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Items: 1 to 50 of 87

1.

A bispecific antibody targeting IGF-IR and EGFR has tumor and metastasis suppressive activity in an orthotopic xenograft osteosarcoma mouse model.

Gvozdenovic A, Boro A, Born W, Muff R, Fuchs B.

Am J Cancer Res. 2017 Jul 1;7(7):1435-1449. eCollection 2017.

2.

Targeting αvβ3 and αvβ5 integrins inhibits pulmonary metastasis in an intratibial xenograft osteosarcoma mouse model.

Gvozdenovic A, Boro A, Meier D, Bode-Lesniewska B, Born W, Muff R, Fuchs B.

Oncotarget. 2016 Aug 23;7(34):55141-55154. doi: 10.18632/oncotarget.10461.

3.

Explant culture of sarcoma patients' tissue.

Muff R, Botter SM, Husmann K, Tchinda J, Selvam P, Seeli-Maduz F, Fuchs B.

Lab Invest. 2016 Jul;96(7):752-62. doi: 10.1038/labinvest.2016.49. Epub 2016 Apr 25.

4.

Genomic instability of osteosarcoma cell lines in culture: impact on the prediction of metastasis relevant genes.

Muff R, Rath P, Ram Kumar RM, Husmann K, Born W, Baudis M, Fuchs B.

PLoS One. 2015 May 19;10(5):e0125611. doi: 10.1371/journal.pone.0125611. eCollection 2015.

5.

An in vitro osteosarcoma 3D microtissue model for drug development.

Rimann M, Laternser S, Gvozdenovic A, Muff R, Fuchs B, Kelm JM, Graf-Hausner U.

J Biotechnol. 2014 Nov 10;189:129-35. doi: 10.1016/j.jbiotec.2014.09.005. Epub 2014 Sep 16.

PMID:
25234575
6.

Reduced Latency in the Metastatic Niche Contributes to the More Aggressive Phenotype of LM8 Compared to Dunn Osteosarcoma Cells.

Arlt MJ, Banke IJ, Bertz J, Ram Kumar RM, Muff R, Born W, Fuchs B.

Sarcoma. 2013;2013:404962. doi: 10.1155/2013/404962. Epub 2013 Dec 4.

7.

Expression of the chemokine receptor CXCR7 in CXCR4-expressing human 143B osteosarcoma cells enhances lung metastasis of intratibial xenografts in SCID mice.

Brennecke P, Arlt MJ, Muff R, Campanile C, Gvozdenovic A, Husmann K, Holzwarth N, Cameroni E, Ehrensperger F, Thelen M, Born W, Fuchs B.

PLoS One. 2013 Sep 10;8(9):e74045. doi: 10.1371/journal.pone.0074045. eCollection 2013.

8.

Silencing of CD44 gene expression in human 143-B osteosarcoma cells promotes metastasis of intratibial tumors in SCID mice.

Gvozdenovic A, Arlt MJ, Campanile C, Brennecke P, Husmann K, Born W, Muff R, Fuchs B.

PLoS One. 2013;8(4):e60329. doi: 10.1371/journal.pone.0060329. Epub 2013 Apr 2.

9.

Evaluation of quercetin as a potential drug in osteosarcoma treatment.

Berndt K, Campanile C, Muff R, Strehler E, Born W, Fuchs B.

Anticancer Res. 2013 Apr;33(4):1297-306.

PMID:
23564766
10.

Caprin-1, a novel Cyr61-interacting protein, promotes osteosarcoma tumor growth and lung metastasis in mice.

Sabile AA, Arlt MJ, Muff R, Husmann K, Hess D, Bertz J, Langsam B, Aemisegger C, Ziegler U, Born W, Fuchs B.

Biochim Biophys Acta. 2013 Aug;1832(8):1173-82. doi: 10.1016/j.bbadis.2013.03.014. Epub 2013 Mar 23.

11.

Genes regulated in metastatic osteosarcoma: evaluation by microarray analysis in four human and two mouse cell line systems.

Muff R, Ram Kumar RM, Botter SM, Born W, Fuchs B.

Sarcoma. 2012;2012:937506. doi: 10.1155/2012/937506. Epub 2012 Nov 13.

12.

Matrix Metalloproteinase 1 promotes tumor formation and lung metastasis in an intratibial injection osteosarcoma mouse model.

Husmann K, Arlt MJ, Muff R, Langsam B, Bertz J, Born W, Fuchs B.

Biochim Biophys Acta. 2013 Feb;1832(2):347-54. doi: 10.1016/j.bbadis.2012.11.006. Epub 2012 Nov 27.

