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Items: 1 to 50 of 135

1.

Statin-induced metabolic reprogramming in head and neck cancer: a biomarker for targeting monocarboxylate transporters.

Mehibel M, Ortiz-Martinez F, Voelxen N, Boyers A, Chadwick A, Telfer BA, Mueller-Klieser W, West CM, Critchlow SE, Williams KJ, Stratford IJ.

Sci Rep. 2018 Nov 14;8(1):16804. doi: 10.1038/s41598-018-35103-1.

2.

LDHA in Neuroblastoma Is Associated with Poor Outcome and Its Depletion Decreases Neuroblastoma Growth Independent of Aerobic Glycolysis.

Dorneburg C, Fischer M, Barth TFE, Mueller-Klieser W, Hero B, Gecht J, Carter DR, de Preter K, Mayer B, Christner L, Speleman F, Marshall GM, Debatin KM, Beltinger C.

Clin Cancer Res. 2018 Nov 15;24(22):5772-5783. doi: 10.1158/1078-0432.CCR-17-2578. Epub 2018 Jun 20.

PMID:
29925504
3.

Comparative metabolic analysis in head and neck cancer and the normal gingiva.

Voelxen NF, Blatt S, Knopf P, Henkel M, Appelhans C, Righesso LAR, Pabst A, Goldschmitt J, Walenta S, Neff A, Mueller-Klieser W, Ziebart T.

Clin Oral Investig. 2018 Mar;22(2):1033-1043. doi: 10.1007/s00784-017-2185-0. Epub 2017 Jul 22.

PMID:
28735466
4.

Uncovering Metabolic Effects of Anti-angiogenic Therapy in Tumors by Induced Metabolic Bioluminescence Imaging.

Indraccolo S, Walenta S, Mueller-Klieser W.

Methods Mol Biol. 2016;1464:175-184.

PMID:
27858366
5.

Lactate as a predictive marker for tumor recurrence in patients with head and neck squamous cell carcinoma (HNSCC) post radiation: a prospective study over 15 years.

Blatt S, Voelxen N, Sagheb K, Pabst AM, Walenta S, Schroeder T, Mueller-Klieser W, Ziebart T.

Clin Oral Investig. 2016 Nov;20(8):2097-2104. Epub 2016 Jan 4.

PMID:
26728026
6.

LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells.

Brand A, Singer K, Koehl GE, Kolitzus M, Schoenhammer G, Thiel A, Matos C, Bruss C, Klobuch S, Peter K, Kastenberger M, Bogdan C, Schleicher U, Mackensen A, Ullrich E, Fichtner-Feigl S, Kesselring R, Mack M, Ritter U, Schmid M, Blank C, Dettmer K, Oefner PJ, Hoffmann P, Walenta S, Geissler EK, Pouyssegur J, Villunger A, Steven A, Seliger B, Schreml S, Haferkamp S, Kohl E, Karrer S, Berneburg M, Herr W, Mueller-Klieser W, Renner K, Kreutz M.

Cell Metab. 2016 Nov 8;24(5):657-671. doi: 10.1016/j.cmet.2016.08.011. Epub 2016 Sep 15.

7.

Lactate-An Integrative Mirror of Cancer Metabolism.

Walenta S, Voelxen NF, Mueller-Klieser W.

Recent Results Cancer Res. 2016;207:23-37. doi: 10.1007/978-3-319-42118-6_2. Review.

PMID:
27557533
8.

Feasibility of induced metabolic bioluminescence imaging in advanced ovarian cancer patients: first results of a pilot study.

Battista MJ, Goetze K, Schmidt M, Cotarelo C, Weyer-Elberich V, Hasenburg A, Mueller-Klieser W, Walenta S.

J Cancer Res Clin Oncol. 2016 Sep;142(9):1909-16. doi: 10.1007/s00432-016-2200-x. Epub 2016 Jun 24.

PMID:
27342420
9.

