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Items: 1 to 50 of 174

1.

Transcription-coupled nucleotide excision repair is coordinated by ubiquitin and SUMO in response to ultraviolet irradiation.

Liebelt F, Schimmel J, Verlaan-de Vries M, Klemann E, van Royen ME, van der Weegen Y, Luijsterburg MS, Mullenders LH, Pines A, Vermeulen W, Vertegaal ACO.

Nucleic Acids Res. 2020 Jan 10;48(1):231-248. doi: 10.1093/nar/gkz977.

PMID:
31722399
2.

Solar UV damage to cellular DNA: from mechanisms to biological effects.

Mullenders LHF.

Photochem Photobiol Sci. 2018 Dec 5;17(12):1842-1852. doi: 10.1039/c8pp00182k. Review.

PMID:
30065996
3.

TRiC controls transcription resumption after UV damage by regulating Cockayne syndrome protein A.

Pines A, Dijk M, Makowski M, Meulenbroek EM, Vrouwe MG, van der Weegen Y, Baltissen M, French PJ, van Royen ME, Luijsterburg MS, Mullenders LH, Vermeulen M, Vermeulen W, Pannu NS, van Attikum H.

Nat Commun. 2018 Mar 12;9(1):1040. doi: 10.1038/s41467-018-03484-6.

4.

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation.

Luijsterburg MS, Typas D, Caron MC, Wiegant WW, van den Heuvel D, Boonen RA, Couturier AM, Mullenders LH, Masson JY, van Attikum H.

Elife. 2017 Feb 27;6. pii: e20922. doi: 10.7554/eLife.20922.

5.

The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.

Typas D, Luijsterburg MS, Wiegant WW, Diakatou M, Helfricht A, Thijssen PE, van den Broek B, Mullenders LH, van Attikum H.

Nucleic Acids Res. 2016 Apr 7;44(6):2976. doi: 10.1093/nar/gkv1480. Epub 2015 Dec 15. No abstract available.

6.

The core spliceosome as target and effector of non-canonical ATM signalling.

Tresini M, Warmerdam DO, Kolovos P, Snijder L, Vrouwe MG, Demmers JA, van IJcken WF, Grosveld FG, Medema RH, Hoeijmakers JH, Mullenders LH, Vermeulen W, Marteijn JA.

Nature. 2015 Jul 2;523(7558):53-8. doi: 10.1038/nature14512. Epub 2015 Jun 24.

7.

The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80.

Typas D, Luijsterburg MS, Wiegant WW, Diakatou M, Helfricht A, Thijssen PE, van den Broek B, Mullenders LH, van Attikum H.

Nucleic Acids Res. 2015 Aug 18;43(14):6919-33. doi: 10.1093/nar/gkv613. Epub 2015 Jun 22. Erratum in: Nucleic Acids Res. 2016 Apr 7;44(6):2976. van de Broek, Bram [Corrected to van den Broek, Bram].

8.

The E3 ubiquitin ligase ARIH1 protects against genotoxic stress by initiating a 4EHP-mediated mRNA translation arrest.

von Stechow L, Typas D, Carreras Puigvert J, Oort L, Siddappa R, Pines A, Vrieling H, van de Water B, Mullenders LH, Danen EH.

Mol Cell Biol. 2015 Apr;35(7):1254-68. doi: 10.1128/MCB.01152-14. Epub 2015 Jan 26.

9.

Persistently stalled replication forks inhibit nucleotide excision repair in trans by sequestering Replication protein A.

Tsaalbi-Shtylik A, Moser J, Mullenders LH, Jansen JG, de Wind N.

Nucleic Acids Res. 2014 Apr;42(7):4406-13. doi: 10.1093/nar/gkt1412. Epub 2014 Jan 23.

10.

Touching base with PARPs: moonlighting in the repair of UV lesions and double-strand breaks.

Pines A, Mullenders LH, van Attikum H, Luijsterburg MS.

Trends Biochem Sci. 2013 Jun;38(6):321-30. doi: 10.1016/j.tibs.2013.03.002. Epub 2013 Apr 4. Review.

PMID:
23562323
11.

