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Items: 1 to 50 of 103

1.

Mutations of α1F45 residue of GABAA receptor Loop G reveal its involvement in agonist binding and channel opening/closing transitions.

Brodzki M, Michałowski MA, Gos M, Mozrzymas JW.

Biochem Pharmacol. 2020 Mar 16:113917. doi: 10.1016/j.bcp.2020.113917. [Epub ahead of print]

2.

GABAA Receptor β2E155 Residue Located at the Agonist-Binding Site Is Involved in the Receptor Gating.

Jatczak-Śliwa M, Kisiel M, Czyzewska MM, Brodzki M, Mozrzymas JW.

Front Cell Neurosci. 2020 Feb 11;14:2. doi: 10.3389/fncel.2020.00002. eCollection 2020.

3.

The C loop at the orthosteric binding site is critically involved in GABAA receptor gating.

Terejko K, Kaczor PT, Michałowski MA, Dąbrowska A, Mozrzymas JW.

Neuropharmacology. 2020 Apr;166:107903. doi: 10.1016/j.neuropharm.2019.107903. Epub 2019 Dec 3.

4.

Matrix metalloproteinase-3 in brain physiology and neurodegeneration.

Lech AM, Wiera G, Mozrzymas JW.

Adv Clin Exp Med. 2019 Dec;28(12):1717-1722. doi: 10.17219/acem/110319. Review.

5.

Protons modulate gating of recombinant α1β2γ2 GABAA receptor by affecting desensitization and opening transitions.

Kisiel M, Jatczak-Śliwa M, Mozrzymas JW.

Neuropharmacology. 2019 Mar 1;146:300-315. doi: 10.1016/j.neuropharm.2018.10.016. Epub 2018 Oct 13.

PMID:
30326242
6.

MMP‑3 deficiency does not influence the length and number of CA1 dendrites of hippocampus of adult mice.

Nowak D, Groef L, Moons L, Mozrzymas JW.

Acta Neurobiol Exp (Wars). 2018;78(3):281-286.

7.

Distinct Modulation of Spontaneous and GABA-Evoked Gating by Flurazepam Shapes Cross-Talk Between Agonist-Free and Liganded GABAA Receptor Activity.

Jatczak-Śliwa M, Terejko K, Brodzki M, Michałowski MA, Czyzewska MM, Nowicka JM, Andrzejczak A, Srinivasan R, Mozrzymas JW.

Front Cell Neurosci. 2018 Aug 28;12:237. doi: 10.3389/fncel.2018.00237. eCollection 2018.

8.

Synaptic Potentiation at Basal and Apical Dendrites of Hippocampal Pyramidal Neurons Involves Activation of a Distinct Set of Extracellular and Intracellular Molecular Cues.

Brzdak P, Wójcicka O, Zareba-Koziol M, Minge D, Henneberger C, Wlodarczyk J, Mozrzymas JW, Wójtowicz T.

Cereb Cortex. 2019 Jan 1;29(1):283-304. doi: 10.1093/cercor/bhx324.

PMID:
29228131
9.

Spontaneous activity, singly bound states and the impact of alpha1Phe64 mutation on GABAAR gating in the novel kinetic model based on the single-channel recordings.

Kisiel M, Jatczak M, Brodzki M, Mozrzymas JW.

Neuropharmacology. 2018 Mar 15;131:453-474. doi: 10.1016/j.neuropharm.2017.11.030. Epub 2017 Nov 21.

PMID:
29162430
10.

Multifaceted Roles of Metzincins in CNS Physiology and Pathology: From Synaptic Plasticity and Cognition to Neurodegenerative Disorders.

Brzdak P, Nowak D, Wiera G, Mozrzymas JW.

Front Cell Neurosci. 2017 Jun 30;11:178. doi: 10.3389/fncel.2017.00178. eCollection 2017. Review.

11.

Key Metabolic Enzymes Underlying Astrocytic Upregulation of GABAergic Plasticity.

Kaczor PT, Mozrzymas JW.

Front Cell Neurosci. 2017 May 16;11:144. doi: 10.3389/fncel.2017.00144. eCollection 2017.

12.

Binding site opening by loop C shift and chloride ion-pore interaction in the GABAA receptor model.

Michałowski MA, Kraszewski S, Mozrzymas JW.

Phys Chem Chem Phys. 2017 May 31;19(21):13664-13678. doi: 10.1039/c7cp00582b.

PMID:
28429004
13.

Mechanisms of NMDA Receptor- and Voltage-Gated L-Type Calcium Channel-Dependent Hippocampal LTP Critically Rely on Proteolysis That Is Mediated by Distinct Metalloproteinases.

