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A cryo-EM grid preparation device for time-resolved structural studies.

Kontziampasis D, Klebl DP, Iadanza MG, Scarff CA, Kopf F, Sobott F, Monteiro DCF, Trebbin M, Muench SP, White HD.

IUCrJ. 2019 Sep 5;6(Pt 6):1024-1031. doi: 10.1107/S2052252519011345. eCollection 2019 Nov 1.


Structural Insight into Eukaryotic Sterol Transport through Niemann-Pick Type C Proteins.

Winkler MBL, Kidmose RT, Szomek M, Thaysen K, Rawson S, Muench SP, Wüstner D, Pedersen BP.

Cell. 2019 Oct 3;179(2):485-497.e18. doi: 10.1016/j.cell.2019.08.038. Epub 2019 Sep 19.


Dimeric structures of quinol-dependent nitric oxide reductases (qNORs) revealed by cryo-electron microscopy.

Gopalasingam CC, Johnson RM, Chiduza GN, Tosha T, Yamamoto M, Shiro Y, Antonyuk SV, Muench SP, Hasnain SS.

Sci Adv. 2019 Aug 28;5(8):eaax1803. doi: 10.1126/sciadv.aax1803. eCollection 2019 Aug.


Emerging Role of Electron Microscopy in Drug Discovery.

Johnson RM, Higgins AJ, Muench SP.

Trends Biochem Sci. 2019 Oct;44(10):897-898. doi: 10.1016/j.tibs.2019.07.003. Epub 2019 Aug 10. No abstract available.


LAT1 (SLC7A5) and CD98hc (SLC3A2) complex dynamics revealed by single-particle cryo-EM.

Chiduza GN, Johnson RM, Wright GSA, Antonyuk SV, Muench SP, Hasnain SS.

Acta Crystallogr D Struct Biol. 2019 Jul 1;75(Pt 7):660-669. doi: 10.1107/S2059798319009094. Epub 2019 Jun 28.


SMA-PAGE: A new method to examine complexes of membrane proteins using SMALP nano-encapsulation and native gel electrophoresis.

Pollock NL, Rai M, Simon KS, Hesketh SJ, Teo ACK, Parmar M, Sridhar P, Collins R, Lee SC, Stroud ZN, Bakker SE, Muench SP, Barton CH, Hurlbut G, Roper DI, Smith CJI, Knowles TJ, Spickett CM, East JM, Postis VLG, Dafforn TR.

Biochim Biophys Acta Biomembr. 2019 Aug 1;1861(8):1437-1445. doi: 10.1016/j.bbamem.2019.05.011. Epub 2019 May 28.


The expanding toolkit for structural biology: synchrotrons, X-ray lasers and cryoEM.

Muench SP, Antonyuk SV, Hasnain SS.

IUCrJ. 2019 Mar 1;6(Pt 2):167-177. doi: 10.1107/S2052252519002422. eCollection 2019 Mar 1. Review.


Substrate polyspecificity and conformational relevance in ABC transporters: new insights from structural studies.

Wright J, Muench SP, Goldman A, Baker A.

Biochem Soc Trans. 2018 Dec 17;46(6):1475-1484. doi: 10.1042/BST20180146. Epub 2018 Dec 4. Review.


CSGID Solves Structures and Identifies Phenotypes for Five Enzymes in Toxoplasma gondii.

Lykins JD, Filippova EV, Halavaty AS, Minasov G, Zhou Y, Dubrovska I, Flores KJ, Shuvalova LA, Ruan J, El Bissati K, Dovgin S, Roberts CW, Woods S, Moulton JD, Moulton H, McPhillie MJ, Muench SP, Fishwick CWG, Sabini E, Shanmugam D, Roos DS, McLeod R, Anderson WF, Ngô HM.

Front Cell Infect Microbiol. 2018 Oct 5;8:352. doi: 10.3389/fcimb.2018.00352. eCollection 2018.


Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states.

Agip AA, Blaza JN, Bridges HR, Viscomi C, Rawson S, Muench SP, Hirst J.

Nat Struct Mol Biol. 2018 Jul;25(7):548-556. doi: 10.1038/s41594-018-0073-1. Epub 2018 Jun 18.


Approaches to altering particle distributions in cryo-electron microscopy sample preparation.