Systems biology approach identifies the kinase Csnk1a1 as a regulator of the DNA damage response in embryonic stem cells.

Carreras Puigvert J, von Stechow L, Siddappa R, Pines A, Bahjat M, Haazen LC, Olsen JV, Vrieling H, Meerman JH, Mullenders LH, van de Water B, Danen EH.

Sci Signal. 2013 Jan 22;6(259):ra5. doi: 10.1126/scisignal.2003208.

PMID:
23354688
12.

Effects of arsenite and UVA-1 radiation on calcineurin signaling.

Musson RE, Mullenders LH, Smit NP.

Mutat Res. 2012 Jul 1;735(1-2):32-8. doi: 10.1016/j.mrfmmm.2012.04.007. Epub 2012 May 4.

PMID:
22564430
13.

DDB2 promotes chromatin decondensation at UV-induced DNA damage.

Luijsterburg MS, Lindh M, Acs K, Vrouwe MG, Pines A, van Attikum H, Mullenders LH, Dantuma NP.

J Cell Biol. 2012 Apr 16;197(2):267-81. doi: 10.1083/jcb.201106074. Epub 2012 Apr 9.

14.

No threshold for the induction of chromosomal damage at clinically relevant low doses of X rays.

Boei JJ, Vermeulen S, Skubakova MM, Meijers M, Loenen WA, Wolterbeek R, Mullenders LH, Vrieling H, Giphart-Gassler M.

Radiat Res. 2012 May;177(5):602-13. Epub 2012 Apr 2.

PMID:
22468706
15.

Enhanced nucleotide excision repair in human fibroblasts pre-exposed to ionizing radiation.

Cramers P, Filon AR, Pines A, Kleinjans JC, Mullenders LH, van Zeeland AA.

Photochem Photobiol. 2012 Jan-Feb;88(1):147-53. doi: 10.1111/j.1751-1097.2011.01019.x. Epub 2011 Nov 17.

PMID:
22017241
16.

Global phosphoproteome profiling reveals unanticipated networks responsive to cisplatin treatment of embryonic stem cells.

Pines A, Kelstrup CD, Vrouwe MG, Puigvert JC, Typas D, Misovic B, de Groot A, von Stechow L, van de Water B, Danen EH, Vrieling H, Mullenders LH, Olsen JV.

Mol Cell Biol. 2011 Dec;31(24):4964-77. doi: 10.1128/MCB.05258-11. Epub 2011 Oct 17.

17.

The role of XPC: implications in cancer and oxidative DNA damage.

Melis JP, Luijten M, Mullenders LH, van Steeg H.

Mutat Res. 2011 Nov-Dec;728(3):107-17. doi: 10.1016/j.mrrev.2011.07.001. Epub 2011 Jul 7.

18.

DNA damage response and transcription.

Lagerwerf S, Vrouwe MG, Overmeer RM, Fousteri MI, Mullenders LH.

DNA Repair (Amst). 2011 Jul 15;10(7):743-50. doi: 10.1016/j.dnarep.2011.04.024. Epub 2011 May 31. Review.

PMID:
21622031
19.

Opposite modifying effects of HR and NHEJ deficiency on cancer risk in Ptc1 heterozygous mouse cerebellum.

Tanori M, Pasquali E, Leonardi S, Giardullo P, Di Majo V, Taccioli G, Essers J, Kanaar R, Mullenders LH, Atkinson MJ, Mancuso M, Saran A, Pazzaglia S.

Oncogene. 2011 Nov 24;30(47):4740-9. doi: 10.1038/onc.2011.178. Epub 2011 May 23.

PMID:
21602895
20.

UVA1 radiation inhibits calcineurin through oxidative damage mediated by photosensitization.

Musson RE, Hensbergen PJ, Westphal AH, Temmink WP, Deelder AM, van Pelt J, Mullenders LH, Smit NP.

Free Radic Biol Med. 2011 May 15;50(10):1392-9. doi: 10.1016/j.freeradbiomed.2011.02.019. Epub 2011 Feb 24.

PMID:
21354304
21.

Transcription-coupled repair and apoptosis provide specific protection against transcription-associated mutagenesis by ultraviolet light.

