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Mitochondria Permeability Transition versus Necroptosis in Oxalate-Induced AKI.

Mulay SR, Honarpisheh MM, Foresto-Neto O, Shi C, Desai J, Zhao ZB, Marschner JA, Popper B, Buhl EM, Boor P, Linkermann A, Liapis H, Bilyy R, Herrmann M, Romagnani P, Belevich I, Jokitalo E, Becker JU, Anders HJ.

J Am Soc Nephrol. 2019 Jul 11. pii: ASN.2018121218. doi: 10.1681/ASN.2018121218. [Epub ahead of print]


The gut flora modulates intestinal barrier integrity but not progression of chronic kidney disease in hyperoxaluria-related nephrocalcinosis.

Konrad L, Andersen K, Kesper MS, Kumar SV, Mulay SR, Anders HJ.

Nephrol Dial Transplant. 2019 May 12. pii: gfz080. doi: 10.1093/ndt/gfz080. [Epub ahead of print]


Editorial: Nano- and Microparticle-Induced Cell Death, Inflammation and Immune Responses.

Mulay SR, Herrmann M, Bilyy R, Gabibov A, Anders HJ.

Front Immunol. 2019 Apr 17;10:844. doi: 10.3389/fimmu.2019.00844. eCollection 2019. No abstract available.


Multifactorial functions of the inflammasome component NLRP3 in pathogenesis of chronic kidney diseases.

Mulay SR.

Kidney Int. 2019 Jul;96(1):58-66. doi: 10.1016/j.kint.2019.01.014. Epub 2019 Mar 4. Review.


CXCL12 blockade preferentially regenerates lost podocytes in cortical nephrons by targeting an intrinsic podocyte-progenitor feedback mechanism.

Romoli S, Angelotti ML, Antonelli G, Kumar Vr S, Mulay SR, Desai J, Anguiano Gomez L, Thomasova D, Eulberg D, Klussmann S, Melica ME, Conte C, Lombardi D, Lasagni L, Anders HJ, Romagnani P.

Kidney Int. 2018 Dec;94(6):1111-1126. doi: 10.1016/j.kint.2018.08.013. Epub 2018 Oct 29.


Genetic mitochondrial glycine amidinotransferase protein aggregate formation triggers microparticle sensing and kidney failure.

Mulay SR, Anders HJ.

Ann Transl Med. 2018 Aug;6(16):315. doi: 10.21037/atm.2018.07.09. No abstract available.


The Long Pentraxin PTX3 Is an Endogenous Inhibitor of Hyperoxaluria-Related Nephrocalcinosis and Chronic Kidney Disease.

Marschner JA, Mulay SR, Steiger S, Anguiano L, Zhao Z, Boor P, Rahimi K, Inforzato A, Garlanda C, Mantovani A, Anders HJ.

Front Immunol. 2018 Sep 25;9:2173. doi: 10.3389/fimmu.2018.02173. eCollection 2018.


IL-22 sustains epithelial integrity in progressive kidney remodeling and fibrosis.

Weidenbusch M, Song S, Iwakura T, Shi C, Rodler S, Kobold S, Mulay SR, Honarpisheh MM, Anders HJ.

Physiol Rep. 2018 Aug;6(16):e13817. doi: 10.14814/phy2.13817.


Activated platelets induce MLKL-driven neutrophil necroptosis and release of neutrophil extracellular traps in venous thrombosis.

Nakazawa D, Desai J, Steiger S, Müller S, Devarapu SK, Mulay SR, Iwakura T, Anders HJ.

Cell Death Discov. 2018 Jun 28;4:6. doi: 10.1038/s41420-018-0073-2. eCollection 2018. Erratum in: Cell Death Discov. 2019 Jul 10;5:116.


Novel Insights into Crystal-Induced Kidney Injury.

Mulay SR, Shi C, Ma X, Anders HJ.

Kidney Dis (Basel). 2018 Jun;4(2):49-57. doi: 10.1159/000487671. Epub 2018 Apr 3. Review.


Author Correction: Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin.

