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Identification of a Water-Soluble Indirubin Derivative as Potent Inhibitor of Insulin-like Growth Factor 1 Receptor through Structural Modification of the Parent Natural Molecule.

Cheng X, Merz KH, Vatter S, Zeller J, Muehlbeyer S, Thommet A, Christ J, W├Âlfl S, Eisenbrand G.

J Med Chem. 2017 Jun 22;60(12):4949-4962. doi: 10.1021/acs.jmedchem.7b00324. Epub 2017 Jun 6.


Indirubin derivatives inhibit Stat3 signaling and induce apoptosis in human cancer cells.

Nam S, Buettner R, Turkson J, Kim D, Cheng JQ, Muehlbeyer S, Hippe F, Vatter S, Merz KH, Eisenbrand G, Jove R.

Proc Natl Acad Sci U S A. 2005 Apr 26;102(17):5998-6003. Epub 2005 Apr 18.


Molecular mechanisms of indirubin and its derivatives: novel anticancer molecules with their origin in traditional Chinese phytomedicine.

Eisenbrand G, Hippe F, Jakobs S, Muehlbeyer S.

J Cancer Res Clin Oncol. 2004 Nov;130(11):627-35. Epub 2004 Aug 31. Review.


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