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Activation of β-catenin cooperates with loss of Pten to drive AR-independent castration-resistant prostate cancer.

Patel R, Brzezinska EA, Repiscak P, Ahmad I, Mui E, Gao M, Blomme A, Harle V, Tan EH, Malviya G, Mrowinska A, Loveridge CJ, Rushworth LK, Edwards J, Ntala C, Nixon C, Hedley A, Mackay G, Tardito S, Sansom OJ, Leung HY.

Cancer Res. 2019 Nov 12. pii: canres.1684.2019. doi: 10.1158/0008-5472.CAN-19-1684. [Epub ahead of print]


Development of Kinase Inactive PD173955 Analogues for Reducing Production of Aβ Peptides.

Sinha A, Gindinova K, Mui E, Netzer WJ, Sinha SC.

ACS Med Chem Lett. 2019 Sep 6;10(10):1430-1435. doi: 10.1021/acsmedchemlett.9b00213. eCollection 2019 Oct 10.


Cognitive behavioural family intervention for people diagnosed with severe mental illness and their families: A systematic review and meta-analysis of randomized controlled trials.

Ma CF, Chan SKW, Chien WT, Bressington D, Mui EYW, Lee EHM, Chen EYH.

J Psychiatr Ment Health Nurs. 2019 Sep 24. doi: 10.1111/jpm.12567. [Epub ahead of print] Review.


Systematic review (meta-aggregation) of qualitative studies on the experiences of family members caring for individuals with early psychosis.

Mui EYW, Chan SKW, Chan PY, Hui CLM, Chang WC, Lee EHM, Chen EYH.

Int Rev Psychiatry. 2019 Aug - Sep;31(5-6):491-509. doi: 10.1080/09540261.2019.1659236. Epub 2019 Sep 23.


Publisher Correction: Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer.

Ngô HM, Zhou Y, Lorenzi H, Wang K, Kim TK, Zhou Y, El Bissati K, Mui E, Fraczek L, Rajagopala SV, Roberts CW, Henriquez FL, Montpetit A, Blackwell JM, Jamieson SE, Wheeler K, Begeman IJ, Naranjo-Galvis C, Alliey-Rodriguez N, Davis RG, Soroceanu L, Cobbs C, Steindler DA, Boyer K, Noble AG, Swisher CN, Heydemann PT, Rabiah P, Withers S, Soteropoulos P, Hood L, McLeod R.

Sci Rep. 2019 May 28;9(1):8110. doi: 10.1038/s41598-019-44545-0.


Conversion from Vancomycin Trough Concentration-Guided Dosing to Area Under the Curve-Guided Dosing Using Two Sample Measurements in Adults: Implementation at an Academic Medical Center.

Meng L, Wong T, Huang S, Mui E, Nguyen V, Espinosa G, Desai J, Holubar M, Deresinski S.

Pharmacotherapy. 2019 Apr;39(4):433-442. doi: 10.1002/phar.2234. Epub 2019 Mar 18.


Family medicine training in housecalls: Survey of residency program directors across Canada.

Mui E, Pham TT, McMurren CE.

Can Fam Physician. 2018 Nov;64(11):e498-e506.


Sprouty2 loss-induced IL6 drives castration-resistant prostate cancer through scavenger receptor B1.

Patel R, Fleming J, Mui E, Loveridge C, Repiscak P, Blomme A, Harle V, Salji M, Ahmad I, Teo K, Hamdy FC, Hedley A, van den Broek N, Mackay G, Edwards J, Sansom OJ, Leung HY.

EMBO Mol Med. 2018 Apr;10(4). pii: e8347. doi: 10.15252/emmm.201708347.


Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity.

Loveridge CJ, van 't Hof RJ, Charlesworth G, King A, Tan EH, Rose L, Daroszewska A, Prior A, Ahmad I, Welsh M, Mui EJ, Ford C, Salji M, Sansom O, Blyth K, Leung HY.

Sci Rep. 2017 Oct 16;7(1):13241. doi: 10.1038/s41598-017-13346-8.


Toxoplasma Modulates Signature Pathways of Human Epilepsy, Neurodegeneration & Cancer.

Ngô HM, Zhou Y, Lorenzi H, Wang K, Kim TK, Zhou Y, El Bissati K, Mui E, Fraczek L, Rajagopala SV, Roberts CW, Henriquez FL, Montpetit A, Blackwell JM, Jamieson SE, Wheeler K, Begeman IJ, Naranjo-Galvis C, Alliey-Rodriguez N, Davis RG, Soroceanu L, Cobbs C, Steindler DA, Boyer K, Noble AG, Swisher CN, Heydemann PT, Rabiah P, Withers S, Soteropoulos P, Hood L, McLeod R.

