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Items: 45


T cell toxicity of HIV latency reversing agents.

Zhao M, De Crignis E, Rokx C, Verbon A, van Gelder T, Mahmoudi T, Katsikis PD, Mueller YM.

Pharmacol Res. 2019 Jan;139:524-534. doi: 10.1016/j.phrs.2018.10.023. Epub 2018 Oct 23.


Transcriptome Analysis of Infected and Bystander Type 2 Alveolar Epithelial Cells during Influenza A Virus Infection Reveals In Vivo Wnt Pathway Downregulation.

Hancock AS, Stairiker CJ, Boesteanu AC, Monzón-Casanova E, Lukasiak S, Mueller YM, Stubbs AP, García-Sastre A, Turner M, Katsikis PD.

J Virol. 2018 Oct 12;92(21). pii: e01325-18. doi: 10.1128/JVI.01325-18. Print 2018 Nov 1.


Exhaustion of the CD8+ T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta.

Wentink MWJ, Mueller YM, Dalm VASH, Driessen GJ, van Hagen PM, van Montfrans JM, van der Burg M, Katsikis PD.

Front Immunol. 2018 Mar 7;9:446. doi: 10.3389/fimmu.2018.00446. eCollection 2018.


Allele-specific long-distance regulation dictates IL-32 isoform switching and mediates susceptibility to HIV-1.

Palstra RJ, de Crignis E, Röling MD, van Staveren T, Kan TW, van Ijcken W, Mueller YM, Katsikis PD, Mahmoudi T.

Sci Adv. 2018 Feb 21;4(2):e1701729. doi: 10.1126/sciadv.1701729. eCollection 2018 Feb.


The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+ T Cells via SHIP-1.

Hope JL, Stairiker CJ, Spantidea PI, Gracias DT, Carey AJ, Fike AJ, van Meurs M, Brouwers-Haspels I, Rijsbergen LC, Fraietta JA, Mueller YM, Klop RC, Stelekati E, Wherry EJ, Erkeland SJ, Katsikis PD.

Front Immunol. 2017 Dec 6;8:1696. doi: 10.3389/fimmu.2017.01696. eCollection 2017.


Public Clonotypes and Convergent Recombination Characterize the Naïve CD8+ T-Cell Receptor Repertoire of Extremely Preterm Neonates.

Carey AJ, Hope JL, Mueller YM, Fike AJ, Kumova OK, van Zessen DBH, Steegers EAP, van der Burg M, Katsikis PD.

Front Immunol. 2017 Dec 19;8:1859. doi: 10.3389/fimmu.2017.01859. eCollection 2017.


Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice.

Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB, Katsikis PD.

J Immunol. 2016 Mar 15;196(6):2602-13. doi: 10.4049/jimmunol.1502126. Epub 2016 Feb 12.


Phosphatidylinositol 3-Kinase p110δ Isoform Regulates CD8+ T Cell Responses during Acute Viral and Intracellular Bacterial Infections.

Gracias DT, Boesteanu AC, Fraietta JA, Hope JL, Carey AJ, Mueller YM, Kawalekar OU, Fike AJ, June CH, Katsikis PD.

J Immunol. 2016 Feb 1;196(3):1186-98. doi: 10.4049/jimmunol.1501890. Epub 2016 Jan 6.


Acute exposure to ZnO nanoparticles induces autophagic immune cell death.

Johnson BM, Fraietta JA, Gracias DT, Hope JL, Stairiker CJ, Patel PR, Mueller YM, McHugh MD, Jablonowski LJ, Wheatley MA, Katsikis PD.

Nanotoxicology. 2015;9(6):737-48. doi: 10.3109/17435390.2014.974709. Epub 2014 Nov 7.


Abasic phosphorothioate oligomers inhibit HIV-1 reverse transcription and block virus transmission across polarized ectocervical organ cultures.

Fraietta JA, Mueller YM, Lozenski KL, Ratner D, Boesteanu AC, Hancock AS, Lackman-Smith C, Zentner IJ, Chaiken IM, Chung S, LeGrice SF, Snyder BA, Mankowski MK, Jones NM, Hope JL, Gupta P, Anderson SH, Wigdahl B, Katsikis PD.

Antimicrob Agents Chemother. 2014 Dec;58(12):7056-71. doi: 10.1128/AAC.02991-14. Epub 2014 Sep 15.


Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection.

Fraietta JA, Mueller YM, Yang G, Boesteanu AC, Gracias DT, Do DH, Hope JL, Kathuria N, McGettigan SE, Lewis MG, Giavedoni LD, Jacobson JM, Katsikis PD.

PLoS Pathog. 2013;9(10):e1003658. doi: 10.1371/journal.ppat.1003658. Epub 2013 Oct 10.


The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.

Gracias DT, Stelekati E, Hope JL, Boesteanu AC, Doering TA, Norton J, Mueller YM, Fraietta JA, Wherry EJ, Turner M, Katsikis PD.