13.

CD44 enhances tumor formation and lung metastasis in experimental osteosarcoma and is an additional predictor for poor patient outcome.

Gvozdenovic A, Arlt MJ, Campanile C, Brennecke P, Husmann K, Li Y, Born W, Muff R, Fuchs B.

J Bone Miner Res. 2013 Apr;28(4):838-47. doi: 10.1002/jbmr.1817.

14.

mTHPC-mediated photodynamic therapy is effective in the metastatic human 143B osteosarcoma cells.

Reidy K, Campanile C, Muff R, Born W, Fuchs B.

Photochem Photobiol. 2012 May-Jun;88(3):721-7. doi: 10.1111/j.1751-1097.2012.01096.x. Epub 2012 Feb 21.

PMID:
22268498
15.

Cyr61 expression in osteosarcoma indicates poor prognosis and promotes intratibial growth and lung metastasis in mice.

Sabile AA, Arlt MJ, Muff R, Bode B, Langsam B, Bertz J, Jentzsch T, Puskas GJ, Born W, Fuchs B.

J Bone Miner Res. 2012 Jan;27(1):58-67. doi: 10.1002/jbmr.535.

16.

Antimetastatic activity of honokiol in osteosarcoma.

Steinmann P, Walters DK, Arlt MJ, Banke IJ, Ziegler U, Langsam B, Arbiser J, Muff R, Born W, Fuchs B.

Cancer. 2012 Apr 15;118(8):2117-27. doi: 10.1002/cncr.26434. Epub 2011 Sep 20.

17.

LacZ transgene expression in the subcutaneous Dunn/LM8 osteosarcoma mouse model allows for the identification of micrometastasis.

Arlt MJ, Banke IJ, Walters DK, Puskas GJ, Steinmann P, Muff R, Born W, Fuchs B.

J Orthop Res. 2011 Jun;29(6):938-46. doi: 10.1002/jor.21304. Epub 2011 Jan 31.

18.

A novel method for assessing adherent single-cell stiffness in tension: design and testing of a substrate-based live cell functional imaging device.

Bartalena G, Grieder R, Sharma RI, Zambelli T, Muff R, Snedeker JG.

Biomed Microdevices. 2011 Apr;13(2):291-301. doi: 10.1007/s10544-010-9493-3.

19.

Altered morphology, nuclear stability and adhesion of highly metastatic derivatives of osteoblast-like SAOS-2 osteosarcoma cells.

Muff R, Nigg N, Gruber P, Walters D, Born W, Fuchs B.

Anticancer Res. 2007 Nov-Dec;27(6B):3973-9.

20.

Cytotoxic effects of curcumin on osteosarcoma cell lines.

Walters DK, Muff R, Langsam B, Born W, Fuchs B.

Invest New Drugs. 2008 Aug;26(4):289-97. Epub 2007 Dec 11.

21.

Cathepsins and osteosarcoma: Expression analysis identifies cathepsin K as an indicator of metastasis.

Husmann K, Muff R, Bolander ME, Sarkar G, Born W, Fuchs B.

Mol Carcinog. 2008 Jan;47(1):66-73.

PMID:
17683065
22.

Transgenic mice with ocular overexpression of an adrenomedullin receptor reflect human acute angle-closure glaucoma.

Ittner LM, Schwerdtfeger K, Kunz TH, Muff R, Husmann K, Grimm C, Hafezi F, Lang KS, Kurrer MO, Götz J, Born W, Fischer JA.

Clin Sci (Lond). 2008 Jan;114(1):49-58.

PMID:
17608625
23.

Taurolidine: a novel anti-neoplastic agent induces apoptosis of osteosarcoma cell lines.

Walters DK, Muff R, Langsam B, Gruber P, Born W, Fuchs B.

Invest New Drugs. 2007 Aug;25(4):305-12. Epub 2007 Apr 26.

24.

Rational design of aggregation-resistant bioactive peptides: reengineering human calcitonin.

Fowler SB, Poon S, Muff R, Chiti F, Dobson CM, Zurdo J.

Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10105-10. Epub 2005 Jul 8.

26.

Biological importance of the peptides of the calcitonin family as revealed by disruption and transfer of corresponding genes.

Muff R, Born W, Lutz TA, Fischer JA.

Peptides. 2004 Nov;25(11):2027-38. Review.

PMID:
15501537
27.

Aspartate(69) of the calcitonin-like receptor is required for its functional expression together with receptor-activity-modifying proteins 1 and -2.

Ittner LM, Luessi F, Koller D, Born W, Fischer JA, Muff R.

