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1994 1
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2002 4
2003 8
2004 6
2005 6
2006 8
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2008 7
2009 4
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140 results

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Page 1
A de novo missense mutation in MPP2 confers an increased risk of Vogt-Koyanagi-Harada disease as shown by trio-based whole-exome sequencing.
Liu X, Meng J, Liao X, Liu Y, Zhou Q, Xu Z, Yin S, Cao Q, Su G, He S, Li W, Wang X, Wang G, Li D, Yang P, Hou S. Liu X, et al. Cell Mol Immunol. 2023 Nov;20(11):1379-1392. doi: 10.1038/s41423-023-01088-9. Epub 2023 Oct 12. Cell Mol Immunol. 2023. PMID: 37828081 Free PMC article.
A total of 15 de novo mutations in VKH patients were identified, with one of the most important being the membrane palmitoylated protein 2 (MPP2) p.K315N (MPP2-N315) mutation. The MPP2-N315 mutation was highly deleterious according to bioinformatic prediction …
A total of 15 de novo mutations in VKH patients were identified, with one of the most important being the membrane palmitoylated protein 2 ( …
Epigenetic programming defines haematopoietic stem cell fate restriction.
Meng Y, Carrelha J, Drissen R, Ren X, Zhang B, Gambardella A, Valletta S, Thongjuea S, Jacobsen SE, Nerlov C. Meng Y, et al. Nat Cell Biol. 2023 Jun;25(6):812-822. doi: 10.1038/s41556-023-01137-5. Epub 2023 May 1. Nat Cell Biol. 2023. PMID: 37127714
In contrast, platelet-biased HSCs show elevated levels of epigenetic platelet-lineage priming and give rise to MPP2 progenitors with molecular platelet bias. These MPP2 progenitors generate platelets with faster kinetics and through a more direct cellular pathway co …
In contrast, platelet-biased HSCs show elevated levels of epigenetic platelet-lineage priming and give rise to MPP2 progenitors with …
MPP2 is a postsynaptic MAGUK scaffold protein that links SynCAM1 cell adhesion molecules to core components of the postsynaptic density.
Rademacher N, Schmerl B, Lardong JA, Wahl MC, Shoichet SA. Rademacher N, et al. Sci Rep. 2016 Oct 19;6:35283. doi: 10.1038/srep35283. Sci Rep. 2016. PMID: 27756895 Free PMC article.
MPP2 also colocalises with the synaptic adhesion molecule SynCAM1. We demonstrate that the SynCAM1 C-terminus interacts directly with the MPP2 PDZ domain and that MPP2 does not interact in this manner with other highly abundant postsynaptic transmembrane prot …
MPP2 also colocalises with the synaptic adhesion molecule SynCAM1. We demonstrate that the SynCAM1 C-terminus interacts directly with …
The synaptic scaffold protein MPP2 interacts with GABAA receptors at the periphery of the postsynaptic density of glutamatergic synapses.
Schmerl B, Gimber N, Kuropka B, Stumpf A, Rentsch J, Kunde SA, von Sivers J, Ewers H, Schmitz D, Freund C, Schmoranzer J, Rademacher N, Shoichet SA. Schmerl B, et al. PLoS Biol. 2022 Mar 21;20(3):e3001503. doi: 10.1371/journal.pbio.3001503. eCollection 2022 Mar. PLoS Biol. 2022. PMID: 35312684 Free PMC article.
In order to explore MPP2-associated protein complexes, we used a quantitative comparative proteomics approach and identified multiple gamma-aminobutyric acid (GABA)A receptor subunits among novel synaptic MPP2 interactors. In line with a scaffold function for MPP …
In order to explore MPP2-associated protein complexes, we used a quantitative comparative proteomics approach and identified multiple …
Single-cell and WGCNA uncover a prognostic model and potential oncogenes in colorectal cancer.
Di Z, Zhou S, Xu G, Ren L, Li C, Ding Z, Huang K, Liang L, Yuan Y. Di Z, et al. Biol Proced Online. 2022 Sep 19;24(1):13. doi: 10.1186/s12575-022-00175-x. Biol Proced Online. 2022. PMID: 36117173 Free PMC article.
Lasso Cox regression analysis revealed 8 genes (PBXIP1, MPMZ, SCARA3, INA, ILK, MPP2, L1CAM and FLNA), which were chosen to construct a risk model. In the model, the risk score features had the greatest impact on survival prediction, indicating that the 8-gene risk model c …
Lasso Cox regression analysis revealed 8 genes (PBXIP1, MPMZ, SCARA3, INA, ILK, MPP2, L1CAM and FLNA), which were chosen to construct …
The PDZ protein MPP2 interacts with c-Src in epithelial cells.
