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Modulating Hinge Flexibility in the APP Transmembrane Domain Alters γ-Secretase Cleavage.

Götz A, Mylonas N, Högel P, Silber M, Heinel H, Menig S, Vogel A, Feyrer H, Huster D, Luy B, Langosch D, Scharnagl C, Muhle-Goll C, Kamp F, Steiner H.

Biophys J. 2019 Jun 4;116(11):2103-2120. doi: 10.1016/j.bpj.2019.04.030. Epub 2019 May 3.


Increased H-Bond Stability Relates to Altered ε-Cleavage Efficiency and Aβ Levels in the I45T Familial Alzheimer's Disease Mutant of APP.

Götz A, Högel P, Silber M, Chaitoglou I, Luy B, Muhle-Goll C, Scharnagl C, Langosch D.

Sci Rep. 2019 Mar 29;9(1):5321. doi: 10.1038/s41598-019-41766-1.


Efficient Extraction from Mice Feces for NMR Metabolomics Measurements with Special Emphasis on SCFAs.

Hauser A, Eisenmann P, Muhle-Goll C, Luy B, Dötsch A, Graf D, Tzvetkova P.

Metabolites. 2019 Mar 21;9(3). pii: E55. doi: 10.3390/metabo9030055.


Integrated Process for the Enzymatic Production of Fatty Acid Sugar Esters Completely Based on Lignocellulosic Substrates.

Siebenhaller S, Kirchhoff J, Kirschhöfer F, Brenner-Weiß G, Muhle-Goll C, Luy B, Haitz F, Hahn T, Zibek S, Syldatk C, Ochsenreither K.

Front Chem. 2018 Sep 13;6:421. doi: 10.3389/fchem.2018.00421. eCollection 2018.


Lipase-Catalyzed Synthesis of Sugar Esters in Honey and Agave Syrup.

Siebenhaller S, Gentes J, Infantes A, Muhle-Goll C, Kirschhöfer F, Brenner-Weiß G, Ochsenreither K, Syldatk C.

Front Chem. 2018 Feb 12;6:24. doi: 10.3389/fchem.2018.00024. eCollection 2018.


Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer.

Cato L, Neeb A, Sharp A, Buzón V, Ficarro SB, Yang L, Muhle-Goll C, Kuznik NC, Riisnaes R, Nava Rodrigues D, Armant O, Gourain V, Adelmant G, Ntim EA, Westerling T, Dolling D, Rescigno P, Figueiredo I, Fauser F, Wu J, Rottenberg JT, Shatkina L, Ester C, Luy B, Puchta H, Troppmair J, Jung N, Bräse S, Strähle U, Marto JA, Nienhaus GU, Al-Lazikani B, Salvatella X, de Bono JS, Cato AC, Brown M.

Elife. 2017 Aug 10;6. pii: e27159. doi: 10.7554/eLife.27159.


Beechwood carbohydrates for enzymatic synthesis of sustainable glycolipids.

Siebenhaller S, Hajek T, Muhle-Goll C, Himmelsbach M, Luy B, Kirschhöfer F, Brenner-Weiß G, Hahn T, Zibek S, Syldatk C.

Bioresour Bioprocess. 2017;4(1):25. doi: 10.1186/s40643-017-0155-7. Epub 2017 Jun 7.


Untargeted NMR Spectroscopic Analysis of the Metabolic Variety of New Apple Cultivars.

Eisenmann P, Ehlers M, Weinert CH, Tzvetkova P, Silber M, Rist MJ, Luy B, Muhle-Goll C.

Metabolites. 2016 Sep 19;6(3). pii: E29. doi: 10.3390/metabo6030029.


Profiling human blood serum metabolites by nuclear magnetic resonance spectroscopy: a comprehensive tool for the evaluation of hemodialysis efficiency.

Kromke M, Palomino-Schätzlein M, Mayer H, Pfeffer S, Pineda-Lucena A, Luy B, Hausberg M, Muhle-Goll C.

Transl Res. 2016 May;171:71-82.e1-9. doi: 10.1016/j.trsl.2016.02.003. Epub 2016 Feb 10.


Glycolipids produced by Rouxiella sp. DSM 100043 and isolation of the biosurfactants via foam-fractionation.

Kügler JH, Muhle-Goll C, Hansen SH, Völp AR, Kirschhöfer F, Kühl B, Brenner-Weiss G, Luy B, Syldatk C, Hausmann R.

AMB Express. 2015 Dec;5(1):82. doi: 10.1186/s13568-015-0167-7. Epub 2015 Dec 23.