Wiera G, Nowak D, van Hove I, Dziegiel P, Moons L, Mozrzymas JW.

J Neurosci. 2017 Feb 1;37(5):1240-1256. doi: 10.1523/JNEUROSCI.2170-16.2016. Epub 2017 Jan 9.

14.

CD44: a novel synaptic cell adhesion molecule regulating structural and functional plasticity of dendritic spines.

Roszkowska M, Skupien A, Wójtowicz T, Konopka A, Gorlewicz A, Kisiel M, Bekisz M, Ruszczycki B, Dolezyczek H, Rejmak E, Knapska E, Mozrzymas JW, Wlodarczyk J, Wilczynski GM, Dzwonek J.

Mol Biol Cell. 2016 Dec 15;27(25):4055-4066. Epub 2016 Oct 19.

15.

Spike Timing-Dependent Plasticity in the Mouse Barrel Cortex Is Strongly Modulated by Sensory Learning and Depends on Activity of Matrix Metalloproteinase 9.

Lebida K, Mozrzymas JW.

Mol Neurobiol. 2017 Nov;54(9):6723-6736. doi: 10.1007/s12035-016-0174-y. Epub 2016 Oct 15.

16.

Matrix Metalloprotease 3 Activity Supports Hippocampal EPSP-to-Spike Plasticity Following Patterned Neuronal Activity via the Regulation of NMDAR Function and Calcium Flux.

Brzdąk P, Włodarczyk J, Mozrzymas JW, Wójtowicz T.

Mol Neurobiol. 2017 Jan;54(1):804-816. doi: 10.1007/s12035-016-9970-7. Epub 2016 Jun 28.

17.

Comparison of kinetic and pharmacological profiles of recombinant α1γ2L and α1β2γ2L GABAA receptors - A clue to the role of intersubunit interactions.

Brodzki M, Rutkowski R, Jatczak M, Kisiel M, Czyzewska MM, Mozrzymas JW.

Eur J Pharmacol. 2016 Aug 5;784:81-9. doi: 10.1016/j.ejphar.2016.05.015. Epub 2016 May 11.

PMID:
27179992
18.

Editorial: Neuroplasticity and Extracellular Proteolysis.

Mozrzymas JW, Kaczmarek L.

Front Cell Neurosci. 2016 Mar 11;10:59. doi: 10.3389/fncel.2016.00059. eCollection 2016. No abstract available.

19.

Matrix metalloprotease activity shapes the magnitude of EPSPs and spike plasticity within the hippocampal CA3 network.

Wójtowicz T, Mozrzymas JW.

Hippocampus. 2016 Mar;26(3):414. doi: 10.1002/hipo.22563. Epub 2016 Jan 18. No abstract available.

PMID:
26891267
20.

Extracellular proteolysis in structural and functional plasticity of mossy fiber synapses in hippocampus.

Wiera G, Mozrzymas JW.

Front Cell Neurosci. 2015 Nov 4;9:427. doi: 10.3389/fncel.2015.00427. eCollection 2015. Review.

21.

Diverse impact of acute and long-term extracellular proteolytic activity on plasticity of neuronal excitability.

Wójtowicz T, Brzdąk P, Mozrzymas JW.

Front Cell Neurosci. 2015 Aug 10;9:313. doi: 10.3389/fncel.2015.00313. eCollection 2015. Review.

22.

Involvement of cellular metabolism in age-related LTP modifications in rat hippocampal slices.

Drulis-Fajdasz D, Wójtowicz T, Wawrzyniak M, Wlodarczyk J, Mozrzymas JW, Rakus D.

Oncotarget. 2015 Jun 10;6(16):14065-81.

23.

Neuron-astrocyte interaction enhance GABAergic synaptic transmission in a manner dependent on key metabolic enzymes.

Kaczor P, Rakus D, Mozrzymas JW.

Front Cell Neurosci. 2015 Apr 9;9:120. doi: 10.3389/fncel.2015.00120. eCollection 2015.

24.

Impact of matrix metalloproteinase-9 overexpression on synaptic excitatory transmission and its plasticity in rat CA3-CA1 hippocampal pathway.

Wiera G, Szczot M, Wojtowicz T, Lebida K, Koza P, Mozrzymas JW.

J Physiol Pharmacol. 2015 Apr;66(2):309-15.

25.

Diverse impact of neuronal activity at θ frequency on hippocampal long-term plasticity.

Wójtowicz T, Mozrzymas JW.

