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Items: 1 to 50 of 308

1.

Microglia changes associated to Alzheimer's disease pathology in aged chimpanzees.

Edler MK, Sherwood CC, Meindl RS, Munger E, Hopkins WD, Ely JJ, Erwin JM, Perl DP, Mufson EJ, Hof PR, Raghanti MA.

J Comp Neurol. 2018 Aug 1. doi: 10.1002/cne.24484. [Epub ahead of print]

PMID:
30069930
2.

Selective disruption of TLR2/MyD88 interaction inhibits inflammation and attenuates Alzheimer's pathology.

Rangasamy SB, Jana M, Roy A, Corbett GT, Kundu M, Chandra S, Mondal S, Dasarathi S, Mufson EJ, Mishra RK, Luan CH, Bennett DA, Pahan K.

J Clin Invest. 2018 Jul 10. pii: 96209. doi: 10.1172/JCI96209. [Epub ahead of print]

3.

Impact of age on acute post-TBI neuropathology in mice expressing humanized tau: a Chronic Effects of Neurotrauma Consortium Study.

Mouzon B, Saltiel N, Ferguson S, Ojo J, Lungmus C, Lynch C, Algamal M, Morin A, Carper B, Bieler G, Mufson EJ, Stewart W, Mullan M, Crawford F.

Brain Inj. 2018 Jun 21:1-10. doi: 10.1080/02699052.2018.1486457. [Epub ahead of print]

PMID:
29927671
4.

Pretangle pathology within cholinergic nucleus basalis neurons coincides with neurotrophic and neurotransmitter receptor gene dysregulation during the progression of Alzheimer's disease.

Tiernan CT, Ginsberg SD, He B, Ward SM, Guillozet-Bongaarts AL, Kanaan NM, Mufson EJ, Counts SE.

Neurobiol Dis. 2018 Sep;117:125-136. doi: 10.1016/j.nbd.2018.05.021. Epub 2018 May 31.

PMID:
29859871
5.

Frontal Cortex Epigenetic Dysregulation During the Progression of Alzheimer's Disease.

Mahady L, Nadeem M, Malek-Ahmadi M, Chen K, Perez SE, Mufson EJ.

J Alzheimers Dis. 2018;62(1):115-131. doi: 10.3233/JAD-171032.

PMID:
29439356
6.

Static and Dynamic Cognitive Reserve Proxy Measures: Interactions with Alzheimer's Disease Neuropathology and Cognition.

Malek-Ahmadi M, Lu S, Chan Y, Perez SE, Chen K, Mufson EJ.

J Alzheimers Dis Parkinsonism. 2017;7(6). pii: 390. doi: 10.4172/2161-0460.1000390. Epub 2017 Oct 25.

7.

Tau Oligomer Pathology in Nucleus Basalis Neurons During the Progression of Alzheimer Disease.

Tiernan CT, Mufson EJ, Kanaan NM, Counts SE.

J Neuropathol Exp Neurol. 2018 Mar 1;77(3):246-259. doi: 10.1093/jnen/nlx120.

PMID:
29378005
8.

Gene Profiling of Nucleus Basalis Tau Containing Neurons in Chronic Traumatic Encephalopathy: A Chronic Effects of Neurotrauma Consortium Study.

Mufson EJ, He B, Ginsberg SD, Carper BA, Bieler GS, Crawford F, Alvarez VE, Huber BR, Stein TD, McKee AC, Perez SE.

J Neurotrauma. 2018 Jun 1;35(11):1260-1271. doi: 10.1089/neu.2017.5368. Epub 2018 Apr 5.

PMID:
29338612
9.

Negative Impact of Female Sex on Outcomes from Repetitive Mild Traumatic Brain Injury in hTau Mice Is Age Dependent: A Chronic Effects of Neurotrauma Consortium Study.

Ferguson SA, Mouzon BC, Lynch C, Lungmus C, Morin A, Crynen G, Carper B, Bieler G, Mufson EJ, Stewart W, Mullan M, Crawford F.