Menthols as Chiral Auxiliaries for Asymmetric Cycloadditive Oligomerization: Syntheses and Studies of β-Proline Hexamers.

Kudryavtsev KV, Ivantcova PM, Muhle-Goll C, Churakov AV, Sokolov MN, Dyuba AV, Arutyunyan AM, Howard JA, Yu CC, Guh JH, Zefirov NS, Bräse S.

Org Lett. 2015 Dec 18;17(24):6178-81. doi: 10.1021/acs.orglett.5b03154. Epub 2015 Dec 1.


Extracellular aromatic biosurfactant produced by Tsukamurella pseudospumae and T. spumae during growth on n-hexadecane.

Kügler JH, Kraft A, Heißler S, Muhle-Goll C, Luy B, Schwack W, Syldatk C, Hausmann R.

J Biotechnol. 2015 Oct 10;211:107-14. doi: 10.1016/j.jbiotec.2015.06.424. Epub 2015 Jul 26.


Autoinduced catalysis and inverse equilibrium isotope effect in the frustrated Lewis pair catalyzed hydrogenation of imines.

Tussing S, Greb L, Tamke S, Schirmer B, Muhle-Goll C, Luy B, Paradies J.

Chemistry. 2015 May 26;21(22):8056-9. doi: 10.1002/chem.201500805. Epub 2015 Apr 15.


Dendrimer-type peptoid-decorated hexaphenylxylenes and tetraphenylmethanes: synthesis and structure in solution and in the gas phase.

Peschko K, Schade A, Vollrath SB, Schwarz U, Luy B, Muhle-Goll C, Weis P, Bräse S.

Chemistry. 2014 Dec 1;20(49):16273-8. doi: 10.1002/chem.201404024. Epub 2014 Oct 8.


Trehalose lipid biosurfactants produced by the actinomycetes Tsukamurella spumae and T. pseudospumae.

Kügler JH, Muhle-Goll C, Kühl B, Kraft A, Heinzler R, Kirschhöfer F, Henkel M, Wray V, Luy B, Brenner-Weiss G, Lang S, Syldatk C, Hausmann R.

Appl Microbiol Biotechnol. 2014 Nov;98(21):8905-15. doi: 10.1007/s00253-014-5972-4. Epub 2014 Aug 5.


Structure of the membrane anchor of pestivirus glycoprotein E(rns), a long tilted amphipathic helix.

Aberle D, Muhle-Goll C, Bürck J, Wolf M, Reißer S, Luy B, Wenzel W, Ulrich AS, Meyers G.

PLoS Pathog. 2014 Feb 27;10(2):e1003973. doi: 10.1371/journal.ppat.1003973. eCollection 2014 Feb.


Coregulator control of androgen receptor action by a novel nuclear receptor-binding motif.

Jehle K, Cato L, Neeb A, Muhle-Goll C, Jung N, Smith EW, Buzon V, Carbó LR, Estébanez-Perpiñá E, Schmitz K, Fruk L, Luy B, Chen Y, Cox MB, Bräse S, Brown M, Cato AC.

J Biol Chem. 2014 Mar 28;289(13):8839-51. doi: 10.1074/jbc.M113.534859. Epub 2014 Feb 12.


Alternating asymmetric self-induction in functionalized pyrrolidine oligomers.

Kudryavtsev KV, Ivantcova PM, Churakov AV, Wiedmann S, Luy B, Muhle-Goll C, Zefirov NS, Bräse S.

Angew Chem Int Ed Engl. 2013 Nov 25;52(48):12736-40. doi: 10.1002/anie.201302862. Epub 2013 Oct 10. No abstract available.


Influence of Freezing and Storage Procedure on Human Urine Samples in NMR-Based Metabolomics.

Rist MJ, Muhle-Goll C, Görling B, Bub A, Heissler S, Watzl B, Luy B.

Metabolites. 2013 Apr 9;3(2):243-58. doi: 10.3390/metabo3020243.


Structural characterization of a peptoid with lysine-like side chains and biological activity using NMR and computational methods.

Sternberg U, Birtalan E, Jakovkin I, Luy B, Schepers U, Bräse S, Muhle-Goll C.

Org Biomol Chem. 2013 Jan 28;11(4):640-7. doi: 10.1039/c2ob27039k. Epub 2012 Dec 5.


A peptidic unconjugated GRP78/BiP ligand modulates the unfolded protein response and induces prostate cancer cell death.

Maddalo D, Neeb A, Jehle K, Schmitz K, Muhle-Goll C, Shatkina L, Walther TV, Bruchmann A, Gopal SM, Wenzel W, Ulrich AS, Cato AC.

