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Items: 19

1.

Comparison of Semi-Automated Versus Manual Quantitative Right Ventricular Assessment in Hypoplastic Left Heart Syndrome.

Penk J, Mukadam S, Zaidi SJ, Cui V, Metzger R, Roberson DA, Li Y.

Pediatr Cardiol. 2019 Oct 28. doi: 10.1007/s00246-019-02223-y. [Epub ahead of print]

PMID:
31659391
2.

Phase I/II Study of Palliative Triple Metronomic Chemotherapy in Platinum-Refractory/Early-Failure Oral Cancer.

Patil VM, Noronha V, Joshi A, Dhumal S, Mahimkar M, Bhattacharjee A, Gota V, Pandey M, Menon N, Mahajan A, Sable N, Kumar S, Nawale K, Mukadam S, Solanki B, Das S, Simha V, Abraham G, Chandrasekharan A, Talreja V, DSouza H, Srinivas S, Kashyap L, Banavali S, Prabhash K.

J Clin Oncol. 2019 Nov 10;37(32):3032-3041. doi: 10.1200/JCO.19.01076. Epub 2019 Sep 20.

PMID:
31539316
3.

Preclinical assessment of the ADME, efficacy and drug-drug interaction potential of a novel NAMPT inhibitor.

Liederer BM, Cheong J, Chou KJ, Dragovich PS, Le H, Liang X, Ly J, Mukadam S, Oeh J, Sampath D, Wang L, Wong S.

Xenobiotica. 2019 Sep;49(9):1063-1077. doi: 10.1080/00498254.2018.1528407. Epub 2019 Jan 17.

PMID:
30257601
4.

Subaortic Stenosis Resection in Children: Emphasis on Recurrence and the Fate of the Aortic Valve.

Mukadam S, Gordon BM, Olson JT, Newcombe JB, Hasaniya NW, Razzouk AJ, Bailey LL.

World J Pediatr Congenit Heart Surg. 2018 Sep;9(5):522-528. doi: 10.1177/2150135118776931.

PMID:
30157731
5.

Differential effects of obesity on eosinophilic vs. non-eosinophilic asthma subtypes.

Mukadam S, Zacharias J, Henao MP, Kraschnewski J, Ishmael F.

J Asthma. 2018 Jul;55(7):720-725. doi: 10.1080/02770903.2017.1365886. Epub 2017 Oct 13.

PMID:
28846451
6.

Prediction of Drug-Drug Interactions Arising from CYP3A induction Using a Physiologically Based Dynamic Model.

Almond LM, Mukadam S, Gardner I, Okialda K, Wong S, Hatley O, Tay S, Rowland-Yeo K, Jamei M, Rostami-Hodjegan A, Kenny JR.

Drug Metab Dispos. 2016 Jun;44(6):821-32. doi: 10.1124/dmd.115.066845. Epub 2016 Mar 29. Erratum in: Drug Metab Dispos. 2016 Jun;44(6):877.

7.

In vitro and in vivo characterization of CYP inhibition by 1-aminobenzotriazole in rats.

Parrish KE, Mao J, Chen J, Jaochico A, Ly J, Ho Q, Mukadam S, Wright M.

Biopharm Drug Dispos. 2016 May;37(4):200-11. doi: 10.1002/bdd.2000.

PMID:
26637499
8.

Physiologically based pharmacokinetic modeling as a tool to predict drug interactions for antibody-drug conjugates.

Chen Y, Samineni D, Mukadam S, Wong H, Shen BQ, Lu D, Girish S, Hop C, Jin JY, Li C.

Clin Pharmacokinet. 2015 Jan;54(1):81-93. doi: 10.1007/s40262-014-0182-x.

PMID:
25223698
9.

1-Aminobenzotriazole coincubated with (S)-warfarin results in potent inactivation of CYP2C9.

Sodhi JK, Ford KA, Mukadam S, Wong S, Hop CE, Khojasteh SC, Halladay JS.

Drug Metab Dispos. 2014 May;42(5):813-7. doi: 10.1124/dmd.113.055913. Epub 2014 Feb 18.

PMID:
24550229
10.

Discovery of potent and efficacious urea-containing nicotinamide phosphoribosyltransferase (NAMPT) inhibitors with reduced CYP2C9 inhibition properties.

Gunzner-Toste J, Zhao G, Bauer P, Baumeister T, Buckmelter AJ, Caligiuri M, Clodfelter KH, Fu B, Han B, Ho YC, Kley N, Liang X, Liederer BM, Lin J, Mukadam S, O'Brien T, Oh A, Reynolds DJ, Sharma G, Skelton N, Smith CC, Sodhi J, Wang W, Wang Z, Xiao Y, Yuen PW, Zak M, Zhang L, Zheng X, Bair KW, Dragovich PS.