Baumgartner M, Weiss A, Fritzius T, Heinrich J, Moelling K. Baumgartner M, et al. Exp Cell Res. 2009 Oct 15;315(17):2888-98. doi: 10.1016/j.yexcr.2009.07.028. Epub 2009 Aug 6. Exp Cell Res. 2009. PMID: 19665017
The function of MPP2 has not been established and the functional significance of the MPP2 c-Src interaction is not known. ...MPP2 and c-Src interacted in cells, where c-Src kinase activity promoted increased interaction of c-Src with MPP2. ...
The function of MPP2 has not been established and the functional significance of the MPP2 c-Src interaction is not known. ... …
MPP2 interacts with SK2 to rescue the excitability of glutamatergic neurons in the BLA and facilitate the extinction of conditioned fear in mice.
Peng X, Chen P, Zhang Y, Wu K, Ji N, Gao J, Wang H, Zhang YM, Xu T, Hua R. Peng X, et al. CNS Neurosci Ther. 2024 Jan;30(1):e14362. doi: 10.1111/cns.14362. Epub 2023 Jul 19. CNS Neurosci Ther. 2024. PMID: 37469037 Free PMC article.
The excitability of glutamatergic neurons in the BLA correlates with fear memory, and the afterhyperpolarization current (I(AHP) ) mediated by small-conductance calcium-activated potassium channel subtype 2 (SK2) dominates the excitability of glutamatergicneurons. This study aime …
The excitability of glutamatergic neurons in the BLA correlates with fear memory, and the afterhyperpolarization current (I(AHP) ) mediated …
Involvement of membrane palmitoylated protein 2 (MPP2) in the synaptic molecular complex at the mouse cerebellar glomerulus.
Yamada T, Saitoh Y, Kametani K, Kamijo A, Sakamoto T, Terada N. Yamada T, et al. Histochem Cell Biol. 2022 Nov;158(5):497-511. doi: 10.1007/s00418-022-02137-6. Epub 2022 Jul 19. Histochem Cell Biol. 2022. PMID: 35854144
Immunostaining for MPP2 was observed at cerebellar glomeruli (CG) in the granular layer after postnatal day 14. ...An immunoprecipitation analysis revealed that MPP2 formed a molecular complex with CADM1, CASK, M-cadherin, and Lin7. ...
Immunostaining for MPP2 was observed at cerebellar glomeruli (CG) in the granular layer after postnatal day 14. ...An immunoprecipita …
Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.
Pietras EM, Reynaud D, Kang YA, Carlin D, Calero-Nieto FJ, Leavitt AD, Stuart JM, Göttgens B, Passegué E. Pietras EM, et al. Cell Stem Cell. 2015 Jul 2;17(1):35-46. doi: 10.1016/j.stem.2015.05.003. Epub 2015 Jun 18. Cell Stem Cell. 2015. PMID: 26095048 Free PMC article.
Despite great advances in understanding the mechanisms underlying blood production, lineage specification at the level of multipotent progenitors (MPPs) remains poorly understood. Here, we show that MPP2 and MPP3 are distinct myeloid-biased MPP subsets that work together w …
Despite great advances in understanding the mechanisms underlying blood production, lineage specification at the level of multipotent progen …
Mouse multipotent progenitor 5 cells are located at the interphase between hematopoietic stem and progenitor cells.
Sommerkamp P, Romero-Mulero MC, Narr A, Ladel L, Hustin L, Schönberger K, Renders S, Altamura S, Zeisberger P, Jäcklein K, Klimmeck D, Rodriguez-Fraticelli A, Camargo FD, Perié L, Trumpp A, Cabezas-Wallscheid N. Sommerkamp P, et al. Blood. 2021 Jun 10;137(23):3218-3224. doi: 10.1182/blood.2020007876. Blood. 2021. PMID: 33754628 Free PMC article.
In agreement with functional reconstitution activity, MPP5 is located immediately downstream of HSCs but upstream of the more committed MPP2-4. This study provides a comprehensive analysis of the LSK compartment, focusing on the functional and molecular characteristics of …
In agreement with functional reconstitution activity, MPP5 is located immediately downstream of HSCs but upstream of the more committed M …
140 results