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Items: 25

1.

2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition.

Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JL, Huryn D, Arkin M, Subramaniam S.

Science. 2016 Feb 19;351(6275):871-5. doi: 10.1126/science.aad7974. Epub 2016 Jan 28.

2.

Structure based drug design of crizotinib (PF-02341066), a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK).

Cui JJ, Tran-Dubé M, Shen H, Nambu M, Kung PP, Pairish M, Jia L, Meng J, Funk L, Botrous I, McTigue M, Grodsky N, Ryan K, Padrique E, Alton G, Timofeevski S, Yamazaki S, Li Q, Zou H, Christensen J, Mroczkowski B, Bender S, Kania RS, Edwards MP.

J Med Chem. 2011 Sep 22;54(18):6342-63. doi: 10.1021/jm2007613. Epub 2011 Aug 18.

PMID:
21812414
3.

Structure-based design of novel human Pin1 inhibitors (I).

Guo C, Hou X, Dong L, Dagostino E, Greasley S, Ferre R, Marakovits J, Johnson MC, Matthews D, Mroczkowski B, Parge H, Vanarsdale T, Popoff I, Piraino J, Margosiak S, Thomson J, Los G, Murray BW.

Bioorg Med Chem Lett. 2009 Oct 1;19(19):5613-6. doi: 10.1016/j.bmcl.2009.08.034. Epub 2009 Aug 13.

PMID:
19729306
4.

Phase 0 clinical trials: conceptions and misconceptions.

Kummar S, Rubinstein L, Kinders R, Parchment RE, Gutierrez ME, Murgo AJ, Ji J, Mroczkowski B, Pickeral OK, Simpson M, Hollingshead M, Yang SX, Helman L, Wiltrout R, Collins J, Tomaszewski JE, Doroshow JH.

Cancer J. 2008 May-Jun;14(3):133-7. doi: 10.1097/PPO.0b013e318172d6f3. Review.

PMID:
18536551
5.

Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma.

Christensen JG, Zou HY, Arango ME, Li Q, Lee JH, McDonnell SR, Yamazaki S, Alton GR, Mroczkowski B, Los G.

Mol Cancer Ther. 2007 Dec;6(12 Pt 1):3314-22.

6.

Structure activity relationships of quinoline-containing c-Met inhibitors.

Kung PP, Funk L, Meng J, Alton G, Padrique E, Mroczkowski B.

Eur J Med Chem. 2008 Jun;43(6):1321-9. Epub 2007 Sep 11.

PMID:
17964000
7.

Identification and characterization of a novel and functional murine Pin1 isoform.

Zhu JX, Dagostino E, Rejto PA, Mroczkowski B, Murray B.

Biochem Biophys Res Commun. 2007 Aug 3;359(3):529-35. Epub 2007 May 25.

PMID:
17548053
8.

An orally available small-molecule inhibitor of c-Met, PF-2341066, exhibits cytoreductive antitumor efficacy through antiproliferative and antiangiogenic mechanisms.

Zou HY, Li Q, Lee JH, Arango ME, McDonnell SR, Yamazaki S, Koudriakova TB, Alton G, Cui JJ, Kung PP, Nambu MD, Los G, Bender SL, Mroczkowski B, Christensen JG.

Cancer Res. 2007 May 1;67(9):4408-17.

9.

Transgenic expression of epidermal growth factor and keratinocyte growth factor in beta-cells results in substantial morphological changes.

Krakowski ML, Kritzik MR, Jones EM, Krahl T, Lee J, Arnush M, Gu D, Mroczkowski B, Sarvetnick N.

J Endocrinol. 1999 Aug;162(2):167-75.

PMID:
10425454
10.

Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis.

McTigue MA, Wickersham JA, Pinko C, Showalter RE, Parast CV, Tempczyk-Russell A, Gehring MR, Mroczkowski B, Kan CC, Villafranca JE, Appelt K.

Structure. 1999 Mar 15;7(3):319-30.

11.

Characterization and kinetic mechanism of catalytic domain of human vascular endothelial growth factor receptor-2 tyrosine kinase (VEGFR2 TK), a key enzyme in angiogenesis.

Parast CV, Mroczkowski B, Pinko C, Misialek S, Khambatta G, Appelt K.

Biochemistry. 1998 Nov 24;37(47):16788-801.

PMID:
9843450
12.

Growth factors in the regenerating pancreas of gamma-interferon transgenic mice.

Arnush M, Gu D, Baugh C, Sawyer SP, Mroczkowski B, Krahl T, Sarvetnick N.

Lab Invest. 1996 Jun;74(6):985-90.

PMID:
8667616
13.

Secretion of thermostable DNA polymerase using a novel baculovirus vector.

Mroczkowski BS, Huvar A, Lernhardt W, Misono K, Nielson K, Scott B.

J Biol Chem. 1994 May 6;269(18):13522-8.

14.

Preparation and characterization of a bifunctionally spin-labeled mutant of murine epidermal growth factor for saturation-transfer electron paramagnetic resonance studies of the growth factor/receptor complex.

Rousseau DL Jr, Guyer CA, Beth AH, Papayannopoulos IA, Wang B, Wu R, Mroczkowski B, Staros JV.

Biochemistry. 1993 Aug 10;32(31):7893-903.

PMID:
8394119
15.
16.

Expression of epidermal growth factor precursor cDNA in animal cells.

Mroczkowski B.

Methods Enzymol. 1991;198:175-85.

PMID:
1649948
17.

Recombinant human epidermal growth factor precursor is a glycosylated membrane protein with biological activity.

Mroczkowski B, Reich M, Chen K, Bell GI, Cohen S.

Mol Cell Biol. 1989 Jul;9(7):2771-8.

18.

Differentiation of HL-60 cells is associated with an increase in the 35-kDa protein lipocortin I.

William F, Mroczkowski B, Cohen S, Kraft AS.

J Cell Physiol. 1988 Dec;137(3):402-10.

PMID:
2973467
19.

Epidermal growth factor.

Mroczkowski B, Carpenter G.

Prog Clin Biol Res. 1988;262:207-16. No abstract available.

PMID:
3259699
20.

Expression of human epidermal growth factor precursor cDNA in transfected mouse NIH 3T3 cells.

Mroczkowski B, Reich M, Whittaker J, Bell GI, Cohen S.

Proc Natl Acad Sci U S A. 1988 Jan;85(1):126-30.

21.

A calcium-dependent 35-kilodalton substrate for epidermal growth factor receptor/kinase isolated from normal tissue.

De BK, Misono KS, Lukas TJ, Mroczkowski B, Cohen S.

J Biol Chem. 1986 Oct 15;261(29):13784-92.

22.

ATP-stimulated interaction between epidermal growth factor receptor and supercoiled DNA.

Mroczkowski B, Mosig G, Cohen S.

Nature. 1984 May 17-23;309(5965):270-3.

PMID:
6325948
23.

Characterization of translational-control ribonucleic acid isolated from embryonic chick muscle.

McCarthy TL, Siegel E, Mroczkowski B, Heywood SM.

Biochemistry. 1983 Feb 15;22(4):935-41.

PMID:
6188483
24.

The role of small cytoplasmic RNAs in muscle differentiation.

McCarthy TL, Mroczkowski B, Heywood SM.

Prog Clin Biol Res. 1982;110 Pt B:409-16. No abstract available.

PMID:
6188177
25.

Uptake and utilization of mRNA by myogenic cells in culture.

Mroczkowski B, Dym HP, Siegel EJ, Heywood SM.

J Cell Biol. 1980 Oct;87(1):65-71.

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