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What can early Canadian experience screening for COVID-19 teach us about how to prepare for a pandemic?

Lin M, Beliavsky A, Katz K, Powis JE, Ng W, Williams V, Science M, Groves H, Muller MP, Vaisman A, Hota S, Johnstone J, Leis JA.

CMAJ. 2020 Mar 6. pii: cmaj.200305. doi: 10.1503/cmaj.200305. [Epub ahead of print] No abstract available.


Sources of viral respiratory infections in Canadian acute care hospital healthcare personnel.

Buckrell S, Coleman BL, McNeil SA, Katz K, Muller MP, Simor A, Loeb M, Powis J, Kuster SP, Di Bella JM, Coleman KKL, Drews SJ, Kohler P, McGeer A; Canadian Healthcare Worker Study Group.

J Hosp Infect. 2020 Jan 16. pii: S0195-6701(20)30012-8. doi: 10.1016/j.jhin.2020.01.009. [Epub ahead of print]


Inhibition of osimertinib-resistant epidermal growth factor receptor EGFR-T790M/C797S.

Lategahn J, Keul M, Klövekorn P, Tumbrink HL, Niggenaber J, Müller MP, Hodson L, Flaßhoff M, Hardick J, Grabe T, Engel J, Schultz-Fademrecht C, Baumann M, Ketzer J, Mühlenberg T, Hiller W, Günther G, Unger A, Müller H, Heimsoeth A, Golz C, Blank-Landeshammer B, Kollipara L, Zahedi RP, Strohmann C, Hengstler JG, van Otterlo WAL, Bauer S, Rauh D.

Chem Sci. 2019 Oct 4;10(46):10789-10801. doi: 10.1039/c9sc03445e. eCollection 2019 Dec 14.


External validation of clinical prediction rules for complications and mortality following Clostridioides difficile infection.

Beauregard-Paultre C, Abou Chakra CN, McGeer A, Labbé AC, Simor AE, Gold W, Muller MP, Powis J, Katz K, Cadarette SM, Pépin J, Valiquette L.

PLoS One. 2019 Dec 17;14(12):e0226672. doi: 10.1371/journal.pone.0226672. eCollection 2019.


Augmented Reality in Scientific Publications - Taking the Visualization of 3D Structures to the Next Level.

Wolle P, Müller MP, Rauh D.

ACS Chem Biol. 2020 Jan 17;15(1):296-297. doi: 10.1021/acschembio.9b00951. Epub 2019 Dec 12. No abstract available.


Morbidity in an adenosine deaminase-deficient patient during 27 years of enzyme replacement therapy.

Grunebaum E, Reid B, Naqvi A, Hershfield MS, Kim VH, Muller MP, Hicks LK, Lee E, Betschel S, Roifman CM.

Clin Immunol. 2020 Feb;211:108321. doi: 10.1016/j.clim.2019.108321. Epub 2019 Dec 5.


Predictors of Treatment Failure for Hip and Knee Prosthetic Joint Infections in the Setting of 1- and 2-Stage Exchange Arthroplasty: A Multicenter Retrospective Cohort.

Kandel CE, Jenkinson R, Daneman N, Backstein D, Hansen BE, Muller MP, Katz KC, Widdifield J, Bogoch E, Ward S, Sajja A, Jeldes FG, McGeer A.

Open Forum Infect Dis. 2019 Oct 21;6(11):ofz452. doi: 10.1093/ofid/ofz452. eCollection 2019 Nov.


Covalent-Allosteric Inhibitors to Achieve Akt Isoform-Selectivity.

Quambusch L, Landel I, Depta L, Weisner J, Uhlenbrock N, Müller MP, Glanemann F, Althoff K, Siveke JT, Rauh D.

Angew Chem Int Ed Engl. 2019 Dec 19;58(52):18823-18829. doi: 10.1002/anie.201909857. Epub 2019 Nov 8.


Coherence and Asymmetry Cannot be Broadcast.

Lostaglio M, Müller MP.

