doi: 10.1038/cr.2014.37. Epub 2014 Mar 28.


RUNX2 correlates with subtype-specific breast cancer in a human tissue microarray, and ectopic expression of Runx2 perturbs differentiation in the mouse mammary gland.

McDonald L, Ferrari N, Terry A, Bell M, Mohammed ZM, Orange C, Jenkins A, Muller WJ, Gusterson BA, Neil JC, Edwards J, Morris JS, Cameron ER, Blyth K.

Dis Model Mech. 2014 May;7(5):525-34. doi: 10.1242/dmm.015040. Epub 2014 Mar 13.


Inactivation of the Hippo tumour suppressor pathway by integrin-linked kinase.

Serrano I, McDonald PC, Lock F, Muller WJ, Dedhar S.

Nat Commun. 2013;4:2976. doi: 10.1038/ncomms3976.


Transgenic mouse models--a seminal breakthrough in oncogene research.

Smith HW, Muller WJ.

Cold Spring Harb Protoc. 2013 Dec 1;2013(12):1099-108. doi: 10.1101/pdb.top069765. Review.


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