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Items: 1 to 50 of 191

1.

Monitoring the Integrity of the Blood-Testis Barrier (BTB): An In Vivo Assay.

Chen H, Lui WY, Mruk DD, Xiao X, Ge R, Lian Q, Lee WM, Silvestrini B, Cheng CY.

Methods Mol Biol. 2018;1748:245-252. doi: 10.1007/978-1-4939-7698-0_17.

2.

Regulation of Blood-Testis Barrier (BTB) Dynamics, Role of Actin-, and Microtubule-Based Cytoskeletons.

Wen Q, Tang EI, Li N, Mruk DD, Lee WM, Silvestrini B, Cheng CY.

Methods Mol Biol. 2018;1748:229-243. doi: 10.1007/978-1-4939-7698-0_16. Review.

3.

Rescue of PFOS-induced human Sertoli cell injury by overexpressing a p-FAK-Y407E phosphomimetic mutant.

Chen H, Gao Y, Mruk DD, Xiao X, John CM, Turek PJ, Lui WY, Lee WM, Silvestrini B, Cheng CY.

Sci Rep. 2017 Nov 17;7(1):15810. doi: 10.1038/s41598-017-15671-4.

4.

Cell polarity and planar cell polarity (PCP) in spermatogenesis.

Chen H, Mruk DD, Lui WY, Wong CKC, Lee WM, Cheng CY.

Semin Cell Dev Biol. 2018 Sep;81:71-77. doi: 10.1016/j.semcdb.2017.09.008. Epub 2017 Sep 29. Review.

5.

Erratum: Perfluorooctanesulfonate (PFOS)-induced Sertoli cell injury through a disruption of F-actin and microtubule organization is mediated by Akt1/2.

Gao Y, Chen H, Xiao X, Lui WY, Lee WM, Mruk DD, Cheng CY.

Sci Rep. 2017 Jul 26;7(1):6950. doi: 10.1038/s41598-017-04863-7.

6.

Regulation of spermatogenesis by a local functional axis in the testis: role of the basement membrane-derived noncollagenous 1 domain peptide.

Chen H, Mruk DD, Lee WM, Cheng CY.

FASEB J. 2017 Aug;31(8):3587-3607. doi: 10.1096/fj.201700052R. Epub 2017 May 9.

7.
8.

Perfluorooctanesulfonate (PFOS)-induced Sertoli cell injury through a disruption of F-actin and microtubule organization is mediated by Akt1/2.

Gao Y, Chen H, Xiao X, Lui WY, Lee WM, Mruk DD, Cheng CY.

Sci Rep. 2017 Apr 24;7(1):1110. doi: 10.1038/s41598-017-01016-8. Erratum in: Sci Rep. 2017 Jul 26;7(1):6950.

9.

Transport of germ cells across the seminiferous epithelium during spermatogenesis-the involvement of both actin- and microtubule-based cytoskeletons.

Wen Q, Tang EI, Xiao X, Gao Y, Chu DS, Mruk DD, Silvestrini B, Cheng CY.

Tissue Barriers. 2016 Nov 28;4(4):e1265042. doi: 10.1080/21688370.2016.1265042. eCollection 2016. Review.

10.

Annexin A2 is critical for blood-testis barrier integrity and spermatid disengagement in the mammalian testis.

Chojnacka K, Bilinska B, Mruk DD.

Biochim Biophys Acta Mol Cell Res. 2017 Mar;1864(3):527-545. doi: 10.1016/j.bbamcr.2016.12.012. Epub 2016 Dec 11.

11.

F5-peptide induces aspermatogenesis by disrupting organization of actin- and microtubule-based cytoskeletons in the testis.

Gao Y, Mruk DD, Lui WY, Lee WM, Cheng CY.

Oncotarget. 2016 Sep 27;7(39):64203-64220. doi: 10.18632/oncotarget.11887.

12.

Rescue of perfluorooctanesulfonate (PFOS)-mediated Sertoli cell injury by overexpression of gap junction protein connexin 43.

Li N, Mruk DD, Chen H, Wong CK, Lee WM, Cheng CY.

Sci Rep. 2016 Jul 20;6:29667. doi: 10.1038/srep29667.

13.

Biology of the Sertoli Cell in the Fetal, Pubertal, and Adult Mammalian Testis.

Chojnacka K, Zarzycka M, Mruk DD.