J Neurosci Res. 2015 Sep;93(9):1330-44. doi: 10.1002/jnr.23581. Epub 2015 Mar 18.

PMID:
25789967
26.

Dietary acetylenic oxylipin falcarinol differentially modulates GABAA receptors.

Czyzewska MM, Chrobok L, Kania A, Jatczak M, Pollastro F, Appendino G, Mozrzymas JW.

J Nat Prod. 2014 Dec 26;77(12):2671-7. doi: 10.1021/np500615j. Epub 2014 Dec 4.

PMID:
25474700
27.

α1F64 Residue at GABA(A) receptor binding site is involved in gating by influencing the receptor flipping transitions.

Szczot M, Kisiel M, Czyzewska MM, Mozrzymas JW.

J Neurosci. 2014 Feb 26;34(9):3193-209. doi: 10.1523/JNEUROSCI.2533-13.2014. Erratum in: J Neurosci. 2016 Feb 10;36(6):2074.

28.

Matrix metalloprotease activity shapes the magnitude of EPSPs and spike plasticity within the hippocampal CA3 network.

Wójtowicz T, Mozrzymas JW.

Hippocampus. 2014 Feb;24(2):135-53. doi: 10.1002/hipo.22205. Epub 2013 Oct 15. Erratum in: Hippocampus. 2016 Mar;26(3):414.

PMID:
24115249
29.

Maintenance of long-term potentiation in hippocampal mossy fiber-CA3 pathway requires fine-tuned MMP-9 proteolytic activity.

Wiera G, Wozniak G, Bajor M, Kaczmarek L, Mozrzymas JW.

Hippocampus. 2013 Jun;23(6):529-43. doi: 10.1002/hipo.22112. Epub 2013 Apr 5.

PMID:
23418057
30.

Monoterpene α-thujone exerts a differential inhibitory action on GABA(A) receptors implicated in phasic and tonic GABAergic inhibition.

Czyzewska MM, Mozrzymas JW.

Eur J Pharmacol. 2013 Feb 28;702(1-3):38-43. doi: 10.1016/j.ejphar.2013.01.032. Epub 2013 Jan 31.

PMID:
23376563
31.

Long term potentiation affects intracellular metalloproteinases activity in the mossy fiber-CA3 pathway.

Wiera G, Wójtowicz T, Lebida K, Piotrowska A, Drulis-Fajdasz D, Gomułkiewicz A, Gendosz D, Podhorska-Okołów M, Capogna M, Wilczyński G, Dzięgiel P, Kaczmarek L, Mozrzymas JW.

Mol Cell Neurosci. 2012 Jun;50(2):147-59. doi: 10.1016/j.mcn.2012.04.005. Epub 2012 Apr 25. Erratum in: Mol Cell Neurosci. 2013 Jan;52:181-2.

PMID:
22555058
32.

Inhibitory effects of oenanthotoxin analogues on GABAergic currents in cultured rat hippocampal neurons depend on the polyacetylenes' polarity.

Wyrembek P, Negri R, Appendino G, Mozrzymas JW.

Eur J Pharmacol. 2012 May 15;683(1-3):35-42. doi: 10.1016/j.ejphar.2012.03.005. Epub 2012 Mar 15.

PMID:
22445880
33.

Falcarindiol allosterically modulates GABAergic currents in cultured rat hippocampal neurons.

Wyrembek P, Negri R, Kaczor P, Czyżewska M, Appendino G, Mozrzymas JW.

J Nat Prod. 2012 Apr 27;75(4):610-6. doi: 10.1021/np2008522. Epub 2012 Mar 20.

PMID:
22432736
34.

Modulation of GABAergic synaptic currents and current responses by α-thujone and dihydroumbellulone.

Szczot M, Czyzewska MM, Appendino G, Mozrzymas JW.

J Nat Prod. 2012 Apr 27;75(4):622-9. doi: 10.1021/np200863q. Epub 2012 Feb 24.

PMID:
22364543
35.

Influence of matrix metalloproteinase MMP-9 on dendritic spine morphology.

Michaluk P, Wawrzyniak M, Alot P, Szczot M, Wyrembek P, Mercik K, Medvedev N, Wilczek E, De Roo M, Zuschratter W, Muller D, Wilczynski GM, Mozrzymas JW, Stewart MG, Kaczmarek L, Wlodarczyk J.

J Cell Sci. 2011 Oct 1;124(Pt 19):3369-80. doi: 10.1242/jcs.090852. Epub 2011 Sep 6.

36.

Impact of synaptic neurotransmitter concentration time course on the kinetics and pharmacological modulation of inhibitory synaptic currents.