Drulyte I, Johnson RM, Hesketh EL, Hurdiss DL, Scarff CA, Porav SA, Ranson NA, Muench SP, Thompson RF.

Acta Crystallogr D Struct Biol. 2018 Jun 1;74(Pt 6):560-571. doi: 10.1107/S2059798318006496. Epub 2018 May 18. Review.


X-ray and cryo-EM structures of inhibitor-bound cytochrome bc1 complexes for structure-based drug discovery.

Amporndanai K, Johnson RM, O'Neill PM, Fishwick CWG, Jamson AH, Rawson S, Muench SP, Hasnain SS, Antonyuk SV.

IUCrJ. 2018 Feb 20;5(Pt 2):200-210. doi: 10.1107/S2052252518001616. eCollection 2018 Mar 1.


No Longer Hidden Secrets of Proton Pumping: The Resolution Revolution Enlightens V-ATPases.

Muench SP, van der Laan M.

Mol Cell. 2018 Mar 15;69(6):921-922. doi: 10.1016/j.molcel.2018.02.031.


Spherical-supported membranes as platforms for screening against membrane protein targets.

Vasilca V, Sadeghpour A, Rawson S, Hawke LE, Baldwin SA, Wilkinson T, Bannister D, Postis VLG, Rappolt M, Muench SP, Jeuken LJC.

Anal Biochem. 2018 May 15;549:58-65. doi: 10.1016/j.ab.2018.03.006. Epub 2018 Mar 13.


The Vacuolar ATPase - A Nano-scale Motor That Drives Cell Biology.

Harrison MA, Muench SP.

Subcell Biochem. 2018;87:409-459. doi: 10.1007/978-981-10-7757-9_14. Review.


Elucidating the structural basis for differing enzyme inhibitor potency by cryo-EM.

Rawson S, Bisson C, Hurdiss DL, Fazal A, McPhillie MJ, Sedelnikova SE, Baker PJ, Rice DW, Muench SP.

Proc Natl Acad Sci U S A. 2018 Feb 20;115(8):1795-1800. doi: 10.1073/pnas.1708839115. Epub 2018 Feb 6.


A reconstitution method for integral membrane proteins in hybrid lipid-polymer vesicles for enhanced functional durability.

Seneviratne R, Khan S, Moscrop E, Rappolt M, Muench SP, Jeuken LJC, Beales PA.

Methods. 2018 Sep 1;147:142-149. doi: 10.1016/j.ymeth.2018.01.021. Epub 2018 Feb 2.


The Growing Role of Electron Microscopy in Anti-parasitic Drug Discovery.

Johnson RM, Rawson S, McPhillie MJ, Fishwick CWG, Muench SP.

Curr Med Chem. 2018;25(39):5279-5290. doi: 10.2174/0929867324666171109120526. Review.


Using a SMALP platform to determine a sub-nm single particle cryo-EM membrane protein structure.

Parmar M, Rawson S, Scarff CA, Goldman A, Dafforn TR, Muench SP, Postis VLG.

Biochim Biophys Acta Biomembr. 2018 Feb;1860(2):378-383. doi: 10.1016/j.bbamem.2017.10.005. Epub 2017 Oct 6.


AtSPX1 affects the AtPHR1-DNA-binding equilibrium by binding monomeric AtPHR1 in solution.

Qi W, Manfield IW, Muench SP, Baker A.

Biochem J. 2017 Oct 23;474(21):3675-3687. doi: 10.1042/BCJ20170522.


Everyone needs good neighbours - the intricate relationship between the acetylcholine-receptor channel and its membrane environment.

Muench SP.

IUCrJ. 2017 Jun 29;4(Pt 4):306-307. doi: 10.1107/S2052252517009058. eCollection 2017 Jul 1.


The potential use of single-particle electron microscopy as a tool for structure-based inhibitor design.

Rawson S, McPhillie MJ, Johnson RM, Fishwick CWG, Muench SP.

Acta Crystallogr D Struct Biol. 2017 Jun 1;73(Pt 6):534-540. doi: 10.1107/S2059798317004077. Epub 2017 Apr 20.


Durable vesicles for reconstitution of membrane proteins in biotechnology.

Beales PA, Khan S, Muench SP, Jeuken LJ.

Biochem Soc Trans. 2017 Feb 8;45(1):15-26. doi: 10.1042/BST20160019. Review.


