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Items: 1 to 50 of 203

1.

Nucleation and Propagation of Heterochromatin by the Histone Methyltransferase PRC2: Geometric Constraints and Impact of the Regulatory Subunit JARID2.

Ge EJ, Jani KS, Diehl KL, Müller MM, Muir TW.

J Am Chem Soc. 2019 Sep 17. doi: 10.1021/jacs.9b02321. [Epub ahead of print]

PMID:
31479253
2.

Proximity Induced Splicing Utilizing Caged Split Inteins.

Gramespacher JA, Burton AJ, Guerra LF, Muir TW.

J Am Chem Soc. 2019 Sep 4;141(35):13708-13712. doi: 10.1021/jacs.9b05721. Epub 2019 Aug 21.

PMID:
31418547
3.

Single-Particle Dynamic Light Scattering: Shapes of Individual Nanoparticles.

Guerra LF, Muir TW, Yang H.

Nano Lett. 2019 Aug 14;19(8):5530-5536. doi: 10.1021/acs.nanolett.9b02066. Epub 2019 Jul 9.

PMID:
31272153
4.

Protein engineering through tandem transamidation.

Thompson RE, Stevens AJ, Muir TW.

Nat Chem. 2019 Aug;11(8):737-743. doi: 10.1038/s41557-019-0281-2. Epub 2019 Jul 1.

PMID:
31263208
5.

Identification of a DNA N6-Adenine Methyltransferase Complex and Its Impact on Chromatin Organization.

Beh LY, Debelouchina GT, Clay DM, Thompson RE, Lindblad KA, Hutton ER, Bracht JR, Sebra RP, Muir TW, Landweber LF.

Cell. 2019 Jun 13;177(7):1781-1796.e25. doi: 10.1016/j.cell.2019.04.028. Epub 2019 May 16.

PMID:
31104845
6.

PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism.

Jain SU, Do TJ, Lund PJ, Rashoff AQ, Diehl KL, Cieslik M, Bajic A, Juretic N, Deshmukh S, Venneti S, Muir TW, Garcia BA, Jabado N, Lewis PW.

Nat Commun. 2019 May 13;10(1):2146. doi: 10.1038/s41467-019-09981-6.

7.

Histone H3 tail binds a unique sensing pocket in EZH2 to activate the PRC2 methyltransferase.

Jani KS, Jain SU, Ge EJ, Diehl KL, Lundgren SM, Müller MM, Lewis PW, Muir TW.

Proc Natl Acad Sci U S A. 2019 Apr 23;116(17):8295-8300. doi: 10.1073/pnas.1819029116. Epub 2019 Apr 9.

PMID:
30967505
8.

The expanding landscape of 'oncohistone' mutations in human cancers.

Nacev BA, Feng L, Bagert JD, Lemiesz AE, Gao J, Soshnev AA, Kundra R, Schultz N, Muir TW, Allis CD.

Nature. 2019 Mar;567(7749):473-478. doi: 10.1038/s41586-019-1038-1. Epub 2019 Mar 20.

9.

Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.

Farrelly LA, Thompson RE, Zhao S, Lepack AE, Lyu Y, Bhanu NV, Zhang B, Loh YE, Ramakrishnan A, Vadodaria KC, Heard KJ, Erikson G, Nakadai T, Bastle RM, Lukasak BJ, Zebroski H 3rd, Alenina N, Bader M, Berton O, Roeder RG, Molina H, Gage FH, Shen L, Garcia BA, Li H, Muir TW, Maze I.

Nature. 2019 Mar;567(7749):535-539. doi: 10.1038/s41586-019-1024-7. Epub 2019 Mar 13.

10.

Identification of a Molecular Latch that Regulates Staphylococcal Virulence.

Xie Q, Zhao A, Jeffrey PD, Kim MK, Bassler BL, Stone HA, Novick RP, Muir TW.

Cell Chem Biol. 2019 Apr 18;26(4):548-558.e4. doi: 10.1016/j.chembiol.2019.01.006. Epub 2019 Feb 14.

PMID:
30773482
11.

Overactive Bladder Symptoms After Pelvic Organ Prolapse Repair.

Johnson JR, High RA, Dziadek O, Ocon A, Muir TW, Xu J, Antosh DD.