Phys Rev Lett. 2019 Jul 12;123(2):020403. doi: 10.1103/PhysRevLett.123.020403.


Mutant-Specific Targeting of Ras G12C Activity by Covalently Reacting Small Molecules.

Goody RS, Müller MP, Rauh D.

Cell Chem Biol. 2019 Oct 17;26(10):1338-1348. doi: 10.1016/j.chembiol.2019.07.005. Epub 2019 Aug 1. Review.


Von Neumann Entropy from Unitarity.

Boes P, Eisert J, Gallego R, Müller MP, Wilming H.

Phys Rev Lett. 2019 May 31;122(21):210402. doi: 10.1103/PhysRevLett.122.210402.


Infection prevention and control practices related to carbapenemase-producing Enterobacteriaceae (CPE) in acute-care hospitals in Ontario, Canada.

Jamal AJ, Garcia-Jeldes F, Baqi M, Borgia S, Johnstone J, Katz K, Kohler P, Muller MP, McGeer AJ; CPE Investigators of the Toronto Invasive Bacterial Diseases Network.

Infect Control Hosp Epidemiol. 2019 Sep;40(9):1006-1012. doi: 10.1017/ice.2019.173. Epub 2019 Jun 27.


Which healthcare workers work with acute respiratory illness? Evidence from Canadian acute-care hospitals during 4 influenza seasons: 2010-2011 to 2013-2014.

Jiang L, McGeer A, McNeil S, Katz K, Loeb M, Muller MP, Simor A, Powis J, Kohler P, Di Bella JM, Coleman BL; Canadian Healthcare Worker Study Group.

Infect Control Hosp Epidemiol. 2019 Aug;40(8):889-896. doi: 10.1017/ice.2019.141. Epub 2019 Jun 18.


Structural and chemical insights into the covalent-allosteric inhibition of the protein kinase Akt.

Uhlenbrock N, Smith S, Weisner J, Landel I, Lindemann M, Le TA, Hardick J, Gontla R, Scheinpflug R, Czodrowski P, Janning P, Depta L, Quambusch L, Müller MP, Engels B, Rauh D.

Chem Sci. 2019 Feb 13;10(12):3573-3585. doi: 10.1039/c8sc05212c. eCollection 2019 Mar 28.


Characterization of Lipid-Protein Interactions and Lipid-Mediated Modulation of Membrane Protein Function through Molecular Simulation.

Muller MP, Jiang T, Sun C, Lihan M, Pant S, Mahinthichaichan P, Trifan A, Tajkhorshid E.

Chem Rev. 2019 May 8;119(9):6086-6161. doi: 10.1021/acs.chemrev.8b00608. Epub 2019 Apr 12.


2-Azo-, 2-diazocine-thiazols and 2-azo-imidazoles as photoswitchable kinase inhibitors: limitations and pitfalls of the photoswitchable inhibitor approach.

Schehr M, Ianes C, Weisner J, Heintze L, Müller MP, Pichlo C, Charl J, Brunstein E, Ewert J, Lehr M, Baumann U, Rauh D, Knippschild U, Peifer C, Herges R.

Photochem Photobiol Sci. 2019 Jun 12;18(6):1398-1407. doi: 10.1039/c9pp00010k.


The measurement postulates of quantum mechanics are operationally redundant.

Masanes L, Galley TD, Müller MP.

Nat Commun. 2019 Mar 25;10(1):1361. doi: 10.1038/s41467-019-09348-x.


Preclinical Efficacy of Covalent-Allosteric AKT Inhibitor Borussertib in Combination with Trametinib in KRAS-Mutant Pancreatic and Colorectal Cancer.

Weisner J, Landel I, Reintjes C, Uhlenbrock N, Trajkovic-Arsic M, Dienstbier N, Hardick J, Ladigan S, Lindemann M, Smith S, Quambusch L, Scheinpflug R, Depta L, Gontla R, Unger A, Müller H, Baumann M, Schultz-Fademrecht C, Günther G, Maghnouj A, Müller MP, Pohl M, Teschendorf C, Wolters H, Viebahn R, Tannapfel A, Uhl W, Hengstler JG, Hahn SA, Siveke JT, Rauh D.