Desai J, Foresto-Neto O, Honarpisheh M, Steiger S, Nakazawa D, Popper B, Buhl EM, Boor P, Mulay SR, Anders HJ.

Sci Rep. 2018 Apr 24;8(1):6663. doi: 10.1038/s41598-018-24793-2.


RGMb protects against acute kidney injury by inhibiting tubular cell necroptosis via an MLKL-dependent mechanism.

Liu W, Chen B, Wang Y, Meng C, Huang H, Huang XR, Qin J, Mulay SR, Anders HJ, Qiu A, Yang B, Freeman GJ, Lu HJ, Lin HY, Zheng ZH, Lan HY, Huang Y, Xia Y.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1475-E1484. doi: 10.1073/pnas.1716959115. Epub 2018 Jan 30.


The macrophage phenotype and inflammasome component NLRP3 contributes to nephrocalcinosis-related chronic kidney disease independent from IL-1-mediated tissue injury.

Anders HJ, Suarez-Alvarez B, Grigorescu M, Foresto-Neto O, Steiger S, Desai J, Marschner JA, Honarpisheh M, Shi C, Jordan J, Müller L, Burzlaff N, Bäuerle T, Mulay SR.

Kidney Int. 2018 Mar;93(3):656-669. doi: 10.1016/j.kint.2017.09.022. Epub 2017 Dec 12.


Phagocytosis of environmental or metabolic crystalline particles induces cytotoxicity by triggering necroptosis across a broad range of particle size and shape.

Honarpisheh M, Foresto-Neto O, Desai J, Steiger S, Gómez LA, Popper B, Boor P, Anders HJ, Mulay SR.

Sci Rep. 2017 Nov 14;7(1):15523. doi: 10.1038/s41598-017-15804-9.


Particles of different sizes and shapes induce neutrophil necroptosis followed by the release of neutrophil extracellular trap-like chromatin.

Desai J, Foresto-Neto O, Honarpisheh M, Steiger S, Nakazawa D, Popper B, Buhl EM, Boor P, Mulay SR, Anders HJ.

Sci Rep. 2017 Nov 3;7(1):15003. doi: 10.1038/s41598-017-15106-0. Erratum in: Sci Rep. 2018 Apr 24;8(1):6663.


Gene expression profiling of the Notch-AhR-IL22 axis at homeostasis and in response to tissue injury.

Weidenbusch M, Rodler S, Song S, Romoli S, Marschner JA, Kraft F, Holderied A, Kumar S, Mulay SR, Honarpisheh M, Kumar Devarapu S, Lech M, Anders HJ.

Biosci Rep. 2017 Dec 22;37(6). pii: BSR20170099. doi: 10.1042/BSR20170099. Print 2017 Dec 22.


Tumor necrosis factor superfamily ligand mRNA expression profiles differ between humans and mice during homeostasis and between various murine kidney injuries.

Devarapu SK, Grill JF, Xie J, Weidenbusch M, Honarpisheh M, Vielhauer V, Anders HJ, Mulay SR.

J Biomed Sci. 2017 Sep 19;24(1):77. doi: 10.1186/s12929-017-0383-3.


Cathepsin S inhibition combines control of systemic and peripheral pathomechanisms of autoimmune tissue injury.

Tato M, Kumar SV, Liu Y, Mulay SR, Moll S, Popper B, Eberhard JN, Thomasova D, Rufer AC, Gruner S, Haap W, Hartmann G, Anders HJ.

Sci Rep. 2017 Jun 5;7(1):2775. doi: 10.1038/s41598-017-01894-y.


Cellular and Molecular Mechanisms of Autoimmunity and Lupus Nephritis.

Devarapu SK, Lorenz G, Kulkarni OP, Anders HJ, Mulay SR.

Int Rev Cell Mol Biol. 2017;332:43-154. doi: 10.1016/bs.ircmb.2016.12.001. Epub 2017 Feb 4. Review.


Circulating cathepsin-S levels correlate with GFR decline and sTNFR1 and sTNFR2 levels in mice and humans.