Female Pelvic Med Reconstr Surg. 2019 Jan 23. doi: 10.1097/SPV.0000000000000700. [Epub ahead of print]

PMID:
30681419
12.

Crosstalk among Set1 complex subunits involved in H2B ubiquitylation-dependent H3K4 methylation.

Jeon J, McGinty RK, Muir TW, Kim JA, Kim J.

Nucleic Acids Res. 2018 Nov 30;46(21):11129-11143. doi: 10.1093/nar/gky920.

13.

An Atypical Mechanism of Split Intein Molecular Recognition and Folding.

Stevens AJ, Sekar G, Gramespacher JA, Cowburn D, Muir TW.

J Am Chem Soc. 2018 Sep 19;140(37):11791-11799. doi: 10.1021/jacs.8b07334. Epub 2018 Sep 10.

PMID:
30156841
14.

Nucleic Acid-Barcoding Technologies: Converting DNA Sequencing into a Broad-Spectrum Molecular Counter.

Liszczak G, Muir TW.

Angew Chem Int Ed Engl. 2019 Mar 22;58(13):4144-4162. doi: 10.1002/anie.201808956. Epub 2019 Feb 6. Review.

PMID:
30153374
15.

Acetylation blocks DNA damage-induced chromatin ADP-ribosylation.

Liszczak G, Diehl KL, Dann GP, Muir TW.

Nat Chem Biol. 2018 Sep;14(9):837-840. doi: 10.1038/s41589-018-0097-1. Epub 2018 Jul 16.

16.

Functional crosstalk between histone H2B ubiquitylation and H2A modifications and variants.

Wojcik F, Dann GP, Beh LY, Debelouchina GT, Hofmann R, Muir TW.

Nat Commun. 2018 Apr 11;9(1):1394. doi: 10.1038/s41467-018-03895-5.

17.

A Chemical Probe for Protein Crotonylation.

Bos J, Muir TW.

J Am Chem Soc. 2018 Apr 11;140(14):4757-4760. doi: 10.1021/jacs.7b13141. Epub 2018 Apr 2.

18.

How many human proteoforms are there?

Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B.

Nat Chem Biol. 2018 Feb 14;14(3):206-214. doi: 10.1038/nchembio.2576.

19.

HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome.

Jenness C, Giunta S, Müller MM, Kimura H, Muir TW, Funabiki H.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E876-E885. doi: 10.1073/pnas.1717509115. Epub 2018 Jan 16.

20.

A molecular engineering toolbox for the structural biologist.

Debelouchina GT, Muir TW.

Q Rev Biophys. 2017 Jan;50:e7. doi: 10.1017/S0033583517000051. Review.

21.

Improved protein splicing using embedded split inteins.

Gramespacher JA, Stevens AJ, Thompson RE, Muir TW.

Protein Sci. 2018 Mar;27(3):614-619. doi: 10.1002/pro.3357. Epub 2018 Jan 17.

22.

Molecular analysis of PRC2 recruitment to DNA in chromatin and its inhibition by RNA.

Wang X, Paucek RD, Gooding AR, Brown ZZ, Ge EJ, Muir TW, Cech TR.

Nat Struct Mol Biol. 2017 Dec;24(12):1028-1038. doi: 10.1038/nsmb.3487. Epub 2017 Oct 23.

23.

Bisphosphoglycerate mutase controls serine pathway flux via 3-phosphoglycerate.

Oslund RC, Su X, Haugbro M, Kee JM, Esposito M, David Y, Wang B, Ge E, Perlman DH, Kang Y, Muir TW, Rabinowitz JD.

Nat Chem Biol. 2017 Oct;13(10):1081-1087. doi: 10.1038/nchembio.2453. Epub 2017 Aug 7.

24.

ISWI chromatin remodellers sense nucleosome modifications to determine substrate preference.

Dann GP, Liszczak GP, Bagert JD, Müller MM, Nguyen UTT, Wojcik F, Brown ZZ, Bos J, Panchenko T, Pihl R, Pollock SB, Diehl KL, Allis CD, Muir TW.

Nature. 2017 Aug 31;548(7669):607-611. doi: 10.1038/nature23671. Epub 2017 Aug 2.

25.

Long-term hepatitis B infection in a scalable hepatic co-culture system.