Biochem Biophys Res Commun. 2004 Jul 9;319(4):1203-9.

PMID:
15194494
28.

Selective inactivation of adrenomedullin over calcitonin gene-related peptide receptor function by the deletion of amino acids 14-20 of the mouse calcitonin-like receptor.

Koller D, Ittner LM, Muff R, Husmann K, Fischer JA, Born W.

J Biol Chem. 2004 May 7;279(19):20387-91. Epub 2004 Mar 8.

29.

Cellular internalization of human calcitonin derived peptides in MDCK monolayers: a comparative study with Tat(47-57) and penetratin(43-58).

Tréhin R, Krauss U, Muff R, Meinecke M, Beck-Sickinger AG, Merkle HP.

Pharm Res. 2004 Jan;21(1):33-42.

PMID:
14984255
30.
31.
32.

Adrenomedullin selectivity of calcitonin-like receptor/receptor activity modifying proteins.

Muff R, Born W, Fischer JA.

Hypertens Res. 2003 Feb;26 Suppl:S3-8. Review.

33.
34.

The extreme N-terminus of the calcitonin-like receptor contributes to the selective interaction with adrenomedullin or calcitonin gene-related peptide.

Koller D, Born W, Leuthäuser K, Flühmann B, McKinney RA, Fischer JA, Muff R.

FEBS Lett. 2002 Nov 20;531(3):464-8.

35.

Paracrine/autocrine function of adrenomedullin in peripheral nerves of rats.

Dumont CE, Muff R, Flühmann B, Fischer JA, Born W.

Brain Res. 2002 Nov 15;955(1-2):64-71.

PMID:
12419522
36.
37.
38.

International Union of Pharmacology. XXXII. The mammalian calcitonin gene-related peptides, adrenomedullin, amylin, and calcitonin receptors.

Poyner DR, Sexton PM, Marshall I, Smith DM, Quirion R, Born W, Muff R, Fischer JA, Foord SM.

Pharmacol Rev. 2002 Jun;54(2):233-46. Review.

PMID:
12037140
39.
40.

Adrenomedullin and related peptides: receptors and accessory proteins.

Muff R, Born W, Fischer JA.

Peptides. 2001 Nov;22(11):1765-72. Review.

PMID:
11754962
41.

Mutations of the asparagine117 residue of a receptor activity-modifying protein 1-dependent human calcitonin gene-related peptide receptor result in selective loss of function.

Gujer R, Aldecoa A, Bühlmann N, Leuthäuser K, Muff R, Fischer JA, Born W.

Biochemistry. 2001 May 8;40(18):5392-8.

PMID:
11331002
42.

Glycosylation of the calcitonin receptor-like receptor at Asn(60) or Asn(112) is important for cell surface expression.

Bühlmann N, Aldecoa A, Leuthäuser K, Gujer R, Muff R, Fischer JA, Born W.

FEBS Lett. 2000 Dec 15;486(3):320-4.

43.

Receptor-activity-modifying protein 1 forms heterodimers with two G-protein-coupled receptors to define ligand recognition.

Leuthäuser K, Gujer R, Aldecoa A, McKinney RA, Muff R, Fischer JA, Born W.

Biochem J. 2000 Oct 15;351 Pt 2:347-51.

44.

Maxadilan interacts with receptors for pituitary adenylyl cyclase activating peptide in human SH-SY5Y and SK-N-MC neuroblastoma cells.

Eggenberger M, Born W, Zimmermann U, Lerner EA, Fischer JA, Muff R.

Neuropeptides. 1999 Apr;33(2):107-14.

PMID:
10657479
45.
46.
47.

Receptor activity modifying proteins regulate the activity of a calcitonin gene-related peptide receptor in rabbit aortic endothelial cells.

Muff R, Leuthäuser K, Bühlmann N, Foord SM, Fischer JA, Born W.

FEBS Lett. 1998 Dec 28;441(3):366-8.

48.

Parathyroid hormone responses of cyclic AMP-, serum- and phorbol ester-responsive reporter genes in osteoblast-like UMR-106 cells.

Flühmann B, Zimmermann U, Muff R, Bilbe G, Fischer JA, Born W.

Mol Cell Endocrinol. 1998 Apr 30;139(1-2):89-98.

PMID:
9705077
49.
50.

Coexistence of novel amylin-binding sites with calcitonin receptors in human breast carcinoma MCF-7 cells.

Zimmermann U, Fluehmann B, Born W, Fischer JA, Muff R.

J Endocrinol. 1997 Dec;155(3):423-31.

PMID:
9487987

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