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Items: 1 to 50 of 270

1.

Converging and Differential Brain Phospholipid Dysregulation in the Pathogenesis of Repetitive Mild Traumatic Brain Injury and Alzheimer's Disease.

Ojo JO, Algamal M, Leary P, Abdullah L, Mouzon B, Evans JE, Mullan M, Crawford F.

Front Neurosci. 2019 Feb 19;13:103. doi: 10.3389/fnins.2019.00103. eCollection 2019.

2.

APOE Genotype Specific Effects on the Early Neurodegenerative Sequelae Following Chronic Repeated Mild Traumatic Brain Injury.

Muza P, Bachmeier C, Mouzon B, Algamal M, Rafi NG, Lungmus C, Abdullah L, Evans JE, Ferguson S, Mullan M, Crawford F, Ojo JO.

Neuroscience. 2019 Feb 1;404:297-313. doi: 10.1016/j.neuroscience.2019.01.049. [Epub ahead of print]

PMID:
30711612
3.

Unbiased Proteomic Approach Identifies Unique and Coincidental Plasma Biomarkers in Repetitive mTBI and AD Pathogenesis.

Ojo JO, Crynen G, Reed JM, Ajoy R, Vallabhaneni P, Algamal M, Leary P, Rafi NG, Mouzon B, Mullan M, Crawford F.

Front Aging Neurosci. 2018 Dec 18;10:405. doi: 10.3389/fnagi.2018.00405. eCollection 2018.

4.

Disruption in Brain Phospholipid Content in a Humanized Tau Transgenic Model Following Repetitive Mild Traumatic Brain Injury.

Ojo JO, Algamal M, Leary P, Abdullah L, Mouzon B, Evans JE, Mullan M, Crawford F.

Front Neurosci. 2018 Dec 4;12:893. doi: 10.3389/fnins.2018.00893. eCollection 2018.

5.

Subchronic Pathobiological Response Following Chronic Repetitive Mild Traumatic Brain Injury in an Aged Preclinical Model of Amyloid Pathogenesis.

Ojo JO, Leary P, Lungmus C, Algamal M, Mouzon B, Bachmeier C, Mullan M, Stewart W, Crawford F.

J Neuropathol Exp Neurol. 2018 Dec 1;77(12):1144-1162. doi: 10.1093/jnen/nly101.

PMID:
30395237
6.

Treatment With Nilvadipine Mitigates Inflammatory Pathology and Improves Spatial Memory in Aged hTau Mice After Repetitive Mild TBI.

Morin A, Mouzon B, Ferguson S, Paris D, Saltiel N, Lungmus C, Mullan M, Crawford F.

Front Aging Neurosci. 2018 Oct 11;10:292. doi: 10.3389/fnagi.2018.00292. eCollection 2018.

7.

Nilvadipine in mild to moderate Alzheimer disease: A randomised controlled trial.

Lawlor B, Segurado R, Kennelly S, Olde Rikkert MGM, Howard R, Pasquier F, Börjesson-Hanson A, Tsolaki M, Lucca U, Molloy DW, Coen R, Riepe MW, Kálmán J, Kenny RA, Cregg F, O'Dwyer S, Walsh C, Adams J, Banzi R, Breuilh L, Daly L, Hendrix S, Aisen P, Gaynor S, Sheikhi A, Taekema DG, Verhey FR, Nemni R, Nobili F, Franceschi M, Frisoni G, Zanetti O, Konsta A, Anastasios O, Nenopoulou S, Tsolaki-Tagaraki F, Pakaski M, Dereeper O, de la Sayette V, Sénéchal O, Lavenu I, Devendeville A, Calais G, Crawford F, Mullan M; NILVAD Study Group.

PLoS Med. 2018 Sep 24;15(9):e1002660. doi: 10.1371/journal.pmed.1002660. eCollection 2018 Sep.

8.

Oleoylethanolamide treatment reduces neurobehavioral deficits and brain pathology in a mouse model of Gulf War Illness.

Joshi U, Evans JE, Joseph R, Emmerich T, Saltiel N, Lungmus C, Oberlin S, Langlois H, Ojo J, Mouzon B, Paris D, Mullan M, Jin C, Klimas N, Sullivan K, Crawford F, Abdullah L.

Sci Rep. 2018 Aug 27;8(1):12921. doi: 10.1038/s41598-018-31242-7.

9.

Chronic Hippocampal Abnormalities and Blunted HPA Axis in an Animal Model of Repeated Unpredictable Stress.

Algamal M, Ojo JO, Lungmus CP, Muza P, Cammarata C, Owens MJ, Mouzon BC, Diamond DM, Mullan M, Crawford F.