Winer BY, Huang TS, Pludwinski E, Heller B, Wojcik F, Lipkowitz GE, Parekh A, Cho C, Shrirao A, Muir TW, Novik E, Ploss A.

Nat Commun. 2017 Jul 25;8(1):125. doi: 10.1038/s41467-017-00200-8.

26.

A promiscuous split intein with expanded protein engineering applications.

Stevens AJ, Sekar G, Shah NH, Mostafavi AZ, Cowburn D, Muir TW.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8538-8543. doi: 10.1073/pnas.1701083114. Epub 2017 Jul 24.

27.

Emerging Chemistry Strategies for Engineering Native Chromatin.

David Y, Muir TW.

J Am Chem Soc. 2017 Jul 12;139(27):9090-9096. doi: 10.1021/jacs.7b03430. Epub 2017 Jun 27.

28.

Intein Zymogens: Conditional Assembly and Splicing of Split Inteins via Targeted Proteolysis.

Gramespacher JA, Stevens AJ, Nguyen DP, Chin JW, Muir TW.

J Am Chem Soc. 2017 Jun 21;139(24):8074-8077. doi: 10.1021/jacs.7b02618. Epub 2017 Jun 7.

29.

Surface-attached molecules control Staphylococcus aureus quorum sensing and biofilm development.

Kim MK, Zhao A, Wang A, Brown ZZ, Muir TW, Stone HA, Bassler BL.

Nat Microbiol. 2017 May 22;2:17080. doi: 10.1038/nmicrobiol.2017.80.

30.

Genomic targeting of epigenetic probes using a chemically tailored Cas9 system.

Liszczak GP, Brown ZZ, Kim SH, Oslund RC, David Y, Muir TW.

Proc Natl Acad Sci U S A. 2017 Jan 24;114(4):681-686. doi: 10.1073/pnas.1615723114. Epub 2017 Jan 9.

31.

Functional Plasticity of the AgrC Receptor Histidine Kinase Required for Staphylococcal Virulence.

Wang B, Zhao A, Xie Q, Olinares PD, Chait BT, Novick RP, Muir TW.

Cell Chem Biol. 2017 Jan 19;24(1):76-86. doi: 10.1016/j.chembiol.2016.12.008. Epub 2017 Jan 5.

32.

Ubiquitin utilizes an acidic surface patch to alter chromatin structure.

Debelouchina GT, Gerecht K, Muir TW.

Nat Chem Biol. 2017 Jan;13(1):105-110. doi: 10.1038/nchembio.2235. Epub 2016 Nov 21.

33.

Access to site-specific Fc-cRGD peptide conjugates through streamlined expressed protein ligation.

Frutos S, Jordan JB, Bio MM, Muir TW, Thiel OR, Vila-Perelló M.

Org Biomol Chem. 2016 Oct 12;14(40):9549-9553.

34.

Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.

Lu C, Jain SU, Hoelper D, Bechet D, Molden RC, Ran L, Murphy D, Venneti S, Hameed M, Pawel BR, Wunder JS, Dickson BC, Lundgren SM, Jani KS, De Jay N, Papillon-Cavanagh S, Andrulis IL, Sawyer SL, Grynspan D, Turcotte RE, Nadaf J, Fahiminiyah S, Muir TW, Majewski J, Thompson CB, Chi P, Garcia BA, Allis CD, Jabado N, Lewis PW.

Science. 2016 May 13;352(6287):844-9. doi: 10.1126/science.aac7272.

35.

Regulation of Virulence in Staphylococcus aureus: Molecular Mechanisms and Remaining Puzzles.

Wang B, Muir TW.

Cell Chem Biol. 2016 Feb 18;23(2):214-224. doi: 10.1016/j.chembiol.2016.01.004. Review.

36.

Design of a Split Intein with Exceptional Protein Splicing Activity.

Stevens AJ, Brown ZZ, Shah NH, Sekar G, Cowburn D, Muir TW.

J Am Chem Soc. 2016 Feb 24;138(7):2162-5. doi: 10.1021/jacs.5b13528. Epub 2016 Feb 8.

37.

Evidence that ubiquitylated H2B corrals hDot1L on the nucleosomal surface to induce H3K79 methylation.

Zhou L, Holt MT, Ohashi N, Zhao A, Müller MM, Wang B, Muir TW.