Steubl D, Kumar SV, Tato M, Mulay SR, Larsson A, Lind L, Risérus U, Renders L, Heemann U, Carlsson AC, Ärnlöv J, Anders HJ.

Sci Rep. 2017 Feb 27;7:43538. doi: 10.1038/srep43538.


Crystal nephropathies: mechanisms of crystal-induced kidney injury.

Mulay SR, Anders HJ.

Nat Rev Nephrol. 2017 Apr;13(4):226-240. doi: 10.1038/nrneph.2017.10. Epub 2017 Feb 20. Review.


Regulated necrosis-related molecule mRNA expression in humans and mice and in murine acute tissue injury and systemic autoimmunity leading to progressive organ damage, and progressive fibrosis.

Honarpisheh M, Desai J, Marschner JA, Weidenbusch M, Lech M, Vielhauer V, Anders HJ, Mulay SR.

Biosci Rep. 2016 Dec 9;36(6). pii: e00425. doi: 10.1042/BSR20160336. Print 2016 Dec.


Systems biology analysis reveals role of MDM2 in diabetic nephropathy.

Saito R, Rocanin-Arjo A, You YH, Darshi M, Van Espen B, Miyamoto S, Pham J, Pu M, Romoli S, Natarajan L, Ju W, Kretzler M, Nelson R, Ono K, Thomasova D, Mulay SR, Ideker T, D'Agati V, Beyret E, Belmonte JCI, Anders HJ, Sharma K.

JCI Insight. 2016 Oct 20;1(17):e87877. doi: 10.1172/jci.insight.87877.



Mulay SR, Anders H-J.

N Engl J Med. 2016 Sep 29;375(13):e29. doi: 10.1056/NEJMc1609332. No abstract available.


Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease.

Mulay SR, Eberhard JN, Desai J, Marschner JA, Kumar SV, Weidenbusch M, Grigorescu M, Lech M, Eltrich N, Müller L, Hans W, Hrabě de Angelis M, Vielhauer V, Hoppe B, Asplin J, Burzlaff N, Herrmann M, Evan A, Anders HJ.

J Am Soc Nephrol. 2017 Mar;28(3):761-768. doi: 10.1681/ASN.2016040486. Epub 2016 Sep 9.


The Immune System in Tissue Environments Regaining Homeostasis after Injury: Is "Inflammation" Always Inflammation?

Kulkarni OP, Lichtnekert J, Anders HJ, Mulay SR.

Mediators Inflamm. 2016;2016:2856213. doi: 10.1155/2016/2856213. Epub 2016 Aug 11. Review.


How Kidney Cell Death Induces Renal Necroinflammation.

Mulay SR, Kumar SV, Lech M, Desai J, Anders HJ.

Semin Nephrol. 2016 May;36(3):162-73. doi: 10.1016/j.semnephrol.2016.03.004. Review.



Mulay SR, Anders HJ.

N Engl J Med. 2016 Jun 23;374(25):2465-76. doi: 10.1056/NEJMra1601611. Review. No abstract available.


Intestinal Dysbiosis, Barrier Dysfunction, and Bacterial Translocation Account for CKD-Related Systemic Inflammation.

Andersen K, Kesper MS, Marschner JA, Konrad L, Ryu M, Kumar Vr S, Kulkarni OP, Mulay SR, Romoli S, Demleitner J, Schiller P, Dietrich A, Müller S, Gross O, Ruscheweyh HJ, Huson DH, Stecher B, Anders HJ.

J Am Soc Nephrol. 2017 Jan;28(1):76-83. doi: 10.1681/ASN.2015111285. Epub 2016 May 5.


Murine Double Minute-2 Inhibition Ameliorates Established Crescentic Glomerulonephritis.

Mulay SR, Romoli S, Desai J, Honarpisheh MM, Kumar SV, Anders HJ, Thomasova D.

Am J Pathol. 2016 Jun;186(6):1442-53. doi: 10.1016/j.ajpath.2016.01.017. Epub 2016 Apr 18.


Targeting Inflammation in So-Called Acute Kidney Injury.

Mulay SR, Holderied A, Kumar SV, Anders HJ.

