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Items: 13


Metabolic targeting of HIF-dependent glycolysis reduces lactate, increases oxygen consumption and enhances response to high-dose single-fraction radiotherapy in hypoxic solid tumors.

Leung E, Cairns RA, Chaudary N, Vellanki RN, Kalliomaki T, Moriyama EH, Mujcic H, Wilson BC, Wouters BG, Hill R, Milosevic M.

BMC Cancer. 2017 Jun 15;17(1):418. doi: 10.1186/s12885-017-3402-6.


In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model.

Maeda A, Chen Y, Bu J, Mujcic H, Wouters BG, DaCosta RS.

Int J Radiat Oncol Biol Phys. 2017 Jan 1;97(1):184-194. doi: 10.1016/j.ijrobp.2016.09.005. Epub 2016 Sep 14.


Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium.

Pettersen EO, Ebbesen P, Gieling RG, Williams KJ, Dubois L, Lambin P, Ward C, Meehan J, Kunkler IH, Langdon SP, Ree AH, Flatmark K, Lyng H, Calzada MJ, Peso LD, Landazuri MO, Görlach A, Flamm H, Kieninger J, Urban G, Weltin A, Singleton DC, Haider S, Buffa FM, Harris AL, Scozzafava A, Supuran CT, Moser I, Jobst G, Busk M, Toustrup K, Overgaard J, Alsner J, Pouyssegur J, Chiche J, Mazure N, Marchiq I, Parks S, Ahmed A, Ashcroft M, Pastorekova S, Cao Y, Rouschop KM, Wouters BG, Koritzinsky M, Mujcic H, Cojocari D.

J Enzyme Inhib Med Chem. 2015;30(5):689-721. doi: 10.3109/14756366.2014.966704. Epub 2014 Oct 27. Review.


Hypoxia signaling and the metastatic phenotype.

Mujcic H, Hill RP, Koritzinsky M, Wouters BG.

Curr Mol Med. 2014;14(5):565-79. Review.


Hypoxic activation of the PERK/eIF2α arm of the unfolded protein response promotes metastasis through induction of LAMP3.

Mujcic H, Nagelkerke A, Rouschop KM, Chung S, Chaudary N, Span PN, Clarke B, Milosevic M, Sykes J, Hill RP, Koritzinsky M, Wouters BG.

Clin Cancer Res. 2013 Nov 15;19(22):6126-37. doi: 10.1158/1078-0432.CCR-13-0526. Epub 2013 Sep 17.


Hypoxia and metastasis in an orthotopic cervix cancer xenograft model.

Chaudary N, Mujcic H, Wouters BG, Hill RP.

Radiother Oncol. 2013 Sep;108(3):506-10. doi: 10.1016/j.radonc.2013.06.019. Epub 2013 Jul 12.


Hypoxia stimulates migration of breast cancer cells via the PERK/ATF4/LAMP3-arm of the unfolded protein response.

Nagelkerke A, Bussink J, Mujcic H, Wouters BG, Lehmann S, Sweep FC, Span PN.

Breast Cancer Res. 2013 Jan 7;15(1):R2. doi: 10.1186/bcr3373.


Hypoxic regulation and prognostic value of LAMP3 expression in breast cancer.

Nagelkerke A, Mujcic H, Bussink J, Wouters BG, van Laarhoven HW, Sweep FC, Span PN.

Cancer. 2011 Aug 15;117(16):3670-81. doi: 10.1002/cncr.25938. Epub 2011 Feb 11.


18S is an appropriate housekeeping gene for in vitro hypoxia experiments.

Nagelkerke A, Mujcic H, Wouters B, Span PN.

Br J Cancer. 2010 Aug 10;103(4):590; author reply 591-2. doi: 10.1038/sj.bjc.6605754. Epub 2010 Jul 20. No abstract available.


The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.

Rouschop KM, van den Beucken T, Dubois L, Niessen H, Bussink J, Savelkouls K, Keulers T, Mujcic H, Landuyt W, Voncken JW, Lambin P, van der Kogel AJ, Koritzinsky M, Wouters BG.

J Clin Invest. 2010 Jan;120(1):127-41. doi: 10.1172/JCI40027. Epub 2009 Dec 14.


Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3.

Mujcic H, Rzymski T, Rouschop KM, Koritzinsky M, Milani M, Harris AL, Wouters BG.

Radiother Oncol. 2009 Sep;92(3):450-9. doi: 10.1016/j.radonc.2009.08.017. Epub 2009 Aug 31.


Hypoxia-induced expression of carbonic anhydrase 9 is dependent on the unfolded protein response.

van den Beucken T, Koritzinsky M, Niessen H, Dubois L, Savelkouls K, Mujcic H, Jutten B, Kopacek J, Pastorekova S, van der Kogel AJ, Lambin P, Voncken W, Rouschop KM, Wouters BG.

J Biol Chem. 2009 Sep 4;284(36):24204-12. doi: 10.1074/jbc.M109.006510. Epub 2009 Jun 29.


P55 tumour necrosis factor receptor in bone marrow-derived cells promotes atherosclerosis development in low-density lipoprotein receptor knock-out mice.

Xanthoulea S, Gijbels MJ, van der Made I, Mujcic H, Thelen M, Vergouwe MN, Ambagts MH, Hofker MH, de Winther MP.

Cardiovasc Res. 2008 Nov 1;80(2):309-18. doi: 10.1093/cvr/cvn193. Epub 2008 Jul 15.


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