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Patient Characteristics and General Practitioners' Advice to Stop Statins in Oldest-Old Patients: a Survey Study Across 30 Countries.

van der Ploeg MA, Streit S, Achterberg WP, Beers E, Bohnen AM, Burman RA, Collins C, Franco FG, Gerasimovska-Kitanovska B, Gintere S, Gomez Bravo R, Hoffmann K, Iftode C, Peštić SK, Koskela TH, Kurpas D, Maisonneuve H, Mallen CD, Merlo C, Mueller Y, Muth C, Petrazzuoli F, Rodondi N, Rosemann T, Sattler M, Schermer T, Šter MP, Švadlenková Z, Tatsioni A, Thulesius H, Tkachenko V, Torzsa P, Tsopra R, Tuz C, Vaes B, Viegas RPA, Vinker S, Wallis KA, Zeller A, Gussekloo J, Poortvliet RKE.

J Gen Intern Med. 2019 Jan 16. doi: 10.1007/s11606-018-4795-x. [Epub ahead of print]


GalNAc Conjugation Attenuates the Cytotoxicity of Antisense Oligonucleotide Drugs in Renal Tubular Cells.

Sewing S, Gubler M, Gérard R, Avignon B, Mueller Y, Braendli-Baiocco A, Odin M, Moisan A.

Mol Ther Nucleic Acids. 2018 Nov 20;14:67-79. doi: 10.1016/j.omtn.2018.11.005. [Epub ahead of print]


Early diagnosis and management of dementia in general practice - how do Swiss GPs meet the challenge?

Giezendanner S, Monsch AU, Kressig RW, Mueller Y, Streit S, Essig S, Zeller A, Bally K.

Swiss Med Wkly. 2018 Dec 21;148:w14695. doi: 10.4414/smw.2018.14695. eCollection 2018 Dec 17.


What is the profile of older drivers considered medically unfit to drive? A cross-sectional survey in Western Switzerland.

Sebo P, Vaucher P, Haller D, Huber P, Mueller Y, Favrat B.

Swiss Med Wkly. 2018 Nov 18;148:w14684. doi: 10.4414/smw.2018.14684. eCollection 2018 Nov 5.


T cell toxicity of HIV latency reversing agents.

Zhao M, De Crignis E, Rokx C, Verbon A, van Gelder T, Mahmoudi T, Katsikis PD, Mueller YM.

Pharmacol Res. 2019 Jan;139:524-534. doi: 10.1016/j.phrs.2018.10.023. Epub 2018 Oct 23.


Diagnosis and treatment of community-acquired pneumonia in patients with acute cough: a quantitative study of decision thresholds in primary care.

Ebell MH, Locatelli I, Mueller Y, Senn N, Morgan K.

Br J Gen Pract. 2018 Nov;68(676):e765-e774. doi: 10.3399/bjgp18X699545.


Antimicrobial treatment practices among Ugandan children with suspicion of central nervous system infection.

Kemigisha E, Nanjebe D, Boum Y 2nd, Langendorf C, Aberrane S, Nyehangane D, Nackers F, Mueller Y, Charrel R, Murphy RA, Page AL, Mwanga-Amumpaire J.

PLoS One. 2018 Oct 9;13(10):e0205316. doi: 10.1371/journal.pone.0205316. eCollection 2018.


Transcriptome Analysis of Infected and Bystander Type 2 Alveolar Epithelial Cells during Influenza A Virus Infection Reveals In Vivo Wnt Pathway Downregulation.

Hancock AS, Stairiker CJ, Boesteanu AC, Monzón-Casanova E, Lukasiak S, Mueller YM, Stubbs AP, García-Sastre A, Turner M, Katsikis PD.

J Virol. 2018 Oct 12;92(21). pii: e01325-18. doi: 10.1128/JVI.01325-18. Print 2018 Nov 1.


Adherence to guidelines when evaluating fitness-to-drive in the elderly: a practice review of Swiss physicians.

Sebo P, Haller DM, Favrat B, Huber P, Mueller Y, Vaucher P.

Swiss Med Wkly. 2018 Jul 9;148:w14632. doi: 10.4414/smw.2018.14632. eCollection 2018. Review.


Swiss students and young physicians want a flexible goal-oriented GP training curriculum.

Rozsnyai Z, Tal K, Bachofner M, Maisonneuve H, Moser-Bucher C, Mueller Y, Scherz N, Martin S, Streit S.

