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Items: 38

1.

Classical and novel strategies to develop a Shigella glycoconjugate vaccine: from concept to efficacy in human.

Barel LA, Mulard LA.

Hum Vaccin Immunother. 2019 Jun 3. doi: 10.1080/21645515.2019.1606972. [Epub ahead of print]

PMID:
31158047
2.

ADP-heptose is a newly identified pathogen-associated molecular pattern of Shigella flexneri.

García-Weber D, Dangeard AS, Cornil J, Thai L, Rytter H, Zamyatina A, Mulard LA, Arrieumerlou C.

EMBO Rep. 2018 Dec;19(12). pii: e46943. doi: 10.15252/embr.201846943. Epub 2018 Nov 19.

PMID:
30455202
3.

Bacteriophage Sf6 Tailspike Protein for Detection of Shigella flexneri Pathogens.

Kunstmann S, Scheidt T, Buchwald S, Helm A, Mulard LA, Fruth A, Barbirz S.

Viruses. 2018 Aug 15;10(8). pii: E431. doi: 10.3390/v10080431.

4.

Efficient Iterative Synthesis of O-Acetylated Tri- to Pentadecasaccharides Related to the Lipopolysaccharide of Shigella flexneri Type 3 a through Di- and Trisaccharide Glycosyl Donors.

Hu Z, Bongat White AF, Mulard LA.

Chem Asian J. 2017 Feb 16;12(4):419-439. doi: 10.1002/asia.201600819. Epub 2017 Jan 12.

PMID:
27385615
5.

Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation as Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy for Shigella flexneri 3a.

Boutet J, Blasco P, Guerreiro C, Thouron F, Dartevelle S, Nato F, Cañada FJ, Ardá A, Phalipon A, Jiménez-Barbero J, Mulard LA.

Chemistry. 2016 Jul 25;22(31):10892-911. doi: 10.1002/chem.201600567. Epub 2016 Jul 4.

PMID:
27376496
6.

A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity.

van der Put RM, Kim TH, Guerreiro C, Thouron F, Hoogerhout P, Sansonetti PJ, Westdijk J, Stork M, Phalipon A, Mulard LA.

Bioconjug Chem. 2016 Apr 20;27(4):883-92. doi: 10.1021/acs.bioconjchem.5b00617. Epub 2016 Mar 21.

PMID:
26918643
7.

Investigation on the Synthesis of Shigella flexneri Specific Oligosaccharides Using Disaccharides as Potential Transglucosylase Acceptor Substrates.

Salamone S, Guerreiro C, Cambon E, Hargreaves JM, Tarrat N, Remaud-Siméon M, André I, Mulard LA.

J Org Chem. 2015 Nov 20;80(22):11237-57. doi: 10.1021/acs.joc.5b01407. Epub 2015 Nov 10.

PMID:
26340432
8.

Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate.

Salamone S, Guerreiro C, Cambon E, André I, Remaud-Siméon M, Mulard LA.

Chem Commun (Camb). 2015 Feb 14;51(13):2581-4. doi: 10.1039/c4cc08805k.

PMID:
25569152
9.

Synthesis of the zwitterionic repeating unit of the O-antigen from Shigella sonnei and chain elongation at both ends.

Pfister HB, Mulard LA.

Org Lett. 2014 Sep 19;16(18):4892-5. doi: 10.1021/ol502395k. Epub 2014 Sep 11.

PMID:
25210812
10.

Linear synthesis of the branched pentasaccharide repeats of O-antigens from Shigella flexneri 1a and 1b demonstrating the major steric hindrance associated with type-specific glucosylation.

Hargreaves JM, Le Guen Y, Guerreiro C, Descroix K, Mulard LA.

Org Biomol Chem. 2014 Oct 21;12(39):7728-49. doi: 10.1039/c4ob01200c. Epub 2014 Aug 21.

PMID:
25141906
11.

Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity.

Gauthier C, Chassagne P, Theillet FX, Guerreiro C, Thouron F, Nato F, Delepierre M, Sansonetti PJ, Phalipon A, Mulard LA.

Org Biomol Chem. 2014 Jun 28;12(24):4218-32. doi: 10.1039/c3ob42586j.

PMID:
24836582
12.

CGTase-catalysed cis-glucosylation of L-rhamnosides for the preparation of Shigella flexneri 2a and 3a haptens.

Urbach C, Halila S, Guerreiro C, Driguez H, Mulard LA, Armand S.

Chembiochem. 2014 Jan 24;15(2):293-300. doi: 10.1002/cbic.201300597. Epub 2013 Dec 20.

PMID:
24376024
13.

Applying pairwise combinations of amino acid mutations for sorting out highly efficient glucosylation tools for chemo-enzymatic synthesis of bacterial oligosaccharides.

Champion E, Guérin F, Moulis C, Barbe S, Tran TH, Morel S, Descroix K, Monsan P, Mourey L, Mulard LA, Tranier S, Remaud-Siméon M, André I.

J Am Chem Soc. 2012 Nov 14;134(45):18677-88. doi: 10.1021/ja306845b. Epub 2012 Oct 30.

PMID:
23072374
14.

Dynamic aspects of antibody:oligosaccharide complexes characterized by molecular dynamics simulations and saturation transfer difference nuclear magnetic resonance.

Theillet FX, Frank M, Vulliez-Le Normand B, Simenel C, Hoos S, Chaffotte A, Bélot F, Guerreiro C, Nato F, Phalipon A, Mulard LA, Delepierre M.

Glycobiology. 2011 Dec;21(12):1570-9. doi: 10.1093/glycob/cwr059. Epub 2011 May 24.

PMID:
21610193
15.

Effects of backbone substitutions on the conformational behavior of Shigella flexneri O-antigens: implications for vaccine strategy.