Quantitative Imaging of D-2-Hydroxyglutarate in Selected Histological Tissue Areas by a Novel Bioluminescence Technique.

Voelxen NF, Walenta S, Proescholdt M, Dettmer K, Pusch S, Mueller-Klieser W.

Front Oncol. 2016 Mar 7;6:46. doi: 10.3389/fonc.2016.00046. eCollection 2016.

10.
11.

Potential of Induced Metabolic Bioluminescence Imaging to Uncover Metabolic Effects of Antiangiogenic Therapy in Tumors.

Indraccolo S, Mueller-Klieser W.

Front Oncol. 2016 Feb 1;6:15. doi: 10.3389/fonc.2016.00015. eCollection 2016. Review.

12.

Hypoxia-Associated Marker CA IX Does Not Predict the Response of Locally Advanced Rectal Cancers to Neoadjuvant Chemoradiotherapy.

Mayer A, Vaupel P, Oberholzer K, Ebert M, Dimitrow M, Kreft A, Mueller-Klieser W, Schmidberger H.

Adv Exp Med Biol. 2016;876:195-200. doi: 10.1007/978-1-4939-3023-4_24.

PMID:
26782212
13.

Low density lipoprotein receptor-related protein 1 mediated endocytosis of β1-integrin influences cell adhesion and cell migration.

Rabiej VK, Pflanzner T, Wagner T, Goetze K, Storck SE, Eble JA, Weggen S, Mueller-Klieser W, Pietrzik CU.

Exp Cell Res. 2016 Jan 1;340(1):102-15. doi: 10.1016/j.yexcr.2015.11.020. Epub 2015 Nov 22.

PMID:
26610862
14.

Manipulation of tumor metabolism for therapeutic approaches: ovarian cancer-derived cell lines as a model system.

Goetze K, Fabian CG, Siebers A, Binz L, Faber D, Indraccolo S, Nardo G, Sattler UG, Mueller-Klieser W.

Cell Oncol (Dordr). 2015 Oct;38(5):377-85. doi: 10.1007/s13402-015-0237-5. Epub 2015 Aug 19.

PMID:
26288178
15.

VEGF-targeted therapy stably modulates the glycolytic phenotype of tumor cells.

Curtarello M, Zulato E, Nardo G, Valtorta S, Guzzo G, Rossi E, Esposito G, Msaki A, Pastò A, Rasola A, Persano L, Ciccarese F, Bertorelle R, Todde S, Plebani M, Schroer H, Walenta S, Mueller-Klieser W, Amadori A, Moresco RM, Indraccolo S.

Cancer Res. 2015 Jan 1;75(1):120-33. doi: 10.1158/0008-5472.CAN-13-2037. Epub 2014 Nov 7.

16.

Carbon ions and X‑rays induce pro‑inflammatory effects in 3D oral mucosa models with and without PBMCs.

Tschachojan V, Schroer H, Averbeck N, Mueller-Klieser W.

Oncol Rep. 2014 Nov;32(5):1820-8. doi: 10.3892/or.2014.3441. Epub 2014 Aug 22.

PMID:
25174410
17.

The Microenvironment of Cervical Carcinoma Xenografts: Associations with Lymph Node Metastasis and Its Assessment by DCE-MRI.

Ellingsen C, Walenta S, Hompland T, Mueller-Klieser W, Rofstad EK.

Transl Oncol. 2013 Oct 1;6(5):607-17. eCollection 2013.

18.

MYCN and survivin cooperatively contribute to malignant transformation of fibroblasts.

Hipp NI, Christner L, Wirth T, Mueller-Klieser W, Walenta S, Schröck E, Debatin KM, Beltinger C.

Carcinogenesis. 2014 Feb;35(2):479-88. doi: 10.1093/carcin/bgt341. Epub 2013 Oct 15.

PMID:
24130166
19.

Synthetic lethal metabolic targeting of cellular senescence in cancer therapy.

