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The chromatin remodeling protein Lsh alters nucleosome occupancy at putative enhancers and modulates binding of lineage specific transcription factors.

Ren J, Finney R, Ni K, Cam M, Muegge K.

Epigenetics. 2019 Mar;14(3):277-293. doi: 10.1080/15592294.2019.1582275. Epub 2019 Mar 12.


Activation of AhR with nuclear IKKα regulates cancer stem-like properties in the occurrence of radioresistance.

Yan B, Liu S, Shi Y, Liu N, Chen L, Wang X, Xiao D, Liu X, Mao C, Jiang Y, Lai W, Xin X, Tang CE, Luo D, Tan T, Jia J, Liu Y, Yang R, Huang J, Zhou H, Cheng Y, Cao Y, Yu W, Muegge K, Tao Y.

Cell Death Dis. 2018 May 1;9(5):490. doi: 10.1038/s41419-018-0542-9.


A G3BP1-Interacting lncRNA Promotes Ferroptosis and Apoptosis in Cancer via Nuclear Sequestration of p53.

Mao C, Wang X, Liu Y, Wang M, Yan B, Jiang Y, Shi Y, Shen Y, Liu X, Lai W, Yang R, Xiao D, Cheng Y, Liu S, Zhou H, Cao Y, Yu W, Muegge K, Yu H, Tao Y.

Cancer Res. 2018 Jul 1;78(13):3484-3496. doi: 10.1158/0008-5472.CAN-17-3454. Epub 2018 Mar 27.


Tethering of Lsh at the Oct4 locus promotes gene repression associated with epigenetic changes.

Ren J, Hathaway NA, Crabtree GR, Muegge K.

Epigenetics. 2018;13(2):173-181. doi: 10.1080/15592294.2017.1338234. Epub 2018 Feb 6.


Lsh/HELLS regulates self-renewal/proliferation of neural stem/progenitor cells.

Han Y, Ren J, Lee E, Xu X, Yu W, Muegge K.

Sci Rep. 2017 Apr 25;7(1):1136. doi: 10.1038/s41598-017-00804-6.


Chromatin Remodeling Factor LSH Drives Cancer Progression by Suppressing the Activity of Fumarate Hydratase.

He X, Yan B, Liu S, Jia J, Lai W, Xin X, Tang CE, Luo D, Tan T, Jiang Y, Shi Y, Liu Y, Xiao D, Chen L, Liu S, Mao C, Yin G, Cheng Y, Fan J, Cao Y, Muegge K, Tao Y.

Cancer Res. 2016 Oct 1;76(19):5743-5755. Epub 2016 Jun 14.


Advanced Applications of RNA Sequencing and Challenges.

Han Y, Gao S, Muegge K, Zhang W, Zhou B.

Bioinform Biol Insights. 2015 Nov 15;9(Suppl 1):29-46. doi: 10.4137/BBI.S28991. eCollection 2015. Review.


Effect of high fat diet on paternal sperm histone distribution and male offspring liver gene expression.

Terashima M, Barbour S, Ren J, Yu W, Han Y, Muegge K.

Epigenetics. 2015;10(9):861-71. doi: 10.1080/15592294.2015.1075691.


An ATPase-deficient variant of the SNF2 family member HELLS shows altered dynamics at pericentromeric heterochromatin.

Lungu C, Muegge K, Jeltsch A, Jurkowska RZ.

J Mol Biol. 2015 May 22;427(10):1903-15. doi: 10.1016/j.jmb.2015.03.014. Epub 2015 Mar 28.


Repression of Hox genes by LMP1 in nasopharyngeal carcinoma and modulation of glycolytic pathway genes by HoxC8.

Jiang Y, Yan B, Lai W, Shi Y, Xiao D, Jia J, Liu S, Li H, Lu J, Li Z, Chen L, Chen X, Sun L, Muegge K, Cao Y, Tao Y.

Oncogene. 2015 Dec 10;34(50):6079-91. doi: 10.1038/onc.2015.53. Epub 2015 Mar 9.


The ATP binding site of the chromatin remodeling homolog Lsh is required for nucleosome density and de novo DNA methylation at repeat sequences.

Ren J, Briones V, Barbour S, Yu W, Han Y, Terashima M, Muegge K.

Nucleic Acids Res. 2015 Feb 18;43(3):1444-55. doi: 10.1093/nar/gku1371. Epub 2015 Jan 10.


Genome-wide DNA methylation patterns in LSH mutant reveals de-repression of repeat elements and redundant epigenetic silencing pathways.

Yu W, McIntosh C, Lister R, Zhu I, Han Y, Ren J, Landsman D, Lee E, Briones V, Terashima M, Leighty R, Ecker JR, Muegge K.

Genome Res. 2014 Oct;24(10):1613-23. doi: 10.1101/gr.172015.114. Epub 2014 Aug 28.