Sci Rep. 2017 Sep 13;7(1):11496. doi: 10.1038/s41598-017-10675-6. Erratum in: Sci Rep. 2019 May 28;9(1):8110.


Comprehensive Guidance for Antibiotic Dosing in Obese Adults.

Meng L, Mui E, Holubar MK, Deresinski SC.

Pharmacotherapy. 2017 Nov;37(11):1415-1431. doi: 10.1002/phar.2023. Epub 2017 Oct 30. Review. Erratum in: Pharmacotherapy. 2018 Feb;38(2):302.


Increased T-cell Infiltration Elicited by Erk5 Deletion in a Pten-Deficient Mouse Model of Prostate Carcinogenesis.

Loveridge CJ, Mui EJ, Patel R, Tan EH, Ahmad I, Welsh M, Galbraith J, Hedley A, Nixon C, Blyth K, Sansom O, Leung HY.

Cancer Res. 2017 Jun 15;77(12):3158-3168. doi: 10.1158/0008-5472.CAN-16-2565. Epub 2017 May 17.


Adjuvanted multi-epitope vaccines protect HLA-A*11:01 transgenic mice against Toxoplasma gondii.

El Bissati K, Chentoufi AA, Krishack PA, Zhou Y, Woods S, Dubey JP, Vang L, Lykins J, Broderick KE, Mui E, Suzuki Y, Sa Q, Bi S, Cardona N, Verma SK, Frazeck L, Reardon CA, Sidney J, Alexander J, Sette A, Vedvick T, Fox C, Guderian JA, Reed S, Roberts CW, McLeod R.

JCI Insight. 2016 Sep 22;1(15):e85955. doi: 10.1172/jci.insight.85955.


Sleeping Beauty screen reveals Pparg activation in metastatic prostate cancer.

Ahmad I, Mui E, Galbraith L, Patel R, Tan EH, Salji M, Rust AG, Repiscak P, Hedley A, Markert E, Loveridge C, van der Weyden L, Edwards J, Sansom OJ, Adams DJ, Leung HY.

Proc Natl Acad Sci U S A. 2016 Jul 19;113(29):8290-5. doi: 10.1073/pnas.1601571113. Epub 2016 Jun 29.


Urology residents experience comparable workload profiles when performing live porcine nephrectomies and robotic surgery virtual reality training modules.

Mouraviev V, Klein M, Schommer E, Thiel DD, Samavedi S, Kumar A, Leveillee RJ, Thomas R, Pow-Sang JM, Su LM, Mui E, Smith R, Patel V.

J Robot Surg. 2016 Mar;10(1):49-56. doi: 10.1007/s11701-015-0540-1. Epub 2016 Jan 11.


Clustering of Toxoplasma gondii Infections Within Families of Congenitally Infected Infants.

Contopoulos-Ioannidis D, Wheeler KM, Ramirez R, Press C, Mui E, Zhou Y, Van Tubbergen C, Prasad S, Maldonado Y, Withers S, Boyer KM, Noble AG, Rabiah P, Swisher CN, Heydemann P, Wroblewski K, Karrison T, Grigg ME, Montoya JG, McLeod R.

Clin Infect Dis. 2015 Dec 15;61(12):1815-24. doi: 10.1093/cid/civ721. Epub 2015 Sep 24.


Safeguarding children’s right to the best form of nurture: an interview with Dr Patricia Ip.

Ip P, Chung JL, Mui EH.

Hong Kong Med J. 2015 Jun;21(3):288-9. No abstract available.


ALOX12 in human toxoplasmosis.

Witola WH, Liu SR, Montpetit A, Welti R, Hypolite M, Roth M, Zhou Y, Mui E, Cesbron-Delauw MF, Fournie GJ, Cavailles P, Bisanz C, Boyer K, Withers S, Noble AG, Swisher CN, Heydemann PT, Rabiah P, Muench SP, McLeod R.

Infect Immun. 2014 Jul;82(7):2670-9. doi: 10.1128/IAI.01505-13. Epub 2014 Mar 31.


Spiroindolone that inhibits PfATPase4 is a potent, cidal inhibitor of Toxoplasma gondii tachyzoites in vitro and in vivo.

Zhou Y, Fomovska A, Muench S, Lai BS, Mui E, McLeod R.