Front Aging Neurosci. 2017 Dec 22;9:416. doi: 10.3389/fnagi.2017.00416. eCollection 2017.

10.

Aged chimpanzees exhibit pathologic hallmarks of Alzheimer's disease.

Edler MK, Sherwood CC, Meindl RS, Hopkins WD, Ely JJ, Erwin JM, Mufson EJ, Hof PR, Raghanti MA.

Neurobiol Aging. 2017 Nov;59:107-120. doi: 10.1016/j.neurobiolaging.2017.07.006. Epub 2017 Aug 1.

PMID:
28888720
11.

Selective decline of neurotrophin and neurotrophin receptor genes within CA1 pyramidal neurons and hippocampus proper: Correlation with cognitive performance and neuropathology in mild cognitive impairment and Alzheimer's disease.

Ginsberg SD, Malek-Ahmadi MH, Alldred MJ, Che S, Elarova I, Chen Y, Jeanneteau F, Kranz TM, Chao MV, Counts SE, Mufson EJ.

Hippocampus. 2017 Sep 9. doi: 10.1002/hipo.22802. [Epub ahead of print]

PMID:
28888073
12.

Frontal Cortex and Hippocampal γ-Secretase Activating Protein Levels in Prodromal Alzheimer Disease.

Perez SE, Nadeem M, Malek-Ahmadi MH, He B, Mufson EJ.

Neurodegener Dis. 2017;17(6):235-241. doi: 10.1159/000477937. Epub 2017 Jul 26.

13.

Cognitive Domain Dispersion Association with Alzheimer's Disease Pathology.

Malek-Ahmadi M, Lu S, Chan Y, Perez SE, Chen K, Mufson EJ.

J Alzheimers Dis. 2017;58(2):575-583. doi: 10.3233/JAD-161233.

PMID:
28453479
14.

Neocortical and hippocampal TREM2 protein levels during the progression of Alzheimer's disease.

Perez SE, Nadeem M, He B, Miguel JC, Malek-Ahmadi MH, Chen K, Mufson EJ.

Neurobiol Aging. 2017 Jun;54:133-143. doi: 10.1016/j.neurobiolaging.2017.02.012. Epub 2017 Mar 9.

PMID:
28365005
15.

Loss of precuneus dendritic spines immunopositive for spinophilin is related to cognitive impairment in early Alzheimer's disease.

Mi Z, Abrahamson EE, Ryu AY, Fish KN, Sweet RA, Mufson EJ, Ikonomovic MD.

Neurobiol Aging. 2017 Jul;55:159-166. doi: 10.1016/j.neurobiolaging.2017.01.022. Epub 2017 Feb 4.

16.

Locus coeruleus cellular and molecular pathology during the progression of Alzheimer's disease.

Kelly SC, He B, Perez SE, Ginsberg SD, Mufson EJ, Counts SE.

Acta Neuropathol Commun. 2017 Jan 21;5(1):8. doi: 10.1186/s40478-017-0411-2.

17.

Regulator of Cell Cycle (RGCC) Expression During the Progression of Alzheimer's Disease.

Counts SE, Mufson EJ.

Cell Transplant. 2017 Apr 13;26(4):693-702. doi: 10.3727/096368916X694184. Epub 2016 Nov 30.

18.

Maternal choline supplementation in a mouse model of Down syndrome: Effects on attention and nucleus basalis/substantia innominata neuron morphology in adult offspring.

Powers BE, Kelley CM, Velazquez R, Ash JA, Strawderman MS, Alldred MJ, Ginsberg SD, Mufson EJ, Strupp BJ.

Neuroscience. 2017 Jan 6;340:501-514. doi: 10.1016/j.neuroscience.2016.11.001. Epub 2016 Nov 10.

19.

Progression of tau pathology within cholinergic nucleus basalis neurons in chronic traumatic encephalopathy: A chronic effects of neurotrauma consortium study.

