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Air pollution and cognition.

Griffiths CJ, Mudway IS.

BMJ. 2018 Nov 27;363:k4904. doi: 10.1136/bmj.k4904. No abstract available.


Impact of London's low emission zone on air quality and children's respiratory health: a sequential annual cross-sectional study.

Mudway IS, Dundas I, Wood HE, Marlin N, Jamaludin JB, Bremner SA, Cross L, Grieve A, Nanzer A, Barratt BM, Beevers S, Dajnak D, Fuller GW, Font A, Colligan G, Sheikh A, Walton R, Grigg J, Kelly FJ, Lee TH, Griffiths CJ.

Lancet Public Health. 2018 Nov 14. pii: S2468-2667(18)30202-0. doi: 10.1016/S2468-2667(18)30202-0. [Epub ahead of print]


Effects of vitamin D on inflammatory and oxidative stress responses of human bronchial epithelial cells exposed to particulate matter.

Pfeffer PE, Lu H, Mann EH, Chen YH, Ho TR, Cousins DJ, Corrigan C, Kelly FJ, Mudway IS, Hawrylowicz CM.

PLoS One. 2018 Aug 29;13(8):e0200040. doi: 10.1371/journal.pone.0200040. eCollection 2018.


The Impact of Real-World Particulate Matter Air Pollution on the Airways of Susceptible Individuals.

Pfeffer PE, Mudway IS.

Am J Respir Crit Care Med. 2018 Dec 1;198(11):1362-1363. doi: 10.1164/rccm.201807-1206ED. No abstract available.


E-cigarette vapour enhances pneumococcal adherence to airway epithelial cells.

Miyashita L, Suri R, Dearing E, Mudway I, Dove RE, Neill DR, Van Zyl-Smit R, Kadioglu A, Grigg J.

Eur Respir J. 2018 Feb 7;51(2). pii: 1701592. doi: 10.1183/13993003.01592-2017. Print 2018 Feb.


Genotoxicity of fine and coarse fraction ambient particulate matter in immortalised normal (TT1) and cancer-derived (A549) alveolar epithelial cells.

Jarvis IWH, Enlo-Scott Z, Nagy E, Mudway IS, Tetley TD, Arlt VM, Phillips DH.

Environ Mol Mutagen. 2018 May;59(4):290-301. doi: 10.1002/em.22166. Epub 2018 Jan 25.


Urban particulate matter stimulation of human dendritic cells enhances priming of naive CD8 T lymphocytes.

Pfeffer PE, Ho TR, Mann EH, Kelly FJ, Sehlstedt M, Pourazar J, Dove RE, Sandstrom T, Mudway IS, Hawrylowicz CM.

Immunology. 2018 Apr;153(4):502-512. doi: 10.1111/imm.12852. Epub 2017 Nov 28.


Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans.

Kumar A, Bicer EM, Pfeffer P, Monopoli MP, Dawson KA, Eriksson J, Edwards K, Lynham S, Arno M, Behndig AF, Blomberg A, Somers G, Hassall D, Dailey LA, Forbes B, Mudway I.

Nanomedicine. 2017 Nov;13(8):2517-2521. doi: 10.1016/j.nano.2017.06.008. Epub 2017 Jun 22.


A Biocompatible Synthetic Lung Fluid Based on Human Respiratory Tract Lining Fluid Composition.

Kumar A, Terakosolphan W, Hassoun M, Vandera KK, Novicky A, Harvey R, Royall PG, Bicer EM, Eriksson J, Edwards K, Valkenborg D, Nelissen I, Hassall D, Mudway IS, Forbes B.

Pharm Res. 2017 Dec;34(12):2454-2465. doi: 10.1007/s11095-017-2169-4. Epub 2017 May 30.


Mechanistic link between diesel exhaust particles and respiratory reflexes.

Robinson RK, Birrell MA, Adcock JJ, Wortley MA, Dubuis ED, Chen S, McGilvery CM, Hu S, Shaffer MSP, Bonvini SJ, Maher SA, Mudway IS, Porter AE, Carlsten C, Tetley TD, Belvisi MG.

J Allergy Clin Immunol. 2018 Mar;141(3):1074-1084.e9. doi: 10.1016/j.jaci.2017.04.038. Epub 2017 May 19.