Front Behav Neurosci. 2018 Jul 20;12:150. doi: 10.3389/fnbeh.2018.00150. eCollection 2018.

10.

Chronic White Matter Degeneration, but No Tau Pathology at One-Year Post-Repetitive Mild Traumatic Brain Injury in a Tau Transgenic Model.

Mouzon B, Bachmeier C, Ojo J, Acker C, Ferguson S, Crynen G, Davies P, Mullan M, Stewart W, Crawford F.

J Neurotrauma. 2019 Feb 15;36(4):576-588. doi: 10.1089/neu.2018.5720. Epub 2018 Sep 6.

PMID:
29993324
11.

Impact of age on acute post-TBI neuropathology in mice expressing humanized tau: a Chronic Effects of Neurotrauma Consortium Study.

Mouzon B, Saltiel N, Ferguson S, Ojo J, Lungmus C, Lynch C, Algamal M, Morin A, Carper B, Bieler G, Mufson EJ, Stewart W, Mullan M, Crawford F.

Brain Inj. 2018;32(10):1285-1294. doi: 10.1080/02699052.2018.1486457. Epub 2018 Jun 21.

PMID:
29927671
12.

Lifelong behavioral and neuropathological consequences of repetitive mild traumatic brain injury.

Mouzon BC, Bachmeier C, Ojo JO, Acker CM, Ferguson S, Paris D, Ait-Ghezala G, Crynen G, Davies P, Mullan M, Stewart W, Crawford F.

Ann Clin Transl Neurol. 2017 Dec 14;5(1):64-80. doi: 10.1002/acn3.510. eCollection 2018 Jan.

13.

Negative Impact of Female Sex on Outcomes from Repetitive Mild Traumatic Brain Injury in hTau Mice Is Age Dependent: A Chronic Effects of Neurotrauma Consortium Study.

Ferguson SA, Mouzon BC, Lynch C, Lungmus C, Morin A, Crynen G, Carper B, Bieler G, Mufson EJ, Stewart W, Mullan M, Crawford F.

Front Aging Neurosci. 2017 Dec 22;9:416. doi: 10.3389/fnagi.2017.00416. eCollection 2017.

14.

Synoptic operative reporting: assessing the completeness, accuracy, reliability, and efficiency of synoptic reporting for Roux-en-Y gastric bypass.

Stogryn SE, Hardy K, Mullan MJ, Park J, Andrew C, Vergis A.

Surg Endosc. 2018 Apr;32(4):1729-1739. doi: 10.1007/s00464-017-5855-8. Epub 2017 Sep 15.

PMID:
28917006
15.

Alzheimer's disease pathological lesions activate the spleen tyrosine kinase.

Schweig JE, Yao H, Beaulieu-Abdelahad D, Ait-Ghezala G, Mouzon B, Crawford F, Mullan M, Paris D.

Acta Neuropathol Commun. 2017 Sep 6;5(1):69. doi: 10.1186/s40478-017-0472-2.

16.

Plasma cytokine IL-6 levels and subjective cognitive decline: preliminary findings.

Keegan AP, Paris D, Luis CA, Abdullah L, Ait-Ghezala G, Beaulieu-Abdelahad D, Pryor M, Chaykin J, Crynen G, Crawford F, Mullan M.

Int J Geriatr Psychiatry. 2018 Feb;33(2):358-363. doi: 10.1002/gps.4752. Epub 2017 Jun 22.

PMID:
28639714
17.

Pathways linking car transport for young adults and the public health in Northern Ireland: a qualitative study to inform the evaluation of graduated driver licensing.

Christie N, Steinbach R, Green J, Mullan MP, Prior L.

BMC Public Health. 2017 Jun 7;17(1):551. doi: 10.1186/s12889-017-4470-x.

18.

High-Throughput Screening To Identify Potent and Specific Inhibitors of Microbial Sulfate Reduction.

Carlson HK, Mullan MR, Mosqueda LA, Chen S, Arkin MR, Coates JD.

Environ Sci Technol. 2017 Jun 20;51(12):7278-7285. doi: 10.1021/acs.est.7b00686. Epub 2017 May 26.

PMID:
28492331
19.

Phospholipid profiling of plasma from GW veterans and rodent models to identify potential biomarkers of Gulf War Illness.

Emmerich T, Zakirova Z, Klimas N, Sullivan K, Shetty AK, Evans JE, Ait-Ghezala G, Laco GS, Hattiangady B, Shetty GA, Mullan M, Crynen G, Abdullah L, Crawford F.