Antimicrob Agents Chemother. 2014;58(3):1789-92. doi: 10.1128/AAC.02225-13. Epub 2013 Dec 23.


Next-generation sequencing of advanced prostate cancer treated with androgen-deprivation therapy.

Rajan P, Sudbery IM, Villasevil ME, Mui E, Fleming J, Davis M, Ahmad I, Edwards J, Sansom OJ, Sims D, Ponting CP, Heger A, McMenemin RM, Pedley ID, Leung HY.

Eur Urol. 2014 Jul;66(1):32-9. doi: 10.1016/j.eururo.2013.08.011. Epub 2013 Aug 14.


Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase.

Cheng G, Muench SP, Zhou Y, Afanador GA, Mui EJ, Fomovska A, Lai BS, Prigge ST, Woods S, Roberts CW, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Rice DW, McLeod R.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2035-43. doi: 10.1016/j.bmcl.2013.02.019. Epub 2013 Feb 13.


Impaired innate immunity in mice deficient in interleukin-1 receptor-associated kinase 4 leads to defective type 1 T cell responses, B cell expansion, and enhanced susceptibility to infection with Toxoplasma gondii.

Béla SR, Dutra MS, Mui E, Montpetit A, Oliveira FS, Oliveira SC, Arantes RM, Antonelli LR, McLeod R, Gazzinelli RT.

Infect Immun. 2012 Dec;80(12):4298-308. doi: 10.1128/IAI.00328-12. Epub 2012 Oct 1.


Salicylanilide inhibitors of Toxoplasma gondii.

Fomovska A, Wood RD, Mui E, Dubey JP, Ferreira LR, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Welsh WJ, Sommerville C, Woods S, Roberts C, McLeod R.

J Med Chem. 2012 Oct 11;55(19):8375-91. doi: 10.1021/jm3007596. Epub 2012 Sep 26.


Molecular target validation, antimicrobial delivery, and potential treatment of Toxoplasma gondii infections.

Lai BS, Witola WH, El Bissati K, Zhou Y, Mui E, Fomovska A, McLeod R.

Proc Natl Acad Sci U S A. 2012 Aug 28;109(35):14182-7. doi: 10.1073/pnas.1208775109. Epub 2012 Aug 13.


Prematurity and severity are associated with Toxoplasma gondii alleles (NCCCTS, 1981-2009).

McLeod R, Boyer KM, Lee D, Mui E, Wroblewski K, Karrison T, Noble AG, Withers S, Swisher CN, Heydemann PT, Sautter M, Babiarz J, Rabiah P, Meier P, Grigg ME; Toxoplasmosis Study Group.

Clin Infect Dis. 2012 Jun;54(11):1595-605. doi: 10.1093/cid/cis258. Epub 2012 Apr 11.


Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.

Fomovska A, Huang Q, El Bissati K, Mui EJ, Witola WH, Cheng G, Zhou Y, Sommerville C, Roberts CW, Bettis S, Prigge ST, Afanador GA, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Pieroni M, Stec J, Muench SP, Rice DW, Kozikowski AP, McLeod R.

Antimicrob Agents Chemother. 2012 May;56(5):2666-82. doi: 10.1128/AAC.06450-11. Epub 2012 Feb 21.


Synthesis, biological evaluation, and structure-activity relationships of N-benzoyl-2-hydroxybenzamides as agents active against P. falciparum (K1 strain), Trypanosomes, and Leishmania.

Stec J, Huang Q, Pieroni M, Kaiser M, Fomovska A, Mui E, Witola WH, Bettis S, McLeod R, Brun R, Kozikowski AP.

J Med Chem. 2012 Apr 12;55(7):3088-100. doi: 10.1021/jm2015183. Epub 2012 Mar 20.


Toxoplasma gondii HLA-B*0702-restricted GRA7(20-28) peptide with adjuvants and a universal helper T cell epitope elicits CD8(+) T cells producing interferon-γ and reduces parasite burden in HLA-B*0702 mice.

Cong H, Mui EJ, Witola WH, Sidney J, Alexander J, Sette A, Maewal A, El Bissati K, Zhou Y, Suzuki Y, Lee D, Woods S, Sommerville C, Henriquez FL, Roberts CW, McLeod R.

Hum Immunol. 2012 Jan;73(1):1-10. doi: 10.1016/j.humimm.2011.10.006. Epub 2011 Oct 12.


Unrecognized ingestion of Toxoplasma gondii oocysts leads to congenital toxoplasmosis and causes epidemics in North America.

