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Items: 1 to 50 of 74

1.

Bioresponsive release of insulin-like growth factor-I from its PEGylated conjugate.

Braun AC, Gutmann M, Mueller TD, Lühmann T, Meinel L.

J Control Release. 2018 Jun 10;279:17-28. doi: 10.1016/j.jconrel.2018.04.009. Epub 2018 Apr 7.

PMID:
29634992
2.

Structure and Function of TPC1 Vacuole SV Channel Gains Shape.

Hedrich R, Mueller TD, Becker D, Marten I.

Mol Plant. 2018 Jun 4;11(6):764-775. doi: 10.1016/j.molp.2018.03.017. Epub 2018 Mar 31. Review.

3.

Collagen I derived recombinant protein microspheres as novel delivery vehicles for bone morphogenetic protein-2.

Mumcuoglu D, de Miguel L, Jekhmane S, Siverino C, Nickel J, Mueller TD, van Leeuwen JP, van Osch GJ, Kluijtmans SG.

Mater Sci Eng C Mater Biol Appl. 2018 Mar 1;84:271-280. doi: 10.1016/j.msec.2017.11.031. Epub 2017 Dec 1.

PMID:
29519439
4.

Assay Conditions Influence Affinities of Rat Organic Cation Transporter 1: Analysis of Mutagenesis in the Modeled Outward-Facing Cleft by Measuring Effects of Substrates and Inhibitors on Initial Uptake.

Gorboulev V, Rehman S, Albert CM, Roth U, Meyer MJ, Tzvetkov MV, Mueller TD, Koepsell H.

Mol Pharmacol. 2018 Apr;93(4):402-415. doi: 10.1124/mol.117.110767. Epub 2018 Jan 16.

PMID:
29339398
5.

TGF-β family co-receptor function and signaling.

Nickel J, Ten Dijke P, Mueller TD.

Acta Biochim Biophys Sin (Shanghai). 2018 Jan 1;50(1):12-36. doi: 10.1093/abbs/gmx126. Review.

PMID:
29293886
6.

Low doses of cholera toxin and its mediator cAMP induce CTLA-2 secretion by dendritic cells to enhance regulatory T cell conversion.

Silva-Vilches C, Pletinckx K, Lohnert M, Pavlovic V, Ashour D, John V, Vendelova E, Kneitz S, Zhou J, Chen R, Reinheckel T, Mueller TD, Bodem J, Lutz MB.

PLoS One. 2017 Jul 31;12(7):e0178114. doi: 10.1371/journal.pone.0178114. eCollection 2017.

7.

BMP15 Mutations Associated With Primary Ovarian Insufficiency Reduce Expression, Activity, or Synergy With GDF9.

Patiño LC, Walton KL, Mueller TD, Johnson KE, Stocker W, Richani D, Agapiou D, Gilchrist RB, Laissue P, Harrison CA.

J Clin Endocrinol Metab. 2017 Mar 1;102(3):1009-1019. doi: 10.1210/jc.2016-3503.

PMID:
28359091
8.

Site-Directed Immobilization of BMP-2: Two Approaches for the Production of Innovative Osteoinductive Scaffolds.

Tabisz B, Schmitz W, Schmitz M, Luehmann T, Heusler E, Rybak JC, Meinel L, Fiebig JE, Mueller TD, Nickel J.

Biomacromolecules. 2017 Mar 13;18(3):695-708. doi: 10.1021/acs.biomac.6b01407. Epub 2017 Feb 17.

PMID:
28211679
9.

Interleukin-4-Clicked Surfaces Drive M2 Macrophage Polarization.

Lühmann T, Spieler V, Werner V, Ludwig MG, Fiebig J, Mueller TD, Meinel L.

Chembiochem. 2016 Nov 17;17(22):2123-2128. doi: 10.1002/cbic.201600480. Epub 2016 Oct 19.

PMID:
27595549
10.

