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Oral treprostinil in transition or as add-on therapy in pediatric pulmonary arterial hypertension.

Ivy DD, Feinstein JA, Yung D, Mullen MP, Kirkpatrick EC, Hirsch R, Austin ED, Fineman J, Truong U, Solum D, Deng CQ, Hopper RK.

Pulm Circ. 2019 Jul-Sep;9(3):2045894019856471. doi: 10.1177/2045894019856471.


Racial and Ethnic Differences in Pediatric Pulmonary Hypertension: An Analysis of the Pediatric Pulmonary Hypertension Network Registry.

Ong MS, Abman S, Austin ED, Feinstein JA, Hopper RK, Krishnan US, Mullen MP, Natter MD, Raj JU, Rosenzweig EB, Mandl KD; Pediatric Pulmonary Hypertension Network and National Heart, Lung, and Blood Institute Pediatric Pulmonary Vascular Disease Outcomes Bioinformatics Clinical Coordinating Center Investigators.

J Pediatr. 2019 Jun 5. pii: S0022-3476(19)30529-3. doi: 10.1016/j.jpeds.2019.04.046. [Epub ahead of print]


Phenotype characterisation of TBX4 mutation and deletion carriers with neonatal and pediatric pulmonary hypertension.

Galambos C, Mullen MP, Shieh JT, Schwerk N, Kielt MJ, Ullmann N, Boldrini R, Stucin-Gantar I, Haass C, Bansal M, Agrawal PB, Johnson J, Peca D, Surace C, Cutrera R, Pauciulo MW, Nichols WC, Griese M, Ivy D, Abman SH, Austin ED, Danhaive O.

Eur Respir J. 2019 May 31. pii: 1801965. doi: 10.1183/13993003.01965-2018. [Epub ahead of print]


Pulmonary Artery Banding in Post-tricuspid Congenital Cardiac Shunting Defects with High Pulmonary Vascular Resistance.

Kulik TJ, McSweeney JE, Tella J, Mullen MP.

Pediatr Cardiol. 2019 Apr;40(4):719-725. doi: 10.1007/s00246-019-02054-x. Epub 2019 Jan 23.


The Left Ventricle in Congenital Diaphragmatic Hernia: Implications for the Management of Pulmonary Hypertension.

Kinsella JP, Steinhorn RH, Mullen MP, Hopper RK, Keller RL, Ivy DD, Austin ED, Krishnan US, Rosenzweig EB, Fineman JR, Everett AD, Hanna BD, Humpl T, Raj JU, Abman SH; Pediatric Pulmonary Hypertension Network (PPHNet).

J Pediatr. 2018 Jun;197:17-22. doi: 10.1016/j.jpeds.2018.02.040. Epub 2018 Apr 5. Review. No abstract available.


Evaluation and Management of Pulmonary Hypertension in Children with Bronchopulmonary Dysplasia.

Krishnan U, Feinstein JA, Adatia I, Austin ED, Mullen MP, Hopper RK, Hanna B, Romer L, Keller RL, Fineman J, Steinhorn R, Kinsella JP, Ivy DD, Rosenzweig EB, Raj U, Humpl T, Abman SH; Pediatric Pulmonary Hypertension Network (PPHNet).

J Pediatr. 2017 Sep;188:24-34.e1. doi: 10.1016/j.jpeds.2017.05.029. Epub 2017 Jun 20. Review. No abstract available.


A Computable Phenotype Improves Cohort Ascertainment in a Pediatric Pulmonary Hypertension Registry.

Geva A, Gronsbell JL, Cai T, Cai T, Murphy SN, Lyons JC, Heinz MM, Natter MD, Patibandla N, Bickel J, Mullen MP, Mandl KD; Pediatric Pulmonary Hypertension Network and National Heart, Lung, and Blood Institute Pediatric Pulmonary Vascular Disease Outcomes Bioinformatics Clinical Coordinating Center Investigators.

J Pediatr. 2017 Sep;188:224-231.e5. doi: 10.1016/j.jpeds.2017.05.037. Epub 2017 Jun 16.