Mufson EJ, Perez SE, Nadeem M, Mahady L, Kanaan NM, Abrahamson EE, Ikonomovic MD, Crawford F, Alvarez V, Stein T, McKee AC.

Brain Inj. 2016;30(12):1399-1413.

20.

Neuronal exosomes reveal Alzheimer's disease biomarkers in Down syndrome.

Hamlett ED, Goetzl EJ, Ledreux A, Vasilevko V, Boger HA, LaRosa A, Clark D, Carroll SL, Carmona-Iragui M, Fortea J, Mufson EJ, Sabbagh M, Mohammed AH, Hartley D, Doran E, Lott IT, Granholm AC.

Alzheimers Dement. 2017 May;13(5):541-549. doi: 10.1016/j.jalz.2016.08.012. Epub 2016 Oct 15.

21.

Biomarkers for the Early Detection and Progression of Alzheimer's Disease.

Counts SE, Ikonomovic MD, Mercado N, Vega IE, Mufson EJ.

Neurotherapeutics. 2017 Jan;14(1):35-53. doi: 10.1007/s13311-016-0481-z. Review.

22.

Neuritic and Diffuse Plaque Associations with Memory in Non-Cognitively Impaired Elderly.

Malek-Ahmadi M, Perez SE, Chen K, Mufson EJ.

J Alzheimers Dis. 2016 Jul 14;53(4):1641-52. doi: 10.3233/JAD-160365.

PMID:
27540968
23.

Cholinergic profiles in the Goettingen miniature pig (Sus scrofa domesticus) brain.

Mahady LJ, Perez SE, Emerich DF, Wahlberg LU, Mufson EJ.

J Comp Neurol. 2017 Feb 15;525(3):553-573. doi: 10.1002/cne.24087. Epub 2016 Aug 30.

24.

Tenascin-C Is Associated with Cored Amyloid-β Plaques in Alzheimer Disease and Pathology Burdened Cognitively Normal Elderly.

Mi Z, Halfter W, Abrahamson EE, Klunk WE, Mathis CA, Mufson EJ, Ikonomovic MD.

J Neuropathol Exp Neurol. 2016 Sep;75(9):868-76. doi: 10.1093/jnen/nlw062. Epub 2016 Jul 21.

25.

NPT088 reduces both amyloid-β and tau pathologies in transgenic mice.

Levenson JM, Schroeter S, Carroll JC, Cullen V, Asp E, Proschitsky M, Chung CH, Gilead S, Nadeem M, Dodiya HB, Shoaga S, Mufson EJ, Tsubery H, Krishnan R, Wright J, Solomon B, Fisher R, Gannon KS.

Alzheimers Dement (N Y). 2016 Jul 14;2(3):141-155. doi: 10.1016/j.trci.2016.06.004. eCollection 2016 Sep.

26.

Braak stage and trajectory of cognitive decline in noncognitively impaired elders.

Mufson EJ, Malek-Ahmadi M, Snyder N, Ausdemore J, Chen K, Perez SE.

Neurobiol Aging. 2016 Jul;43:101-10. doi: 10.1016/j.neurobiolaging.2016.03.003. Epub 2016 Mar 10.

27.

Molecular and cellular pathophysiology of preclinical Alzheimer's disease.

Mufson EJ, Ikonomovic MD, Counts SE, Perez SE, Malek-Ahmadi M, Scheff SW, Ginsberg SD.

Behav Brain Res. 2016 Sep 15;311:54-69. doi: 10.1016/j.bbr.2016.05.030. Epub 2016 May 13. Review.

28.

Protein homeostasis gene dysregulation in pretangle-bearing nucleus basalis neurons during the progression of Alzheimer's disease.

Tiernan CT, Ginsberg SD, Guillozet-Bongaarts AL, Ward SM, He B, Kanaan NM, Mufson EJ, Binder LI, Counts SE.

Neurobiol Aging. 2016 Jun;42:80-90. doi: 10.1016/j.neurobiolaging.2016.02.031. Epub 2016 Mar 8.