Vitamin D Counteracts an IL-23-Dependent IL-17A+IFN-γ+ Response Driven by Urban Particulate Matter.

Mann EH, Ho TR, Pfeffer PE, Matthews NC, Chevretton E, Mudway I, Kelly FJ, Hawrylowicz CM.

Am J Respir Cell Mol Biol. 2017 Sep;57(3):355-366. doi: 10.1165/rcmb.2016-0409OC.


Air pollution, ethnicity and telomere length in east London schoolchildren: An observational study.

Walton RT, Mudway IS, Dundas I, Marlin N, Koh LC, Aitlhadj L, Vulliamy T, Jamaludin JB, Wood HE, Barratt BM, Beevers S, Dajnak D, Sheikh A, Kelly FJ, Griffiths CJ, Grigg J.

Environ Int. 2016 Nov;96:41-47. doi: 10.1016/j.envint.2016.08.021. Epub 2016 Sep 1.


Differential health effects of short-term exposure to source-specific particles in London, U.K.

Samoli E, Atkinson RW, Analitis A, Fuller GW, Beddows D, Green DC, Mudway IS, Harrison RM, Anderson HR, Kelly FJ.

Environ Int. 2016 Dec;97:246-253. doi: 10.1016/j.envint.2016.09.017. Epub 2016 Sep 29.


Short-term associations between particle oxidative potential and daily mortality and hospital admissions in London.

Atkinson RW, Samoli E, Analitis A, Fuller GW, Green DC, Anderson HR, Purdie E, Dunster C, Aitlhadj L, Kelly FJ, Mudway IS.

Int J Hyg Environ Health. 2016 Aug;219(6):566-72. doi: 10.1016/j.ijheh.2016.06.004. Epub 2016 Jun 5.


Associations of short-term exposure to traffic-related air pollution with cardiovascular and respiratory hospital admissions in London, UK.

Samoli E, Atkinson RW, Analitis A, Fuller GW, Green DC, Mudway I, Anderson HR, Kelly FJ.

Occup Environ Med. 2016 May;73(5):300-7. doi: 10.1136/oemed-2015-103136. Epub 2016 Feb 16.


Quantifying the magnitude of the oxygen artefact inherent in culturing airway cells under atmospheric oxygen versus physiological levels.

Kumar A, Dailey LA, Swedrowska M, Siow R, Mann GE, Vizcay-Barrena G, Arno M, Mudway IS, Forbes B.

FEBS Lett. 2016 Jan;590(2):258-69. doi: 10.1002/1873-3468.12026. Epub 2016 Jan 23.


Enrichment of immunoregulatory proteins in the biomolecular corona of nanoparticles within human respiratory tract lining fluid.

Kumar A, Bicer EM, Morgan AB, Pfeffer PE, Monopoli M, Dawson KA, Eriksson J, Edwards K, Lynham S, Arno M, Behndig AF, Blomberg A, Somers G, Hassall D, Dailey LA, Forbes B, Mudway IS.

Nanomedicine. 2016 May;12(4):1033-1043. doi: 10.1016/j.nano.2015.12.369. Epub 2016 Jan 6.


Cigarette smoke-induced induction of antioxidant enzyme activities in airway leukocytes is absent in active smokers with COPD.

Dove RE, Leong-Smith P, Roos-Engstrand E, Pourazar J, Shah M, Behndig AF, Mudway IS, Blomberg A.

Eur Clin Respir J. 2015 Jul 16;2. doi: 10.3402/ecrj.v2.27837. eCollection 2015.


Acute exposure to wood smoke from incomplete combustion--indications of cytotoxicity.

Muala A, Rankin G, Sehlstedt M, Unosson J, Bosson JA, Behndig A, Pourazar J, Nyström R, Pettersson E, Bergvall C, Westerholm R, Jalava PI, Happo MS, Uski O, Hirvonen MR, Kelly FJ, Mudway IS, Blomberg A, Boman C, Sandström T.

Part Fibre Toxicol. 2015 Oct 29;12:33. doi: 10.1186/s12989-015-0111-7.


Short-term exposure to traffic-related air pollution and daily mortality in London, UK.

Atkinson RW, Analitis A, Samoli E, Fuller GW, Green DC, Mudway IS, Anderson HR, Kelly FJ.

