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Items: 1 to 50 of 154

1.

Diaryl hydroxylamines as pan or dual inhibitors of indoleamine 2,3-dioxygenase-1, indoleamine 2,3-dioxygenase-2 and tryptophan dioxygenase.

Winters M, DuHadaway JB, Pham KN, Lewis-Ballester A, Badir S, Wai J, Sheikh E, Yeh SR, Prendergast GC, Muller AJ, Malachowski WP.

Eur J Med Chem. 2018 Nov 14;162:455-464. doi: 10.1016/j.ejmech.2018.11.010. [Epub ahead of print]

PMID:
30469041
2.

CD11c-expressing Ly6C+CCR2+ monocytes constitute a reservoir for efficient Leishmania proliferation and cell-to-cell transmission.

Heyde S, Philipsen L, Formaglio P, Fu Y, Baars I, Höbbel G, Kleinholz CL, Seiß EA, Stettin J, Gintschel P, Dudeck A, Bousso P, Schraven B, Müller AJ.

PLoS Pathog. 2018 Oct 22;14(10):e1007374. doi: 10.1371/journal.ppat.1007374. eCollection 2018 Oct.

3.

Cold shock Y-box binding protein-1 acetylation status in monocytes is associated with systemic inflammation and vascular damage.

Ewert L, Fischer A, Brandt S, Scurt FG, Philipsen L, Müller AJ, Girndt M, Zenclussen AC, Lindquist JA, Gorny X, Mertens PR.

Atherosclerosis. 2018 Nov;278:156-165. doi: 10.1016/j.atherosclerosis.2018.09.020. Epub 2018 Sep 22.

PMID:
30278358
4.

Host IDO2 Gene Status Influences Tumor Progression and Radiotherapy Response in KRAS-Driven Sporadic Pancreatic Cancers.

Nevler A, Muller AJ, Sutanto-Ward E, DuHadaway JB, Nagatomo K, Londin E, O'Hayer K, Cozzitorto JA, Lavu H, Yeo TP, Curtis M, Villatoro T, Leiby BE, Mandik-Nayak L, Winter JM, Yeo CJ, Prendergast GC, Brody JR.

Clin Cancer Res. 2018 Sep 28. doi: 10.1158/1078-0432.CCR-18-0814. [Epub ahead of print]

PMID:
30266763
5.

Indoximod: An Immunometabolic Adjuvant That Empowers T Cell Activity in Cancer.

Fox E, Oliver T, Rowe M, Thomas S, Zakharia Y, Gilman PB, Muller AJ, Prendergast GC.

Front Oncol. 2018 Sep 11;8:370. doi: 10.3389/fonc.2018.00370. eCollection 2018. Review.

6.

Inhibiting IDO pathways to treat cancer: lessons from the ECHO-301 trial and beyond.

Muller AJ, Manfredi MG, Zakharia Y, Prendergast GC.

Semin Immunopathol. 2018 Sep 10. doi: 10.1007/s00281-018-0702-0. [Epub ahead of print] Review.

PMID:
30203227
7.

Evidence for subtypes of freezing of gait in Parkinson's disease.

Ehgoetz Martens KA, Shine JM, Walton CC, Georgiades MJ, Gilat M, Hall JM, Muller AJ, Szeto JYY, Lewis SJG.

Mov Disord. 2018 Jul;33(7):1174-1178. doi: 10.1002/mds.27417.

PMID:
30153383
8.

JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation.

Edelmann B, Gupta N, Schnoeder TM, Oelschlegel AM, Shahzad K, Goldschmidt J, Philipsen L, Weinert S, Ghosh A, Saalfeld FC, Nimmagadda SC, Müller P, Braun-Dullaeus R, Mohr J, Wolleschak D, Kliche S, Amthauer H, Heidel FH, Schraven B, Isermann B, Müller AJ, Fischer T.

J Clin Invest. 2018 Oct 1;128(10):4359-4371. doi: 10.1172/JCI90312. Epub 2018 Jul 19.

9.

CO2 Selective PolyActive Membrane: Thermal Transitions and Gas Permeance as a Function of Thickness.

Rahman MM, Abetz C, Shishatskiy S, Martin J, Müller AJ, Abetz V.

ACS Appl Mater Interfaces. 2018 Aug 8;10(31):26733-26744. doi: 10.1021/acsami.8b09259. Epub 2018 Jul 31.