Dörr JR, Yu Y, Milanovic M, Beuster G, Zasada C, Däbritz JH, Lisec J, Lenze D, Gerhardt A, Schleicher K, Kratzat S, Purfürst B, Walenta S, Mueller-Klieser W, Gräler M, Hummel M, Keller U, Buck AK, Dörken B, Willmitzer L, Reimann M, Kempa S, Lee S, Schmitt CA.

Nature. 2013 Sep 19;501(7467):421-5. doi: 10.1038/nature12437. Epub 2013 Aug 14.

PMID:
23945590
20.

Glycolysis-related gene induction and ATP reduction during fractionated irradiation. Markers for radiation responsiveness of human tumor xenografts.

Goetze K, Meyer SS, Yaromina A, Zips D, Baumann M, Mueller-Klieser W.

Strahlenther Onkol. 2013 Sep;189(9):782-8. doi: 10.1007/s00066-013-0371-9. Epub 2013 Jul 6.

PMID:
23828461
21.

Impact of carbon ion irradiation on epidermal growth factor receptor signaling and glioma cell migration in comparison to conventional photon irradiation.

Stahler C, Roth J, Cordes N, Taucher-Scholz G, Mueller-Klieser W.

Int J Radiat Biol. 2013 Jun;89(6):454-61. doi: 10.3109/09553002.2013.766769. Epub 2013 Feb 21.

PMID:
23363301
22.

[Tumor pathophysiology].

Kunz-Schughart LA, Mueller-Klieser W, Vaupel P.

Strahlenther Onkol. 2012 Nov;188 Suppl 3:299-303. doi: 10.1007/s00066-012-0203-3. Review. German. No abstract available.

PMID:
23053151
23.

Three-dimensional invasion of human glioblastoma cells remains unchanged by X-ray and carbon ion irradiation in vitro.

Eke I, Storch K, Kästner I, Vehlow A, Faethe C, Mueller-Klieser W, Taucher-Scholz G, Temme A, Schackert G, Cordes N.

Int J Radiat Oncol Biol Phys. 2012 Nov 15;84(4):e515-23. doi: 10.1016/j.ijrobp.2012.06.012. Epub 2012 Aug 15.

PMID:
22901381
24.

Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo.

Yaromina A, Meyer S, Fabian C, Zaleska K, Sattler UG, Kunz-Schughart LA, Mueller-Klieser W, Zips D, Baumann M.

Strahlenther Onkol. 2012 May;188(5):431-7. doi: 10.1007/s00066-011-0054-3. Epub 2012 Feb 16.

PMID:
22349632
25.

Protein profiles in human ovarian cancer cell lines correspond to their metabolic activity and to metabolic profiles of respective tumor xenografts.

Fabian C, Koetz L, Favaro E, Indraccolo S, Mueller-Klieser W, Sattler UG.

FEBS J. 2012 Mar;279(5):882-91. doi: 10.1111/j.1742-4658.2012.08479.x. Epub 2012 Feb 6.

26.

Lactate: a metabolic key player in cancer.

Hirschhaeuser F, Sattler UG, Mueller-Klieser W.

Cancer Res. 2011 Nov 15;71(22):6921-5. doi: 10.1158/0008-5472.CAN-11-1457. Review.

27.

Semiautomatic growth analysis of multicellular tumor spheroids.

Rodday B, Hirschhaeuser F, Walenta S, Mueller-Klieser W.

J Biomol Screen. 2011 Oct;16(9):1119-24. doi: 10.1177/1087057111419501. Epub 2011 Sep 9.

PMID:
21908797
28.

Differential utilization of ketone bodies by neurons and glioma cell lines: a rationale for ketogenic diet as experimental glioma therapy.

Maurer GD, Brucker DP, Bähr O, Harter PN, Hattingen E, Walenta S, Mueller-Klieser W, Steinbach JP, Rieger J.