The Nonspecific Lipid Transfer Protein AtLtpI-4 Is Involved in Suberin Formation of Arabidopsis thaliana Crown Galls.

Deeken R, Saupe S, Klinkenberg J, Riedel M, Leide J, Hedrich R, Mueller TD.

Plant Physiol. 2016 Nov;172(3):1911-1927. Epub 2016 Sep 29. Erratum in: Plant Physiol. 2017 Mar;173(3):1936.

11.

Structural Biology and Evolution of the TGF-β Family.

Hinck AP, Mueller TD, Springer TA.

Cold Spring Harb Perspect Biol. 2016 Dec 1;8(12). pii: a022103. doi: 10.1101/cshperspect.a022103. Review.

12.

The sclerostin-neutralizing antibody AbD09097 recognizes an epitope adjacent to sclerostin's binding site for the Wnt co-receptor LRP6.

Boschert V, Frisch C, Back JW, van Pee K, Weidauer SE, Muth EM, Schmieder P, Beerbaum M, Knappik A, Timmerman P, Mueller TD.

Open Biol. 2016 Aug;6(8). pii: 160120. doi: 10.1098/rsob.160120.

13.

Protein RS1 (RSC1A1) Downregulates the Exocytotic Pathway of Glucose Transporter SGLT1 at Low Intracellular Glucose via Inhibition of Ornithine Decarboxylase.

Chintalapati C, Keller T, Mueller TD, Gorboulev V, Schäfer N, Zilkowski I, Veyhl-Wichmann M, Geiger D, Groll J, Koepsell H.

Mol Pharmacol. 2016 Nov;90(5):508-521. Epub 2016 Aug 23.

14.

Gating of the two-pore cation channel AtTPC1 in the plant vacuole is based on a single voltage-sensing domain.

Jaślan D, Mueller TD, Becker D, Schultz J, Cuin TA, Marten I, Dreyer I, Schönknecht G, Hedrich R.

Plant Biol (Stuttg). 2016 Sep;18(5):750-60. doi: 10.1111/plb.12478. Epub 2016 Jul 12.

PMID:
27270880
15.

The Venus Flytrap Dionaea muscipula Counts Prey-Induced Action Potentials to Induce Sodium Uptake.

Böhm J, Scherzer S, Krol E, Kreuzer I, von Meyer K, Lorey C, Mueller TD, Shabala L, Monte I, Solano R, Al-Rasheid KA, Rennenberg H, Shabala S, Neher E, Hedrich R.

Curr Biol. 2016 Feb 8;26(3):286-95. doi: 10.1016/j.cub.2015.11.057. Epub 2016 Jan 21.

16.

Structural insights into BMP receptors: Specificity, activation and inhibition.

Yadin D, Knaus P, Mueller TD.

Cytokine Growth Factor Rev. 2016 Feb;27:13-34. doi: 10.1016/j.cytogfr.2015.11.005. Epub 2015 Nov 24. Review.

PMID:
26690041
17.

Biological activity and in vivo half-life of pro-activin A in male rats.

Johnson KE, Makanji Y, Temple-Smith P, Kelly EK, Barton PA, Al-Musawi SL, Mueller TD, Walton KL, Harrison CA.

Mol Cell Endocrinol. 2016 Feb 15;422:84-92. doi: 10.1016/j.mce.2015.12.007. Epub 2015 Dec 11.

PMID:
26687063
18.

Venus Flytrap HKT1-Type Channel Provides for Prey Sodium Uptake into Carnivorous Plant Without Conflicting with Electrical Excitability.

Böhm J, Scherzer S, Shabala S, Krol E, Neher E, Mueller TD, Hedrich R.

Mol Plant. 2016 Mar 7;9(3):428-436. doi: 10.1016/j.molp.2015.09.017. Epub 2015 Oct 9.

19.

GDF-5 can act as a context-dependent BMP-2 antagonist.