PLoS One. 2017 Apr 28;12(4):e0176634. doi: 10.1371/journal.pone.0176634. eCollection 2017.

20.

Electronic synoptic reporting: assessing the completeness of synoptic and narrative reports for Roux-en-Y gastric bypass.

Vergis A, Stogryn SE, Mullan MJ, Hardy K.

Surg Obes Relat Dis. 2017 Nov;13(11):1863-1868. doi: 10.1016/j.soard.2017.02.027. Epub 2017 Mar 7.

PMID:
28433464
21.

Complementary proteomic approaches reveal mitochondrial dysfunction, immune and inflammatory dysregulation in a mouse model of Gulf War Illness.

Zakirova Z, Reed J, Crynen G, Horne L, Hassan S, Mathura V, Mullan M, Crawford F, Ait-Ghezala G.

Proteomics Clin Appl. 2017 Sep;11(9-10). doi: 10.1002/prca.201600190. Epub 2017 May 12.

22.

Increased Plasma Beta-Secretase 1 May Predict Conversion to Alzheimer's Disease Dementia in Individuals With Mild Cognitive Impairment.

Shen Y, Wang H, Sun Q, Yao H, Keegan AP, Mullan M, Wilson J, Lista S, Leyhe T, Laske C, Rujescu D, Levey A, Wallin A, Blennow K, Li R, Hampel H.

Biol Psychiatry. 2018 Mar 1;83(5):447-455. doi: 10.1016/j.biopsych.2017.02.007. Epub 2017 Mar 27.

23.

APOE ε4 specific imbalance of arachidonic acid and docosahexaenoic acid in serum phospholipids identifies individuals with preclinical Mild Cognitive Impairment/Alzheimer's Disease.

Abdullah L, Evans JE, Emmerich T, Crynen G, Shackleton B, Keegan AP, Luis C, Tai L, LaDu MJ, Mullan M, Crawford F, Bachmeier C.

Aging (Albany NY). 2017 Mar 23;9(3):964-985. doi: 10.18632/aging.101203.

24.

Translational potential of long-term decreases in mitochondrial lipids in a mouse model of Gulf War Illness.

Abdullah L, Evans JE, Joshi U, Crynen G, Reed J, Mouzon B, Baumann S, Montague H, Zakirova Z, Emmerich T, Bachmeier C, Klimas N, Sullivan K, Mullan M, Ait-Ghezala G, Crawford F.

Toxicology. 2016 Nov 30;372:22-33. doi: 10.1016/j.tox.2016.10.012. Epub 2016 Oct 29.

PMID:
27931520
25.

Acute or Delayed Treatment with Anatabine Improves Spatial Memory and Reduces Pathological Sequelae at Late Time-Points after Repetitive Mild Traumatic Brain Injury.

Ferguson S, Mouzon B, Paris D, Aponte D, Abdullah L, Stewart W, Mullan M, Crawford F.

J Neurotrauma. 2017 Apr 15;34(8):1676-1691. doi: 10.1089/neu.2016.4636. Epub 2017 Jan 20.

26.

Mild TBI Results in a Long-Term Decrease in Circulating Phospholipids in a Mouse Model of Injury.

Emmerich T, Abdullah L, Ojo J, Mouzon B, Nguyen T, Laco GS, Crynen G, Evans JE, Reed J, Mullan M, Crawford F.

Neuromolecular Med. 2017 Mar;19(1):122-135. doi: 10.1007/s12017-016-8436-4. Epub 2016 Aug 19.

PMID:
27540748
27.

European multicentre double-blind placebo-controlled trial of Nilvadipine in mild-to-moderate Alzheimer's disease-the substudy protocols: NILVAD frailty; NILVAD blood and genetic biomarkers; NILVAD cerebrospinal fluid biomarkers; NILVAD cerebral blood flow.

Meulenbroek O, O'Dwyer S, de Jong D, van Spijker G, Kennelly S, Cregg F, Olde Rikkert M, Abdullah L, Wallin A, Walsh C, Coen R, Kenny RA, Daly L, Segurado R, Borjesson-Hanson A, Crawford F, Mullan M, Lucca U, Banzi R, Pasquier F, Breuilh L, Riepe M, Kalman J, Molloy W, Tsolaki M, Howard R, Adams J, Gaynor S, Lawlor B.

BMJ Open. 2016 Jul 19;6(7):e011584. doi: 10.1136/bmjopen-2016-011584.

28.

Chronic Repetitive Mild Traumatic Brain Injury Results in Reduced Cerebral Blood Flow, Axonal Injury, Gliosis, and Increased T-Tau and Tau Oligomers.