BMC Cancer. 2011 Jul 26;11:315. doi: 10.1186/1471-2407-11-315.

29.

Inhibition of tumor lactate oxidation: consequences for the tumor microenvironment.

Busk M, Walenta S, Mueller-Klieser W, Steiniche T, Jakobsen S, Horsman MR, Overgaard J.

Radiother Oncol. 2011 Jun;99(3):404-11. doi: 10.1016/j.radonc.2011.05.053. Epub 2011 Jun 23.

PMID:
21704401
30.

Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release.

Goetze K, Walenta S, Ksiazkiewicz M, Kunz-Schughart LA, Mueller-Klieser W.

Int J Oncol. 2011 Aug;39(2):453-63. doi: 10.3892/ijo.2011.1055. Epub 2011 May 25.

PMID:
21617859
31.

Glycolytic phenotype and AMP kinase modify the pathologic response of tumor xenografts to VEGF neutralization.

Nardo G, Favaro E, Curtarello M, Moserle L, Zulato E, Persano L, Rossi E, Esposito G, Crescenzi M, Casanovas O, Sattler U, Mueller-Klieser W, Biesalski B, Thews O, Canese R, Iorio E, Zanovello P, Amadori A, Indraccolo S.

Cancer Res. 2011 Jun 15;71(12):4214-25. doi: 10.1158/0008-5472.CAN-11-0242. Epub 2011 May 5.

32.

[Metabolic micromilieu in tumours].

Mueller-Klieser W.

Nuklearmedizin. 2010;49 Suppl 1:S16-20. German.

PMID:
21152692
33.

Efficacy of catumaxomab in tumor spheroid killing is mediated by its trifunctional mode of action.

Hirschhaeuser F, Walenta S, Mueller-Klieser W.

Cancer Immunol Immunother. 2010 Nov;59(11):1675-84. doi: 10.1007/s00262-010-0894-1. Epub 2010 Jul 21.

PMID:
20652245
34.

Tumor cell migration is not influenced by p21 in colon carcinoma cell lines after irradiation with X-ray or (12)C heavy ions.

Goetze K, Scholz M, Taucher-Scholz G, Mueller-Klieser W.

Radiat Environ Biophys. 2010 Aug;49(3):427-35. doi: 10.1007/s00411-010-0297-x. Epub 2010 Jun 10.

PMID:
20535615
35.

Metabolic and proteomic differentials in head and neck squamous cell carcinomas and normal gingival tissue.

Ziebart T, Walenta S, Kunkel M, Reichert TE, Wagner W, Mueller-Klieser W.

J Cancer Res Clin Oncol. 2011 Feb;137(2):193-9. doi: 10.1007/s00432-010-0875-y. Epub 2010 Apr 11.

PMID:
20383719
36.

Multicellular tumor spheroids: an underestimated tool is catching up again.

Hirschhaeuser F, Menne H, Dittfeld C, West J, Mueller-Klieser W, Kunz-Schughart LA.

J Biotechnol. 2010 Jul 1;148(1):3-15. doi: 10.1016/j.jbiotec.2010.01.012. Epub 2010 Jan 25. Review.

PMID:
20097238
37.

Glycolytic metabolism and tumour response to fractionated irradiation.

Sattler UG, Meyer SS, Quennet V, Hoerner C, Knoerzer H, Fabian C, Yaromina A, Zips D, Walenta S, Baumann M, Mueller-Klieser W.

Radiother Oncol. 2010 Jan;94(1):102-9. doi: 10.1016/j.radonc.2009.11.007. Epub 2009 Dec 28.

PMID:
20036432
38.

Manipulation of glycolysis in malignant tumors: fantasy or therapy?

Sattler UG, Hirschhaeuser F, Mueller-Klieser WF.

Curr Med Chem. 2010;17(2):96-108. Review.

PMID:
19941476
39.

Impact of exogenous lactate on survival and radioresponse of carcinoma cells in vitro.