J Expo Sci Environ Epidemiol. 2016 Mar-Apr;26(2):125-32. doi: 10.1038/jes.2015.65. Epub 2015 Oct 14.


Effects of controlled diesel exhaust exposure on apoptosis and proliferation markers in bronchial epithelium - an in vivo bronchoscopy study on asthmatics, rhinitics and healthy subjects.

Behndig AF, Shanmuganathan K, Whitmarsh L, Stenfors N, Brown JL, Frew AJ, Kelly FJ, Mudway IS, Sandström T, Wilson SJ.

BMC Pulm Med. 2015 Aug 25;15:99. doi: 10.1186/s12890-015-0096-x.


Effects of Air Pollution and the Introduction of the London Low Emission Zone on the Prevalence of Respiratory and Allergic Symptoms in Schoolchildren in East London: A Sequential Cross-Sectional Study.

Wood HE, Marlin N, Mudway IS, Bremner SA, Cross L, Dundas I, Grieve A, Grigg J, Jamaludin JB, Kelly FJ, Lee T, Sheikh A, Walton R, Griffiths CJ.

PLoS One. 2015 Aug 21;10(8):e0109121. doi: 10.1371/journal.pone.0109121. eCollection 2015.


Exposure to welding fumes and lower airway infection with Streptococcus pneumoniae.

Suri R, Periselneris J, Lanone S, Zeidler-Erdely PC, Melton G, Palmer KT, Andujar P, Antonini JM, Cohignac V, Erdely A, Jose RJ, Mudway I, Brown J, Grigg J.

J Allergy Clin Immunol. 2016 Feb;137(2):527-534.e7. doi: 10.1016/j.jaci.2015.06.033. Epub 2015 Aug 12.


Is air pollution associated with increased risk of cognitive decline? A systematic review.

Peters R, Peters J, Booth A, Mudway I.

Age Ageing. 2015 Sep;44(5):755-60. doi: 10.1093/ageing/afv087. Epub 2015 Jul 18. Review.


In Vitro Multiparameter Assay Development Strategy toward Differentiating Macrophage Responses to Inhaled Medicines.

Hoffman E, Kumar A, Kanabar V, Arno M, Preux L, Millar V, Page C, Collins H, Mudway I, Dailey LA, Forbes B.

Mol Pharm. 2015 Aug 3;12(8):2675-87. doi: 10.1021/acs.molpharmaceut.5b00048. Epub 2015 May 19.


Identification of vitamin C transporters in the human airways: a cross-sectional in vivo study.

Larsson N, Rankin GD, Bicer EM, Roos-Engstrand E, Pourazar J, Blomberg A, Mudway IS, Behndig AF.

BMJ Open. 2015 Apr 8;5(4):e006979. doi: 10.1136/bmjopen-2014-006979.


What are the biological and therapeutic implications of biomolecule corona formation on the surface of inhaled nanomedicines?

Kumar A, Forbes B, Mudway I, Bicer EM, Dailey LA.

Nanomedicine (Lond). 2015 Feb;10(3):343-5. doi: 10.2217/nnm.15.2. No abstract available.


Degradation in urban air quality from construction activity and increased traffic arising from a road widening scheme.

Font A, Baker T, Mudway IS, Purdie E, Dunster C, Fuller GW.

Sci Total Environ. 2014 Nov 1;497-498:123-132. doi: 10.1016/j.scitotenv.2014.07.060. Epub 2014 Aug 14.


Assessment of the capacity of vehicle cabin air inlet filters to reduce diesel exhaust-induced symptoms in human volunteers.

Muala A, Sehlstedt M, Bion A, Osterlund C, Bosson JA, Behndig AF, Pourazar J, Bucht A, Boman C, Mudway IS, Langrish JP, Couderc S, Blomberg A, Sandström T.

Environ Health. 2014 Mar 13;13(1):16. doi: 10.1186/1476-069X-13-16.


Carbon in airway macrophages from children with asthma.

Brugha RE, Mushtaq N, Round T, Gadhvi DH, Dundas I, Gaillard E, Koh L, Fleming LJ, Lewis DJ, Sanak M, Wood HE, Barratt B, Mudway IS, Kelly FJ, Griffiths CJ, Grigg J.