Scand J Prim Health Care. 2018 Sep;36(3):249-261. doi: 10.1080/02813432.2018.1487582. Epub 2018 Jun 26.


Surveillance en médecine de famille.

Mueller Y, Dvorak C, Gilgien W, Junod M, Perdrix J.

Rev Med Suisse. 2018 May 23;14(608):1103-1104. French. No abstract available.


[Knee osteoarthritis : assessment and follow-up in family medicine].

Rapin N, Hügle T, Mueller Y.

Rev Med Suisse. 2018 May 9;14(606):993-997. French.


[« It's normal to get old and weak » : should functional decline be addressed with elderly patients in family medicine ?]

Viret O, Schwarz J, Senn N, Mueller Y.

Rev Med Suisse. 2018 May 9;14(606):971-975. French.


Exhaustion of the CD8+ T Cell Compartment in Patients with Mutations in Phosphoinositide 3-Kinase Delta.

Wentink MWJ, Mueller YM, Dalm VASH, Driessen GJ, van Hagen PM, van Montfrans JM, van der Burg M, Katsikis PD.

Front Immunol. 2018 Mar 7;9:446. doi: 10.3389/fimmu.2018.00446. eCollection 2018.


Performance of a brief geriatric evaluation compared to a comprehensive geriatric assessment for detection of geriatric syndromes in family medicine: a prospective diagnostic study.

Mueller YK, Monod S, Locatelli I, Büla C, Cornuz J, Senn N.

BMC Geriatr. 2018 Mar 13;18(1):72. doi: 10.1186/s12877-018-0761-z.


Allele-specific long-distance regulation dictates IL-32 isoform switching and mediates susceptibility to HIV-1.

Palstra RJ, de Crignis E, Röling MD, van Staveren T, Kan TW, van Ijcken W, Mueller YM, Katsikis PD, Mahmoudi T.

Sci Adv. 2018 Feb 21;4(2):e1701729. doi: 10.1126/sciadv.1701729. eCollection 2018 Feb.


Burden of cardiovascular disease across 29 countries and GPs' decision to treat hypertension in oldest-old.

Streit S, Gussekloo J, Burman RA, Collins C, Kitanovska BG, Gintere S, Gómez Bravo R, Hoffmann K, Iftode C, Johansen KL, Kerse N, Koskela TH, Peštić SK, Kurpas D, Mallen CD, Maisonneuve H, Merlo C, Mueller Y, Muth C, Ornelas RH, Šter MP, Petrazzuoli F, Rosemann T, Sattler M, Švadlenková Z, Tatsioni A, Thulesius H, Tkachenko V, Torzsa P, Tsopra R, Tuz C, Verschoor M, Viegas RPA, Vinker S, de Waal MWM, Zeller A, Rodondi N, Poortvliet RKE.

Scand J Prim Health Care. 2018 Mar;36(1):89-98. doi: 10.1080/02813432.2018.1426142. Epub 2018 Jan 25.


The Transcription Factor T-Bet Is Regulated by MicroRNA-155 in Murine Anti-Viral CD8+ T Cells via SHIP-1.

Hope JL, Stairiker CJ, Spantidea PI, Gracias DT, Carey AJ, Fike AJ, van Meurs M, Brouwers-Haspels I, Rijsbergen LC, Fraietta JA, Mueller YM, Klop RC, Stelekati E, Wherry EJ, Erkeland SJ, Katsikis PD.

Front Immunol. 2017 Dec 6;8:1696. doi: 10.3389/fimmu.2017.01696. eCollection 2017.


Public Clonotypes and Convergent Recombination Characterize the Naïve CD8+ T-Cell Receptor Repertoire of Extremely Preterm Neonates.

Carey AJ, Hope JL, Mueller YM, Fike AJ, Kumova OK, van Zessen DBH, Steegers EAP, van der Burg M, Katsikis PD.

Front Immunol. 2017 Dec 19;8:1859. doi: 10.3389/fimmu.2017.01859. eCollection 2017.


Adherence, tolerability, and outcome after 36 months of isoniazid-preventive therapy in 2 rural clinics of Swaziland: A prospective observational feasibility study.

Mueller Y, Mpala Q, Kerschberger B, Rusch B, Mchunu G, Mazibuko S, Bonnet M.

Medicine (Baltimore). 2017 Sep;96(35):e7740. doi: 10.1097/MD.0000000000007740.


[Recommendations for the vaccination of pregnant women : a booster injection].