Grotius J, Dittfeld C, Huether M, Mueller-Klieser W, Baumann M, Kunz-Schughart LA.

Int J Radiat Biol. 2009 Nov;85(11):989-1001. doi: 10.3109/09553000903242156.

PMID:
19895276
40.

Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts.

Yaromina A, Quennet V, Zips D, Meyer S, Shakirin G, Walenta S, Mueller-Klieser W, Baumann M.

Int J Radiat Biol. 2009 Nov;85(11):972-80. doi: 10.3109/09553000903232868.

PMID:
19895274
41.

The anti-oxidant capacity of tumour glycolysis.

Sattler UG, Mueller-Klieser W.

Int J Radiat Biol. 2009 Nov;85(11):963-71. doi: 10.3109/09553000903258889. Review.

PMID:
19895273
42.

Test system for trifunctional antibodies in 3D MCTS culture.

Hirschhaeuser F, Leidig T, Rodday B, Lindemann C, Mueller-Klieser W.

J Biomol Screen. 2009 Sep;14(8):980-90. doi: 10.1177/1087057109341766. Epub 2009 Aug 12.

PMID:
19675312
43.

Hypoxia inducible factor-1alpha inactivation unveils a link between tumor cell metabolism and hypoxia-induced cell death.

Favaro E, Nardo G, Persano L, Masiero M, Moserle L, Zamarchi R, Rossi E, Esposito G, Plebani M, Sattler U, Mann T, Mueller-Klieser W, Ciminale V, Amadori A, Indraccolo S.

Am J Pathol. 2008 Oct;173(4):1186-201. doi: 10.2353/ajpath.2008.071183. Epub 2008 Sep 4.

44.

The impact of conventional and heavy ion irradiation on tumor cell migration in vitro.

Goetze K, Scholz M, Taucher-Scholz G, Mueller-Klieser W.

Int J Radiat Biol. 2007 Nov-Dec;83(11-12):889-96.

PMID:
18058372
45.

Lactate adversely affects the in vitro formation of endothelial cell tubular structures through the action of TGF-beta1.

Schmid SA, Gaumann A, Wondrak M, Eckermann C, Schulte S, Mueller-Klieser W, Wheatley DN, Kunz-Schughart LA.

Exp Cell Res. 2007 Jul 15;313(12):2531-49. Epub 2007 May 18.

PMID:
17574548
46.

Radiobiological characterization of human tumor cell multilayers after conventional and particle irradiation.

Topsch J, Scholz M, Mueller-Klieser W.

Radiat Res. 2007 Jun;167(6):645-54.

PMID:
17523847
47.

[Lactate and redox status in malignant tumors].

Sattler UG, Walenta S, Mueller-Klieser W.

Anaesthesist. 2007 May;56(5):466-9. Review. German.

PMID:
17464488
48.

A bioluminescence technique for quantitative and structure-associated imaging of pyruvate.

Sattler UG, Walenta S, Mueller-Klieser W.

Lab Invest. 2007 Jan;87(1):84-92. Epub 2006 Nov 27.

49.

Tumor lactate content predicts for response to fractionated irradiation of human squamous cell carcinomas in nude mice.

Quennet V, Yaromina A, Zips D, Rosner A, Walenta S, Baumann M, Mueller-Klieser W.

Radiother Oncol. 2006 Nov;81(2):130-5. Epub 2006 Sep 14.

PMID:
16973228
50.

Pimonidazole labelling and response to fractionated irradiation of five human squamous cell carcinoma (hSCC) lines in nude mice: the need for a multivariate approach in biomarker studies.

Yaromina A, Zips D, Thames HD, Eicheler W, Krause M, Rosner A, Haase M, Petersen C, Raleigh JA, Quennet V, Walenta S, Mueller-Klieser W, Baumann M.

Radiother Oncol. 2006 Nov;81(2):122-9. Epub 2006 Sep 7.

PMID:
16956683

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