PMID:
30019890
10.

Cognitive training for freezing of gait in Parkinson's disease: a randomized controlled trial.

Walton CC, Mowszowski L, Gilat M, Hall JM, O'Callaghan C, Muller AJ, Georgiades M, Szeto JYY, Ehgoetz Martens KA, Shine JM, Naismith SL, Lewis SJG.

NPJ Parkinsons Dis. 2018 May 18;4:15. doi: 10.1038/s41531-018-0052-6. eCollection 2018.

11.

Visual Hallucinations Are Characterized by Impaired Sensory Evidence Accumulation: Insights From Hierarchical Drift Diffusion Modeling in Parkinson's Disease.

O'Callaghan C, Hall JM, Tomassini A, Muller AJ, Walpola IC, Moustafa AA, Shine JM, Lewis SJG.

Biol Psychiatry Cogn Neurosci Neuroimaging. 2017 Nov;2(8):680-688. doi: 10.1016/j.bpsc.2017.04.007. Epub 2017 May 3.

PMID:
29560902
12.

Beware the intruder: Real time observation of infiltrated neutrophils and neutrophil-Microglia interaction during stroke in vivo.

Neumann J, Henneberg S, von Kenne S, Nolte N, Müller AJ, Schraven B, Görtler MW, Reymann KG, Gunzer M, Riek-Burchardt M.

PLoS One. 2018 Mar 15;13(3):e0193970. doi: 10.1371/journal.pone.0193970. eCollection 2018.

13.

A Sub-Type of Familial Pancreatic Cancer: Evidence and Implications of Loss-of-Function Polymorphisms in Indoleamine-2,3-Dioxygenase-2.

Nevler A, Muller AJ, Cozzitorto JA, Goetz A, Winter JM, Yeo TP, Lavu H, Yeo CJ, Prendergast GC, Brody JR.

J Am Coll Surg. 2018 Apr;226(4):596-603. doi: 10.1016/j.jamcollsurg.2017.12.052. Epub 2018 Feb 7.

14.

Indoleamine 2,3-Dioxygenase and Its Therapeutic Inhibition in Cancer.

Prendergast GC, Malachowski WJ, Mondal A, Scherle P, Muller AJ.

Int Rev Cell Mol Biol. 2018;336:175-203. doi: 10.1016/bs.ircmb.2017.07.004. Epub 2017 Sep 21. Review.

15.

Inflammatory Reprogramming with IDO1 Inhibitors: Turning Immunologically Unresponsive 'Cold' Tumors 'Hot'.

Prendergast GC, Mondal A, Dey S, Laury-Kleintop LD, Muller AJ.

Trends Cancer. 2018 Jan;4(1):38-58. doi: 10.1016/j.trecan.2017.11.005. Epub 2017 Dec 21. Review.

16.

Supernucleation and Orientation of Poly(butylene terephthalate) Crystals in Nanocomposites Containing Highly Reduced Graphene Oxide.

Colonna S, Pérez-Camargo RA, Chen H, Liu G, Wang D, Müller AJ, Saracco G, Fina A.

Macromolecules. 2017 Dec 12;50(23):9380-9393. doi: 10.1021/acs.macromol.7b01865. Epub 2017 Nov 21.

17.

Discovery of IDO1 Inhibitors: From Bench to Bedside.

Prendergast GC, Malachowski WP, DuHadaway JB, Muller AJ.

Cancer Res. 2017 Dec 15;77(24):6795-6811. doi: 10.1158/0008-5472.CAN-17-2285. Review.

18.

Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy.

Glodde N, Bald T, van den Boorn-Konijnenberg D, Nakamura K, O'Donnell JS, Szczepanski S, Brandes M, Eickhoff S, Das I, Shridhar N, Hinze D, Rogava M, van der Sluis TC, Ruotsalainen JJ, Gaffal E, Landsberg J, Ludwig KU, Wilhelm C, Riek-Burchardt M, Müller AJ, Gebhardt C, Scolyer RA, Long GV, Janzen V, Teng MWL, Kastenmüller W, Mazzone M, Smyth MJ, Tüting T, Hölzel M.

Immunity. 2017 Oct 17;47(4):789-802.e9. doi: 10.1016/j.immuni.2017.09.012.

