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Items: 1 to 50 of 99

1.

An intestinal paracellular pathway biased toward positively-charged macromolecules.

Almansour K, Taverner A, Turner JR, Eggleston IM, Mrsny RJ.

J Control Release. 2018 Sep 6;288:111-125. doi: 10.1016/j.jconrel.2018.09.003. [Epub ahead of print]

PMID:
30194947
2.

Intestinal P-glycoprotein exports endocannabinoids to prevent inflammation and maintain homeostasis.

Szabady RL, Louissaint C, Lubben A, Xie B, Reeksting S, Tuohy C, Demma Z, Foley SE, Faherty CS, Llanos-Chea A, Olive AJ, Mrsny RJ, McCormick BA.

J Clin Invest. 2018 Aug 31;128(9):4044-4056. doi: 10.1172/JCI96817. Epub 2018 Aug 13.

3.

Transporters MRP1 and MRP2 Regulate Opposing Inflammatory Signals To Control Transepithelial Neutrophil Migration during Streptococcus pneumoniae Lung Infection.

Zukauskas A, Mrsny RJ, Cortés Barrantes P, Turner JR, Leong JM, McCormick BA.

mSphere. 2018 Jul 5;3(4). pii: e00303-18. doi: 10.1128/mSphere.00303-18.

4.

Mucosal absorption of therapeutic peptides by harnessing the endogenous sorting of glycosphingolipids.

Garcia-Castillo MD, Chinnapen DJ, Te Welscher YM, Gonzalez RJ, Softic S, Pacheco M, Mrsny RJ, Kahn CR, von Andrian UH, Lau J, Pentelute BL, Lencer WI.

Elife. 2018 May 31;7. pii: e34469. doi: 10.7554/eLife.34469.

5.

Mechanistic studies of a cell-permeant peptide designed to enhance myosin light chain phosphorylation in polarized intestinal epithelia.

Almansour K, Taverner A, Eggleston IM, Mrsny RJ.

J Control Release. 2018 Jun 10;279:208-219. doi: 10.1016/j.jconrel.2018.03.033. Epub 2018 Mar 31.

PMID:
29614254
6.

In vitro model for predicting bioavailability of subcutaneously injected monoclonal antibodies.

Bown HK, Bonn C, Yohe S, Yadav DB, Patapoff TW, Daugherty A, Mrsny RJ.

J Control Release. 2018 Mar 10;273:13-20. doi: 10.1016/j.jconrel.2018.01.015. Epub 2018 Feb 6.

PMID:
29355621
7.

Insights and Lessons from a Scientific Conference on Non-Invasive Delivery of Macromolecules.

Savla R, Mrsny RJ, Park K, Aubert I, Stamoran C.

Pharm Res. 2017 Jun;34(6):1149-1151. doi: 10.1007/s11095-017-2156-9. Epub 2017 Apr 6.

PMID:
28386634
8.

Introduction for the special issue on recent advances in drug delivery across tissue barriers.

Mrsny RJ, Brayden DJ.

Tissue Barriers. 2016 Jun 7;4(2):e1187981. doi: 10.1080/21688370.2016.1187981. eCollection 2016 Apr-Jun.

9.

Intestinal permeation enhancers for oral peptide delivery.

Maher S, Mrsny RJ, Brayden DJ.

Adv Drug Deliv Rev. 2016 Nov 15;106(Pt B):277-319. doi: 10.1016/j.addr.2016.06.005. Epub 2016 Jun 16. Review.

PMID:
27320643
10.

Converting Skin Fibroblasts into Hepatic-like Cells by Transient Programming.

Zhu XQ, Pan XH, Yao L, Li W, Cui J, Wang G, Mrsny RJ, Hoffman AR, Hu JF.

J Cell Biochem. 2016 Mar;117(3):589-98. doi: 10.1002/jcb.25355. Epub 2015 Sep 29.

PMID:
26312781
11.

A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components.

Kinnunen HM, Sharma V, Contreras-Rojas LR, Yu Y, Alleman C, Sreedhara A, Fischer S, Khawli L, Yohe ST, Bumbaca D, Patapoff TW, Daugherty AL, Mrsny RJ.