Cancer Res. 2019 May 1;79(9):2367-2378. doi: 10.1158/0008-5472.CAN-18-2861. Epub 2019 Mar 11.


Emergence of Carbapenemase-Producing Enterobacteriaceae, South-Central Ontario, Canada1.

Kohler PP, Melano RG, Patel SN, Shafinaz S, Faheem A, Coleman BL, Green K, Armstrong I, Almohri H, Borgia S, Borgundvaag E, Johnstone J, Katz K, Lam F, Muller MP, Powis J, Poutanen SM, Richardson D, Rebbapragada A, Sarabia A, Simor A, McGeer A; Toronto Invasive Bacterial Diseases Network (TIBDN).

Emerg Infect Dis. 2018 Sep;24(9):1674-1682. doi: 10.3201/eid2409.180164.


Antimicrobial Stewardship and Intensive Care Unit Mortality: A Systematic Review.

Lindsay PJ, Rohailla S, Taggart LR, Lightfoot D, Havey T, Daneman N, Lowe C, Muller MP.

Clin Infect Dis. 2019 Feb 15;68(5):748-756. doi: 10.1093/cid/ciy550.


Response to Schmidt et al.: Antimicrobial surfaces - huge potential, significant uncertainty.

Muller MP, MacDougall C, Lim M; Ontario Agency for Health Protection and Promotion (Public Health Ontario) the Provincial Infectious Diseases Advisory Committee on Infection Prevention and Control (PIDAC-IPC).

J Hosp Infect. 2018 Nov;100(3):e161-e162. doi: 10.1016/j.jhin.2018.06.001. Epub 2018 Jun 8. No abstract available.


An Unusual Intramolecular Halogen Bond Guides Conformational Selection.

Tesch R, Becker C, Müller MP, Beck ME, Quambusch L, Getlik M, Lategahn J, Uhlenbrock N, Costa FN, Polêto MD, Pinheiro PSM, Rodrigues DA, Sant'Anna CMR, Ferreira FF, Verli H, Fraga CAM, Rauh D.

Angew Chem Int Ed Engl. 2018 Jul 26;57(31):9970-9975. doi: 10.1002/anie.201804917. Epub 2018 Jul 9.


Assays for Nucleotide Competitive Reversible and Irreversible Inhibitors of Ras GTPases.

Jeganathan S, Müller MP, Ali I, Goody RS.

Biochemistry. 2018 Aug 7;57(31):4690-4699. doi: 10.1021/acs.biochem.8b00234. Epub 2018 Jun 11.


Structure of the tandem PX-PH domains of Bem3 from Saccharomyces cerevisiae.

Ali I, Eu S, Koch D, Bleimling N, Goody RS, Müller MP.

Acta Crystallogr F Struct Biol Commun. 2018 May 1;74(Pt 5):315-321. doi: 10.1107/S2053230X18005915. Epub 2018 Apr 24.


Augmented Reality in Scientific Publications-Taking the Visualization of 3D Structures to the Next Level.

Wolle P, Müller MP, Rauh D.

ACS Chem Biol. 2018 Mar 16;13(3):496-499. doi: 10.1021/acschembio.8b00153. Erratum in: ACS Chem Biol. 2020 Jan 17;15(1):296-297.


Try Me: Promiscuous Inhibitors Still Allow for Selective Targeted Protein Degradation.

Müller MP, Rauh D.

Cell Chem Biol. 2018 Jan 18;25(1):4-6. doi: 10.1016/j.chembiol.2018.01.004.


Adenovirus-related epidemic keratoconjunctivitis outbreak at a hospital-affiliated ophthalmology clinic.

Muller MP, Siddiqui N, Ivancic R, Wong D.

Am J Infect Control. 2018 May;46(5):581-583. doi: 10.1016/j.ajic.2017.11.011. Epub 2018 Jan 2.


The complex and quaternionic quantum bit from relativity of simultaneity on an interferometer.