Results Probl Cell Differ. 2016;58:225-51. doi: 10.1007/978-3-319-31973-5_9. Review.

PMID:
27300181
14.

Formin 1 Regulates Microtubule and F-Actin Organization to Support Spermatid Transport During Spermatogenesis in the Rat Testis.

Li N, Mruk DD, Tang EI, Lee WM, Wong CK, Cheng CY.

Endocrinology. 2016 Jul;157(7):2894-908. doi: 10.1210/en.2016-1133. Epub 2016 May 4.

15.

Planar Cell Polarity (PCP) Protein Vangl2 Regulates Ectoplasmic Specialization Dynamics via Its Effects on Actin Microfilaments in the Testes of Male Rats.

Chen H, Mruk DD, Lee WM, Cheng CY.

Endocrinology. 2016 May;157(5):2140-59. doi: 10.1210/en.2015-1987. Epub 2016 Mar 18.

16.

Interleukin 1alpha-induced disruption of the Sertoli cell cytoskeleton affects gap junctional communication.

Chojnacka K, Bilinska B, Mruk DD.

Cell Signal. 2016 May;28(5):469-480. doi: 10.1016/j.cellsig.2016.02.003. Epub 2016 Feb 13.

PMID:
26879129
17.

Regulation of microtubule (MT)-based cytoskeleton in the seminiferous epithelium during spermatogenesis.

Tang EI, Mruk DD, Cheng CY.

Semin Cell Dev Biol. 2016 Nov;59:35-45. doi: 10.1016/j.semcdb.2016.01.004. Epub 2016 Jan 11. Review.

18.

Is toxicant-induced Sertoli cell injury in vitro a useful model to study molecular mechanisms in spermatogenesis?

Li N, Mruk DD, Lee WM, Wong CK, Cheng CY.

Semin Cell Dev Biol. 2016 Nov;59:141-156. doi: 10.1016/j.semcdb.2016.01.003. Epub 2016 Jan 15. Review.

19.

Effective Delivery of Male Contraceptives Behind the Blood-Testis Barrier (BTB) - Lesson from Adjudin.

Chen H, Mruk DD, Xia W, Bonanomi M, Silvestrini B, Cheng CY.

Curr Med Chem. 2016;23(7):701-13. Review.

20.

Connexin 43 reboots meiosis and reseals blood-testis barrier following toxicant-mediated aspermatogenesis and barrier disruption.

Li N, Mruk DD, Mok KW, Li MW, Wong CK, Lee WM, Han D, Silvestrini B, Cheng CY.

FASEB J. 2016 Apr;30(4):1436-52. doi: 10.1096/fj.15-276527. Epub 2015 Dec 17.

21.

Hydroxyflutamide affects connexin 43 via the activation of PI3K/Akt-dependent pathway but has no effect on the crosstalk between PI3K/Akt and ERK1/2 pathways at the Raf-1 kinase level in primary rat Sertoli cells.

Chojnacka K, Zarzycka M, Hejmej A, Mruk DD, Gorowska E, Kotula-Balak M, Klimek M, Bilinska B.

Toxicol In Vitro. 2016 Mar;31:146-57. doi: 10.1016/j.tiv.2015.09.027. Epub 2015 Oct 21.

PMID:
26437446
22.

Emergent roles for intercellular adhesion molecule-1 in the restructuring of the blood-testis barrier during spermatogenesis in the mammal.

Mruk DD.

Histol Histopathol. 2016 Feb;31(2):159-66. doi: 10.14670/HH-11-672. Epub 2015 Sep 30. Review.

PMID:
26419651
23.

Formins: Actin nucleators that regulate cytoskeletal dynamics during spermatogenesis.

Li N, Mruk DD, Tang EI, Wong CK, Lee WM, Silvestrini B, Cheng CY.

Spermatogenesis. 2015 Jun 29;5(2):e1066476. eCollection 2015 May-Aug.

24.

The Mammalian Blood-Testis Barrier: Its Biology and Regulation.

Mruk DD, Cheng CY.

Endocr Rev. 2015 Oct;36(5):564-91. doi: 10.1210/er.2014-1101. Epub 2015 Sep 10. Review. Erratum in: Endocr Rev. 2015 Dec;36(6):681. Endocr Rev. 2016 Feb;2016(1):43.

25.