19.

Ion-macromolecule interactions studied with model polyurethanes.

Fernández-d'Arlas B, Huertos MÁ, Müller AJ.

J Colloid Interface Sci. 2018 Jan 1;509:102-112. doi: 10.1016/j.jcis.2017.08.099. Epub 2017 Sep 2.

PMID:
28892743
20.

TCR signalling network organization at the immunological synapses of murine regulatory T cells.

van Ham M, Teich R, Philipsen L, Niemz J, Amsberg N, Wissing J, Nimtz M, Gröbe L, Kliche S, Thiel N, Klawonn F, Hubo M, Jonuleit H, Reichardt P, Müller AJ, Huehn J, Jänsch L.

Eur J Immunol. 2017 Dec;47(12):2043-2058. doi: 10.1002/eji.201747041. Epub 2017 Sep 12.

21.

Frontline Science: Leishmania mexicana amastigotes can replicate within neutrophils.

Hurrell BP, Beaumann M, Heyde S, Regli IB, Müller AJ, Tacchini-Cottier F.

J Leukoc Biol. 2017 Nov;102(5):1187-1198. doi: 10.1189/jlb.4HI0417-158R. Epub 2017 Aug 10.

PMID:
28798144
22.

Signal integration at the PI3K-p85-XBP1 hub endows coagulation protease activated protein C with insulin-like function.

Madhusudhan T, Wang H, Ghosh S, Dong W, Kumar V, Al-Dabet MM, Manoharan J, Nazir S, Elwakiel A, Bock F, Kohli S, Marquardt A, Sögüt I, Shahzad K, Müller AJ, Esmon CT, Nawroth PP, Reiser J, Chavakis T, Ruf W, Isermann B.

Blood. 2017 Sep 21;130(12):1445-1455. doi: 10.1182/blood-2017-02-767921. Epub 2017 Jul 7.

23.

WIPI3 and WIPI4 β-propellers are scaffolds for LKB1-AMPK-TSC signalling circuits in the control of autophagy.

Bakula D, Müller AJ, Zuleger T, Takacs Z, Franz-Wachtel M, Thost AK, Brigger D, Tschan MP, Frickey T, Robenek H, Macek B, Proikas-Cezanne T.

Nat Commun. 2017 May 31;8:15637. doi: 10.1038/ncomms15637.

24.

Self-Associated Polyamide Alloys with Tailored Polymorphism Transition and Lamellar Thickening for Advanced Mechanical Application.

Wang L, Dong X, Huang M, Müller AJ, Wang D.

ACS Appl Mater Interfaces. 2017 Jun 7;9(22):19238-19247. doi: 10.1021/acsami.7b04691. Epub 2017 May 25.

PMID:
28504516
25.

The Host Microbiome Regulates and Maintains Human Health: A Primer and Perspective for Non-Microbiologists.

Thomas S, Izard J, Walsh E, Batich K, Chongsathidkiet P, Clarke G, Sela DA, Muller AJ, Mullin JM, Albert K, Gilligan JP, DiGuilio K, Dilbarova R, Alexander W, Prendergast GC.

Cancer Res. 2017 Apr 15;77(8):1783-1812. doi: 10.1158/0008-5472.CAN-16-2929. Epub 2017 Mar 14. Review.

26.

Targeted antigen delivery to dendritic cells elicits robust antiviral T cell-mediated immunity in the liver.

Volckmar J, Gereke M, Ebensen T, Riese P, Philipsen L, Lienenklaus S, Wohlleber D, Klopfleisch R, Stegemann-Koniszewski S, Müller AJ, Gruber AD, Knolle P, Guzman CA, Bruder D.

Sci Rep. 2017 Mar 7;7:43985. doi: 10.1038/srep43985.

27.

De novo phosphorylation and conformational opening of the tyrosine kinase Lck act in concert to initiate T cell receptor signaling.

Philipsen L, Reddycherla AV, Hartig R, Gumz J, Kästle M, Kritikos A, Poltorak MP, Prokazov Y, Turbin E, Weber A, Zuschratter W, Schraven B, Simeoni L, Müller AJ.

Sci Signal. 2017 Jan 17;10(462). pii: eaaf4736. doi: 10.1126/scisignal.aaf4736.

PMID:
28096507
28.