PLoS One. 2012;7(10):e45690. doi: 10.1371/journal.pone.0045690. Epub 2012 Oct 1.


Structure analysis of the membrane-bound PhoD signal peptide of the Tat translocase shows an N-terminal amphiphilic helix.

Klein MJ, Grage SL, Muhle-Goll C, Bürck J, Afonin S, Ulrich AS.

Biochim Biophys Acta. 2012 Dec;1818(12):3025-31. doi: 10.1016/j.bbamem.2012.08.002. Epub 2012 Aug 10.


Rapid calculation of protein chemical shifts using bond polarization theory and its application to protein structure refinement.

Jakovkin I, Klipfel M, Muhle-Goll C, Ulrich AS, Luy B, Sternberg U.

Phys Chem Chem Phys. 2012 Sep 21;14(35):12263-76. doi: 10.1039/c2cp41726j. Epub 2012 Aug 7.


Hydrophobic matching controls the tilt and stability of the dimeric platelet-derived growth factor receptor (PDGFR) β transmembrane segment.

Muhle-Goll C, Hoffmann S, Afonin S, Grage SL, Polyansky AA, Windisch D, Zeitler M, Bürck J, Ulrich AS.

J Biol Chem. 2012 Jul 27;287(31):26178-86. doi: 10.1074/jbc.M111.325555. Epub 2012 May 22.


Structural role of the conserved cysteines in the dimerization of the viral transmembrane oncoprotein E5.

Windisch D, Hoffmann S, Afonin S, Vollmer S, Benamira S, Langer B, Bürck J, Muhle-Goll C, Ulrich AS.

Biophys J. 2010 Sep 22;99(6):1764-72. doi: 10.1016/j.bpj.2010.06.073.


Multifaceted approaches including neoglycolipid oligosaccharide microarrays to ligand discovery for malectin.

Palma AS, Liu Y, Muhle-Goll C, Butters TD, Zhang Y, Childs R, Chai W, Feizi T.

Methods Enzymol. 2010;478:265-86. doi: 10.1016/S0076-6879(10)78013-7.


Short cationic antimicrobial peptides interact with ATP.

Hilpert K, McLeod B, Yu J, Elliott MR, Rautenbach M, Ruden S, Bürck J, Muhle-Goll C, Ulrich AS, Keller S, Hancock RE.

Antimicrob Agents Chemother. 2010 Oct;54(10):4480-3. doi: 10.1128/AAC.01664-09. Epub 2010 Jul 26.


The structure of the FnIII Tandem A77-A78 points to a periodically conserved architecture in the myosin-binding region of titin.

Bucher RM, Svergun DI, Muhle-Goll C, Mayans O.

J Mol Biol. 2010 Sep 3;401(5):843-53. doi: 10.1016/j.jmb.2010.06.011. Epub 2010 Jun 11.


The Glc2Man2-fragment of the N-glycan precursor--a novel ligand for the glycan-binding protein malectin?

Müller LN, Muhle-Goll C, Biskup MB.

Org Biomol Chem. 2010 Jul 21;8(14):3294-9. doi: 10.1039/c004502k. Epub 2010 May 26.


Analysis of the specific interactions between the lectin domain of malectin and diglucosides.

Schallus T, Fehér K, Sternberg U, Rybin V, Muhle-Goll C.

Glycobiology. 2010 Aug;20(8):1010-20. doi: 10.1093/glycob/cwq059. Epub 2010 Apr 26.


The conserved Cys76 plays a crucial role for the conformation of reduced glutathione peroxidase-type tryparedoxin peroxidase.

Muhle-Goll C, Füller F, Ulrich AS, Krauth-Siegel RL.

FEBS Lett. 2010 Mar 5;584(5):1027-32. doi: 10.1016/j.febslet.2010.01.054. Epub 2010 Jan 31.


1H, 13C, and 15N assignment of the oxidized and reduced forms of T. brucei glutathione peroxidase-type tryparedoxin peroxidase.

Melchers J, Krauth-Siegel L, Muhle-Goll C.

Biomol NMR Assign. 2008 Jun;2(1):65-8. doi: 10.1007/s12104-008-9086-8. Epub 2008 Apr 10.


Structure and dynamics of the human muscle LIM protein.

Schallus T, Fehér K, Ulrich AS, Stier G, Muhle-Goll C.

FEBS Lett. 2009 Mar 18;583(6):1017-22. doi: 10.1016/j.febslet.2009.02.021. Epub 2009 Feb 21.