Theillet FX, Simenel C, Guerreiro C, Phalipon A, Mulard LA, Delepierre M.

Glycobiology. 2011 Jan;21(1):109-21. doi: 10.1093/glycob/cwq136. Epub 2010 Oct 28.

PMID:
21030536
16.

Rational design and immunogenicity of liposome-based diepitope constructs: application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen.

Said Hassane F, Phalipon A, Tanguy M, Guerreiro C, Bélot F, Frisch B, Mulard LA, Schuber F.

Vaccine. 2009 Aug 27;27(39):5419-26. doi: 10.1016/j.vaccine.2009.06.031. Epub 2009 Jun 24.

PMID:
19559116
17.

Design of alpha-transglucosidases of controlled specificity for programmed chemoenzymatic synthesis of antigenic oligosaccharides.

Champion E, André I, Moulis C, Boutet J, Descroix K, Morel S, Monsan P, Mulard LA, Remaud-Siméon M.

J Am Chem Soc. 2009 Jun 3;131(21):7379-89. doi: 10.1021/ja900183h.

PMID:
19432472
18.

Structural mimicry of O-antigen by a peptide revealed in a complex with an antibody raised against Shigella flexneri serotype 2a.

Theillet FX, Saul FA, Vulliez-Le Normand B, Hoos S, Felici F, Weintraub A, Mulard LA, Phalipon A, Delepierre M, Bentley GA.

J Mol Biol. 2009 May 15;388(4):839-50. doi: 10.1016/j.jmb.2009.03.057. Epub 2009 Mar 27.

PMID:
19328810
20.

A synthetic carbohydrate-protein conjugate vaccine candidate against Shigella flexneri 2a infection.

Phalipon A, Tanguy M, Grandjean C, Guerreiro C, Bélot F, Cohen D, Sansonetti PJ, Mulard LA.

J Immunol. 2009 Feb 15;182(4):2241-7. doi: 10.4049/jimmunol.0803141.

21.

Vaccination against shigellosis: is it the path that is difficult or is it the difficult that is the path?

Phalipon A, Mulard LA, Sansonetti PJ.

Microbes Infect. 2008 Jul;10(9):1057-62. doi: 10.1016/j.micinf.2008.07.016. Epub 2008 Jul 10. Review.

PMID:
18672087
22.

Investigation towards bivalent chemically defined glycoconjugate immunogens prepared from acid-detoxified lipopolysaccharide of Vibrio cholerae O1, serotype Inaba.

Grandjean C, Boutonnier A, Dassy B, Fournier JM, Mulard LA.

Glycoconj J. 2009 Jan;26(1):41-55. doi: 10.1007/s10719-008-9160-6. Epub 2008 Jul 23.

PMID:
18648931
23.

Structures of synthetic O-antigen fragments from serotype 2a Shigella flexneri in complex with a protective monoclonal antibody.

Vulliez-Le Normand B, Saul FA, Phalipon A, Bélot F, Guerreiro C, Mulard LA, Bentley GA.

Proc Natl Acad Sci U S A. 2008 Jul 22;105(29):9976-81. doi: 10.1073/pnas.0801711105. Epub 2008 Jul 10.

24.

Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine.

Phalipon A, Costachel C, Grandjean C, Thuizat A, Guerreiro C, Tanguy M, Nato F, Vulliez-Le Normand B, Bélot F, Wright K, Marcel-Peyre V, Sansonetti PJ, Mulard LA.

J Immunol. 2006 Feb 1;176(3):1686-94.

25.

Toward a better understanding of the basis of the molecular mimicry of polysaccharide antigens by peptides: the example of Shigella flexneri 5a.

Clément MJ, Fortuné A, Phalipon A, Marcel-Peyre V, Simenel C, Imberty A, Delepierre M, Mulard LA.

J Biol Chem. 2006 Jan 27;281(4):2317-32. Epub 2005 Oct 26.

26.

On the preparation of carbohydrate-protein conjugates using the traceless Staudinger ligation.

Grandjean C, Boutonnier A, Guerreiro C, Fournier JM, Mulard LA.

J Org Chem. 2005 Sep 2;70(18):7123-32.

PMID:
16122231
28.

Preparation of synthetic glycoconjugates as potential vaccines against Shigella flexneri serotype 2a disease.

Wright K, Guerreiro C, Laurent I, Baleux F, Mulard LA.

Org Biomol Chem. 2004 May 21;2(10):1518-27. Epub 2004 Apr 26.

PMID:
15136809
30.

Conformational studies of the O-specific polysaccharide of Shigella flexneri 5a and of four related synthetic pentasaccharide fragments using NMR and molecular modeling.

Clément MJ, Imberty A, Phalipon A, Pérez S, Simenel C, Mulard LA, Delepierre M.

J Biol Chem. 2003 Nov 28;278(48):47928-36. Epub 2003 Aug 18.

32.

Immunochemical characterization of an Ogawa-Inaba common antigenic determinant of Vibrio cholerae O1.

Villeneuve S, Boutonnier A, Mulard LA, Fournier JM.

Microbiology. 1999 Sep;145 ( Pt 9):2477-84.

PMID:
10517600
35.
36.

Synthesis of specifically monofluorinated ligands related to the O-polysaccharide of Shigella dysenteriae type 1.

Mulard LA, Kovác P, Glaudemans CP.

Carbohydr Res. 1994 Jun 2;259(1):21-34.

PMID:
7518745
37.

Fluorination at position 6 of derivatives of methyl alpha-D-galactopyranoside.

Mulard LA, Kovác P, Glaudemans CP.

Carbohydr Res. 1994 Jun 2;259(1):117-29. No abstract available.

PMID:
7518742

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