Retrospective Neuropsychological Profile of Patients With Parkinson Disease Prior to Developing Visual Hallucinations.

Muller AJ, O'Callaghan C, Walton CC, Shine JM, Lewis SJ.

J Geriatr Psychiatry Neurol. 2017 Mar;30(2):90-95. doi: 10.1177/0891988716686830. Epub 2017 Jan 8.

PMID:
28067106
29.

D120 and K152 within the PH Domain of T Cell Adapter SKAP55 Regulate Plasma Membrane Targeting of SKAP55 and LFA-1 Affinity Modulation in Human T Lymphocytes.

Witte A, Meineke B, Sticht J, Philipsen L, Kuropka B, Müller AJ, Freund C, Schraven B, Kliche S.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00509-16. doi: 10.1128/MCB.00509-16. Print 2017 Apr 1.

30.

IDO1 is an Integral Mediator of Inflammatory Neovascularization.

Mondal A, Smith C, DuHadaway JB, Sutanto-Ward E, Prendergast GC, Bravo-Nuevo A, Muller AJ.

EBioMedicine. 2016 Dec;14:74-82. doi: 10.1016/j.ebiom.2016.11.013. Epub 2016 Nov 9.

31.

Cognitive Function in Parkinson's Disease Patients with and without Anxiety.

Ehgoetz Martens KA, Szeto JY, Muller AJ, Hall JM, Gilat M, Walton CC, Lewis SJ.

Neurol Res Int. 2016;2016:6254092. Epub 2016 Oct 9.

32.

Synthesis and Characterization of Double Crystalline Cyclic Diblock Copolymers of Poly(ε-caprolactone) and Poly(l(d)-lactide) (c(PCL-b- PL(D)LA)).

Liénard R, Zaldua N, Josse T, Winter J, Zubitur M, Mugica A, Iturrospe A, Arbe A, Coulembier O, Müller AJ.

Macromol Rapid Commun. 2016 Oct;37(20):1676-1681. doi: 10.1002/marc.201600309. Epub 2016 Aug 29.

PMID:
27568984
33.

New Double-Infiltration Methodology to Prepare PCL-PS Core-Shell Nanocylinders Inside Anodic Aluminum Oxide Templates.

Sanz B, Blaszczyk-Lezak I, Mijangos C, Palacios JK, Müller AJ.

Langmuir. 2016 Aug 9;32(31):7860-5. doi: 10.1021/acs.langmuir.6b01258. Epub 2016 Jul 27.

PMID:
27420298
34.

IDO2 Modulates T Cell-Dependent Autoimmune Responses through a B Cell-Intrinsic Mechanism.

Merlo LM, DuHadaway JB, Grabler S, Prendergast GC, Muller AJ, Mandik-Nayak L.

J Immunol. 2016 Jun 1;196(11):4487-97. doi: 10.4049/jimmunol.1600141. Epub 2016 Apr 25.

35.

Activation of AMPK-induced autophagy ameliorates Huntington disease pathology in vitro.

Walter C, Clemens LE, Müller AJ, Fallier-Becker P, Proikas-Cezanne T, Riess O, Metzger S, Nguyen HP.

Neuropharmacology. 2016 Sep;108:24-38. doi: 10.1016/j.neuropharm.2016.04.041. Epub 2016 Apr 28.

PMID:
27133377
36.

Effect of sugar addition on glass transition temperatures of cassava starch with low to intermediate moisture contents.

Figueroa Y, Guevara M, Pérez A, Cova A, Sandoval AJ, Müller AJ.

Carbohydr Polym. 2016 Aug 1;146:231-7. doi: 10.1016/j.carbpol.2016.03.054. Epub 2016 Mar 22.

PMID:
27112870
37.

Dysfunction in attentional processing in patients with Parkinson's disease and visual hallucinations.

Hall JM, O'Callaghan C, Shine JM, Muller AJ, Phillips JR, Walton CC, Lewis SJ, Moustafa AA.

J Neural Transm (Vienna). 2016 May;123(5):503-7. doi: 10.1007/s00702-016-1528-3. Epub 2016 Mar 3.

PMID:
26940598
38.

O-alkylhydroxylamines as rationally-designed mechanism-based inhibitors of indoleamine 2,3-dioxygenase-1.