Learning a Comorbidity-Driven Taxonomy of Pediatric Pulmonary Hypertension.

Ong MS, Mullen MP, Austin ED, Szolovits P, Natter MD, Geva A, Cai T, Kong SW, Mandl KD.

Circ Res. 2017 Aug 4;121(4):341-353. doi: 10.1161/CIRCRESAHA.117.310804. Epub 2017 Jun 13.


Interleukin 8 haplotypes drive divergent responses in uterine endometrial cells and are associated with somatic cell score in Holstein-Friesian cattle.

Stojkovic B, Mullen MP, Donofrio G, McLoughlin RM, Meade KG.

Vet Immunol Immunopathol. 2017 Feb;184:18-28. doi: 10.1016/j.vetimm.2016.12.006. Epub 2016 Dec 16.


Recommendations for the Use of Inhaled Nitric Oxide Therapy in Premature Newborns with Severe Pulmonary Hypertension.

Kinsella JP, Steinhorn RH, Krishnan US, Feinstein JA, Adatia I, Austin ED, Rosenzweig EB, Everett AD, Fineman JR, Hanna BD, Hopper RK, Humpl T, Ivy DD, Keller RL, Mullen MP, Raj JU, Wessel DL, Abman SH.

J Pediatr. 2016 Mar;170:312-4. doi: 10.1016/j.jpeds.2015.11.050. Epub 2015 Dec 15. No abstract available.


Lung Pathology in Pediatric Pulmonary Vein Stenosis.

Pogoriler JE, Kulik TJ, Casey AM, Baird CW, Mullen MP, Jenkins KJ, Vargas SO.

Pediatr Dev Pathol. 2016 May-Jun;19(3):219-29. doi: 10.2350/15-07-1670-OA.1. Epub 2015 Oct 12.


Chromosome microarray testing for patients with congenital heart defects reveals novel disease causing loci and high diagnostic yield.

Geng J, Picker J, Zheng Z, Zhang X, Wang J, Hisama F, Brown DW, Mullen MP, Harris D, Stoler J, Seman A, Miller DT, Fu Q, Roberts AE, Shen Y.

BMC Genomics. 2014 Dec 17;15:1127. doi: 10.1186/1471-2164-15-1127.


Predicting response to vascular endothelial growth factor inhibitor and chemotherapy in metastatic colorectal cancer.

Martin P, Noonan S, Mullen MP, Scaife C, Tosetto M, Nolan B, Wynne K, Hyland J, Sheahan K, Elia G, O'Donoghue D, Fennelly D, O'Sullivan J.

BMC Cancer. 2014 Nov 27;14:887. doi: 10.1186/1471-2407-14-887.


Prothymosin α variants isolated from CD8+ T cells and cervicovaginal fluid suppress HIV-1 replication through type I interferon induction.

Teixeira A, Yen B, Gusella GL, Thomas AG, Mullen MP, Aberg J, Chen X, Hoshida Y, van Bakel H, Schadt E, Basler CF, García-Sastre A, Mosoian A.

J Infect Dis. 2015 May 1;211(9):1467-75. doi: 10.1093/infdis/jiu643. Epub 2014 Nov 17.


Within- and across-breed imputation of high-density genotypes in dairy and beef cattle from medium- and low-density genotypes.

Berry DP, McClure MC, Mullen MP.

J Anim Breed Genet. 2014 Jun;131(3):165-72. doi: 10.1111/jbg.12067. Epub 2013 Dec 5.



Mullen MP, DeMaso DR.

Chest. 2014 Jun;145(6):1439. doi: 10.1378/chest.14-0680. No abstract available.


Imputation of ungenotyped parental genotypes in dairy and beef cattle from progeny genotypes.

Berry DP, McParland S, Kearney JF, Sargolzaei M, Mullen MP.

Animal. 2014 Jun;8(6):895-903. doi: 10.1017/S1751731114000883.


Direct evidence on the contribution of a missense mutation in GDF9 to variation in ovulation rate of Finnsheep.

Mullen MP, Hanrahan JP.