Nat Immunol. 2013 Jun;14(6):593-602. doi: 10.1038/ni.2576. Epub 2013 Apr 21.


The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?

Katsikis PD, Mueller YM, Villinger F.

PLoS Pathog. 2011 Aug;7(8):e1002055. doi: 10.1371/journal.ppat.1002055. Epub 2011 Aug 11. Review.


IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques.

Lugli E, Mueller YM, Lewis MG, Villinger F, Katsikis PD, Roederer M.

Blood. 2011 Sep 1;118(9):2520-9. doi: 10.1182/blood-2011-05-351155. Epub 2011 Jul 14.


Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo.

Dolfi DV, Duttagupta PA, Boesteanu AC, Mueller YM, Oliai CH, Borowski AB, Katsikis PD.

J Immunol. 2011 Apr 15;186(8):4599-608. doi: 10.4049/jimmunol.1001972. Epub 2011 Mar 9.


IL-15 in HIV infection: pathogenic or therapeutic potential?

Mueller YM, Katsikis PD.

Eur Cytokine Netw. 2010 Sep;21(3):219-21. doi: 10.1684/ecn.2010.0198. Epub 2010 Aug 19.


Phosphorothioate 2' deoxyribose oligomers as microbicides that inhibit human immunodeficiency virus type 1 (HIV-1) infection and block Toll-like receptor 7 (TLR7) and TLR9 triggering by HIV-1.

Fraietta JA, Mueller YM, Do DH, Holmes VM, Howett MK, Lewis MG, Boesteanu AC, Alkan SS, Katsikis PD.

Antimicrob Agents Chemother. 2010 Oct;54(10):4064-73. doi: 10.1128/AAC.00367-10. Epub 2010 Jul 12.


CD8+ cell depletion of SHIV89.6P-infected macaques induces CD4+ T cell proliferation that contributes to increased viral loads.

Mueller YM, Do DH, Boyer JD, Kader M, Mattapallil JJ, Lewis MG, Weiner DB, Katsikis PD.

J Immunol. 2009 Oct 15;183(8):5006-12. doi: 10.4049/jimmunol.0900141. Epub 2009 Sep 28.


Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection.

Petrovas C, Chaon B, Ambrozak DR, Price DA, Melenhorst JJ, Hill BJ, Geldmacher C, Casazza JP, Chattopadhyay PK, Roederer M, Douek DC, Mueller YM, Jacobson JM, Kulkarni V, Felber BK, Pavlakis GN, Katsikis PD, Koup RA.

J Immunol. 2009 Jul 15;183(2):1120-32. doi: 10.4049/jimmunol.0900182. Epub 2009 Jun 29.


Chronic antigen stimulation alone is sufficient to drive CD8+ T cell exhaustion.

Bucks CM, Norton JA, Boesteanu AC, Mueller YM, Katsikis PD.

J Immunol. 2009 Jun 1;182(11):6697-708. doi: 10.4049/jimmunol.0800997.


Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection.

Eberly MD, Kader M, Hassan W, Rogers KA, Zhou J, Mueller YM, Mattapallil MJ, Piatak M Jr, Lifson JD, Katsikis PD, Roederer M, Villinger F, Mattapallil JJ.

J Immunol. 2009 Feb 1;182(3):1439-48.


Early divergence in neutrophil apoptosis between pathogenic and nonpathogenic simian immunodeficiency virus infections of nonhuman primates.

Elbim C, Monceaux V, Mueller YM, Lewis MG, François S, Diop O, Akarid K, Hurtrel B, Gougerot-Pocidalo MA, Lévy Y, Katsikis PD, Estaquier J.

J Immunol. 2008 Dec 15;181(12):8613-23.


IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses.

Mueller YM, Do DH, Altork SR, Artlett CM, Gracely EJ, Katsetos CD, Legido A, Villinger F, Altman JD, Brown CR, Lewis MG, Katsikis PD.

J Immunol. 2008 Jan 1;180(1):350-60.


Memory CD8+ T cells require CD28 costimulation.

Borowski AB, Boesteanu AC, Mueller YM, Carafides C, Topham DJ, Altman JD, Jennings SR, Katsikis PD.

J Immunol. 2007 Nov 15;179(10):6494-503.


Actin integrity is indispensable for CD95/Fas-induced apoptosis of HIV-specific CD8+ T cells.

Petrovas C, Mueller YM, Yang G, Altork SR, Jacobson JM, Pitsakis PG, Mounzer KC, Altman JD, Katsikis PD.

Apoptosis. 2007 Dec;12(12):2175-86.


Early establishment and antigen dependence of simian immunodeficiency virus-specific CD8+ T-cell defects.

Mueller YM, Petrovas C, Do DH, Altork SR, Fischer-Smith T, Rappaport J, Altman JD, Lewis MG, Katsikis PD.

J Virol. 2007 Oct;81(20):10861-8. Epub 2007 Aug 1.