Nat Commun. 2016 Feb 2;7:10589. doi: 10.1038/ncomms10589.

38.

A two-state activation mechanism controls the histone methyltransferase Suv39h1.

Müller MM, Fierz B, Bittova L, Liszczak G, Muir TW.

Nat Chem Biol. 2016 Mar;12(3):188-93. doi: 10.1038/nchembio.2008. Epub 2016 Jan 25.

39.

DNA-guided establishment of nucleosome patterns within coding regions of a eukaryotic genome.

Beh LY, Müller MM, Muir TW, Kaplan N, Landweber LF.

Genome Res. 2015 Nov;25(11):1727-38. doi: 10.1101/gr.188516.114. Epub 2015 Sep 1.

40.

Key driving forces in the biosynthesis of autoinducing peptides required for staphylococcal virulence.

Wang B, Zhao A, Novick RP, Muir TW.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10679-84. doi: 10.1073/pnas.1506030112. Epub 2015 Aug 10.

41.

Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin.

Holt MT, David Y, Pollock S, Tang Z, Jeon J, Kim J, Roeder RG, Muir TW.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10365-70. doi: 10.1073/pnas.1504483112. Epub 2015 Aug 3.

42.

Chemical tagging and customizing of cellular chromatin states using ultrafast trans-splicing inteins.

David Y, Vila-Perelló M, Verma S, Muir TW.

Nat Chem. 2015 May;7(5):394-402. doi: 10.1038/nchem.2224. Epub 2015 Apr 6.

43.

Targeted Histone Peptides: Insights into the Spatial Regulation of the Methyltransferase PRC2 by using a Surrogate of Heterotypic Chromatin.

Brown ZZ, Müller MM, Kong HE, Lewis PW, Muir TW.

Angew Chem Int Ed Engl. 2015 May 26;54(22):6457-61. doi: 10.1002/anie.201500085. Epub 2015 Apr 14.

44.

Increasing AIP Macrocycle Size Reveals Key Features of agr Activation in Staphylococcus aureus.

Johnson JG, Wang B, Debelouchina GT, Novick RP, Muir TW.

Chembiochem. 2015 May 4;16(7):1093-100. doi: 10.1002/cbic.201500006. Epub 2015 Mar 20.

45.

A second-generation phosphohistidine analog for production of phosphohistidine antibodies.

Kee JM, Oslund RC, Couvillon AD, Muir TW.

Org Lett. 2015 Jan 16;17(2):187-9. doi: 10.1021/ol503320p. Epub 2014 Dec 22.

PMID:
25531910
46.

Histones: at the crossroads of peptide and protein chemistry.

Müller MM, Muir TW.

Chem Rev. 2015 Mar 25;115(6):2296-349. doi: 10.1021/cr5003529. Epub 2014 Oct 20. Review. No abstract available.

47.

Strategy for "detoxification" of a cancer-derived histone mutant based on mapping its interaction with the methyltransferase PRC2.

Brown ZZ, Müller MM, Jain SU, Allis CD, Lewis PW, Muir TW.

J Am Chem Soc. 2014 Oct 1;136(39):13498-501. doi: 10.1021/ja5060934. Epub 2014 Sep 19.

48.

A phosphohistidine proteomics strategy based on elucidation of a unique gas-phase phosphopeptide fragmentation mechanism.

Oslund RC, Kee JM, Couvillon AD, Bhatia VN, Perlman DH, Muir TW.

J Am Chem Soc. 2014 Sep 17;136(37):12899-911. doi: 10.1021/ja507614f. Epub 2014 Sep 8.

49.

Accelerated chromatin biochemistry using DNA-barcoded nucleosome libraries.

Nguyen UT, Bittova L, Müller MM, Fierz B, David Y, Houck-Loomis B, Feng V, Dann GP, Muir TW.

Nat Methods. 2014 Aug;11(8):834-40. doi: 10.1038/nmeth.3022. Epub 2014 Jul 6.

50.

Structure of the branched intermediate in protein splicing.

Liu Z, Frutos S, Bick MJ, Vila-Perelló M, Debelouchina GT, Darst SA, Muir TW.

Proc Natl Acad Sci U S A. 2014 Jun 10;111(23):8422-7. doi: 10.1073/pnas.1402942111. Epub 2014 Apr 28.

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