Competition saturation transfer difference experiments improved with isotope editing and filtering schemes in NMR-based screening.

Fehér K, Groves P, Batta G, Jiménez-Barbero J, Muhle-Goll C, Kövér KE.

J Am Chem Soc. 2008 Dec 17;130(50):17148-53. doi: 10.1021/ja804468k.


Structural basis for a distinct catalytic mechanism in Trypanosoma brucei tryparedoxin peroxidase.

Melchers J, Diechtierow M, Fehér K, Sinning I, Tews I, Krauth-Siegel RL, Muhle-Goll C.

J Biol Chem. 2008 Oct 31;283(44):30401-11. doi: 10.1074/jbc.M803563200. Epub 2008 Aug 6. Erratum in: J Biol Chem. 2011 Apr 29;286(17):15618.


On the significance of Toc-GTPase homodimers.

Koenig P, Oreb M, Rippe K, Muhle-Goll C, Sinning I, Schleiff E, Tews I.

J Biol Chem. 2008 Aug 22;283(34):23104-12. doi: 10.1074/jbc.M710576200. Epub 2008 Jun 8.


Malectin: a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation.

Schallus T, Jaeckh C, Fehér K, Palma AS, Liu Y, Simpson JC, Mackeen M, Stier G, Gibson TJ, Feizi T, Pieler T, Muhle-Goll C.

Mol Biol Cell. 2008 Aug;19(8):3404-14. doi: 10.1091/mbc.E08-04-0354. Epub 2008 Jun 4.


1H, 13C, and 15N assignment of the muscular LIM protein MLP/CRP3.

Schallus T, Edlich C, Stier G, Muhle-Goll C.

Biomol NMR Assign. 2007 Jul;1(1):41-3. doi: 10.1007/s12104-007-9010-7. Epub 2007 May 10.


The Ig doublet Z1Z2: a model system for the hybrid analysis of conformational dynamics in Ig tandems from titin.

Marino M, Zou P, Svergun D, Garcia P, Edlich C, Simon B, Wilmanns M, Muhle-Goll C, Mayans O.

Structure. 2006 Sep;14(9):1437-47.


New NMR assignment 1H, 13C, and 15N assignment of the second PH domain of human pleckstrin (234-350).

Edlich C, Simon B, Sattler M, Muhle-Goll C.

J Biomol NMR. 2006;36 Suppl 1:21. No abstract available.


Structure and phosphatidylinositol-(3,4)-bisphosphate binding of the C-terminal PH domain of human pleckstrin.

Edlich C, Stier G, Simon B, Sattler M, Muhle-Goll C.

Structure. 2005 Feb;13(2):277-86.


Functional and structural characterization of a novel member of the natriuretic family of peptides from the venom of Pseudocerastes persicus.

Amininasab M, Elmi MM, Endlich N, Endlich K, Parekh N, Naderi-Manesh H, Schaller J, Mostafavi H, Sattler M, Sarbolouki MN, Muhle-Goll C.

FEBS Lett. 2004 Jan 16;557(1-3):104-8.


1H, 13C, and 15N backbone assignment of the first two Ig domains Z1Z2 of the giant muscle protein Titin.

Edlich C, Muhle-Goll C.

J Biomol NMR. 2003 Nov;27(3):283-4. No abstract available.


NMR study of the interaction between Zn(II) ligated bleomycin and Streptoalloteichus hindustanus bleomycin resistance protein.

Vanbelle C, Brutscher B, Blackledge M, Muhle-Goll C, Rémy MH, Masson JM, Marion D.

Biochemistry. 2003 Jan 28;42(3):651-63.


Different molecular mechanics displayed by titin's constitutively and differentially expressed tandem Ig segments.

Watanabe K, Muhle-Goll C, Kellermayer MS, Labeit S, Granzier H.

J Struct Biol. 2002 Jan-Feb;137(1-2):248-58.


1H, 13C, and 15N assignment of a bleomycin resistance protein in its native form and in a complex with Zn2+ ligated bleomycin.

Vanbelle C, Muhle-Goll C, Remy MH, Masson JM, Marion D, Brutscher B.

J Biomol NMR. 2000 Oct;18(2):177-8. No abstract available.


1H and 15N NMR resonance assignments and secondary structure of titin type I domains.

Muhle-Goll C, Nilges M, Pastore A.

J Biomol NMR. 1997 Jan;9(1):2-10.


The leucine zippers of the HLH-LZ proteins Max and c-Myc preferentially form heterodimers.

Muhle-Goll C, Nilges M, Pastore A.

Biochemistry. 1995 Oct 17;34(41):13554-64.


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