Mueller Y, Eberhardt CS, Diana A, Martinez De Tejada B.

Rev Med Suisse. 2016 Oct 12;12(534):1708-1712. French.


Variation in GP decisions on antihypertensive treatment in oldest-old and frail individuals across 29 countries.

Streit S, Verschoor M, Rodondi N, Bonfim D, Burman RA, Collins C, Biljana GK, Gintere S, Gómez Bravo R, Hoffmann K, Iftode C, Johansen KL, Kerse N, Koskela TH, Peštić SK, Kurpas D, Mallen CD, Maisoneuve H, Merlo C, Mueller Y, Muth C, Šter MP, Petrazzuoli F, Rosemann T, Sattler M, Švadlenková Z, Tatsioni A, Thulesius H, Tkachenko V, Torzsa P, Tsopra R, Canan T, Viegas RPA, Vinker S, de Waal MWM, Zeller A, Gussekloo J, Poortvliet RKE.

BMC Geriatr. 2017 Apr 20;17(1):93. doi: 10.1186/s12877-017-0486-4.


Differential Diagnosis of Skin Ulcers in a Mycobacterium ulcerans Endemic Area: Data from a Prospective Study in Cameroon.

Toutous Trellu L, Nkemenang P, Comte E, Ehounou G, Atangana P, Mboua DJ, Rusch B, Njih Tabah E, Etard JF, Mueller YK.

PLoS Negl Trop Dis. 2016 Apr 13;10(4):e0004385. doi: 10.1371/journal.pntd.0004385. eCollection 2016 Apr.


The "Buruli Score": Development of a Multivariable Prediction Model for Diagnosis of Mycobacterium ulcerans Infection in Individuals with Ulcerative Skin Lesions, Akonolinga, Cameroon.

Mueller YK, Bastard M, Nkemenang P, Comte E, Ehounou G, Eyangoh S, Rusch B, Tabah EN, Trellu LT, Etard JF.

PLoS Negl Trop Dis. 2016 Apr 5;10(4):e0004593. doi: 10.1371/journal.pntd.0004593. eCollection 2016 Apr.


Implementation and Operational Research: Feasibility of Using Tuberculin Skin Test Screening for Initiation of 36-Month Isoniazid Preventive Therapy in HIV-Infected Patients in Resource-Constrained Settings.

Huerga H, Mueller Y, Ferlazzo G, Mpala Q, Bevilacqua P, Vasquez B, Noël Mekiedje C, Ouattara A, Mchunu G, Weyenga HO, Varaine F, Bonnet M.

J Acquir Immune Defic Syndr. 2016 Apr 1;71(4):e89-95. doi: 10.1097/QAI.0000000000000895.


Rapid Evolution of the CD8+ TCR Repertoire in Neonatal Mice.

Carey AJ, Gracias DT, Thayer JL, Boesteanu AC, Kumova OK, Mueller YM, Hope JL, Fraietta JA, van Zessen DB, Katsikis PD.

J Immunol. 2016 Mar 15;196(6):2602-13. doi: 10.4049/jimmunol.1502126. Epub 2016 Feb 12.


Phosphatidylinositol 3-Kinase p110δ Isoform Regulates CD8+ T Cell Responses during Acute Viral and Intracellular Bacterial Infections.

Gracias DT, Boesteanu AC, Fraietta JA, Hope JL, Carey AJ, Mueller YM, Kawalekar OU, Fike AJ, June CH, Katsikis PD.

J Immunol. 2016 Feb 1;196(3):1186-98. doi: 10.4049/jimmunol.1501890. Epub 2016 Jan 6.


Determinants of Visceral Leishmaniasis: A Case-Control Study in Gedaref State, Sudan.

Nackers F, Mueller YK, Salih N, Elhag MS, Elbadawi ME, Hammam O, Mumina A, Atia AA, Etard JF, Ritmeijer K, Chappuis F.

PLoS Negl Trop Dis. 2015 Nov 6;9(11):e0004187. doi: 10.1371/journal.pntd.0004187. eCollection 2015 Nov.


Low resistance to first and second line anti-tuberculosis drugs among treatment naive pulmonary tuberculosis patients in southwestern Uganda.

Orikiriza P, Tibenderana B, Siedner MJ, Mueller Y, Byarugaba F, Moore CC, Evans EE, Bonnet M, Page AL, Bazira J, Boum Y 2nd.