PLoS One. 2014 Apr 21;9(4):e95251. doi: 10.1371/journal.pone.0095251. eCollection 2014.


Global gene expression in endometrium of high and low fertility heifers during the mid-luteal phase of the estrous cycle.

Killeen AP, Morris DG, Kenny DA, Mullen MP, Diskin MG, Waters SM.

BMC Genomics. 2014 Mar 26;15:234. doi: 10.1186/1471-2164-15-234.


Telaprevir in the treatment of acute hepatitis C virus infection in HIV-infected men.

Fierer DS, Dieterich DT, Mullen MP, Branch AD, Uriel AJ, Carriero DC, van Seggelen WO, Hijdra RM, Cassagnol DG; New York Acute Hepatitis C Surveillance Network.

Clin Infect Dis. 2014 Mar;58(6):873-9. doi: 10.1093/cid/cit799. Epub 2013 Dec 13.


A feedback regulatory pathway between LDL and alpha-1 proteinase inhibitor in chronic inflammation and infection.

Bristow CL, Modarresi R, Babayeva MA, LaBrunda M, Mukhtarzad R, Trucy M, Franklin A, Reeves RE, Long A, Mullen MP, Cortes J, Winston R.

Discov Med. 2013 Nov;16(89):201-18.


Global proteomic characterization of uterine histotroph recovered from beef heifers yielding good quality and degenerate day 7 embryos.

Beltman ME, Mullen MP, Elia G, Hilliard M, Diskin MG, Evans AC, Crowe MA.

Domest Anim Endocrinol. 2014 Jan;46:49-57. doi: 10.1016/j.domaniend.2013.10.003. Epub 2013 Oct 14.


Pulmonary hypertension associated with scurvy and vitamin deficiencies in an autistic child.

Duvall MG, Pikman Y, Kantor DB, Ariagno K, Summers L, Sectish TC, Mullen MP.

Pediatrics. 2013 Dec;132(6):e1699-703. doi: 10.1542/peds.2012-3054. Epub 2013 Nov 4.


Quality of life and parental adjustment in pediatric pulmonary hypertension.

Mullen MP, Andrus J, Labella MH, Forbes PW, Rao S, McSweeney JE, Kulik TJ, DeMaso DR.

Chest. 2014 Feb;145(2):237-244. doi: 10.1378/chest.13-0636.


Effect of inhaled iloprost on the exercise function of Fontan patients: a demonstration of concept.

Rhodes J, Ubeda-Tikkanen A, Clair M, Fernandes SM, Graham DA, Milliren CE, Daly KP, Mullen MP, Landzberg MJ.

Int J Cardiol. 2013 Oct 3;168(3):2435-40. doi: 10.1016/j.ijcard.2013.03.014. Epub 2013 Mar 29.


Transcatheter Potts shunt creation in patients with severe pulmonary arterial hypertension: initial clinical experience.

Esch JJ, Shah PB, Cockrill BA, Farber HW, Landzberg MJ, Mehra MR, Mullen MP, Opotowsky AR, Waxman AB, Lock JE, Marshall AC.

J Heart Lung Transplant. 2013 Apr;32(4):381-7. doi: 10.1016/j.healun.2013.01.1049. Epub 2013 Feb 14.


Effects of systemic progesterone during the early luteal phase on the availabilities of amino acids and glucose in the bovine uterine lumen.

Mullen MP, Bazer FW, Wu G, Parr MH, Evans AC, Crowe MA, Diskin MG.

Reprod Fertil Dev. 2014 Jan;26(2):282-92. doi: 10.1071/RD12319.


Investigation of prolific sheep from UK and Ireland for evidence on origin of the mutations in BMP15 (FecX(G), FecX(B)) and GDF9 (FecG(H)) in Belclare and Cambridge sheep.

Mullen MP, Hanrahan JP, Howard DJ, Powell R.

PLoS One. 2013;8(1):e53172. doi: 10.1371/journal.pone.0053172. Epub 2013 Jan 2.


Obstruction of the superior vena cava after neonatal extracorporeal membrane oxygenation: association with chylothorax and outcome of transcatheter treatment.