Boyer K, Hill D, Mui E, Wroblewski K, Karrison T, Dubey JP, Sautter M, Noble AG, Withers S, Swisher C, Heydemann P, Hosten T, Babiarz J, Lee D, Meier P, McLeod R; Toxoplasmosis Study Group.

Clin Infect Dis. 2011 Dec;53(11):1081-9. doi: 10.1093/cid/cir667. Epub 2011 Oct 21.


Identification of a sporozoite-specific antigen from Toxoplasma gondii.

Hill D, Coss C, Dubey JP, Wroblewski K, Sautter M, Hosten T, Muñoz-Zanzi C, Mui E, Withers S, Boyer K, Hermes G, Coyne J, Jagdis F, Burnett A, McLeod P, Morton H, Robinson D, McLeod R.

J Parasitol. 2011 Apr;97(2):328-37. doi: 10.1645/GE-2782.1. Epub 2011 Mar 3.


Rapid discovery of inhibitors of Toxoplasma gondii using hybrid structure-based computational approach.

Kortagere S, Mui E, McLeod R, Welsh WJ.

J Comput Aided Mol Des. 2011 May;25(5):403-11. doi: 10.1007/s10822-011-9420-6. Epub 2011 Feb 26.


T. gondii RP promoters & knockdown reveal molecular pathways associated with proliferation and cell-cycle arrest.

Hutson SL, Mui E, Kinsley K, Witola WH, Behnke MS, El Bissati K, Muench SP, Rohrman B, Liu SR, Wollmann R, Ogata Y, Sarkeshik A, Yates JR 3rd, McLeod R.

PLoS One. 2010 Nov 22;5(11):e14057. doi: 10.1371/journal.pone.0014057.


NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondii-infected monocytic cells.

Witola WH, Mui E, Hargrave A, Liu S, Hypolite M, Montpetit A, Cavailles P, Bisanz C, Cesbron-Delauw MF, Fournié GJ, McLeod R.

Infect Immun. 2011 Feb;79(2):756-66. doi: 10.1128/IAI.00898-10. Epub 2010 Nov 22.


Towards an immunosense vaccine to prevent toxoplasmosis: protective Toxoplasma gondii epitopes restricted by HLA-A*0201.

Cong H, Mui EJ, Witola WH, Sidney J, Alexander J, Sette A, Maewal A, McLeod R.

Vaccine. 2011 Jan 17;29(4):754-62. doi: 10.1016/j.vaccine.2010.11.015. Epub 2010 Nov 21.


Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase.

Tipparaju SK, Muench SP, Mui EJ, Ruzheinikov SN, Lu JZ, Hutson SL, Kirisits MJ, Prigge ST, Roberts CW, Henriquez FL, Kozikowski AP, Rice DW, McLeod RL.

J Med Chem. 2010 Sep 9;53(17):6287-300. doi: 10.1021/jm9017724.


Evidence for associations between the purinergic receptor P2X(7) (P2RX7) and toxoplasmosis.

Jamieson SE, Peixoto-Rangel AL, Hargrave AC, Roubaix LA, Mui EJ, Boulter NR, Miller EN, Fuller SJ, Wiley JS, Castellucci L, Boyer K, Peixe RG, Kirisits MJ, Elias Lde S, Coyne JJ, Correa-Oliveira R, Sautter M, Smith NC, Lees MP, Swisher CN, Heydemann P, Noble AG, Patel D, Bardo D, Burrowes D, McLone D, Roizen N, Withers S, Bahia-Oliveira LM, McLeod R, Blackwell JM.

Genes Immun. 2010 Jul;11(5):374-83. doi: 10.1038/gene.2010.31. Epub 2010 Jun 10.


P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages.

Lees MP, Fuller SJ, McLeod R, Boulter NR, Miller CM, Zakrzewski AM, Mui EJ, Witola WH, Coyne JJ, Hargrave AC, Jamieson SE, Blackwell JM, Wiley JS, Smith NC.

J Immunol. 2010 Jun 15;184(12):7040-6. doi: 10.4049/jimmunol.1000012. Epub 2010 May 19.


Evaluation of caspofungin or micafungin as empiric antifungal therapy in adult patients with persistent febrile neutropenia: a retrospective, observational, sequential cohort analysis.

Kubiak DW, Bryar JM, McDonnell AM, Delgado-Flores JO, Mui E, Baden LR, Marty FM.