PLoS One. 2015 Feb 6;10(2):e0118191. doi: 10.1371/journal.pone.0118191. eCollection 2015.


Acute exposure to ZnO nanoparticles induces autophagic immune cell death.

Johnson BM, Fraietta JA, Gracias DT, Hope JL, Stairiker CJ, Patel PR, Mueller YM, McHugh MD, Jablonowski LJ, Wheatley MA, Katsikis PD.

Nanotoxicology. 2015;9(6):737-48. doi: 10.3109/17435390.2014.974709. Epub 2014 Nov 7.


Abasic phosphorothioate oligomers inhibit HIV-1 reverse transcription and block virus transmission across polarized ectocervical organ cultures.

Fraietta JA, Mueller YM, Lozenski KL, Ratner D, Boesteanu AC, Hancock AS, Lackman-Smith C, Zentner IJ, Chaiken IM, Chung S, LeGrice SF, Snyder BA, Mankowski MK, Jones NM, Hope JL, Gupta P, Anderson SH, Wigdahl B, Katsikis PD.

Antimicrob Agents Chemother. 2014 Dec;58(12):7056-71. doi: 10.1128/AAC.02991-14. Epub 2014 Sep 15.


Feasibility and clinical outcomes when using practice guidelines for evaluation of fever in returning travelers and migrants: a validation study.

Mueller Y, D'Acremont V, Ambresin AE, Rossi I, Martin O, Burnand B, Genton B.

J Travel Med. 2014 May-Jun;21(3):169-82. doi: 10.1111/jtm.12099. Epub 2014 Jan 27.


Clinical epidemiology, diagnosis and treatment of visceral leishmaniasis in the Pokot endemic area of Uganda and Kenya.

Mueller YK, Kolaczinski JH, Koech T, Lokwang P, Riongoita M, Velilla E, Brooker SJ, Chappuis F.

Am J Trop Med Hyg. 2014 Jan;90(1):33-9. doi: 10.4269/ajtmh.13-0150. Epub 2013 Nov 11.


Type I interferon upregulates Bak and contributes to T cell loss during human immunodeficiency virus (HIV) infection.

Fraietta JA, Mueller YM, Yang G, Boesteanu AC, Gracias DT, Do DH, Hope JL, Kathuria N, McGettigan SE, Lewis MG, Giavedoni LD, Jacobson JM, Katsikis PD.

PLoS Pathog. 2013;9(10):e1003658. doi: 10.1371/journal.ppat.1003658. Epub 2013 Oct 10.


[Differential diagnoses of infection with Mycobacterium ulcerans: case reports from Akonolinga, Cameroon].

Toutous Trellu L, Nkemenang P, Mboua B, Tschanz E, Ehounou G, Comte E, Etard JF, Njih ET, Mueller Y.

Med Sante Trop. 2013 May 1;23(2):229. doi: 10.1684/mst.2013.0219. French.


[Buruli ulcers: an advocacy agenda to improve its control].

Potet J, Casenghi M, Charitha G, Mueller Y, Etard JF, Comte E.

Med Sante Trop. 2013 May 1;23(2):227-8. doi: 10.1684/mst.2013.0215. French.


The microRNA miR-155 controls CD8(+) T cell responses by regulating interferon signaling.

Gracias DT, Stelekati E, Hope JL, Boesteanu AC, Doering TA, Norton J, Mueller YM, Fraietta JA, Wherry EJ, Turner M, Katsikis PD.

Nat Immunol. 2013 Jun;14(6):593-602. doi: 10.1038/ni.2576. Epub 2013 Apr 21.


Biomedical risk assessment as an aid for smoking cessation.

Bize R, Burnand B, Mueller Y, Rège-Walther M, Camain JY, Cornuz J.

Cochrane Database Syst Rev. 2012 Dec 12;12:CD004705. doi: 10.1002/14651858.CD004705.pub4. Review.


Burden of visceral leishmaniasis in villages of eastern Gedaref State, Sudan: an exhaustive cross-sectional survey.

Mueller YK, Nackers F, Ahmed KA, Boelaert M, Djoumessi JC, Eltigani R, Gorashi HA, Hammam O, Ritmeijer K, Salih N, Worku D, Etard JF, Chappuis F.

PLoS Negl Trop Dis. 2012;6(11):e1872. doi: 10.1371/journal.pntd.0001872. Epub 2012 Nov 1.