29.

Oxidative stress and hippocampal synaptic protein levels in elderly cognitively intact individuals with Alzheimer's disease pathology.

Scheff SW, Ansari MA, Mufson EJ.

Neurobiol Aging. 2016 Jun;42:1-12. doi: 10.1016/j.neurobiolaging.2016.02.030. Epub 2016 Mar 8.

30.

Early Alzheimer's disease-type pathology in the frontal cortex of wild mountain gorillas (Gorilla beringei beringei).

Perez SE, Sherwood CC, Cranfield MR, Erwin JM, Mudakikwa A, Hof PR, Mufson EJ.

Neurobiol Aging. 2016 Mar;39:195-201. doi: 10.1016/j.neurobiolaging.2015.12.017. Epub 2015 Dec 31.

PMID:
26923416
31.

Cerebrospinal Fluid proNGF: A Putative Biomarker for Early Alzheimer's Disease.

Counts SE, He B, Prout JG, Michalski B, Farotti L, Fahnestock M, Mufson EJ.

Curr Alzheimer Res. 2016;13(7):800-8.

32.

Attentional function and basal forebrain cholinergic neuron morphology during aging in the Ts65Dn mouse model of Down syndrome.

Powers BE, Velazquez R, Kelley CM, Ash JA, Strawderman MS, Alldred MJ, Ginsberg SD, Mufson EJ, Strupp BJ.

Brain Struct Funct. 2016 Dec;221(9):4337-4352. Epub 2015 Dec 30.

33.

Evidence for Mitochondrial UPR Gene Activation in Familial and Sporadic Alzheimer's Disease.

Beck JS, Mufson EJ, Counts SE.

Curr Alzheimer Res. 2016;13(6):610-4.

34.

Braak staging, plaque pathology, and APOE status in elderly persons without cognitive impairment.

Mufson EJ, Malek-Ahmadi M, Perez SE, Chen K.

Neurobiol Aging. 2016 Jan;37:147-153. doi: 10.1016/j.neurobiolaging.2015.10.012. Epub 2015 Oct 20.

35.

Evidence for a neuroprotective microRNA pathway in amnestic mild cognitive impairment.

Weinberg RB, Mufson EJ, Counts SE.

Front Neurosci. 2015 Nov 5;9:430. doi: 10.3389/fnins.2015.00430. eCollection 2015.

36.

The Link between Alzheimer's Disease and Down Syndrome. A Historical Perspective.

Salehi A, Ashford JW, Mufson EJ.

Curr Alzheimer Res. 2016;13(1):2-6. No abstract available.

PMID:
26487155
37.

Intranasal Delivery of NEMO-Binding Domain Peptide Prevents Memory Loss in a Mouse Model of Alzheimer's Disease.

Rangasamy SB, Corbett GT, Roy A, Modi KK, Bennett DA, Mufson EJ, Ghosh S, Pahan K.

J Alzheimers Dis. 2015;47(2):385-402. doi: 10.3233/JAD-150040.

38.

Cognitive Impairment, Neuroimaging, and Alzheimer Neuropathology in Mouse Models of Down Syndrome.

Hamlett ED, Boger HA, Ledreux A, Kelley CM, Mufson EJ, Falangola MF, Guilfoyle DN, Nixon RA, Patterson D, Duval N, Granholm AC.

Curr Alzheimer Res. 2016;13(1):35-52. Review.

39.

Maternal Choline Supplementation: A Potential Prenatal Treatment for Down Syndrome and Alzheimer's Disease.

Strupp BJ, Powers BE, Velazquez R, Ash JA, Kelley CM, Alldred MJ, Strawderman M, Caudill MA, Mufson EJ, Ginsberg SD.

Curr Alzheimer Res. 2016;13(1):97-106.

40.

Effects of Maternal Choline Supplementation on the Septohippocampal Cholinergic System in the Ts65Dn Mouse Model of Down Syndrome.