Kazanci SY, McElhinney DB, Thiagarajan R, Bergersen L, Wilson JM, Marshall AC, Lock JE, Mullen MP.

Pediatr Crit Care Med. 2013 Jan;14(1):37-43. doi: 10.1097/PCC.0b013e31825b5270.


Alterations in systemic concentrations of progesterone during the early luteal phase affect RBP4 expression in the bovine uterus.

Mullen MP, Forde N, Parr MH, Diskin MG, Morris DG, Nally JE, Evans AC, Crowe MA.

Reprod Fertil Dev. 2012;24(5):715-22. doi: 10.1071/RD11246.


Early-onset liver fibrosis due to primary hepatitis C virus infection is higher over time in HIV-infected men.

Fierer DS, Mullen MP, Dieterich DT, Isabel Fiel M, Branch AD.

Clin Infect Dis. 2012 Sep;55(6):887-8; author reply 888-9. doi: 10.1093/cid/cis538. Epub 2012 Jun 7. No abstract available.


A comparison of the bovine uterine and plasma proteome using iTRAQ proteomics.

Faulkner S, Elia G, Mullen MP, O'Boyle P, Dunn MJ, Morris D.

Proteomics. 2012 Jun;12(12):2014-23. doi: 10.1002/pmic.201100609.


Bilateral lung transplant for hereditary hemorrhagic telangiectasia in a pediatric patient.

Misra MV, Mullen MP, Vargas SO, Kim HB, Boyer D.

Pediatr Transplant. 2012 Dec;16(8):E364-7. doi: 10.1111/j.1399-3046.2012.01717.x. Epub 2012 May 23.


Relationship between pregnancy per artificial insemination and early luteal concentrations of progesterone and establishment of repeatability estimates for these traits in Holstein-Friesian heifers.

Parr MH, Mullen MP, Crowe MA, Roche JF, Lonergan P, Evans AC, Diskin MG.

J Dairy Sci. 2012 May;95(5):2390-6. doi: 10.3168/jds.2011-4498.


Proteomic characterization of histotroph during the preimplantation phase of the estrous cycle in cattle.

Mullen MP, Elia G, Hilliard M, Parr MH, Diskin MG, Evans AC, Crowe MA.

J Proteome Res. 2012 May 4;11(5):3004-18. doi: 10.1021/pr300144q. Epub 2012 Apr 20.


The integration of 'omic' disciplines and systems biology in cattle breeding.

Berry DP, Meade KG, Mullen MP, Butler S, Diskin MG, Morris D, Creevey CJ.

Animal. 2011 Feb;5(4):493-505. doi: 10.1017/S1751731110002120.


α1Proteinase inhibitor regulates CD4+ lymphocyte levels and is rate limiting in HIV-1 disease.

Bristow CL, Babayeva MA, LaBrunda M, Mullen MP, Winston R.

PLoS One. 2012;7(2):e31383. doi: 10.1371/journal.pone.0031383. Epub 2012 Feb 17.


Single Nucleotide Polymorphisms in the Insulin-Like Growth Factor 1 (IGF-1) Gene are Associated with Performance in Holstein-Friesian Dairy Cattle.

Mullen MP, Berry DP, Howard DJ, Diskin MG, Lynch CO, Giblin L, Kenny DA, Magee DA, Meade KG, Waters SM.

Front Genet. 2011 Feb 16;2:3. doi: 10.3389/fgene.2011.00003. eCollection 2011.


Polymorphism discovery and allele frequency estimation using high-throughput DNA sequencing of target-enriched pooled DNA samples.

Mullen MP, Creevey CJ, Berry DP, McCabe MS, Magee DA, Howard DJ, Killeen AP, Park SD, McGettigan PA, Lucy MC, Machugh DE, Waters SM.

BMC Genomics. 2012 Jan 11;13:16. doi: 10.1186/1471-2164-13-16.


Polymorphisms in genes of the somatotrophic axis are independently associated with milk production, udder health, survival and animal size in Holstein-Friesian dairy cattle.