Bioorg Med Chem Lett. 2013 Jun 15;23(12):3531-8. doi: 10.1016/j.bmcl.2013.04.040. Epub 2013 Apr 25.

PMID:
23668988
11.

Discovery and Biological Profiling of Potent and Selective mTOR Inhibitor GDC-0349.

Pei Z, Blackwood E, Liu L, Malek S, Belvin M, Koehler MF, Ortwine DF, Chen H, Cohen F, Kenny JR, Bergeron P, Lau K, Ly C, Zhao X, Estrada AA, Truong T, Epler JA, Nonomiya J, Trinh L, Sideris S, Lesnick J, Bao L, Vijapurkar U, Mukadam S, Tay S, Deshmukh G, Chen YH, Ding X, Friedman LS, Lyssikatos JP.

ACS Med Chem Lett. 2012 Nov 29;4(1):103-7. doi: 10.1021/ml3003132. eCollection 2013 Jan 10.

12.

Discovery of novel PI3-kinase δ specific inhibitors for the treatment of rheumatoid arthritis: taming CYP3A4 time-dependent inhibition.

Safina BS, Baker S, Baumgardner M, Blaney PM, Chan BK, Chen YH, Cartwright MW, Castanedo G, Chabot C, Cheguillaume AJ, Goldsmith P, Goldstein DM, Goyal B, Hancox T, Handa RK, Iyer PS, Kaur J, Kondru R, Kenny JR, Krintel SL, Li J, Lesnick J, Lucas MC, Lewis C, Mukadam S, Murray J, Nadin AJ, Nonomiya J, Padilla F, Palmer WS, Pang J, Pegg N, Price S, Reif K, Salphati L, Savy PA, Seward EM, Shuttleworth S, Sohal S, Sweeney ZK, Tay S, Tivitmahaisoon P, Waszkowycz B, Wei B, Yue Q, Zhang C, Sutherlin DP.

J Med Chem. 2012 Jun 28;55(12):5887-900. doi: 10.1021/jm3003747. Epub 2012 Jun 11.

PMID:
22626259
13.

Drug-drug interaction potential of marketed oncology drugs: in vitro assessment of time-dependent cytochrome P450 inhibition, reactive metabolite formation and drug-drug interaction prediction.

Kenny JR, Mukadam S, Zhang C, Tay S, Collins C, Galetin A, Khojasteh SC.

Pharm Res. 2012 Jul;29(7):1960-76. doi: 10.1007/s11095-012-0724-6. Epub 2012 Mar 14.

PMID:
22415140
14.

Evaluation of time-dependent cytochrome p450 inhibition in a high-throughput, automated assay: introducing a novel area under the curve shift approach.

Mukadam S, Tay S, Tran D, Wang L, Delarosa EM, Khojasteh SC, Halladay JS, Kenny JR.

Drug Metab Lett. 2012 Mar;6(1):43-53.

PMID:
22372554
15.

Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies.

Chen Y, Jin JY, Mukadam S, Malhi V, Kenny JR.

Biopharm Drug Dispos. 2012 Mar;33(2):85-98. doi: 10.1002/bdd.1769. Epub 2012 Jan 24.

PMID:
22228214
16.

Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus.

Menzella HG, Tran TT, Carney JR, Lau-Wee J, Galazzo J, Reeves CD, Carreras C, Mukadam S, Eng S, Zhong Z, Timmermans PB, Murli S, Ashley GW.

J Med Chem. 2009 Mar 26;52(6):1518-21. doi: 10.1021/jm900012a.

PMID:
19231864
17.

Hypoxia-induced human endonuclease G expression suppresses tumor growth in a xenograft model.

Winnard PT Jr, Botlagunta M, Kluth JB, Mukadam S, Krishnamachary B, Vesuna F, Raman V.

Cancer Gene Ther. 2008 Oct;15(10):645-54. doi: 10.1038/cgt.2008.39. Epub 2008 Jun 13.

18.

Oncogenic role of DDX3 in breast cancer biogenesis.

Botlagunta M, Vesuna F, Mironchik Y, Raman A, Lisok A, Winnard P Jr, Mukadam S, Van Diest P, Chen JH, Farabaugh P, Patel AH, Raman V.

Oncogene. 2008 Jun 26;27(28):3912-22. doi: 10.1038/onc.2008.33. Epub 2008 Feb 11.

19.

Unusual inflicted hot oil burns in a 7-year-old.

Mukadam S, Gilles EE.

Burns. 2003 Feb;29(1):83-6.

PMID:
12543051

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