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Items: 26

1.

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis.

Tu WB, Shiah YJ, Lourenco C, Mullen PJ, Dingar D, Redel C, Tamachi A, Ba-Alawi W, Aman A, Al-Awar R, Cescon DW, Haibe-Kains B, Arrowsmith CH, Raught B, Boutros PC, Penn LZ.

Cancer Cell. 2018 Oct 8;34(4):579-595.e8. doi: 10.1016/j.ccell.2018.09.001.

PMID:
30300580
2.

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization.

Sullivan WJ, Mullen PJ, Schmid EW, Flores A, Momcilovic M, Sharpley MS, Jelinek D, Whiteley AE, Maxwell MB, Wilde BR, Banerjee U, Coller HA, Shackelford DB, Braas D, Ayer DE, de Aguiar Vallim TQ, Lowry WE, Christofk HR.

Cell. 2018 Sep 20;175(1):117-132.e21. doi: 10.1016/j.cell.2018.08.017. Epub 2018 Sep 6.

PMID:
30197082
3.

Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins.

Yu R, Longo J, van Leeuwen JE, Mullen PJ, Ba-Alawi W, Haibe-Kains B, Penn LZ.

Cancer Res. 2018 Mar 1;78(5):1347-1357. doi: 10.1158/0008-5472.CAN-17-1231. Epub 2017 Dec 11.

PMID:
29229608
4.

The interplay between cell signalling and the mevalonate pathway in cancer.

Mullen PJ, Yu R, Longo J, Archer MC, Penn LZ.

Nat Rev Cancer. 2016 Nov;16(11):718-731. doi: 10.1038/nrc.2016.76. Epub 2016 Aug 26. Review.

PMID:
27562463
5.

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death.

Pandyra AA, Mullen PJ, Goard CA, Ericson E, Sharma P, Kalkat M, Yu R, Pong JT, Brown KR, Hart T, Gebbia M, Lang KS, Giaever G, Nislow C, Moffat J, Penn LZ.

Oncotarget. 2015 Sep 29;6(29):26909-21. doi: 10.18632/oncotarget.4817.

6.

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress.

Sriskanthadevan S, Jeyaraju DV, Chung TE, Prabha S, Xu W, Skrtic M, Jhas B, Hurren R, Gronda M, Wang X, Jitkova Y, Sukhai MA, Lin FH, Maclean N, Laister R, Goard CA, Mullen PJ, Xie S, Penn LZ, Rogers IM, Dick JE, Minden MD, Schimmer AD.

Blood. 2015 Mar 26;125(13):2120-30. doi: 10.1182/blood-2014-08-594408. Epub 2015 Jan 28.

7.

Simvastatin induces mitochondrial dysfunction and increased atrogin-1 expression in H9c2 cardiomyocytes and mice in vivo.

Bonifacio A, Mullen PJ, Mityko IS, Navegantes LC, Bouitbir J, Krähenbühl S.

Arch Toxicol. 2016 Jan;90(1):203-15. doi: 10.1007/s00204-014-1378-4. Epub 2014 Oct 10.

PMID:
25300705
8.

Immediate utility of two approved agents to target both the metabolic mevalonate pathway and its restorative feedback loop.

Pandyra A, Mullen PJ, Kalkat M, Yu R, Pong JT, Li Z, Trudel S, Lang KS, Minden MD, Schimmer AD, Penn LZ.

Cancer Res. 2014 Sep 1;74(17):4772-82. doi: 10.1158/0008-5472.CAN-14-0130. Epub 2014 Jul 3.

9.

Largen: a molecular regulator of mammalian cell size control.

Yamamoto K, Gandin V, Sasaki M, McCracken S, Li W, Silvester JL, Elia AJ, Wang F, Wakutani Y, Alexandrova R, Oo YD, Mullen PJ, Inoue S, Itsumi M, Lapin V, Haight J, Wakeham A, Shahinian A, Ikura M, Topisirovic I, Sonenberg N, Mak TW.

Mol Cell. 2014 Mar 20;53(6):904-15. doi: 10.1016/j.molcel.2014.02.028.

10.

Identifying molecular features that distinguish fluvastatin-sensitive breast tumor cells.