Hendriks G, Jansen JG, Mullenders LH, de Wind N.

Transcription. 2010 Sep-Oct;1(2):95-8. doi: 10.4161/trns.1.2.12788.

22.

Impaired repair of ionizing radiation-induced DNA damage in Cockayne syndrome cells.

Cramers P, Verhoeven EE, Filon AR, Rockx DA, Santos SJ, van der Leer AA, Kleinjans JC, van Zeeland AA, Mullenders LH.

Radiat Res. 2011 Apr;175(4):432-43. doi: 10.1667/RR1972.1. Epub 2011 Feb 7.

PMID:
21299404
23.

Replication protein A safeguards genome integrity by controlling NER incision events.

Overmeer RM, Moser J, Volker M, Kool H, Tomkinson AE, van Zeeland AA, Mullenders LH, Fousteri M.

J Cell Biol. 2011 Feb 7;192(3):401-15. doi: 10.1083/jcb.201006011. Epub 2011 Jan 31.

24.

UV-induced photolesions elicit ATR-kinase-dependent signaling in non-cycling cells through nucleotide excision repair-dependent and -independent pathways.

Vrouwe MG, Pines A, Overmeer RM, Hanada K, Mullenders LH.

J Cell Sci. 2011 Feb 1;124(Pt 3):435-46. doi: 10.1242/jcs.075325. Epub 2011 Jan 11.

25.

Transcription factor IIS impacts UV-inhibited transcription.

Jensen A, Mullenders LH.

DNA Repair (Amst). 2010 Nov 10;9(11):1142-50. doi: 10.1016/j.dnarep.2010.08.002. Epub 2010 Aug 21.

PMID:
20729154
26.

Replication factor C recruits DNA polymerase delta to sites of nucleotide excision repair but is not required for PCNA recruitment.

Overmeer RM, Gourdin AM, Giglia-Mari A, Kool H, Houtsmuller AB, Siegal G, Fousteri MI, Mullenders LH, Vermeulen W.

Mol Cell Biol. 2010 Oct;30(20):4828-39. doi: 10.1128/MCB.00285-10. Epub 2010 Aug 16.

27.

A ubiquitin-binding domain in Cockayne syndrome B required for transcription-coupled nucleotide excision repair.

Anindya R, Mari PO, Kristensen U, Kool H, Giglia-Mari G, Mullenders LH, Fousteri M, Vermeulen W, Egly JM, Svejstrup JQ.

Mol Cell. 2010 Jun 11;38(5):637-48. doi: 10.1016/j.molcel.2010.04.017.

28.

Transcription and replication: far relatives make uneasy bedfellows.

Hendriks G, Jansen JG, Mullenders LH, de Wind N.

Cell Cycle. 2010 Jun 15;9(12):2300-4. Epub 2010 Jun 15.

PMID:
20519944
29.

Antimony impairs nucleotide excision repair: XPA and XPE as potential molecular targets.

Grosskopf C, Schwerdtle T, Mullenders LH, Hartwig A.

Chem Res Toxicol. 2010 Jul 19;23(7):1175-83. doi: 10.1021/tx100106x.

PMID:
20509621
30.

Rad51C is essential for embryonic development and haploinsufficiency causes increased DNA damage sensitivity and genomic instability.

Smeenk G, de Groot AJ, Romeijn RJ, van Buul PP, Zdzienicka MZ, Mullenders LH, Pastink A, Godthelp BC.

Mutat Res. 2010 Jul 7;689(1-2):50-8. doi: 10.1016/j.mrfmmm.2010.05.001. Epub 2010 May 13.

PMID:
20471405
31.

Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells.

Ogi T, Limsirichaikul S, Overmeer RM, Volker M, Takenaka K, Cloney R, Nakazawa Y, Niimi A, Miki Y, Jaspers NG, Mullenders LH, Yamashita S, Fousteri MI, Lehmann AR.

Mol Cell. 2010 Mar 12;37(5):714-27. doi: 10.1016/j.molcel.2010.02.009.

32.

Enhanced global genome nucleotide excision repair reduces UV carcinogenesis and nullifies strand bias in p53 mutations in Csb-/- mice.