CG hypomethylation in Lsh-/- mouse embryonic fibroblasts is associated with de novo H3K4me1 formation and altered cellular plasticity.

Yu W, Briones V, Lister R, McIntosh C, Han Y, Lee EY, Ren J, Terashima M, Leighty RM, Ecker JR, Muegge K.

Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):5890-5. doi: 10.1073/pnas.1320945111. Epub 2014 Apr 7.


The ghosts in the machine: DNA methylation and the mystery of differentiation.

Briones V, Muegge K.

Biochim Biophys Acta. 2012 Jul;1819(7):757-62. doi: 10.1016/j.bbagrm.2012.02.013. Epub 2012 Feb 22. Review.


The SNF2-like helicase HELLS mediates E2F3-dependent transcription and cellular transformation.

von Eyss B, Maaskola J, Memczak S, Möllmann K, Schuetz A, Loddenkemper C, Tanh MD, Otto A, Muegge K, Heinemann U, Rajewsky N, Ziebold U.

EMBO J. 2012 Feb 15;31(4):972-85. doi: 10.1038/emboj.2011.451. Epub 2011 Dec 13.


Treatment of breast cancer cells with DNA demethylating agents leads to a release of Pol II stalling at genes with DNA-hypermethylated regions upstream of TSS.

Tao Y, Liu S, Briones V, Geiman TM, Muegge K.

Nucleic Acids Res. 2011 Dec;39(22):9508-20. doi: 10.1093/nar/gkr611. Epub 2011 Aug 31.


Lsh, chromatin remodeling family member, modulates genome-wide cytosine methylation patterns at nonrepeat sequences.

Tao Y, Xi S, Shan J, Maunakea A, Che A, Briones V, Lee EY, Geiman T, Huang J, Stephens R, Leighty RM, Zhao K, Muegge K.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5626-31. doi: 10.1073/pnas.1017000108. Epub 2011 Mar 22. Erratum in: Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15535.


Lymphoid-specific helicase (HELLS) is essential for meiotic progression in mouse spermatocytes.

Zeng W, Baumann C, Schmidtmann A, Honaramooz A, Tang L, Bondareva A, Dores C, Fan T, Xi S, Geiman T, Rathi R, de Rooij D, De La Fuente R, Muegge K, Dobrinski I.

Biol Reprod. 2011 Jun;84(6):1235-41. doi: 10.1095/biolreprod.110.085720. Epub 2011 Feb 23.


Lsh mediated RNA polymerase II stalling at HoxC6 and HoxC8 involves DNA methylation.

Tao Y, Xi S, Briones V, Muegge K.

PLoS One. 2010 Feb 11;5(2):e9163. doi: 10.1371/journal.pone.0009163.


DNA methylation in early development.

Geiman TM, Muegge K.

Mol Reprod Dev. 2010 Feb;77(2):105-13. doi: 10.1002/mrd.21118. Review.


Lsh participates in DNA methylation and silencing of stem cell genes.

Xi S, Geiman TM, Briones V, Guang Tao Y, Xu H, Muegge K.

Stem Cells. 2009 Nov;27(11):2691-702. doi: 10.1002/stem.183.


DNA hypomethylation caused by Lsh deletion promotes erythroleukemia development.

Fan T, Schmidtmann A, Xi S, Briones V, Zhu H, Suh HC, Gooya J, Keller JR, Xu H, Roayaei J, Anver M, Ruscetti S, Muegge K.

Epigenetics. 2008 May-Jun;3(3):134-42. Epub 2008 May 9.


Measurement of soluble and membrane-bound interleukin 1 using a fibroblast bioassay.

Dinarello CA, Muegge K, Durum SK.

Curr Protoc Immunol. 2001 May;Chapter 6:Unit 6.2. doi: 10.1002/0471142735.im0602s37.


Association of ATRX with pericentric heterochromatin and the Y chromosome of neonatal mouse spermatogonia.

Baumann C, Schmidtmann A, Muegge K, De La Fuente R.

BMC Mol Biol. 2008 Mar 13;9:29. doi: 10.1186/1471-2199-9-29.


The see-saw of differentiation: tipping the chromatin balance.

Muegge K, Xi S, Geiman T.

Mol Interv. 2008 Feb;8(1):15-8, 2. doi: 10.1124/mi.8.1.4.


Lsh controls Hox gene silencing during development.

Xi S, Zhu H, Xu H, Schmidtmann A, Geiman TM, Muegge K.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14366-71. Epub 2007 Aug 28. Erratum in: Proc Natl Acad Sci U S A. 2007 Oct 9;104(41):16389.


Lsh is required for meiotic chromosome synapsis and retrotransposon silencing in female germ cells.

De La Fuente R, Baumann C, Fan T, Schmidtmann A, Dobrinski I, Muegge K.