Conformational changes during human P2X7 receptor activation examined by structural modelling and cysteine-based cross-linking studies.

Caseley EA, Muench SP, Jiang LH.

Purinergic Signal. 2017 Mar;13(1):135-141. doi: 10.1007/s11302-016-9553-0. Epub 2016 Dec 26.


The changing landscape of membrane protein structural biology through developments in electron microscopy.

Rawson S, Davies S, Lippiat JD, Muench SP.

Mol Membr Biol. 2016 Mar;33(1-2):12-22. Epub 2016 Sep 9. Review.


Durable proteo-hybrid vesicles for the extended functional lifetime of membrane proteins in bionanotechnology.

Khan S, Li M, Muench SP, Jeuken LJ, Beales PA.

Chem Commun (Camb). 2016 Sep 21;52(73):11020-3. doi: 10.1039/c6cc04207d. Epub 2016 Aug 19.


Structure-based identification and characterisation of structurally novel human P2X7 receptor antagonists.

Caseley EA, Muench SP, Fishwick CW, Jiang LH.

Biochem Pharmacol. 2016 Sep 15;116:130-9. doi: 10.1016/j.bcp.2016.07.020. Epub 2016 Jul 29.


Artificial membranes for membrane protein purification, functionality and structure studies.

Parmar MJ, Lousa Cde M, Muench SP, Goldman A, Postis VL.

Biochem Soc Trans. 2016 Jun 15;44(3):877-82. doi: 10.1042/BST20160054. Review.


The varied functions of aluminium-activated malate transporters-much more than aluminium resistance.

Palmer AJ, Baker A, Muench SP.

Biochem Soc Trans. 2016 Jun 15;44(3):856-62. doi: 10.1042/BST20160027. Review.


Rotating with the brakes on and other unresolved features of the vacuolar ATPase.

Rawson S, Harrison MA, Muench SP.

Biochem Soc Trans. 2016 Jun 15;44(3):851-5. doi: 10.1042/BST20160043. Review.


Pi sensing and signalling: from prokaryotic to eukaryotic cells.

Qi W, Baldwin SA, Muench SP, Baker A.

Biochem Soc Trans. 2016 Jun 15;44(3):766-73. doi: 10.1042/BST20160026. Review.


A method for detergent-free isolation of membrane proteins in their local lipid environment.

Lee SC, Knowles TJ, Postis VL, Jamshad M, Parslow RA, Lin YP, Goldman A, Sridhar P, Overduin M, Muench SP, Dafforn TR.

Nat Protoc. 2016 Jul;11(7):1149-62. doi: 10.1038/nprot.2016.070. Epub 2016 Jun 2.


Corrigendum to 'Methods to account for movement and flexibility in cryo-EM data processing' [Methods 100 (2016) 35-41].

Rawson S, Iadanza MG, Ranson NA, Muench SP.

Methods. 2016 Jul 15;104:207. doi: 10.1016/j.ymeth.2016.05.006. Epub 2016 May 18. No abstract available.


Characterization of the flexibility of the peripheral stalk of prokaryotic rotary A-ATPases by atomistic simulations.

Papachristos K, Muench SP, Paci E.

Proteins. 2016 Sep;84(9):1203-12. doi: 10.1002/prot.25066. Epub 2016 Jun 1.



Muench SP.

Methods. 2016 May 1;100:1-2. doi: 10.1016/j.ymeth.2016.04.006. Epub 2016 Apr 6. No abstract available.


Methods to account for movement and flexibility in cryo-EM data processing.

Rawson S, Iadanza MG, Ranson NA, Muench SP.

Methods. 2016 May 1;100:35-41. doi: 10.1016/j.ymeth.2016.03.011. Epub 2016 Mar 24. Erratum in: Methods. 2016 Jul 15;104:207.


An introduction to sample preparation and imaging by cryo-electron microscopy for structural biology.

Thompson RF, Walker M, Siebert CA, Muench SP, Ranson NA.

Methods. 2016 May 1;100:3-15. doi: 10.1016/j.ymeth.2016.02.017. Epub 2016 Feb 28.


Extracellular and Luminal pH Regulation by Vacuolar H+-ATPase Isoform Expression and Targeting to the Plasma Membrane and Endosomes.