Klammert U, Mueller TD, Hellmann TV, Wuerzler KK, Kotzsch A, Schliermann A, Schmitz W, Kuebler AC, Sebald W, Nickel J.

BMC Biol. 2015 Sep 18;13:77. doi: 10.1186/s12915-015-0183-8.

20.

Mechanisms of BMP-Receptor Interaction and Activation.

Mueller TD.

Vitam Horm. 2015;99:1-61. doi: 10.1016/bs.vh.2015.06.003. Epub 2015 Jul 15. Review.

PMID:
26279372
21.

Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-β Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality.

Mottershead DG, Sugimura S, Al-Musawi SL, Li JJ, Richani D, White MA, Martin GA, Trotta AP, Ritter LJ, Shi J, Mueller TD, Harrison CA, Gilchrist RB.

J Biol Chem. 2015 Sep 25;290(39):24007-20. doi: 10.1074/jbc.M115.671487. Epub 2015 Aug 8.

22.

A hypomorphic BMPR1B mutation causes du Pan acromesomelic dysplasia.

Stange K, Désir J, Kakar N, Mueller TD, Budde BS, Gordon CT, Horn D, Seemann P, Borck G.

Orphanet J Rare Dis. 2015 Jun 24;10:84. doi: 10.1186/s13023-015-0299-5.

23.

RGM co-receptors add complexity to BMP signaling.

Mueller TD.

Nat Struct Mol Biol. 2015 Jun;22(6):439-40. doi: 10.1038/nsmb.3037. No abstract available.

PMID:
26036568
24.

The hypervariable region 4 (HV4) and position 93 of the α chain modulate CD1d-glycolipid binding of iNKT TCRs.

Paletta D, Fichtner AS, Hahn AM, Starick L, Beyersdorf N, Monzon-Casanova E, Mueller TD, Herrmann T.

Eur J Immunol. 2015 Jul;45(7):2122-33. doi: 10.1002/eji.201545534. Epub 2015 May 12.

25.

Crystallization and preliminary X-ray crystallographic analysis of the sclerostin-neutralizing Fab AbD09097.

Boschert V, Muth EM, Knappik A, Frisch C, Mueller TD.

Acta Crystallogr F Struct Biol Commun. 2015 Apr;71(Pt 4):388-92. doi: 10.1107/S2053230X1500360X. Epub 2015 Mar 20.

26.

Modifications of human growth differentiation factor 9 to improve the generation of embryos from low competence oocytes.

Li JJ, Sugimura S, Mueller TD, White MA, Martin GA, Ritter LJ, Liang XY, Gilchrist RB, Mottershead DG.

Mol Endocrinol. 2015 Jan;29(1):40-52. doi: 10.1210/me.2014-1173.

27.

Mutational analysis of sclerostin shows importance of the flexible loop and the cystine-knot for Wnt-signaling inhibition.

Boschert V, van Dinther M, Weidauer S, van Pee K, Muth EM, Ten Dijke P, Mueller TD.

PLoS One. 2013 Nov 29;8(11):e81710. doi: 10.1371/journal.pone.0081710. eCollection 2013. Erratum in: PLoS One. 2014;9(1). doi:10.1371/annotation/067f1197-3290-4d1e-8f77-4d3996a6b9e8.

28.

Homozygous missense and nonsense mutations in BMPR1B cause acromesomelic chondrodysplasia-type Grebe.

Graul-Neumann LM, Deichsel A, Wille U, Kakar N, Koll R, Bassir C, Ahmad J, Cormier-Daire V, Mundlos S, Kubisch C, Borck G, Klopocki E, Mueller TD, Doelken SC, Seemann P.

Eur J Hum Genet. 2014 Jun;22(6):726-33. doi: 10.1038/ejhg.2013.222. Epub 2013 Oct 16.

29.

The clip-segment of the von Willebrand domain 1 of the BMP modulator protein Crossveinless 2 is preformed.