J Control Release. 2015 Sep 28;214:94-102. doi: 10.1016/j.jconrel.2015.07.016. Epub 2015 Jul 22.

PMID:
26210441
12.

Enhanced paracellular transport of insulin can be achieved via transient induction of myosin light chain phosphorylation.

Taverner A, Dondi R, Almansour K, Laurent F, Owens SE, Eggleston IM, Fotaki N, Mrsny RJ.

J Control Release. 2015 Jul 28;210:189-97. doi: 10.1016/j.jconrel.2015.05.270. Epub 2015 May 14.

13.

Hematopoietic recovery of acute radiation syndrome by human superoxide dismutase-expressing umbilical cord mesenchymal stromal cells.

Gan J, Meng F, Zhou X, Li C, He Y, Zeng X, Jiang X, Liu J, Zeng G, Tang Y, Liu M, Mrsny RJ, Hu X, Hu J, Li T.

Cytotherapy. 2015 Apr;17(4):403-17. doi: 10.1016/j.jcyt.2014.11.011. Epub 2015 Jan 21.

PMID:
25618561
14.

Human umbilical cord mesenchymal stromal cells rescue mice from acetaminophen-induced acute liver failure.

Liu Z, Meng F, Li C, Zhou X, Zeng X, He Y, Mrsny RJ, Liu M, Hu X, Hu JF, Li T.

Cytotherapy. 2014 Sep;16(9):1207-19. doi: 10.1016/j.jcyt.2014.05.018.

PMID:
25108650
15.

Cancer stem cell marker Musashi-1 rs2522137 genotype is associated with an increased risk of lung cancer.

Wang X, Hu JF, Tan Y, Cui J, Wang G, Mrsny RJ, Li W.

PLoS One. 2014 May 2;9(5):e95915. doi: 10.1371/journal.pone.0095915. eCollection 2014.

16.

Improving the outcomes of biopharmaceutical delivery via the subcutaneous route by understanding the chemical, physical and physiological properties of the subcutaneous injection site.

Kinnunen HM, Mrsny RJ.

J Control Release. 2014 May 28;182:22-32. doi: 10.1016/j.jconrel.2014.03.011. Epub 2014 Mar 12. Review.

PMID:
24631859
17.

The oxido-reductase enzyme glutathione peroxidase 4 (GPX4) governs Salmonella Typhimurium-induced neutrophil transepithelial migration.

Agbor TA, Demma Z, Mrsny RJ, Castillo A, Boll EJ, McCormick BA.

Cell Microbiol. 2014 Sep;16(9):1339-53. doi: 10.1111/cmi.12290. Epub 2014 May 5.

18.

Unsaturated glycoceramides as molecular carriers for mucosal drug delivery of GLP-1.

te Welscher YM, Chinnapen DJ, Kaoutzani L, Mrsny RJ, Lencer WI.

J Control Release. 2014 Feb 10;175:72-8. doi: 10.1016/j.jconrel.2013.12.013. Epub 2013 Dec 23.

19.

Cell penetrating peptides fail to induce an innate immune response in epithelial cells in vitro: implications for continued therapeutic use.

Carter E, Lau CY, Tosh D, Ward SG, Mrsny RJ.

Eur J Pharm Biopharm. 2013 Sep;85(1):12-9. doi: 10.1016/j.ejpb.2013.03.024.

PMID:
23958314
20.

Intrachromosomal looping is required for activation of endogenous pluripotency genes during reprogramming.

Zhang H, Jiao W, Sun L, Fan J, Chen M, Wang H, Xu X, Shen A, Li T, Niu B, Ge S, Li W, Cui J, Wang G, Sun J, Fan X, Hu X, Mrsny RJ, Hoffman AR, Hu JF.

Cell Stem Cell. 2013 Jul 3;13(1):30-5. doi: 10.1016/j.stem.2013.05.012. Epub 2013 Jun 6.

21.

Oral peptide delivery: prioritizing the leading technologies.

Brayden DJ, Mrsny RJ.

Ther Deliv. 2011 Dec;2(12):1567-73. No abstract available.

PMID:
22833982
22.

A strategy to improve selectivity and targeting to epithelial-derived cancer cells.