Effectiveness of blood transfusions and risk factors for mortality in children aged from 1 month to 4 years at the Bon Marché Hospital, Bunia, Democratic Republic of the Congo.

Mueller Y, Bastard M, Ehounou G, Itama J, Quéré M, de la Tour R, Vala L, Etard JF, Bottineau MC.

Trop Med Int Health. 2012 Dec;17(12):1457-64. doi: 10.1111/j.1365-3156.2012.03095.x. Epub 2012 Oct 11.


The cytokine network of acute HIV infection: a promising target for vaccines and therapy to reduce viral set-point?

Katsikis PD, Mueller YM, Villinger F.

PLoS Pathog. 2011 Aug;7(8):e1002055. doi: 10.1371/journal.ppat.1002055. Epub 2011 Aug 11. Review.


IL-15 delays suppression and fails to promote immune reconstitution in virally suppressed chronically SIV-infected macaques.

Lugli E, Mueller YM, Lewis MG, Villinger F, Katsikis PD, Roederer M.

Blood. 2011 Sep 1;118(9):2520-9. doi: 10.1182/blood-2011-05-351155. Epub 2011 Jul 14.


Dendritic cells and CD28 costimulation are required to sustain virus-specific CD8+ T cell responses during the effector phase in vivo.

Dolfi DV, Duttagupta PA, Boesteanu AC, Mueller YM, Oliai CH, Borowski AB, Katsikis PD.

J Immunol. 2011 Apr 15;186(8):4599-608. doi: 10.4049/jimmunol.1001972. Epub 2011 Mar 9.


Integrating mental health into primary care for displaced populations: the experience of Mindanao, Philippines.

Mueller Y, Cristofani S, Rodriguez C, Malaguiok RT, Gil T, Grais RF, Souza R.

Confl Health. 2011 Mar 7;5:3. doi: 10.1186/1752-1505-5-3.


High mortality among older patients treated with pentavalent antimonials for visceral leishmaniasis in East Africa and rationale for switch to liposomal amphotericin B.

Chappuis F, Alirol E, Worku DT, Mueller Y, Ritmeijer K.

Antimicrob Agents Chemother. 2011 Jan;55(1):455-6. doi: 10.1128/AAC.01298-10. Epub 2010 Nov 15. No abstract available.


IL-15 in HIV infection: pathogenic or therapeutic potential?

Mueller YM, Katsikis PD.

Eur Cytokine Netw. 2010 Sep;21(3):219-21. doi: 10.1684/ecn.2010.0198. Epub 2010 Aug 19.


Phosphorothioate 2' deoxyribose oligomers as microbicides that inhibit human immunodeficiency virus type 1 (HIV-1) infection and block Toll-like receptor 7 (TLR7) and TLR9 triggering by HIV-1.

Fraietta JA, Mueller YM, Do DH, Holmes VM, Howett MK, Lewis MG, Boesteanu AC, Alkan SS, Katsikis PD.

Antimicrob Agents Chemother. 2010 Oct;54(10):4064-73. doi: 10.1128/AAC.00367-10. Epub 2010 Jul 12.


CD8+ cell depletion of SHIV89.6P-infected macaques induces CD4+ T cell proliferation that contributes to increased viral loads.

Mueller YM, Do DH, Boyer JD, Kader M, Mattapallil JJ, Lewis MG, Weiner DB, Katsikis PD.

J Immunol. 2009 Oct 15;183(8):5006-12. doi: 10.4049/jimmunol.0900141. Epub 2009 Sep 28.


Differential association of programmed death-1 and CD57 with ex vivo survival of CD8+ T cells in HIV infection.

Petrovas C, Chaon B, Ambrozak DR, Price DA, Melenhorst JJ, Hill BJ, Geldmacher C, Casazza JP, Chattopadhyay PK, Roederer M, Douek DC, Mueller YM, Jacobson JM, Kulkarni V, Felber BK, Pavlakis GN, Katsikis PD, Koup RA.

J Immunol. 2009 Jul 15;183(2):1120-32. doi: 10.4049/jimmunol.0900182. Epub 2009 Jun 29.


Risk factors for in-hospital mortality of visceral leishmaniasis patients in eastern Uganda.

Mueller Y, Mbulamberi DB, Odermatt P, Hoffmann A, Loutan L, Chappuis F.

Trop Med Int Health. 2009 Aug;14(8):910-7. doi: 10.1111/j.1365-3156.2009.02305.x. Epub 2009 Jun 22.

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