Nat Cell Biol. 2006 Dec;8(12):1448-54. Epub 2006 Nov 19.


Lsh is involved in de novo methylation of DNA.

Zhu H, Geiman TM, Xi S, Jiang Q, Schmidtmann A, Chen T, Li E, Muegge K.

EMBO J. 2006 Jan 25;25(2):335-45. Epub 2006 Jan 5.


Lsh, a guardian of heterochromatin at repeat elements.

Muegge K.

Biochem Cell Biol. 2005 Aug;83(4):548-54. Review.


Lsh controls silencing of the imprinted Cdkn1c gene.

Fan T, Hagan JP, Kozlov SV, Stewart CL, Muegge K.

Development. 2005 Feb;132(4):635-44. Epub 2005 Jan 12.


Lsh, an epigenetic guardian of repetitive elements.

Huang J, Fan T, Yan Q, Zhu H, Fox S, Issaq HJ, Best L, Gangi L, Munroe D, Muegge K.

Nucleic Acids Res. 2004 Sep 24;32(17):5019-28. Print 2004.


Lsh, a modulator of CpG methylation, is crucial for normal histone methylation.

Yan Q, Huang J, Fan T, Zhu H, Muegge K.

EMBO J. 2003 Oct 1;22(19):5154-62.


Lsh-deficient murine embryonal fibroblasts show reduced proliferation with signs of abnormal mitosis.

Fan T, Yan Q, Huang J, Austin S, Cho E, Ferris D, Muegge K.

Cancer Res. 2003 Aug 1;63(15):4677-83.


Epigenetic control during lymphoid development and immune responses: aberrant regulation, viruses, and cancer.

Muegge K, Young H, Ruscetti F, Mikovits J.

Ann N Y Acad Sci. 2003 Mar;983:55-70. Review.


Modifications of histone cores and tails in V(D)J recombination.

Muegge K.

Genome Biol. 2003;4(4):211. Epub 2003 Mar 31. Review.


Bax deficiency partially corrects interleukin-7 receptor alpha deficiency.

Khaled AR, Li WQ, Huang J, Fry TJ, Khaled AS, Mackall CL, Muegge K, Young HA, Durum SK.

Immunity. 2002 Nov;17(5):561-73.


IL-7 withdrawal induces a stress pathway activating p38 and Jun N-terminal kinases.

Rajnavolgyi E, Benbernou N, Rethi B, Reynolds D, Young HA, Magocsi M, Muegge K, Durum SK.

Cell Signal. 2002 Sep;14(9):761-9.


Preparing the target for the bullet.

Muegge K.

Nat Immunol. 2002 Jan;3(1):16-7. No abstract available.


Trophic Factor Withdrawal Induces a Novel Pathway: p38 MAPK Activates NHE1 Resulting in Intracellular Alkalinization, an Early Step in Apoptosis.

Khaled AR, Kim K, Muegge K, Thompson C, Fliegel L, Durum SK.

ScientificWorldJournal. 2001 Dec 1;1:93. doi: 10.1100/tsw.2001.211. eCollection 2001. No abstract available.


Lsh, a member of the SNF2 family, is required for genome-wide methylation.

Dennis K, Fan T, Geiman T, Yan Q, Muegge K.

Genes Dev. 2001 Nov 15;15(22):2940-4.


Trophic factor withdrawal: p38 mitogen-activated protein kinase activates NHE1, which induces intracellular alkalinization.

Khaled AR, Moor AN, Li A, Kim K, Ferris DK, Muegge K, Fisher RJ, Fliegel L, Durum SK.

Mol Cell Biol. 2001 Nov;21(22):7545-57.


Control of chromatin accessibility for V(D)J recombination by interleukin-7.

Huang J, Muegge K.

J Leukoc Biol. 2001 Jun;69(6):907-11. Review.


Lsh, a SNF2 family member, is required for normal murine development.

Geiman TM, Tessarollo L, Anver MR, Kopp JB, Ward JM, Muegge K.

Biochim Biophys Acta. 2001 May 3;1526(2):211-20.


Thymic emigrants isolated by a new method possess unique phenotypic and functional properties.

Lee CK, Kim K, Welniak LA, Murphy WJ, Muegge K, Durum SK.

Blood. 2001 Mar 1;97(5):1360-9.


Induction of oxidative DNA damage in u937 cells by TNF or anti-Fas stimulation.

Nathan I, Dizdaroglu M, Bernstein L, Junker U, Lee C, Muegge K, Durum SK.

Cytokine. 2000 Jul;12(7):881-7.


Lsh, an SNF2/helicase family member, is required for proliferation of mature T lymphocytes.

Geiman TM, Muegge K.

Proc Natl Acad Sci U S A. 2000 Apr 25;97(9):4772-7.


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