Semin Nephrol. 2016 Jan;36(1):17-30. doi: 10.1016/j.semnephrol.2016.01.006. Review.


Matters of life and death. How neutrophils die or survive along NET release and is "NETosis" = necroptosis?

Desai J, Mulay SR, Nakazawa D, Anders HJ.

Cell Mol Life Sci. 2016 Jun;73(11-12):2211-9. doi: 10.1007/s00018-016-2195-0. Epub 2016 Apr 5. Review.


Cytotoxicity of crystals involves RIPK3-MLKL-mediated necroptosis.

Mulay SR, Desai J, Kumar SV, Eberhard JN, Thomasova D, Romoli S, Grigorescu M, Kulkarni OP, Popper B, Vielhauer V, Zuchtriegel G, Reichel C, Bräsen JH, Romagnani P, Bilyy R, Munoz LE, Herrmann M, Liapis H, Krautwald S, Linkermann A, Anders HJ.

Nat Commun. 2016 Jan 28;7:10274. doi: 10.1038/ncomms10274.


Oxalate-induced chronic kidney disease with its uremic and cardiovascular complications in C57BL/6 mice.

Mulay SR, Eberhard JN, Pfann V, Marschner JA, Darisipudi MN, Daniel C, Romoli S, Desai J, Grigorescu M, Kumar SV, Rathkolb B, Wolf E, Hrabě de Angelis M, Bäuerle T, Dietel B, Wagner CA, Amann K, Eckardt KU, Aronson PS, Anders HJ, Knauf F.

Am J Physiol Renal Physiol. 2016 Apr 15;310(8):F785-F795. doi: 10.1152/ajprenal.00488.2015. Epub 2016 Jan 13.


Cathepsin S Cleavage of Protease-Activated Receptor-2 on Endothelial Cells Promotes Microvascular Diabetes Complications.

Kumar Vr S, Darisipudi MN, Steiger S, Devarapu SK, Tato M, Kukarni OP, Mulay SR, Thomasova D, Popper B, Demleitner J, Zuchtriegel G, Reichel C, Cohen CD, Lindenmeyer MT, Liapis H, Moll S, Reid E, Stitt AW, Schott B, Gruner S, Haap W, Ebeling M, Hartmann G, Anders HJ.

J Am Soc Nephrol. 2016 Jun;27(6):1635-49. doi: 10.1681/ASN.2015020208. Epub 2015 Nov 13.


PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling.

Desai J, Kumar SV, Mulay SR, Konrad L, Romoli S, Schauer C, Herrmann M, Bilyy R, Müller S, Popper B, Nakazawa D, Weidenbusch M, Thomasova D, Krautwald S, Linkermann A, Anders HJ.

Eur J Immunol. 2016 Jan;46(1):223-9. doi: 10.1002/eji.201545605. Epub 2015 Nov 30.


Necroinflammation in Kidney Disease.

Mulay SR, Linkermann A, Anders HJ.

J Am Soc Nephrol. 2016 Jan;27(1):27-39. doi: 10.1681/ASN.2015040405. Epub 2015 Sep 2. Review.


MDM2 beyond cancer: podoptosis, development, inflammation, and tissue regeneration.

Ebrahim M, Mulay SR, Anders HJ, Thomasova D.

Histol Histopathol. 2015 Nov;30(11):1271-82. doi: 10.14670/HH-11-636. Epub 2015 Jun 11. Review.


Neutrophil Extracellular Trap-Related Extracellular Histones Cause Vascular Necrosis in Severe GN.

Kumar SV, Kulkarni OP, Mulay SR, Darisipudi MN, Romoli S, Thomasova D, Scherbaum CR, Hohenstein B, Hugo C, Müller S, Liapis H, Anders HJ.

J Am Soc Nephrol. 2015 Oct;26(10):2399-413. doi: 10.1681/ASN.2014070673. Epub 2015 Feb 2.


Synchronized renal tubular cell death involves ferroptosis.