Goard CA, Chan-Seng-Yue M, Mullen PJ, Quiroga AD, Wasylishen AR, Clendening JW, Sendorek DH, Haider S, Lehner R, Boutros PC, Penn LZ.

Breast Cancer Res Treat. 2014 Jan;143(2):301-12. doi: 10.1007/s10549-013-2800-y. Epub 2013 Dec 17.

PMID:
24337703
11.

MYC phosphorylation at novel regulatory regions suppresses transforming activity.

Wasylishen AR, Chan-Seng-Yue M, Bros C, Dingar D, Tu WB, Kalkat M, Chan PK, Mullen PJ, Huang L, Meyer N, Raught B, Boutros PC, Penn LZ.

Cancer Res. 2013 Nov 1;73(21):6504-15. doi: 10.1158/0008-5472.CAN-12-4063. Epub 2013 Sep 12.

12.

Effect of short- and long-term treatment with valproate on carnitine homeostasis in humans.

Morand R, Todesco L, Donzelli M, Fischer-Barnicol D, Mullen PJ, Krähenbühl S.

Ther Drug Monit. 2012 Aug;34(4):406-14. doi: 10.1097/FTD.0b013e3182608e2f.

PMID:
22743351
13.

Susceptibility to simvastatin-induced toxicity is partly determined by mitochondrial respiration and phosphorylation state of Akt.

Mullen PJ, Zahno A, Lindinger P, Maseneni S, Felser A, Krähenbühl S, Brecht K.

Biochim Biophys Acta. 2011 Dec;1813(12):2079-87. doi: 10.1016/j.bbamcr.2011.07.019. Epub 2011 Aug 4.

14.

Matrix metalloproteinases 2 and 9 in the cochlea: expression and activity after aminoglycoside exposition.

Setz C, Brand Y, Radojevic V, Hanusek C, Mullen PJ, Levano S, Listyo A, Bodmer D.

Neuroscience. 2011 May 5;181:28-39. doi: 10.1016/j.neuroscience.2011.02.043. Epub 2011 Feb 24.

PMID:
21354273
15.

Effect of simvastatin on cholesterol metabolism in C2C12 myotubes and HepG2 cells, and consequences for statin-induced myopathy.

Mullen PJ, Lüscher B, Scharnagl H, Krähenbühl S, Brecht K.

Biochem Pharmacol. 2010 Apr 15;79(8):1200-9. doi: 10.1016/j.bcp.2009.12.007. Epub 2009 Dec 14.

PMID:
20018177
16.

Poor bowel preparation: a poor excuse.

Mullen PJ.

Gut. 2004 Jul;53(7):1056. No abstract available.

17.

Immunohistochemical detection of O-acetylated sialomucins in intestinal metaplasia and carcinoma of the stomach.

Mullen PJ, Carr N, Milton JD, Rhodes JM.

Histopathology. 1995 Aug;27(2):161-7.

PMID:
8835264
18.

Faecal urge incontinence caused by exercise.

Mullen PJ.

BMJ. 1992 Oct 17;305(6859):956. No abstract available.

19.

Polyuria and weight-loss associated with cimetidine.

Mullen PJ.

Postgrad Med J. 1992 Sep;68(803):771. No abstract available.

20.

The effect of reducing and non-reducing sugars on the bicinchoninic acid reaction for protein determination.

Milton JD, Mullen PJ.

Clin Chim Acta. 1992 Jun 15;208(1-2):141-3. No abstract available.

PMID:
1638751
21.
22.

Unexpected first dose hypotensive reaction to enalapril.

Mullen PJ.

Postgrad Med J. 1990 Dec;66(782):1087-8. No abstract available.

23.

The dangers of electrocardiography in general practice.

Mullen PJ.

J R Army Med Corps. 1990 Feb;136(1):40-2.

PMID:
2319503
24.

Gastrointestinal endoscopy in the young.

Mullen PJ, Slater A.

Br Med J (Clin Res Ed). 1987 Sep 19;295(6600):724. No abstract available.

25.

Allergic skin reactions provoked by a root canal disinfectant with reduced formaldehyde concentration.

Simon M, Van Mullen PJ, Lamers AC.

Int Endod J. 1984 Oct;17(4):199-206. No abstract available.

PMID:
6593304
26.

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