Kelley CM, Ash JA, Powers BE, Velazquez R, Alldred MJ, Ikonomovic MD, Ginsberg SD, Strupp BJ, Mufson EJ.

Curr Alzheimer Res. 2016;13(1):84-96.

41.

Hippocampal plasticity during the progression of Alzheimer's disease.

Mufson EJ, Mahady L, Waters D, Counts SE, Perez SE, DeKosky ST, Ginsberg SD, Ikonomovic MD, Scheff SW, Binder LI.

Neuroscience. 2015 Nov 19;309:51-67. doi: 10.1016/j.neuroscience.2015.03.006. Epub 2015 Mar 12. Review.

42.

Hippocampal endosomal, lysosomal, and autophagic dysregulation in mild cognitive impairment: correlation with aβ and tau pathology.

Perez SE, He B, Nadeem M, Wuu J, Ginsberg SD, Ikonomovic MD, Mufson EJ.

J Neuropathol Exp Neurol. 2015 Apr;74(4):345-58. doi: 10.1097/NEN.0000000000000179.

43.
44.

Synaptic change in the posterior cingulate gyrus in the progression of Alzheimer's disease.

Scheff SW, Price DA, Ansari MA, Roberts KN, Schmitt FA, Ikonomovic MD, Mufson EJ.

J Alzheimers Dis. 2015;43(3):1073-90. doi: 10.3233/JAD-141518.

45.

Cortical pyroglutamate amyloid-β levels and cognitive decline in Alzheimer's disease.

Pivtoraiko VN, Abrahamson EE, Leurgans SE, DeKosky ST, Mufson EJ, Ikonomovic MD.

Neurobiol Aging. 2015 Jan;36(1):12-9. doi: 10.1016/j.neurobiolaging.2014.06.021. Epub 2014 Jun 24.

46.

Evidence for Alzheimer's disease-linked synapse loss and compensation in mouse and human hippocampal CA1 pyramidal neurons.

Neuman KM, Molina-Campos E, Musial TF, Price AL, Oh KJ, Wolke ML, Buss EW, Scheff SW, Mufson EJ, Nicholson DA.

Brain Struct Funct. 2015 Nov;220(6):3143-65. doi: 10.1007/s00429-014-0848-z. Epub 2014 Jul 17.

47.

Maternal choline supplementation improves spatial mapping and increases basal forebrain cholinergic neuron number and size in aged Ts65Dn mice.

Ash JA, Velazquez R, Kelley CM, Powers BE, Ginsberg SD, Mufson EJ, Strupp BJ.

Neurobiol Dis. 2014 Oct;70:32-42. doi: 10.1016/j.nbd.2014.06.001. Epub 2014 Jun 14.

48.

U1 small nuclear ribonucleoproteins (snRNPs) aggregate in Alzheimer's disease due to autosomal dominant genetic mutations and trisomy 21.

Hales CM, Seyfried NT, Dammer EB, Duong D, Yi H, Gearing M, Troncoso JC, Mufson EJ, Thambisetty M, Levey AI, Lah JJ.

Mol Neurodegener. 2014 Apr 28;9:15. doi: 10.1186/1750-1326-9-15.

49.

Intravenous immunoglobulin (IVIG) treatment exerts antioxidant and neuropreservatory effects in preclinical models of Alzheimer's disease.

Counts SE, Ray B, Mufson EJ, Perez SE, He B, Lahiri DK.

J Clin Immunol. 2014 Jul;34 Suppl 1:S80-5. doi: 10.1007/s10875-014-0020-9. Epub 2014 Apr 24.

50.

Resilience of precuneus neurotrophic signaling pathways despite amyloid pathology in prodromal Alzheimer's disease.

Perez SE, He B, Nadeem M, Wuu J, Scheff SW, Abrahamson EE, Ikonomovic MD, Mufson EJ.

Biol Psychiatry. 2015 Apr 15;77(8):693-703. doi: 10.1016/j.biopsych.2013.12.016. Epub 2014 Jan 11.

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