The Src non-receptor tyrosine kinase paradigm: New insights into mammalian Sertoli cell biology.

Chojnacka K, Mruk DD.

Mol Cell Endocrinol. 2015 Nov 5;415:133-42. doi: 10.1016/j.mce.2015.08.012. Epub 2015 Aug 18. Review.

PMID:
26296907
26.

Actin-bundling protein plastin 3 is a regulator of ectoplasmic specialization dynamics during spermatogenesis in the rat testis.

Li N, Mruk DD, Wong CK, Lee WM, Han D, Cheng CY.

FASEB J. 2015 Sep;29(9):3788-805. doi: 10.1096/fj.14-267997. Epub 2015 Jun 5.

27.

Sertoli cells are the target of environmental toxicants in the testis - a mechanistic and therapeutic insight.

Gao Y, Mruk DD, Cheng CY.

Expert Opin Ther Targets. 2015;19(8):1073-90. doi: 10.1517/14728222.2015.1039513. Epub 2015 Apr 26. Review.

28.

Formin 1 Regulates Ectoplasmic Specialization in the Rat Testis Through Its Actin Nucleation and Bundling Activity.

Li N, Mruk DD, Wong CK, Han D, Lee WM, Cheng CY.

Endocrinology. 2015 Aug;156(8):2969-83. doi: 10.1210/en.2015-1161. Epub 2015 Apr 22.

29.

Actin binding proteins in blood-testis barrier function.

Li N, Mruk DD, Cheng CY.

Curr Opin Endocrinol Diabetes Obes. 2015 Jun;22(3):238-47. doi: 10.1097/MED.0000000000000155. Review.

30.

Flutamide alters the distribution of c-Src and affects the N-cadherin-β-catenin complex in the seminiferous epithelium of adult rat.

Zarzycka M, Chojnacka K, Mruk DD, Gorowska E, Hejmej A, Kotula-Balak M, Pardyak L, Bilinska B.

Andrology. 2015 May;3(3):569-81. doi: 10.1111/andr.12028. Epub 2015 Apr 14.

31.

rpS6 regulates blood-testis barrier dynamics through Akt-mediated effects on MMP-9.

Mok KW, Mruk DD, Cheng CY.

J Cell Sci. 2014 Nov 15;127(Pt 22):4870-82. doi: 10.1242/jcs.152231. Epub 2014 Sep 12.

32.

Differential effects of c-Src and c-Yes on the endocytic vesicle-mediated trafficking events at the Sertoli cell blood-testis barrier: an in vitro study.

Xiao X, Mruk DD, Wong EW, Lee WM, Han D, Wong CK, Cheng CY.

Am J Physiol Endocrinol Metab. 2014 Oct 1;307(7):E553-62. doi: 10.1152/ajpendo.00176.2014. Epub 2014 Aug 12.

33.

Germ cell transport across the seminiferous epithelium during spermatogenesis.

Xiao X, Mruk DD, Wong CK, Cheng CY.

Physiology (Bethesda). 2014 Jul;29(4):286-98. doi: 10.1152/physiol.00001.2014. Review.

34.

N-wasp is required for structural integrity of the blood-testis barrier.

Xiao X, Mruk DD, Tang EI, Massarwa R, Mok KW, Li N, Wong CK, Lee WM, Snapper SB, Shilo BZ, Schejter ED, Cheng CY.

PLoS Genet. 2014 Jun 26;10(6):e1004447. doi: 10.1371/journal.pgen.1004447. eCollection 2014 Jun.

35.

Actin binding proteins, spermatid transport and spermiation.

Qian X, Mruk DD, Cheng YH, Tang EI, Han D, Lee WM, Wong EW, Cheng CY.

Semin Cell Dev Biol. 2014 Jun;30:75-85. doi: 10.1016/j.semcdb.2014.04.018. Epub 2014 Apr 13. Review.

36.

Role of non-receptor protein tyrosine kinases in spermatid transport during spermatogenesis.

Wan HT, Mruk DD, Tang EI, Xiao X, Cheng YH, Wong EW, Wong CK, Cheng CY.

Semin Cell Dev Biol. 2014 Jun;30:65-74. doi: 10.1016/j.semcdb.2014.04.013. Epub 2014 Apr 12. Review.

37.

Focal adhesion kinase and actin regulatory/binding proteins that modulate F-actin organization at the tissue barrier: Lesson from the testis.