Fiebig JE, Weidauer SE, Qiu LY, Bauer M, Schmieder P, Beerbaum M, Zhang JL, Oschkinat H, Sebald W, Mueller TD.

Molecules. 2013 Sep 25;18(10):11658-82. doi: 10.3390/molecules181011658.

30.

An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities.

Hannema SE, van Duyvenvoorde HA, Premsler T, Yang RB, Mueller TD, Gassner B, Oberwinkler H, Roelfsema F, Santen GW, Prickett T, Kant SG, Verkerk AJ, Uitterlinden AG, Espiner E, Ruivenkamp CA, Oostdijk W, Pereira AM, Losekoot M, Kuhn M, Wit JM.

J Clin Endocrinol Metab. 2013 Dec;98(12):E1988-98. doi: 10.1210/jc.2013-2358. Epub 2013 Sep 20.

PMID:
24057292
31.

Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3).

Diestel U, Resch M, Meinhardt K, Weiler S, Hellmann TV, Mueller TD, Nickel J, Eichler J, Muller YA.

PLoS One. 2013 Jun 27;8(6):e67214. doi: 10.1371/journal.pone.0067214. Print 2013.

32.

Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization.

Mottershead DG, Harrison CA, Mueller TD, Stanton PG, Gilchrist RB, McNatty KP.

Proc Natl Acad Sci U S A. 2013 Jun 18;110(25):E2257. doi: 10.1073/pnas.1303459110. Epub 2013 May 6. No abstract available.

33.

Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling.

van Dinther M, Zhang J, Weidauer SE, Boschert V, Muth EM, Knappik A, de Gorter DJ, van Kasteren PB, Frisch C, Mueller TD, ten Dijke P.

PLoS One. 2013 Apr 29;8(4):e62295. doi: 10.1371/journal.pone.0062295. Print 2013.

34.

NOD-scid IL2R γnull mice engrafted with human peripheral blood mononuclear cells as a model to test therapeutics targeting human signaling pathways.

Zadeh-Khorasani M, Nolte T, Mueller TD, Pechlivanis M, Rueff F, Wollenberg A, Fricker G, Wolf E, Siebeck M, Gropp R.

J Transl Med. 2013 Jan 7;11:4. doi: 10.1186/1479-5876-11-4.

35.

Salt stress triggers phosphorylation of the Arabidopsis vacuolar K+ channel TPK1 by calcium-dependent protein kinases (CDPKs).

Latz A, Mehlmer N, Zapf S, Mueller TD, Wurzinger B, Pfister B, Csaszar E, Hedrich R, Teige M, Becker D.

Mol Plant. 2013 Jul;6(4):1274-1289. doi: 10.1093/mp/sss158. Epub 2012 Dec 19.

36.

A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1.

Egenberger B, Gorboulev V, Keller T, Gorbunov D, Gottlieb N, Geiger D, Mueller TD, Koepsell H.

J Biol Chem. 2012 Sep 7;287(37):31561-73. doi: 10.1074/jbc.M112.388793. Epub 2012 Jul 18.

37.

Hyperactivation of constitutively dimerized oncogenic EGF receptors by autocrine loops.

Laisney JA, Mueller TD, Schartl M, Meierjohann S.

Oncogene. 2013 May 9;32(19):2403-11. doi: 10.1038/onc.2012.267. Epub 2012 Jul 2.

PMID:
22751127
38.

Promiscuity and specificity in BMP receptor activation.

Mueller TD, Nickel J.

FEBS Lett. 2012 Jul 4;586(14):1846-59. doi: 10.1016/j.febslet.2012.02.043. Epub 2012 Mar 8. Review.

39.

Enzymatic deglutathionylation to generate interleukin-4 cysteine muteins with free thiol.

Duppatla V, Gjorgjevikj M, Schmitz W, Kottmair M, Mueller TD, Sebald W.