Liu K, Hearne K, Mrsny A, Staka C, Mrsny RJ.

J Control Release. 2012 Dec 10;164(2):205-12. doi: 10.1016/j.jconrel.2012.04.039. Epub 2012 May 2.

PMID:
22579643
23.

Oral drug delivery research in Europe.

Mrsny RJ.

J Control Release. 2012 Jul 20;161(2):247-53. doi: 10.1016/j.jconrel.2012.01.017. Epub 2012 Feb 11. Review.

PMID:
22342473
24.

Sustained release formulations of rhVEGF₁₆₅ produce a durable response in a murine model of peripheral angiogenesis.

Daugherty AL, Rangell LK, Eckert R, Zavala-Solorio J, Peale F, Mrsny RJ.

Eur J Pharm Biopharm. 2011 Jun;78(2):289-97. doi: 10.1016/j.ejpb.2011.03.011. Epub 2011 Mar 21.

PMID:
21426936
25.

Local tissue distribution and cellular fate of vascular endothelial growth factor (VEGF) following intramuscular injection.

Daugherty AL, Mrsny RJ.

J Drug Target. 2010 Jan;18(1):27-35. doi: 10.3109/10611860903134317.

PMID:
19624285
26.

Lessons from nature: "Pathogen-Mimetic" systems for mucosal nano-medicines.

Mrsny RJ.

Adv Drug Deliv Rev. 2009 Feb 27;61(2):172-92. doi: 10.1016/j.addr.2008.09.009. Epub 2008 Dec 24. Review.

PMID:
19146895
27.

Multidrug resistance-associated transporter 2 regulates mucosal inflammation by facilitating the synthesis of hepoxilin A3.

Pazos M, Siccardi D, Mumy KL, Bien JD, Louie S, Shi HN, Gronert K, Mrsny RJ, McCormick BA.

J Immunol. 2008 Dec 1;181(11):8044-52.

28.

A key claudin extracellular loop domain is critical for epithelial barrier integrity.

Mrsny RJ, Brown GT, Gerner-Smidt K, Buret AG, Meddings JB, Quan C, Koval M, Nusrat A.

Am J Pathol. 2008 Apr;172(4):905-15. doi: 10.2353/ajpath.2008.070698. Epub 2008 Mar 18.

29.

Myosin light chain kinase inhibition: correction of increased intestinal epithelial permeability in vitro.

Feighery LM, Cochrane SW, Quinn T, Baird AW, O'Toole D, Owens SE, O'Donoghue D, Mrsny RJ, Brayden DJ.

Pharm Res. 2008 Jun;25(6):1377-86.

PMID:
18163202
30.

Raf 1 represses expression of the tight junction protein occludin via activation of the zinc-finger transcription factor slug.

Wang Z, Wade P, Mandell KJ, Akyildiz A, Parkos CA, Mrsny RJ, Nusrat A.

Oncogene. 2007 Feb 22;26(8):1222-30. Epub 2006 Aug 21.

PMID:
16924233
31.

Formulation and delivery issues for monoclonal antibody therapeutics.

Daugherty AL, Mrsny RJ.

Adv Drug Deliv Rev. 2006 Aug 7;58(5-6):686-706. Epub 2006 May 22. Review.

PMID:
16839640
32.

Intranasal immunization strategy to impede pilin-mediated binding of Pseudomonas aeruginosa to airway epithelial cells.

Hsieh JC, Tham DM, Feng W, Huang F, Embaie S, Liu K, Dean D, Hertle R, Fitzgerald DJ, Mrsny RJ.

Infect Immun. 2005 Nov;73(11):7705-17.

33.

Epithelial myosin light chain kinase-dependent barrier dysfunction mediates T cell activation-induced diarrhea in vivo.

Clayburgh DR, Barrett TA, Tang Y, Meddings JB, Van Eldik LJ, Watterson DM, Clarke LL, Mrsny RJ, Turner JR.

J Clin Invest. 2005 Oct;115(10):2702-15. Epub 2005 Sep 22.

34.

Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane.

Utech M, Ivanov AI, Samarin SN, Bruewer M, Turner JR, Mrsny RJ, Parkos CA, Nusrat A.