Garner AJP, Müller MP, Dahlsten OCO.

Proc Math Phys Eng Sci. 2017 Dec;473(2208):20170596. doi: 10.1098/rspa.2017.0596. Epub 2017 Dec 6.


Proximity-Triggered Covalent Stabilization of Low-Affinity Protein Complexes In Vitro and In Vivo.

Cigler M, Müller TG, Horn-Ghetko D, von Wrisberg MK, Fottner M, Goody RS, Itzen A, Müller MP, Lang K.

Angew Chem Int Ed Engl. 2017 Dec 4;56(49):15737-15741. doi: 10.1002/anie.201706927. Epub 2017 Nov 9.


Virtual Reality for CPR training: How cool is that? Dedicated to the "next generation".

Semeraro F, Scapigliati A, Ristagno G, Luciani A, Gandolfi S, Lockey A, Müller MP, Wingen S, Böttiger BW.

Resuscitation. 2017 Dec;121:e1-e2. doi: 10.1016/j.resuscitation.2017.09.024. Epub 2017 Sep 23. No abstract available.


Structure-based design, synthesis and crystallization of 2-arylquinazolines as lipid pocket ligands of p38α MAPK.

Bührmann M, Wiedemann BM, Müller MP, Hardick J, Ecke M, Rauh D.

PLoS One. 2017 Sep 11;12(9):e0184627. doi: 10.1371/journal.pone.0184627. eCollection 2017.


Lipid specificity of the membrane binding domain of coagulation factor X.

Muller MP, Wang Y, Morrissey JH, Tajkhorshid E.

J Thromb Haemost. 2017 Oct;15(10):2005-2016. doi: 10.1111/jth.13788. Epub 2017 Sep 1.


Nucleotide based covalent inhibitors of KRas can only be efficient in vivo if they bind reversibly with GTP-like affinity.

Müller MP, Jeganathan S, Heidrich A, Campos J, Goody RS.

Sci Rep. 2017 Jun 16;7(1):3687. doi: 10.1038/s41598-017-03973-6.


Hamiltonian for the Zeros of the Riemann Zeta Function.

Bender CM, Brody DC, Müller MP.

Phys Rev Lett. 2017 Mar 31;118(13):130201. doi: 10.1103/PhysRevLett.118.130201. Epub 2017 Mar 30.


Multivalency in Rab effector interactions.

Rai A, Goody RS, Müller MP.

Small GTPases. 2019 Jan;10(1):40-46. doi: 10.1080/21541248.2016.1265700. Epub 2017 Jan 27.


Genome-wide mapping of 10 calving and fertility traits in Holstein dairy cattle with special regard to chromosome 18.

Müller MP, Rothammer S, Seichter D, Russ I, Hinrichs D, Tetens J, Thaller G, Medugorac I.

J Dairy Sci. 2017 Mar;100(3):1987-2006. doi: 10.3168/jds.2016-11506. Epub 2017 Jan 18.


Molecular control of Rab activity by GEFs, GAPs and GDI.

Müller MP, Goody RS.

Small GTPases. 2018 Mar 4;9(1-2):5-21. doi: 10.1080/21541248.2016.1276999. Epub 2017 Feb 1. Review.


Mechanisms of action of Rab proteins, key regulators of intracellular vesicular transport.

Goody RS, Müller MP, Wu YW.

Biol Chem. 2017 May 1;398(5-6):565-575. doi: 10.1515/hsz-2016-0274. Review.


Community- and Healthcare-Associated Methicillin-Resistant Staphylococcus aureus Strains: An Investigation Into Household Transmission, Risk Factors, and Environmental Contamination.

Ng W, Faheem A, McGeer A, Simor AE, Gelosia A, Willey BM, Watt C, Richardson DC, Wong H, Ostrowska K, Vernich L, Muller MP, Gnanasuntharam P, Porter V, Katz K.

Infect Control Hosp Epidemiol. 2017 Jan;38(1):61-67. doi: 10.1017/ice.2016.245. Epub 2016 Nov 8.