Barberis A, Petrini EM, Mozrzymas JW.

Front Cell Neurosci. 2011 Jun 22;5:6. doi: 10.3389/fncel.2011.00006. eCollection 2011.

37.

Sex-specificity of associative learning-induced changes in GABAergic tonic inhibition in layer 4 neurons of mouse barrel cortex.

Urban-Ciecko J, Mozrzymas JW.

Behav Brain Res. 2011 Jun 1;219(2):373-7. doi: 10.1016/j.bbr.2011.01.013. Epub 2011 Jan 14.

PMID:
21238501
38.
40.

Block and allosteric modulation of GABAergic currents by oenanthotoxin in rat cultured hippocampal neurons.

Wyrembek P, Lebida K, Mercik K, Szczuraszek K, Szczot M, Pollastro F, Appendino G, Mozrzymas JW.

Br J Pharmacol. 2010 Jul;160(6):1302-15. doi: 10.1111/j.1476-5381.2010.00644.x.

41.

Sensory learning differentially affects GABAergic tonic currents in excitatory neurons and fast spiking interneurons in layer 4 of mouse barrel cortex.

Urban-Ciecko J, Kossut M, Mozrzymas JW.

J Neurophysiol. 2010 Aug;104(2):746-54. doi: 10.1152/jn.00988.2009. Epub 2010 Jun 23.

42.

Late phase of long-term potentiation in the mossy fiber-CA3 hippocampal pathway is critically dependent on metalloproteinases activity.

Wójtowicz T, Mozrzymas JW.

Hippocampus. 2010 Aug;20(8):917-21. doi: 10.1002/hipo.20787.

PMID:
20572195
43.

Estradiol and GABAergic transmission in the hippocampus.

Wójtowicz T, Mozrzymas JW.

Vitam Horm. 2010;82:279-300. doi: 10.1016/S0083-6729(10)82015-1. Review.

PMID:
20472144
44.

Pharmacological studies reveal novel aspects of the versatility of GABAA receptors.

Mozrzymas JW.

J Physiol. 2010 May 1;588(Pt 9):1381-2. doi: 10.1113/jphysiol.2010.189910. No abstract available.

45.

LEF1/beta-catenin complex regulates transcription of the Cav3.1 calcium channel gene (Cacna1g) in thalamic neurons of the adult brain.

Wisniewska MB, Misztal K, Michowski W, Szczot M, Purta E, Lesniak W, Klejman ME, Dabrowski M, Filipkowski RK, Nagalski A, Mozrzymas JW, Kuznicki J.

J Neurosci. 2010 Apr 7;30(14):4957-69. doi: 10.1523/JNEUROSCI.1425-09.2010.

46.

High affinity carnitine transporters from OCTN family in neural cells.

Januszewicz E, Bekisz M, Mozrzymas JW, Nałecz KA.

Neurochem Res. 2010 May;35(5):743-8. doi: 10.1007/s11064-010-0131-5. Epub 2010 Feb 9.

PMID:
20143157
47.

Matrix metalloproteinase-9 reversibly affects the time course of NMDA-induced currents in cultured rat hippocampal neurons.

Gorkiewicz T, Szczuraszek K, Wyrembek P, Michaluk P, Kaczmarek L, Mozrzymas JW.

Hippocampus. 2010 Oct;20(10):1105-8. doi: 10.1002/hipo.20736.

PMID:
20043284
48.

New insights on the role of gephyrin in regulating both phasic and tonic GABAergic inhibition in rat hippocampal neurons in culture.

Marchionni I, Kasap Z, Mozrzymas JW, Sieghart W, Cherubini E, Zacchi P.

Neuroscience. 2009 Dec 1;164(2):552-62. doi: 10.1016/j.neuroscience.2009.07.063. Epub 2009 Aug 4.

PMID:
19660531
49.

Polyacetylenes from sardinian Oenanthe fistulosa: a molecular clue to risus sardonicus.

Appendino G, Pollastro F, Verotta L, Ballero M, Romano A, Wyrembek P, Szczuraszek K, Mozrzymas JW, Taglialatela-Scafati O.

J Nat Prod. 2009 May 22;72(5):962-5. doi: 10.1021/np8007717.

50.

17beta-estradiol affects GABAergic transmission in developing hippocampus.

Wójtowicz T, Lebida K, Mozrzymas JW.

Brain Res. 2008 Nov 19;1241:7-17. doi: 10.1016/j.brainres.2008.09.005. Epub 2008 Sep 13.

PMID:
18822277

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