Increased mitochondrial mass characterizes the survival defect of HIV-specific CD8(+) T cells.

Petrovas C, Mueller YM, Dimitriou ID, Altork SR, Banerjee A, Sklar P, Mounzer KC, Altman JD, Katsikis PD.

Blood. 2007 Mar 15;109(6):2505-13. Epub 2006 Nov 9.


Apoptosis of HIV-specific CD8+ T cells: an HIV evasion strategy.

Petrovas C, Mueller YM, Katsikis PD.

Cell Death Differ. 2005 Aug;12 Suppl 1:859-70. Review. No abstract available.


Interleukin-15 increases effector memory CD8+ t cells and NK Cells in simian immunodeficiency virus-infected macaques.

Mueller YM, Petrovas C, Bojczuk PM, Dimitriou ID, Beer B, Silvera P, Villinger F, Cairns JS, Gracely EJ, Lewis MG, Katsikis PD.

J Virol. 2005 Apr;79(8):4877-85.


Complement C5a receptor is essential for the optimal generation of antiviral CD8+ T cell responses.

Kim AH, Dimitriou ID, Holland MC, Mastellos D, Mueller YM, Altman JD, Lambris JD, Katsikis PD.

J Immunol. 2004 Aug 15;173(4):2524-9.


HIV-specific CD8+ T cells: serial killers condemned to die?

Petrovas C, Mueller YM, Katsikis PD.

Curr HIV Res. 2004 Apr;2(2):153-62. Review.


A delay in bone marrow transplantation after partial conditioning improves engraftment.

Xu H, Exner BG, Chilton PM, Tanner MK, Mueller YM, Rezzoug F, Ildstad ST.

Transplantation. 2004 Mar 27;77(6):819-26.


HIV-specific CD8+ T cells exhibit markedly reduced levels of Bcl-2 and Bcl-xL.

Petrovas C, Mueller YM, Dimitriou ID, Bojczuk PM, Mounzer KC, Witek J, Altman JD, Katsikis PD.

J Immunol. 2004 Apr 1;172(7):4444-53.


Decreased effector memory CD45RA+ CD62L- CD8+ T cells and increased central memory CD45RA- CD62L+ CD8+ T cells in peripheral blood of rheumatoid arthritis patients.

Maldonado A, Mueller YM, Thomas P, Bojczuk P, O'Connors C, Katsikis PD.

Arthritis Res Ther. 2003;5(2):R91-6. Epub 2003 Jan 6.


IL-15 enhances the function and inhibits CD95/Fas-induced apoptosis of human CD4+ and CD8+ effector-memory T cells.

Mueller YM, Makar V, Bojczuk PM, Witek J, Katsikis PD.

Int Immunol. 2003 Jan;15(1):49-58.


IL-15 enhances survival and function of HIV-specific CD8+ T cells.

Mueller YM, Bojczuk PM, Halstead ES, Kim AH, Witek J, Altman JD, Katsikis PD.

Blood. 2003 Feb 1;101(3):1024-9. Epub 2002 Sep 19.


In vivo stimulation of CD137 broadens primary antiviral CD8+ T cell responses.

Halstead ES, Mueller YM, Altman JD, Katsikis PD.

Nat Immunol. 2002 Jun;3(6):536-41. Epub 2002 May 20.


Hematopoietic stem cells from the marrow of mice treated with Flt3 ligand are significantly expanded but exhibit reduced engraftment potential.

Mueller YM, Cramer DE, Huang Y, Exner BG, Ildstad ST.

Transplantation. 2002 Apr 27;73(8):1177-85.


Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells.

Mueller YM, De Rosa SC, Hutton JA, Witek J, Roederer M, Altman JD, Katsikis PD.

Immunity. 2001 Dec;15(6):871-82.


Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells.

Cocca BA, Seal SN, D'Agnillo P, Mueller YM, Katsikis PD, Rauch J, Weigert M, Radic MZ.

Proc Natl Acad Sci U S A. 2001 Nov 20;98(24):13826-31.


Xenotransplantation: application of disease resistance.

Mueller YM, Davenport C, Ildstad ST.

Clin Exp Pharmacol Physiol. 1999 Dec;26(12):1009-12. Review.


Alpha beta TCR+ T cells play a nonredundant role in the rejection of heart allografts in mice.

Exner BG, Que X, Mueller YM, Domenick MA, Neipp M, Ildstad ST.

Surgery. 1999 Aug;126(2):121-6.


Clinical applications of mixed chimerism.

Exner BG, Domenick MA, Bergheim M, Mueller YM, Ildstad ST.

Ann N Y Acad Sci. 1999 Apr 30;872:377-85; discussion 385-6. Review.


Mixed allogeneic chimerism to induce tolerance to solid organ and cellular grafts.

Exner BG, Acholonu IN, Bergheim M, Mueller YM, Ildstad ST.

Acta Haematol. 1999;101(2):78-81. Review.


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