Thorax. 2014 Jul;69(7):654-9. doi: 10.1136/thoraxjnl-2013-204734. Epub 2014 Feb 24.


Air pollution exposure affects circulating white blood cell counts in healthy subjects: the role of particle composition, oxidative potential and gaseous pollutants - the RAPTES project.

Steenhof M, Janssen NA, Strak M, Hoek G, Gosens I, Mudway IS, Kelly FJ, Harrison RM, Pieters RH, Cassee FR, Brunekreef B.

Inhal Toxicol. 2014 Feb;26(3):141-65. doi: 10.3109/08958378.2013.861884.


Peripheral blood neutrophilia as a biomarker of ozone-induced pulmonary inflammation.

Bosson JA, Blomberg A, Stenfors N, Helleday R, Kelly FJ, Behndig AF, Mudway IS.

PLoS One. 2013 Dec 31;8(12):e81816. doi: 10.1371/journal.pone.0081816. eCollection 2013.


Associations between inflammatory and immune response genes and adverse respiratory outcomes following exposure to outdoor air pollution: a HuGE systematic review.

Vawda S, Mansour R, Takeda A, Funnell P, Kerry S, Mudway I, Jamaludin J, Shaheen S, Griffiths C, Walton R.

Am J Epidemiol. 2014 Feb 15;179(4):432-42. doi: 10.1093/aje/kwt269. Epub 2013 Nov 14. Review.


Composition of PM affects acute vascular inflammatory and coagulative markers - the RAPTES project.

Strak M, Hoek G, Godri KJ, Gosens I, Mudway IS, van Oerle R, Spronk HM, Cassee FR, Lebret E, Kelly FJ, Harrison RM, Brunekreef B, Steenhof M, Janssen NA.

PLoS One. 2013;8(3):e58944. doi: 10.1371/journal.pone.0058944. Epub 2013 Mar 13.


Acute nasal pro-inflammatory response to air pollution depends on characteristics other than particle mass concentration or oxidative potential: the RAPTES project.

Steenhof M, Mudway IS, Gosens I, Hoek G, Godri KJ, Kelly FJ, Harrison RM, Pieters RH, Cassee FR, Lebret E, Brunekreef BA, Strak M, Janssen NA.

Occup Environ Med. 2013 May;70(5):341-8. doi: 10.1136/oemed-2012-100993. Epub 2013 Feb 21.


Airway inflammatory responses to diesel exhaust in allergic rhinitics.

Larsson N, Brown J, Stenfors N, Wilson S, Mudway IS, Pourazar J, Behndig AF.

Inhal Toxicol. 2013 Feb;25(3):160-7. doi: 10.3109/08958378.2013.765932.


Components of ambient air pollution affect thrombin generation in healthy humans: the RAPTES project.

Strak M, Hoek G, Steenhof M, Kilinc E, Godri KJ, Gosens I, Mudway IS, van Oerle R, Spronk HM, Cassee FR, Kelly FJ, Harrison RM, Brunekreef B, Lebret E, Janssen NA.

Occup Environ Med. 2013 May;70(5):332-40. doi: 10.1136/oemed-2012-100992. Epub 2013 Feb 1.


Airborne particulate matter and acute lung inflammation: Strak et al. Respond.

Strak M, Janssen NA, Gosens I, Cassee FR, Lebret E, Godri KJ, Mudway IS, Kelly FJ, Harrison RM, Brunekreef B, Steenhof M, Hoek G.

Environ Health Perspect. 2013 Jan;121(1):A11-2. doi: 10.1289/ehp.1205860R. No abstract available.


Respiratory health effects of airborne particulate matter: the role of particle size, composition, and oxidative potential-the RAPTES project.

Strak M, Janssen NA, Godri KJ, Gosens I, Mudway IS, Cassee FR, Lebret E, Kelly FJ, Harrison RM, Brunekreef B, Steenhof M, Hoek G.

Environ Health Perspect. 2012 Aug;120(8):1183-9. doi: 10.1289/ehp.1104389. Epub 2012 May 2.


The London low emission zone baseline study.

Kelly F, Armstrong B, Atkinson R, Anderson HR, Barratt B, Beevers S, Cook D, Green D, Derwent D, Mudway I, Wilkinson P; HEI Health Review Committee.