Smith GA, Howell GJ, Phillips C, Muench SP, Ponnambalam S, Harrison MA.

J Biol Chem. 2016 Apr 15;291(16):8500-15. doi: 10.1074/jbc.M116.723395. Epub 2016 Feb 24.


In situ formation of magnetopolymersomes via electroporation for MRI.

Bain J, Ruiz-Pérez L, Kennerley AJ, Muench SP, Thompson R, Battaglia G, Staniland SS.

Sci Rep. 2015 Sep 22;5:14311. doi: 10.1038/srep14311.


Docking of competitive inhibitors to the P2X7 receptor family reveals key differences responsible for changes in response between rat and human.

Caseley EA, Muench SP, Baldwin SA, Simmons K, Fishwick CW, Jiang LH.

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3164-7. doi: 10.1016/j.bmcl.2015.06.001. Epub 2015 Jun 6.


Mechanism of inhibition of mouse Slo3 (KCa 5.1) potassium channels by quinine, quinidine and barium.

Wrighton DC, Muench SP, Lippiat JD.

Br J Pharmacol. 2015 Sep;172(17):4355-63. doi: 10.1111/bph.13214. Epub 2015 Jul 14.


Replace, reuse, recycle: improving the sustainable use of phosphorus by plants.

Baker A, Ceasar SA, Palmer AJ, Paterson JB, Qi W, Muench SP, Baldwin SA.

J Exp Bot. 2015 Jun;66(12):3523-40. doi: 10.1093/jxb/erv210. Epub 2015 May 4. Review.


Structure of the vacuolar H+-ATPase rotary motor reveals new mechanistic insights.

Rawson S, Phillips C, Huss M, Tiburcy F, Wieczorek H, Trinick J, Harrison MA, Muench SP.

Structure. 2015 Mar 3;23(3):461-471. doi: 10.1016/j.str.2014.12.016. Epub 2015 Feb 5.


The Acanthamoeba shikimate pathway has a unique molecular arrangement and is essential for aromatic amino acid biosynthesis.

Henriquez FL, Campbell SJ, Sundararaj BK, Cano A, Muench SP, Roberts CW.

Protist. 2015 Feb;166(1):93-105. doi: 10.1016/j.protis.2014.12.001. Epub 2014 Dec 11.


The use of SMALPs as a novel membrane protein scaffold for structure study by negative stain electron microscopy.

Postis V, Rawson S, Mitchell JK, Lee SC, Parslow RA, Dafforn TR, Baldwin SA, Muench SP.

Biochim Biophys Acta. 2015 Feb;1848(2):496-501. doi: 10.1016/j.bbamem.2014.10.018. Epub 2014 Oct 23.


Understanding the apparent stator-rotor connections in the rotary ATPase family using coarse-grained computer modeling.

Richardson RA, Papachristos K, Read DJ, Harlen OG, Harrison M, Paci E, Muench SP, Harris SA.

Proteins. 2014 Dec;82(12):3298-311. doi: 10.1002/prot.24680. Epub 2014 Nov 11.


Non-synonymous single nucleotide polymorphisms in the P2X receptor genes: association with diseases, impact on receptor functions and potential use as diagnosis biomarkers.

Caseley EA, Muench SP, Roger S, Mao HJ, Baldwin SA, Jiang LH.

Int J Mol Sci. 2014 Jul 30;15(8):13344-71. doi: 10.3390/ijms150813344. Review.


PA1b inhibitor binding to subunits c and e of the vacuolar ATPase reveals its insecticidal mechanism.

Muench SP, Rawson S, Eyraud V, Delmas AF, Da Silva P, Phillips C, Trinick J, Harrison MA, Gressent F, Huss M.

J Biol Chem. 2014 Jun 6;289(23):16399-408. doi: 10.1074/jbc.M113.541250. Epub 2014 May 2.


ALOX12 in human toxoplasmosis.

Witola WH, Liu SR, Montpetit A, Welti R, Hypolite M, Roth M, Zhou Y, Mui E, Cesbron-Delauw MF, Fournie GJ, Cavailles P, Bisanz C, Boyer K, Withers S, Noble AG, Swisher CN, Heydemann PT, Rabiah P, Muench SP, McLeod R.

Infect Immun. 2014 Jul;82(7):2670-9. doi: 10.1128/IAI.01505-13. Epub 2014 Mar 31.

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