Linkermann A, Skouta R, Himmerkus N, Mulay SR, Dewitz C, De Zen F, Prokai A, Zuchtriegel G, Krombach F, Welz PS, Weinlich R, Vanden Berghe T, Vandenabeele P, Pasparakis M, Bleich M, Weinberg JM, Reichel CA, Bräsen JH, Kunzendorf U, Anders HJ, Stockwell BR, Green DR, Krautwald S.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16836-41. doi: 10.1073/pnas.1415518111. Epub 2014 Nov 10.


Toll-like receptor 4-induced IL-22 accelerates kidney regeneration.

Kulkarni OP, Hartter I, Mulay SR, Hagemann J, Darisipudi MN, Kumar Vr S, Romoli S, Thomasova D, Ryu M, Kobold S, Anders HJ.

J Am Soc Nephrol. 2014 May;25(5):978-89. doi: 10.1681/ASN.2013050528. Epub 2014 Jan 23.


Macrophage phenotype controls long-term AKI outcomes--kidney regeneration versus atrophy.

Lech M, Gröbmayr R, Ryu M, Lorenz G, Hartter I, Mulay SR, Susanti HE, Kobayashi KS, Flavell RA, Anders HJ.

J Am Soc Nephrol. 2014 Feb;25(2):292-304. doi: 10.1681/ASN.2013020152. Epub 2013 Dec 5.


Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming.

Rupanagudi KV, Kulkarni OP, Lichtnekert J, Darisipudi MN, Mulay SR, Schott B, Gruner S, Haap W, Hartmann G, Anders HJ.

Ann Rheum Dis. 2015 Feb;74(2):452-63. doi: 10.1136/annrheumdis-2013-203717. Epub 2013 Dec 3.


Molecular mechanisms of crystal-related kidney inflammation and injury. Implications for cholesterol embolism, crystalline nephropathies and kidney stone disease.

Mulay SR, Evan A, Anders HJ.

Nephrol Dial Transplant. 2014 Mar;29(3):507-14. doi: 10.1093/ndt/gft248. Epub 2013 Oct 25.


Podocyte loss involves MDM2-driven mitotic catastrophe.

Mulay SR, Thomasova D, Ryu M, Kulkarni OP, Migliorini A, Bruns H, Gröbmayr R, Lazzeri E, Lasagni L, Liapis H, Romagnani P, Anders HJ.

J Pathol. 2013 Jul;230(3):322-35. doi: 10.1002/path.4193.


The antiviral cytokines IFN-α and IFN-β modulate parietal epithelial cells and promote podocyte loss: implications for IFN toxicity, viral glomerulonephritis, and glomerular regeneration.

Migliorini A, Angelotti ML, Mulay SR, Kulkarni OO, Demleitner J, Dietrich A, Sagrinati C, Ballerini L, Peired A, Shankland SJ, Liapis H, Romagnani P, Anders HJ.

Am J Pathol. 2013 Aug;183(2):431-40. doi: 10.1016/j.ajpath.2013.04.017. Epub 2013 Jun 5.


Nrf2 signalling promotes ex vivo tubular epithelial cell survival and regeneration via murine double minute (MDM)-2.

Hagemann JH, Thomasova D, Mulay SR, Anders HJ.

Nephrol Dial Transplant. 2013 Aug;28(8):2028-37. doi: 10.1093/ndt/gft037. Epub 2013 Mar 8.


Analysis of TNF-mediated recruitment and activation of glomerular dendritic cells in mouse kidneys by compartment-specific flow cytometry.

Schwarz M, Taubitz A, Eltrich N, Mulay SR, Allam R, Vielhauer V.

Kidney Int. 2013 Jul;84(1):116-29. doi: 10.1038/ki.2013.46. Epub 2013 Mar 6.


Calcium oxalate crystals induce renal inflammation by NLRP3-mediated IL-1β secretion.

Mulay SR, Kulkarni OP, Rupanagudi KV, Migliorini A, Darisipudi MN, Vilaysane A, Muruve D, Shi Y, Munro F, Liapis H, Anders HJ.

J Clin Invest. 2013 Jan;123(1):236-46. doi: 10.1172/JCI63679. Epub 2012 Dec 10.

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