Ojo JO, Mouzon B, Algamal M, Leary P, Lynch C, Abdullah L, Evans J, Mullan M, Bachmeier C, Stewart W, Crawford F.

J Neuropathol Exp Neurol. 2016 Jul;75(7):636-55. doi: 10.1093/jnen/nlw035. Epub 2016 May 31.

29.

Sub-Chronic Neuropathological and Biochemical Changes in Mouse Visual System after Repetitive Mild Traumatic Brain Injury.

Tzekov R, Dawson C, Orlando M, Mouzon B, Reed J, Evans J, Crynen G, Mullan M, Crawford F.

PLoS One. 2016 Apr 18;11(4):e0153608. doi: 10.1371/journal.pone.0153608. eCollection 2016.

30.

Comparison of the psychometric properties of four dementia knowledge measures: Which test should be used with dementia care staff?

Sullivan KA, Mullan MA.

Australas J Ageing. 2017 Mar;36(1):38-45. doi: 10.1111/ajag.12299. Epub 2016 Mar 11.

PMID:
26970426
31.

Plasma Lipidomic Profiling in a Military Population of Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder with Apolipoprotein E ɛ4-Dependent Effect.

Emmerich T, Abdullah L, Crynen G, Dretsch M, Evans J, Ait-Ghezala G, Reed J, Montague H, Chaytow H, Mathura V, Martin J, Pelot R, Ferguson S, Bishop A, Phillips J, Mullan M, Crawford F.

J Neurotrauma. 2016 Jul 15;33(14):1331-48. doi: 10.1089/neu.2015.4061. Epub 2016 Mar 9.

PMID:
26714394
32.

Ultrastructural Changes in the White and Gray Matter of Mice at Chronic Time Points After Repeated Concussive Head Injury.

Ojo JO, Bachmeier C, Mouzon BC, Tzekov R, Mullan M, Davies H, Stewart MG, Crawford F.

J Neuropathol Exp Neurol. 2015 Oct;74(10):1012-35. doi: 10.1097/NEN.0000000000000247.

PMID:
26360375
33.

Correction: Chronic Anatabine Treatment Reduces Alzheimer's Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD.

Verma M, Beaulieu-Abdelahad D, Ait-Ghezala G, Li R, Crawford F, Mullan M, Paris D.

PLoS One. 2015 Jul 31;10(7):e0134776. doi: 10.1371/journal.pone.0134776. eCollection 2015.

34.

Chronic Anatabine Treatment Reduces Alzheimer's Disease (AD)-Like Pathology and Improves Socio-Behavioral Deficits in a Transgenic Mouse Model of AD.

Verma M, Beaulieu-Abdelahad D, Ait-Ghezala G, Li R, Crawford F, Mullan M, Paris D.

PLoS One. 2015 May 26;10(5):e0128224. doi: 10.1371/journal.pone.0128224. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0134776.

35.

Gulf War agent exposure causes impairment of long-term memory formation and neuropathological changes in a mouse model of Gulf War Illness.

Zakirova Z, Tweed M, Crynen G, Reed J, Abdullah L, Nissanka N, Mullan M, Mullan MJ, Mathura V, Crawford F, Ait-Ghezala G.

PLoS One. 2015 Mar 18;10(3):e0119579. doi: 10.1371/journal.pone.0119579. eCollection 2015.

36.

Positive attitudes and person-centred care predict of sense of competence in dementia care staff.

Mullan MA, Sullivan KA.

Aging Ment Health. 2016;20(4):407-14. doi: 10.1080/13607863.2015.1018865. Epub 2015 Mar 11.

PMID:
25760319
37.

Monofluorophosphate is a selective inhibitor of respiratory sulfate-reducing microorganisms.

Carlson HK, Stoeva MK, Justice NB, Sczesnak A, Mullan MR, Mosqueda LA, Kuehl JV, Deutschbauer AM, Arkin AP, Coates JD.

Environ Sci Technol. 2015 Mar 17;49(6):3727-36. doi: 10.1021/es505843z. Epub 2015 Mar 4.

PMID:
25698072
38.

Mechanisms of direct inhibition of the respiratory sulfate-reduction pathway by (per)chlorate and nitrate.

Carlson HK, Kuehl JV, Hazra AB, Justice NB, Stoeva MK, Sczesnak A, Mullan MR, Iavarone AT, Engelbrektson A, Price MN, Deutschbauer AM, Arkin AP, Coates JD.

ISME J. 2015 Jun;9(6):1295-305. doi: 10.1038/ismej.2014.216. Epub 2014 Nov 18.