Malachowski WP, Winters M, DuHadaway JB, Lewis-Ballester A, Badir S, Wai J, Rahman M, Sheikh E, LaLonde JM, Yeh SR, Prendergast GC, Muller AJ.

Eur J Med Chem. 2016 Jan 27;108:564-576. doi: 10.1016/j.ejmech.2015.12.028. Epub 2015 Dec 17.

39.

Rapid Sequestration of Leishmania mexicana by Neutrophils Contributes to the Development of Chronic Lesion.

Hurrell BP, Schuster S, Grün E, Coutaz M, Williams RA, Held W, Malissen B, Malissen M, Yousefi S, Simon HU, Müller AJ, Tacchini-Cottier F.

PLoS Pathog. 2015 May 28;11(5):e1004929. doi: 10.1371/journal.ppat.1004929. eCollection 2015 May.

40.

Function of human WIPI proteins in autophagosomal rejuvenation of endomembranes?

Müller AJ, Proikas-Cezanne T.

FEBS Lett. 2015 Jun 22;589(14):1546-51. doi: 10.1016/j.febslet.2015.05.008. Epub 2015 May 14. Review.

41.

Cardiac-specific disruption of Bin1 in mice enables a model of stress- and age-associated dilated cardiomyopathy.

Laury-Kleintop LD, Mulgrew JR, Heletz I, Nedelcoviciu RA, Chang MY, Harris DM, Koch WJ, Schneider MD, Muller AJ, Prendergast GC.

J Cell Biochem. 2015 Nov;116(11):2541-51. doi: 10.1002/jcb.25198.

42.

Abnormal connectivity between the default mode and the visual system underlies the manifestation of visual hallucinations in Parkinson's disease: a task-based fMRI study.

Shine JM, Muller AJ, O'Callaghan C, Hornberger M, Halliday GM, Lewis SJ.

NPJ Parkinsons Dis. 2015 Apr 22;1:15003. doi: 10.1038/npjparkd.2015.3. eCollection 2015.

43.

IDO2 in Immunomodulation and Autoimmune Disease.

Prendergast GC, Metz R, Muller AJ, Merlo LM, Mandik-Nayak L.

Front Immunol. 2014 Nov 20;5:585. doi: 10.3389/fimmu.2014.00585. eCollection 2014. Review.

44.

Imagine that: elevated sensory strength of mental imagery in individuals with Parkinson's disease and visual hallucinations.

Shine JM, Keogh R, O'Callaghan C, Muller AJ, Lewis SJ, Pearson J.

Proc Biol Sci. 2015 Jan 7;282(1798):20142047. doi: 10.1098/rspb.2014.2047.

45.

Clarifying the role of neural networks in complex hallucinatory phenomena.

O'Callaghan C, Muller AJ, Shine JM.

J Neurosci. 2014 Sep 3;34(36):11865-7. doi: 10.1523/JNEUROSCI.2429-14.2014. No abstract available.

46.
47.

Visual hallucinations in Parkinson's disease: theoretical models.

Muller AJ, Shine JM, Halliday GM, Lewis SJ.

Mov Disord. 2014 Nov;29(13):1591-8. doi: 10.1002/mds.26004. Epub 2014 Aug 22. Review.

PMID:
25154807
48.

1-Methyl-tryptophan synergizes with methotrexate to alleviate arthritis in a mouse model of arthritis.

Pigott E, DuHadaway JB, Muller AJ, Gilmour S, Prendergast GC, Mandik-Nayak L.

Autoimmunity. 2014 Sep;47(6):409-18. doi: 10.3109/08916934.2014.914507. Epub 2014 May 6.

49.

Indoleamine 2,3-dioxygenase pathways of pathogenic inflammation and immune escape in cancer.

Prendergast GC, Smith C, Thomas S, Mandik-Nayak L, Laury-Kleintop L, Metz R, Muller AJ.

Cancer Immunol Immunother. 2014 Jul;63(7):721-35. doi: 10.1007/s00262-014-1549-4. Epub 2014 Apr 8. Review.

50.

Glass transitions and physical aging of cassava starch - corn oil blends.

Pérez A, Sandoval AJ, Cova A, Müller AJ.

Carbohydr Polym. 2014 May 25;105:244-52. doi: 10.1016/j.carbpol.2014.01.032. Epub 2014 Jan 31.

PMID:
24708977

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