Cheng CY, Lie PP, Wong EW, Mruk DD.

Tissue Barriers. 2013 Apr 1;1(2):e24252. doi: 10.4161/tisb.24252.

38.

New insights into FAK function and regulation during spermatogenesis.

Gungor-Ordueri NE, Mruk DD, Wan HT, Wong EW, Celik-Ozenci C, Lie PP, Cheng CY.

Histol Histopathol. 2014 Aug;29(8):977-89. doi: 10.14670/HH-29.977. Epub 2014 Feb 27. Review.

39.

Environmental toxicants perturb human Sertoli cell adhesive function via changes in F-actin organization mediated by actin regulatory proteins.

Xiao X, Mruk DD, Tang EI, Wong CK, Lee WM, John CM, Turek PJ, Silvestrini B, Cheng CY.

Hum Reprod. 2014 Jun;29(6):1279-91. doi: 10.1093/humrep/deu011. Epub 2014 Feb 13.

40.

Sertolin mediates blood-testis barrier restructuring.

Li MW, Cheng CY, Mruk DD.

Endocrinology. 2014 Apr;155(4):1520-31. doi: 10.1210/en.2013-1850. Epub 2014 Jan 27.

41.

Why do we need male contraceptives?

Cheng CY, Mruk DD.

Spermatogenesis. 2013 Jul 1;3(3):e25888. Epub 2013 Jul 25.

42.

Focal adhesion kinase is a regulator of F-actin dynamics: New insights from studies in the testis.

Li SY, Mruk DD, Cheng CY.

Spermatogenesis. 2013 Jul 1;3(3):e25385. Epub 2013 Jun 21. Review.

43.

Cytokines, polarity proteins, and endosomal protein trafficking and signaling-the sertoli cell blood-testis barrier system in vitro as a study model.

Xiao X, Wong EW, Lie PP, Mruk DD, Wong CK, Cheng CY.

Methods Enzymol. 2014;534:181-94. doi: 10.1016/B978-0-12-397926-1.00010-X.

44.

Perfluorooctanesulfonate (PFOS) perturbs male rat Sertoli cell blood-testis barrier function by affecting F-actin organization via p-FAK-Tyr(407): an in vitro study.

Wan HT, Mruk DD, Wong CK, Cheng CY.

Endocrinology. 2014 Jan;155(1):249-62. doi: 10.1210/en.2013-1657. Epub 2013 Dec 4.

45.

Intercellular adhesion molecule 1: recent findings and new concepts involved in mammalian spermatogenesis.

Mruk DD, Xiao X, Lydka M, Li MW, Bilinska B, Cheng CY.

Semin Cell Dev Biol. 2014 May;29:43-54. doi: 10.1016/j.semcdb.2013.07.003. Epub 2013 Aug 11. Review.

46.

Adjudin disrupts spermatogenesis by targeting drug transporters: Lesson from the breast cancer resistance protein (BCRP).

Qian X, Cheng YH, Jenardhanan P, Mruk DD, Mathur PP, Xia W, Silvestrini B, Cheng CY.

Spermatogenesis. 2013 Apr 1;3(2):e24993.

47.

RAI14 (retinoic acid induced protein 14) is an F-actin regulator: Lesson from the testis.

Qian X, Mruk DD, Cheng YH, Cheng CY.

Spermatogenesis. 2013 Apr 1;3(2):e24824.

48.

p-FAK-Tyr(397) regulates spermatid adhesion in the rat testis via its effects on F-actin organization at the ectoplasmic specialization.

Wan HT, Mruk DD, Li SY, Mok KW, Lee WM, Wong CK, Cheng CY.

Am J Physiol Endocrinol Metab. 2013 Sep 15;305(6):E687-99. doi: 10.1152/ajpendo.00254.2013. Epub 2013 Jul 23.

49.

Actin cross-linking protein palladin and spermatogenesis.

Qian X, Mruk DD, Cheng YH, Cheng CY.

Spermatogenesis. 2013 Jan 1;3(1):e23473.

50.

Breast cancer resistance protein (Bcrp) and the testis--an unexpected turn of events.

Qian X, Cheng YH, Mruk DD, Cheng CY.

Asian J Androl. 2013 Jul;15(4):455-60. doi: 10.1038/aja.2013.24. Epub 2013 May 13. Review.

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