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Items: 18


A bioluminescent caspase-1 activity assay rapidly monitors inflammasome activation in cells.

O'Brien M, Moehring D, Muñoz-Planillo R, Núñez G, Callaway J, Ting J, Scurria M, Ugo T, Bernad L, Cali J, Lazar D.

J Immunol Methods. 2017 Aug;447:1-13. doi: 10.1016/j.jim.2017.03.004. Epub 2017 Mar 6.


Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock.

Yang D, He Y, Muñoz-Planillo R, Liu Q, Núñez G.

Immunity. 2015 Nov 17;43(5):923-32. doi: 10.1016/j.immuni.2015.10.009. Epub 2015 Nov 10.


Distinct Commensals Induce Interleukin-1β via NLRP3 Inflammasome in Inflammatory Monocytes to Promote Intestinal Inflammation in Response to Injury.

Seo SU, Kamada N, Muñoz-Planillo R, Kim YG, Kim D, Koizumi Y, Hasegawa M, Himpsl SD, Browne HP, Lawley TD, Mobley HL, Inohara N, Núñez G.

Immunity. 2015 Apr 21;42(4):744-55. doi: 10.1016/j.immuni.2015.03.004. Epub 2015 Apr 7.


A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases.

Coll RC, Robertson AA, Chae JJ, Higgins SC, Muñoz-Planillo R, Inserra MC, Vetter I, Dungan LS, Monks BG, Stutz A, Croker DE, Butler MS, Haneklaus M, Sutton CE, Núñez G, Latz E, Kastner DL, Mills KH, Masters SL, Schroder K, Cooper MA, O'Neill LA.

Nat Med. 2015 Mar;21(3):248-55. doi: 10.1038/nm.3806. Epub 2015 Feb 16.


Interleukin-22 regulates the complement system to promote resistance against pathobionts after pathogen-induced intestinal damage.

Hasegawa M, Yada S, Liu MZ, Kamada N, Muñoz-Planillo R, Do N, Núñez G, Inohara N.

Immunity. 2014 Oct 16;41(4):620-32. doi: 10.1016/j.immuni.2014.09.010.


Cytosolic double-stranded RNA activates the NLRP3 inflammasome via MAVS-induced membrane permeabilization and K+ efflux.

Franchi L, Eigenbrod T, Muñoz-Planillo R, Ozkurede U, Kim YG, Arindam C, Gale M Jr, Silverman RH, Colonna M, Akira S, Núñez G.

J Immunol. 2014 Oct 15;193(8):4214-4222. doi: 10.4049/jimmunol.1400582. Epub 2014 Sep 15.


In vivo mapping of a protective linear neutralizing epitope at the N-terminus of alpha hemolysin from Staphylococcus aureus.

Oscherwitz J, Muñoz-Planillo R, Yu F, Núñez G, Cease KB.

Mol Immunol. 2014 Jul;60(1):62-71. doi: 10.1016/j.molimm.2014.03.012. Epub 2014 Apr 24.


Shigella type III secretion protein MxiI is recognized by Naip2 to induce Nlrc4 inflammasome activation independently of Pkcδ.

Suzuki S, Franchi L, He Y, Muñoz-Planillo R, Mimuro H, Suzuki T, Sasakawa C, Núñez G.

PLoS Pathog. 2014 Feb 6;10(2):e1003926. doi: 10.1371/journal.ppat.1003926. eCollection 2014 Feb.


3,4-methylenedioxy-β-nitrostyrene inhibits NLRP3 inflammasome activation by blocking assembly of the inflammasome.

He Y, Varadarajan S, Muñoz-Planillo R, Burberry A, Nakamura Y, Núñez G.

J Biol Chem. 2014 Jan 10;289(2):1142-50. doi: 10.1074/jbc.M113.515080. Epub 2013 Nov 21.


Staphylococcus δ-toxin induces allergic skin disease by activating mast cells.

Nakamura Y, Oscherwitz J, Cease KB, Chan SM, Muñoz-Planillo R, Hasegawa M, Villaruz AE, Cheung GY, McGavin MJ, Travers JB, Otto M, Inohara N, Núñez G.

Nature. 2013 Nov 21;503(7476):397-401. doi: 10.1038/nature12655. Epub 2013 Oct 30.


K⁺ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter.

Muñoz-Planillo R, Kuffa P, Martínez-Colón G, Smith BL, Rajendiran TM, Núñez G.

Immunity. 2013 Jun 27;38(6):1142-53. doi: 10.1016/j.immuni.2013.05.016.


Bacterial RNA mediates activation of caspase-1 and IL-1β release independently of TLRs 3, 7, 9 and TRIF but is dependent on UNC93B.

Eigenbrod T, Franchi L, Muñoz-Planillo R, Kirschning CJ, Freudenberg MA, Núñez G, Dalpke A.

J Immunol. 2012 Jul 1;189(1):328-36. doi: 10.4049/jimmunol.1103258. Epub 2012 May 25.


Sensing and reacting to microbes through the inflammasomes.

Franchi L, Muñoz-Planillo R, Núñez G.

Nat Immunol. 2012 Mar 19;13(4):325-32. doi: 10.1038/ni.2231. Review.


Inflammasomes as microbial sensors.

Franchi L, Muñoz-Planillo R, Reimer T, Eigenbrod T, Núñez G.

Eur J Immunol. 2010 Mar;40(3):611-5. doi: 10.1002/eji.200940180. Review.


Activation of the Nlrp3 inflammasome by Streptococcus pyogenes requires streptolysin O and NF-kappa B activation but proceeds independently of TLR signaling and P2X7 receptor.

Harder J, Franchi L, Muñoz-Planillo R, Park JH, Reimer T, Núñez G.

J Immunol. 2009 Nov 1;183(9):5823-9. doi: 10.4049/jimmunol.0900444. Epub 2009 Oct 7.


A critical role for hemolysins and bacterial lipoproteins in Staphylococcus aureus-induced activation of the Nlrp3 inflammasome.

Muñoz-Planillo R, Franchi L, Miller LS, Núñez G.

J Immunol. 2009 Sep 15;183(6):3942-8. doi: 10.4049/jimmunol.0900729. Epub 2009 Aug 28.


The inflammasome: a caspase-1-activation platform that regulates immune responses and disease pathogenesis.

Franchi L, Eigenbrod T, Muñoz-Planillo R, Nuñez G.

Nat Immunol. 2009 Mar;10(3):241-7. doi: 10.1038/ni.1703. Review.


The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation.

Lamkanfi M, Amer A, Kanneganti TD, Muñoz-Planillo R, Chen G, Vandenabeele P, Fortier A, Gros P, Núñez G.

J Immunol. 2007 Jun 15;178(12):8022-7.

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