Bioconjug Chem. 2012 Jul 18;23(7):1396-405. doi: 10.1021/bc2004389. Epub 2012 Jun 20.

PMID:
22681442
40.

Selecting highly structure-specific antibodies using structured synthetic mimics of the cystine knot protein sclerostin.

Back JW, Frisch C, Van Pee K, Boschert V, van Vught R, Puijk W, Mueller TD, Knappik A, Timmerman P.

Protein Eng Des Sel. 2012 May;25(5):251-9. doi: 10.1093/protein/gzs012. Epub 2012 Mar 27.

PMID:
22454505
41.

Crystal structure of D-serine dehydratase from Escherichia coli.

Urusova DV, Isupov MN, Antonyuk S, Kachalova GS, Obmolova G, Vagin AA, Lebedev AA, Burenkov GP, Dauter Z, Bartunik HD, Lamzin VS, Melik-Adamyan WR, Mueller TD, Schnackerz KD.

Biochim Biophys Acta. 2012 Mar;1824(3):422-32. doi: 10.1016/j.bbapap.2011.10.017. Epub 2011 Nov 27.

PMID:
22197591
42.

Structure analysis of the IL-5 ligand-receptor complex reveals a wrench-like architecture for IL-5Rα.

Patino E, Kotzsch A, Saremba S, Nickel J, Schmitz W, Sebald W, Mueller TD.

Structure. 2011 Dec 7;19(12):1864-75. doi: 10.1016/j.str.2011.08.015.

43.

Glycosylation of Twisted Gastrulation is Required for BMP Binding and Activity during Craniofacial Development.

Billington CJ Jr, Fiebig JE, Forsman CL, Pham L, Burbach N, Sun M, Jaskoll T, Mansky K, Gopalakrishnan R, O'Connor MB, Mueller TD, Petryk A.

Front Physiol. 2011 Sep 12;2:59. doi: 10.3389/fphys.2011.00059. eCollection 2011.

44.

Purification, crystallization and preliminary data analysis of the ligand-receptor complex of the growth and differentiation factor 5 variant R57A (GDF5R57A) and BMP receptor IA (BRIA).

Nickel J, Kotzsch A, Sebald W, Mueller TD.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 May 1;67(Pt 5):551-5. doi: 10.1107/S1744309111006907. Epub 2011 Apr 21.

45.
46.

Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways.

Krause C, Korchynskyi O, de Rooij K, Weidauer SE, de Gorter DJ, van Bezooijen RL, Hatsell S, Economides AN, Mueller TD, Löwik CW, ten Dijke P.

J Biol Chem. 2010 Dec 31;285(53):41614-26. doi: 10.1074/jbc.M110.153890. Epub 2010 Oct 15.

47.

A selection fit mechanism in BMP receptor IA as a possible source for BMP ligand-receptor promiscuity.

Harth S, Kotzsch A, Hu J, Sebald W, Mueller TD.

PLoS One. 2010 Sep 28;5(9). pii: e13049. doi: 10.1371/journal.pone.0013049.

48.

Crystallization of BMP receptor type IA bound to the antibody Fab fragment AbD1556.

Harth S, Kotzsch A, Sebald W, Mueller TD.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Aug 1;66(Pt 8):964-8. doi: 10.1107/S1744309110024681. Epub 2010 Jul 29.

49.

Molecular basis of cytokine signalling--theme and variations.

Sebald W, Nickel J, Zhang JL, Mueller TD.

FEBS J. 2010 Jan;277(1):106-18. doi: 10.1111/j.1742-4658.2009.07480.x. Epub 2009 Nov 27.

50.

Intricacies of BMP receptor assembly.

Nickel J, Sebald W, Groppe JC, Mueller TD.

Cytokine Growth Factor Rev. 2009 Oct-Dec;20(5-6):367-77. doi: 10.1016/j.cytogfr.2009.10.022. Review.

PMID:
19926516

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