39.

The spleen tyrosine kinase (Syk) regulates Alzheimer amyloid-β production and Tau hyperphosphorylation.

Paris D, Ait-Ghezala G, Bachmeier C, Laco G, Beaulieu-Abdelahad D, Lin Y, Jin C, Crawford F, Mullan M.

J Biol Chem. 2014 Dec 5;289(49):33927-44. doi: 10.1074/jbc.M114.608091. Epub 2014 Oct 20.

40.

NILVAD protocol: a European multicentre double-blind placebo-controlled trial of nilvadipine in mild-to-moderate Alzheimer's disease.

Lawlor B, Kennelly S, O'Dwyer S, Cregg F, Walsh C, Coen R, Kenny RA, Howard R, Murphy C, Adams J, Daly L, Segurado R, Gaynor S, Crawford F, Mullan M, Lucca U, Banzi R, Pasquier F, Breuilh L, Riepe M, Kalman J, Wallin A, Borjesson A, Molloy W, Tsolaki M, Olde Rikkert M.

BMJ Open. 2014 Oct 9;4(10):e006364. doi: 10.1136/bmjopen-2014-006364. Erratum in: BMJ Open. 2015;5(9):e006364.

41.

Lipidomic analyses identify injury-specific phospholipid changes 3 mo after traumatic brain injury.

Abdullah L, Evans JE, Ferguson S, Mouzon B, Montague H, Reed J, Crynen G, Emmerich T, Crocker M, Pelot R, Mullan M, Crawford F.

FASEB J. 2014 Dec;28(12):5311-21. doi: 10.1096/fj.14-258228. Epub 2014 Sep 10.

PMID:
25208845
42.

Apolipoprotein E isoform-specific effects on lipoprotein receptor processing.

Bachmeier C, Shackleton B, Ojo J, Paris D, Mullan M, Crawford F.

Neuromolecular Med. 2014 Dec;16(4):686-96.

43.

Neurobehavioral, neuropathological and biochemical profiles in a novel mouse model of co-morbid post-traumatic stress disorder and mild traumatic brain injury.

Ojo JO, Greenberg MB, Leary P, Mouzon B, Bachmeier C, Mullan M, Diamond DM, Crawford F.

Front Behav Neurosci. 2014 Jun 23;8:213. doi: 10.3389/fnbeh.2014.00213. eCollection 2014.

44.

General paediatric surgery: a survey of Northern Ireland general surgery specialist registrars.

Mullan MJ, Grannell M, Dick AC.

Ulster Med J. 2014 Jan;83(1):50-1. No abstract available.

45.

Repetitive mild traumatic brain injury causes optic nerve and retinal damage in a mouse model.

Tzekov R, Quezada A, Gautier M, Biggins D, Frances C, Mouzon B, Jamison J, Mullan M, Crawford F.

J Neuropathol Exp Neurol. 2014 Apr;73(4):345-61. doi: 10.1097/NEN.0000000000000059.

PMID:
24607965
46.

Vision function abnormalities in Alzheimer disease.

Tzekov R, Mullan M.

Surv Ophthalmol. 2014 Jul-Aug;59(4):414-33. doi: 10.1016/j.survophthal.2013.10.002. Epub 2013 Oct 22. Review.

PMID:
24309127
47.

Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model.

Mouzon BC, Bachmeier C, Ferro A, Ojo JO, Crynen G, Acker CM, Davies P, Mullan M, Stewart W, Crawford F.

Ann Neurol. 2014 Feb;75(2):241-54. doi: 10.1002/ana.24064. Epub 2014 Feb 20.

PMID:
24243523
48.

Chronic elevation of phosphocholine containing lipids in mice exposed to Gulf War agents pyridostigmine bromide and permethrin.

Abdullah L, Evans JE, Montague H, Reed JM, Moser A, Crynen G, Gonzalez A, Zakirova Z, Ross I, Mullan C, Mullan M, Ait-Ghezala G, Crawford F.

Neurotoxicol Teratol. 2013 Nov-Dec;40:74-84. doi: 10.1016/j.ntt.2013.10.002. Epub 2013 Oct 17.

PMID:
24140745
49.
50.

Effect of venlafaxine and desvenlafaxine on drug efflux protein expression and biodistribution in vivo.

Bachmeier C, Levin GM, Beaulieu-Abdelahad D, Reed J, Mullan M.

J Pharm Sci. 2013 Oct;102(10):3838-43. doi: 10.1002/jps.23680. Epub 2013 Jul 29.

PMID:
23897419

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