Reduction in total patient isolation days with a change in influenza testing methodology.

Muller MP, Junaid S, Matukas LM.

Am J Infect Control. 2016 Nov 1;44(11):1346-1349. doi: 10.1016/j.ajic.2016.03.019. Epub 2016 May 5.


Pollinator adaptation and the evolution of floral nectar sugar composition.

Abrahamczyk S, Kessler M, Hanley D, Karger DN, Müller MP, Knauer AC, Keller F, Schwerdtfeger M, Humphreys AM.

J Evol Biol. 2017 Jan;30(1):112-127. doi: 10.1111/jeb.12991. Epub 2016 Nov 14.


Measuring hand hygiene when it matters.

Muller MP.

Lancet Infect Dis. 2016 Dec;16(12):1306-1307. doi: 10.1016/S1473-3099(16)30335-8. Epub 2016 Sep 3. No abstract available.


bMERB domains are bivalent Rab8 family effectors evolved by gene duplication.

Rai A, Oprisko A, Campos J, Fu Y, Friese T, Itzen A, Goody RS, Gazdag EM, Müller MP.

Elife. 2016 Aug 23;5. pii: e18675. doi: 10.7554/eLife.18675.


Microscopic Characterization of Membrane Transporter Function by In Silico Modeling and Simulation.

Vermaas JV, Trebesch N, Mayne CG, Thangapandian S, Shekhar M, Mahinthichaichan P, Baylon JL, Jiang T, Wang Y, Muller MP, Shinn E, Zhao Z, Wen PC, Tajkhorshid E.

Methods Enzymol. 2016;578:373-428. doi: 10.1016/bs.mie.2016.05.042. Epub 2016 Jul 11. Review.


Atomic-level description of protein-lipid interactions using an accelerated membrane model.

Baylon JL, Vermaas JV, Muller MP, Arcario MJ, Pogorelov TV, Tajkhorshid E.

Biochim Biophys Acta. 2016 Jul;1858(7 Pt B):1573-83. doi: 10.1016/j.bbamem.2016.02.027. Epub 2016 Mar 2. Review.


A pull-down procedure for the identification of unknown GEFs for small GTPases.

Koch D, Rai A, Ali I, Bleimling N, Friese T, Brockmeyer A, Janning P, Goud B, Itzen A, Müller MP, Goody RS.

Small GTPases. 2016 Apr 2;7(2):93-106. doi: 10.1080/21541248.2016.1156803. Epub 2016 Feb 26.


Cumulative Antimicrobial Susceptibility Data from Intensive Care Units at One Institution: Should Data Be Combined?

Campigotto A, Muller MP, Taggart LR, Haj R, Leung E, Nadarajah J, Matukas LM.

J Clin Microbiol. 2016 Apr;54(4):956-9. doi: 10.1128/JCM.02992-15. Epub 2016 Jan 20.


Clostridium difficile infection incidence: impact of audit and feedback programme to improve room cleaning.

Smith A, Taggart LR, Lebovic G, Zeynalova N, Khan A, Muller MP.

J Hosp Infect. 2016 Feb;92(2):161-6. doi: 10.1016/j.jhin.2015.11.001. Epub 2015 Nov 11.


Antimicrobial surfaces to prevent healthcare-associated infections: a systematic review.

Muller MP, MacDougall C, Lim M; Ontario Agency for Health Protection and Promotion Public Health Ontario; Provincial Infectious Diseases Advisory Committee on Infection Prevention and Control; Provincial Infectious Diseases Advisory Committee on Infection Prevention and Control.

J Hosp Infect. 2016 Jan;92(1):7-13. doi: 10.1016/j.jhin.2015.09.008. Epub 2015 Oct 3. Review.


Stochastic Independence as a Resource in Small-Scale Thermodynamics.

Lostaglio M, Müller MP, Pastena M.

Phys Rev Lett. 2015 Oct 9;115(15):150402. doi: 10.1103/PhysRevLett.115.150402. Epub 2015 Oct 9.


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