Res Rep Health Eff Inst. 2011 Nov;(163):3-79.


Ascorbate prevents placental oxidative stress and enhances birth weight in hypoxic pregnancy in rats.

Richter HG, Camm EJ, Modi BN, Naeem F, Cross CM, Cindrova-Davies T, Spasic-Boskovic O, Dunster C, Mudway IS, Kelly FJ, Burton GJ, Poston L, Giussani DA.

J Physiol. 2012 Mar 15;590(6):1377-87. doi: 10.1113/jphysiol.2011.226340. Epub 2012 Jan 30.


In vitro toxicity of particulate matter (PM) collected at different sites in the Netherlands is associated with PM composition, size fraction and oxidative potential--the RAPTES project.

Steenhof M, Gosens I, Strak M, Godri KJ, Hoek G, Cassee FR, Mudway IS, Kelly FJ, Harrison RM, Lebret E, Brunekreef B, Janssen NA, Pieters RH.

Part Fibre Toxicol. 2011 Sep 2;8:26. doi: 10.1186/1743-8977-8-26.


The impact of the congestion charging scheme on air quality in London. Part 2. Analysis of the oxidative potential of particulate matter.

Kelly F, Anderson HR, Armstrong B, Atkinson R, Barratt B, Beevers S, Derwent D, Green D, Mudway I, Wilkinson P; HEI Health Review Committee.

Res Rep Health Eff Inst. 2011 Apr;(155):73-144.


The impact of the congestion charging scheme on air quality in London. Part 1. Emissions modeling and analysis of air pollution measurements.

Kelly F, Anderson HR, Armstrong B, Atkinson R, Barratt B, Beevers S, Derwent D, Green D, Mudway I, Wilkinson P; HEI Health Review Committee.

Res Rep Health Eff Inst. 2011 Apr;(155):5-71.


Increased oxidative burden associated with traffic component of ambient particulate matter at roadside and urban background schools sites in London.

Godri KJ, Harrison RM, Evans T, Baker T, Dunster C, Mudway IS, Kelly FJ.

PLoS One. 2011;6(7):e21961. doi: 10.1371/journal.pone.0021961. Epub 2011 Jul 27.


Adhesion of Streptococcus pneumoniae to human airway epithelial cells exposed to urban particulate matter.

Mushtaq N, Ezzati M, Hall L, Dickson I, Kirwan M, Png KM, Mudway IS, Grigg J.

J Allergy Clin Immunol. 2011 May;127(5):1236-42.e2. doi: 10.1016/j.jaci.2010.11.039. Epub 2011 Jan 17.


Particulate oxidative burden associated with firework activity.

Godri KJ, Green DC, Fuller GW, Dall'Osto M, Beddows DC, Kelly FJ, Harrison RM, Mudway IS.

Environ Sci Technol. 2010 Nov 1;44(21):8295-301. doi: 10.1021/es1016284.


Proinflammatory doses of diesel exhaust in healthy subjects fail to elicit equivalent or augmented airway inflammation in subjects with asthma.

Behndig AF, Larsson N, Brown JL, Stenfors N, Helleday R, Duggan ST, Dove RE, Wilson SJ, Sandstrom T, Kelly FJ, Mudway IS, Blomberg A.

Thorax. 2011 Jan;66(1):12-9. doi: 10.1136/thx.2010.140053. Epub 2010 Sep 13.


Antioxidant airway responses following experimental exposure to wood smoke in man.

Sehlstedt M, Dove R, Boman C, Pagels J, Swietlicki E, Löndahl J, Westerholm R, Bosson J, Barath S, Behndig AF, Pourazar J, Sandström T, Mudway IS, Blomberg A.

Part Fibre Toxicol. 2010 Aug 20;7:21. doi: 10.1186/1743-8977-7-21.


Determinants of the proinflammatory action of ambient particulate matter in immortalized murine macrophages.

Guastadisegni C, Kelly FJ, Cassee FR, Gerlofs-Nijland ME, Janssen NA, Pozzi R, Brunekreef B, Sandström T, Mudway I.

Environ Health Perspect. 2010 Dec;118(12):1728-34. doi: 10.1289/ehp.1002105. Epub 2010 Jul 27.

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