Waters SM, Berry DP, Mullen MP.

J Anim Breed Genet. 2012 Feb;129(1):70-8. doi: 10.1111/j.1439-0388.2011.00938.x. Epub 2011 Jun 27.


Single nucleotide polymorphisms in the imprinted bovine insulin-like growth factor 2 receptor gene (IGF2R) are associated with body size traits in Irish Holstein-Friesian cattle.

Berkowicz EW, Magee DA, Berry DP, Sikora KM, Howard DJ, Mullen MP, Evans RD, Spillane C, MacHugh DE.

Anim Genet. 2012 Feb;43(1):81-7. doi: 10.1111/j.1365-2052.2011.02211.x. Epub 2011 May 23.


Single nucleotide polymorphisms in the growth hormone and insulin-like growth factor-1 genes are associated with milk production, body condition score and fertility traits in dairy cows.

Mullen MP, Lynch CO, Waters SM, Howard DJ, O'Boyle P, Kenny DA, Buckley F, Horan B, Diskin MG.

Genet Mol Res. 2011 Aug 26;10(3):1819-30. doi: 10.4238/vol10-3gmr1173.


Treatment of segmental pulmonary artery hypertension in adults with congenital heart disease.

Schuuring MJ, Bouma BJ, Cordina R, Gatzoulis MA, Budts W, Mullen MP, Vis JC, Celermajer D, Mulder BJ.

Int J Cardiol. 2013 Mar 20;164(1):106-10. doi: 10.1016/j.ijcard.2011.06.084. Epub 2011 Jul 18.


Pulmonary arterial hypertension: what the large pulmonary arteries tell us.

Kulik TJ, Clark RL, Hasan BS, Keane JF, Springmuller D, Mullen MP.

Pediatr Cardiol. 2011 Aug;32(6):759-65. doi: 10.1007/s00246-011-9963-2. Epub 2011 Apr 1.


DNA sequence polymorphisms within the bovine guanine nucleotide-binding protein Gs subunit alpha (Gsα)-encoding (GNAS) genomic imprinting domain are associated with performance traits.

Sikora KM, Magee DA, Berkowicz EW, Berry DP, Howard DJ, Mullen MP, Evans RD, Machugh DE, Spillane C.

BMC Genet. 2011 Jan 7;12:4. doi: 10.1186/1471-2156-12-4.


Associations between novel single nucleotide polymorphisms in the Bos taurus growth hormone gene and performance traits in Holstein-Friesian dairy cattle.

Mullen MP, Berry DP, Howard DJ, Diskin MG, Lynch CO, Berkowicz EW, Magee DA, MacHugh DE, Waters SM.

J Dairy Sci. 2010 Dec;93(12):5959-69. doi: 10.3168/jds.2010-3385. Erratum in: J Dairy Sci. 2011 Feb;94(2):1069.


DNA sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in Irish Holstein-Friesian cattle.

Magee DA, Sikora KM, Berkowicz EW, Berry DP, Howard DJ, Mullen MP, Evans RD, Spillane C, MacHugh DE.

BMC Genet. 2010 Oct 13;11:93. doi: 10.1186/1471-2156-11-93.


Single nucleotide polymorphisms at the imprinted bovine insulin-like growth factor 2 (IGF2) locus are associated with dairy performance in Irish Holstein-Friesian cattle.

Berkowicz EW, Magee DA, Sikora KM, Berry DP, Howard DJ, Mullen MP, Evans RD, Spillane C, MacHugh DE.

J Dairy Res. 2011 Feb;78(1):1-8. doi: 10.1017/S0022029910000567. Epub 2010 Sep 8.


Single nucleotide polymorphisms within the bovine DLK1-DIO3 imprinted domain are associated with economically important production traits in cattle.

Magee DA, Berry DP, Berkowicz EW, Sikora KM, Howard DJ, Mullen MP, Evans RD, Spillane C, MacHugh DE.

J Hered. 2011 Jan-Feb;102(1):94-101. doi: 10.1093/jhered/esq097. Epub 2010 Sep 3.


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