Mol Biol Cell. 2005 Oct;16(10):5040-52. Epub 2005 Jul 29.

35.

Modification of epithelial tight junction integrity to enhance transmucosal absorption.

Mrsny RJ.

Crit Rev Ther Drug Carrier Syst. 2005;22(4):331-418. Review.

PMID:
15952935
36.

A strategy to identify stable membrane-permeant peptide inhibitors of myosin light chain kinase.

Owens SE, Graham WV, Siccardi D, Turner JR, Mrsny RJ.

Pharm Res. 2005 May;22(5):703-9. Epub 2005 May 17.

PMID:
15906163
37.

Distinct temporal-spatial roles for rho kinase and myosin light chain kinase in epithelial purse-string wound closure.

Russo JM, Florian P, Shen L, Graham WV, Tretiakova MS, Gitter AH, Mrsny RJ, Turner JR.

Gastroenterology. 2005 Apr;128(4):987-1001.

38.

The second loop of occludin is required for suppression of Raf1-induced tumor growth.

Wang Z, Mandell KJ, Parkos CA, Mrsny RJ, Nusrat A.

Oncogene. 2005 Jun 23;24(27):4412-20.

PMID:
15806147
39.

Multiple protein interactions involving proposed extracellular loop domains of the tight junction protein occludin.

Nusrat A, Brown GT, Tom J, Drake A, Bui TT, Quan C, Mrsny RJ.

Mol Biol Cell. 2005 Apr;16(4):1725-34. Epub 2005 Jan 19.

40.
41.

Polymorphonuclear cell transmigration induced by Pseudomonas aeruginosa requires the eicosanoid hepoxilin A3.

Hurley BP, Siccardi D, Mrsny RJ, McCormick BA.

J Immunol. 2004 Nov 1;173(9):5712-20.

42.

Identification of hepoxilin A3 in inflammatory events: a required role in neutrophil migration across intestinal epithelia.

Mrsny RJ, Gewirtz AT, Siccardi D, Savidge T, Hurley BP, Madara JL, McCormick BA.

Proc Natl Acad Sci U S A. 2004 May 11;101(19):7421-6. Epub 2004 May 3.

43.

Strategies for targeting protein therapeutics to selected tissues and cells.

Mrsny RJ.

Expert Opin Biol Ther. 2004 Jan;4(1):65-73. Review.

PMID:
14680469
44.

Emerging technologies that overcome biological barriers for therapeutic protein delivery.

Daugherty AL, Mrsny RJ.

Expert Opin Biol Ther. 2003 Oct;3(7):1071-81. Review.

PMID:
14519072
45.

Cdc42 and Rac1 regulate late events in Salmonella typhimurium-induced interleukin-8 secretion from polarized epithelial cells.

Hobert ME, Sands KA, Mrsny RJ, Madara JL.

J Biol Chem. 2002 Dec 27;277(52):51025-32. Epub 2002 Oct 14.

46.

A membrane-permeant peptide that inhibits MLC kinase restores barrier function in in vitro models of intestinal disease.

Zolotarevsky Y, Hecht G, Koutsouris A, Gonzalez DE, Quan C, Tom J, Mrsny RJ, Turner JR.

Gastroenterology. 2002 Jul;123(1):163-72. Erratum in: Gastroenterology 2002 Oct;123(4):1412.

PMID:
12105845
48.

Bacterial toxins as tools for mucosal vaccination.

Mrsny RJ, Daugherty AL, McKee ML, FitzGerald DJ.

Drug Discov Today. 2002 Feb 15;7(4):247-58. Review.

PMID:
11839522
49.

Noninvasive in vivo analysis of human small intestinal paracellular absorption: regulation by Na+-glucose cotransport.

Turner JR, Cohen DE, Mrsny RJ, Madara JL.

Dig Dis Sci. 2000 Nov;45(11):2122-6.

PMID:
11215725
50.

Characterization of huJAM: evidence for involvement in cell-cell contact and tight junction regulation.

Liang TW, DeMarco RA, Mrsny RJ, Gurney A, Gray A, Hooley J, Aaron HL, Huang A, Klassen T, Tumas DB, Fong S.

Am J Physiol Cell Physiol. 2000 Dec;279(6):C1733-43.

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