Pines A, Hameetman L, de Wilde J, Alekseev S, de Gruijl FR, Vrieling H, Mullenders LH.

J Invest Dermatol. 2010 Jun;130(6):1746-9. doi: 10.1038/jid.2010.18. Epub 2010 Feb 11. No abstract available.

33.

Proteins of nucleotide and base excision repair pathways interact in mitochondria to protect from loss of subcutaneous fat, a hallmark of aging.

Kamenisch Y, Fousteri M, Knoch J, von Thaler AK, Fehrenbacher B, Kato H, Becker T, Dollé ME, Kuiper R, Majora M, Schaller M, van der Horst GT, van Steeg H, Röcken M, Rapaport D, Krutmann J, Mullenders LH, Berneburg M.

J Exp Med. 2010 Feb 15;207(2):379-90. doi: 10.1084/jem.20091834. Epub 2010 Jan 25.

34.

Genotoxicity of soluble and particulate cadmium compounds: impact on oxidative DNA damage and nucleotide excision repair.

Schwerdtle T, Ebert F, Thuy C, Richter C, Mullenders LH, Hartwig A.

Chem Res Toxicol. 2010 Feb 15;23(2):432-42. doi: 10.1021/tx900444w.

PMID:
20092276
35.

A novel radiosensitive SCID patient with a pronounced G(2)/M sensitivity.

Wiegant WW, Meyers M, Verkaik NS, van der Burg M, Darroudi F, Romeijn R, Bernatowska E, Wolska-Kusnierz B, Mikoluc B, Jaspers NG, Vreeken C, Ijspeert H, Esveldt-van Lange RE, Friedl AA, de Villartay JP, Mullenders LH, van Dongen JJ, van Gent DC, Pastink A, Zdzienicka MZ.

DNA Repair (Amst). 2010 Apr 4;9(4):365-73. doi: 10.1016/j.dnarep.2009.12.004. Epub 2010 Jan 15.

PMID:
20079696
36.

Transcription-dependent cytosine deamination is a novel mechanism in ultraviolet light-induced mutagenesis.

Hendriks G, Calléja F, Besaratinia A, Vrieling H, Pfeifer GP, Mullenders LH, Jansen JG, de Wind N.

Curr Biol. 2010 Jan 26;20(2):170-5. doi: 10.1016/j.cub.2009.11.061. Epub 2009 Dec 31.

37.

Heterochromatin protein 1 is recruited to various types of DNA damage.

Luijsterburg MS, Dinant C, Lans H, Stap J, Wiernasz E, Lagerwerf S, Warmerdam DO, Lindh M, Brink MC, Dobrucki JW, Aten JA, Fousteri MI, Jansen G, Dantuma NP, Vermeulen W, Mullenders LH, Houtsmuller AB, Verschure PJ, van Driel R.

J Cell Biol. 2009 May 18;185(4):577-86. doi: 10.1083/jcb.200810035.

38.

Association between transcriptional activity, local chromatin structure, and the efficiencies of both subpathways of nucleotide excision repair of melphalan adducts.

Episkopou H, Kyrtopoulos SA, Sfikakis PP, Fousteri M, Dimopoulos MA, Mullenders LH, Souliotis VL.

Cancer Res. 2009 May 15;69(10):4424-33. doi: 10.1158/0008-5472.CAN-08-3489. Epub 2009 May 5.

39.

Impact of arsenic on nucleotide excision repair: XPC function, protein level, and gene expression.

Nollen M, Ebert F, Moser J, Mullenders LH, Hartwig A, Schwerdtle T.

Mol Nutr Food Res. 2009 May;53(5):572-82. doi: 10.1002/mnfr.200800480.

PMID:
19382146
40.

Persistent transcription-blocking DNA lesions trigger somatic growth attenuation associated with longevity.

Garinis GA, Uittenboogaard LM, Stachelscheid H, Fousteri M, van Ijcken W, Breit TM, van Steeg H, Mullenders LH, van der Horst GT, Brüning JC, Niessen CM, Hoeijmakers JH, Schumacher B.

Nat Cell Biol. 2009 May;11(5):604-15. doi: 10.1038/ncb1866. Epub 2009 Apr 12.