Clin Ther. 2010 Apr;32(4):637-48. doi: 10.1016/j.clinthera.2010.04.005.


Dye adsorption onto activated carbons from tyre rubber waste using surface coverage analysis.

Mui EL, Cheung WH, Valix M, McKay G.

J Colloid Interface Sci. 2010 Jul 15;347(2):290-300. doi: 10.1016/j.jcis.2010.03.061. Epub 2010 Apr 2.


Identification of T. gondii epitopes, adjuvants, and host genetic factors that influence protection of mice and humans.

Tan TG, Mui E, Cong H, Witola WH, Montpetit A, Muench SP, Sidney J, Alexander J, Sette A, Grigg ME, Maewal A, McLeod R.

Vaccine. 2010 May 21;28(23):3977-89. doi: 10.1016/j.vaccine.2010.03.028. Epub 2010 Mar 26.


Compensation effect during the pyrolysis of tyres and bamboo.

Mui EL, Cheung WH, Lee VK, McKay G.

Waste Manag. 2010 May;30(5):821-30. doi: 10.1016/j.wasman.2010.01.014. Epub 2010 Feb 4.


Dye adsorption onto char from bamboo.

Mui EL, Cheung WH, Valix M, McKay G.

J Hazard Mater. 2010 May 15;177(1-3):1001-5. doi: 10.1016/j.jhazmat.2010.01.018. Epub 2010 Jan 11.


Tyre char preparation from waste tyre rubber for dye removal from effluents.

Mui EL, Cheung WH, McKay G.

J Hazard Mater. 2010 Mar 15;175(1-3):151-8. doi: 10.1016/j.jhazmat.2009.09.142. Epub 2009 Oct 2.


Neurological and behavioral abnormalities, ventricular dilatation, altered cellular functions, inflammation, and neuronal injury in brains of mice due to common, persistent, parasitic infection.

Hermes G, Ajioka JW, Kelly KA, Mui E, Roberts F, Kasza K, Mayr T, Kirisits MJ, Wollmann R, Ferguson DJ, Roberts CW, Hwang JH, Trendler T, Kennan RP, Suzuki Y, Reardon C, Hickey WF, Chen L, McLeod R.

J Neuroinflammation. 2008 Oct 23;5:48. doi: 10.1186/1742-2094-5-48.


Genetic and epigenetic factors at COL2A1 and ABCA4 influence clinical outcome in congenital toxoplasmosis.

Jamieson SE, de Roubaix LA, Cortina-Borja M, Tan HK, Mui EJ, Cordell HJ, Kirisits MJ, Miller EN, Peacock CS, Hargrave AC, Coyne JJ, Boyer K, Bessieres MH, Buffolano W, Ferret N, Franck J, Kieffer F, Meier P, Nowakowska DE, Paul M, Peyron F, Stray-Pedersen B, Prusa AR, Thulliez P, Wallon M, Petersen E, McLeod R, Gilbert RE, Blackwell JM.

PLoS One. 2008 Jun 4;3(6):e2285. doi: 10.1371/journal.pone.0002285.


Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo.

Mui EJ, Schiehser GA, Milhous WK, Hsu H, Roberts CW, Kirisits M, Muench S, Rice D, Dubey JP, Fowble JW, Rathod PK, Queener SF, Liu SR, Jacobus DP, McLeod R.

PLoS Negl Trop Dis. 2008 Mar 5;2(3):e190. doi: 10.1371/journal.pntd.0000190.


Subcellular localization and dynamics of a digalactolipid-like epitope in Toxoplasma gondii.

Botté C, Saïdani N, Mondragon R, Mondragón M, Isaac G, Mui E, McLeod R, Dubremetz JF, Vial H, Welti R, Cesbron-Delauw MF, Mercier C, Maréchal E.

J Lipid Res. 2008 Apr;49(4):746-62. doi: 10.1194/jlr.M700476-JLR200. Epub 2008 Jan 8.


Lipidomic analysis of Toxoplasma gondii reveals unusual polar lipids.

Welti R, Mui E, Sparks A, Wernimont S, Isaac G, Kirisits M, Roth M, Roberts CW, Botté C, Maréchal E, McLeod R.

Biochemistry. 2007 Dec 4;46(48):13882-90. Epub 2007 Nov 8.


Type I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structure.

Lu JZ, Muench SP, Allary M, Campbell S, Roberts CW, Mui E, McLeod RL, Rice DW, Prigge ST.

Parasitology. 2007 Dec;134(Pt.14):1949-62. Epub 2007 Aug 13.

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