41.

Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.

Jansen JG, Tsaalbi-Shtylik A, Hendriks G, Gali H, Hendel A, Johansson F, Erixon K, Livneh Z, Mullenders LH, Haracska L, de Wind N.

Mol Cell Biol. 2009 Jun;29(11):3113-23. doi: 10.1128/MCB.00071-09. Epub 2009 Mar 30.

42.

Site-specific analysis of UV-induced cyclobutane pyrimidine dimers in nucleotide excision repair-proficient and -deficient hamster cells: Lack of correlation with mutational spectra.

Vreeswijk MP, Meijers CM, Giphart-Gassler M, Vrieling H, van Zeeland AA, Mullenders LH, Loenen WA.

Mutat Res. 2009 Apr 26;663(1-2):7-14. doi: 10.1016/j.mrfmmm.2008.12.007. Epub 2008 Dec 27.

PMID:
19150617
43.

Differential activity of UV-DDB in mouse keratinocytes and fibroblasts: impact on DNA repair and UV-induced skin cancer.

Pines A, Backendorf C, Alekseev S, Jansen JG, de Gruijl FR, Vrieling H, Mullenders LH.

DNA Repair (Amst). 2009 Feb 1;8(2):153-61. doi: 10.1016/j.dnarep.2008.09.011. Epub 2008 Dec 4.

PMID:
18996499
44.

Cellular concentrations of DDB2 regulate dynamic binding of DDB1 at UV-induced DNA damage.

Alekseev S, Luijsterburg MS, Pines A, Geverts B, Mari PO, Giglia-Mari G, Lans H, Houtsmuller AB, Mullenders LH, Hoeijmakers JH, Vermeulen W.

Mol Cell Biol. 2008 Dec;28(24):7402-13. doi: 10.1128/MCB.01108-08. Epub 2008 Oct 20.

45.

Gene transcription increases DNA damage-induced mutagenesis in mammalian stem cells.

Hendriks G, Calléja F, Vrieling H, Mullenders LH, Jansen JG, de Wind N.

DNA Repair (Amst). 2008 Aug 2;7(8):1330-9. doi: 10.1016/j.dnarep.2008.04.015. Epub 2008 Jun 9.

PMID:
18539547
46.

Transcription-coupled nucleotide excision repair in mammalian cells: molecular mechanisms and biological effects.

Fousteri M, Mullenders LH.

Cell Res. 2008 Jan;18(1):73-84. doi: 10.1038/cr.2008.6. Review.

47.

Growth stimulation of UV-induced DNA damage retaining epidermal basal cells gives rise to clusters of p53 overexpressing cells.

Nijhof JG, Mulder AM, Speksnijder EN, Hoogervorst EM, Mullenders LH, de Gruijl FR.

DNA Repair (Amst). 2007 Nov;6(11):1642-50. Epub 2007 Jul 17.

PMID:
17644448
48.

Sealing of chromosomal DNA nicks during nucleotide excision repair requires XRCC1 and DNA ligase III alpha in a cell-cycle-specific manner.

Moser J, Kool H, Giakzidis I, Caldecott K, Mullenders LH, Fousteri MI.

Mol Cell. 2007 Jul 20;27(2):311-23.

49.

Dynamic in vivo interaction of DDB2 E3 ubiquitin ligase with UV-damaged DNA is independent of damage-recognition protein XPC.

Luijsterburg MS, Goedhart J, Moser J, Kool H, Geverts B, Houtsmuller AB, Mullenders LH, Vermeulen W, van Driel R.

J Cell Sci. 2007 Aug 1;120(Pt 15):2706-16. Epub 2007 Jul 17.

50.

Increased DNA damage sensitivity of Cornelia de Lange syndrome cells: evidence for impaired recombinational repair.

Vrouwe MG, Elghalbzouri-Maghrani E, Meijers M, Schouten P, Godthelp BC, Bhuiyan ZA, Redeker EJ, Mannens MM, Mullenders LH, Pastink A, Darroudi F.

Hum Mol Genet. 2007 Jun 15;16(12):1478-87. Epub 2007 Apr 27.

PMID:
17468178

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