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Items: 1 to 50 of 70

1.

Gasdermin D in peripheral myeloid cells drives neuroinflammation in experimental autoimmune encephalomyelitis.

Li S, Wu Y, Yang D, Wu C, Ma C, Liu X, Moynagh PN, Wang B, Hu G, Yang S.

J Exp Med. 2019 Aug 29. pii: jem.20190377. doi: 10.1084/jem.20190377. [Epub ahead of print]

PMID:
31467036
2.

Parkin Impairs Antiviral Immunity by Suppressing the Mitochondrial Reactive Oxygen Species-Nlrp3 Axis and Antiviral Inflammation.

Li J, Ma C, Long F, Yang D, Liu X, Hu Y, Wu C, Wang B, Wang M, Chen Y, Liu G, Moynagh PN, Zhou J, Peng T, Yang S.

iScience. 2019 Jun 28;16:468-484. doi: 10.1016/j.isci.2019.06.008. Epub 2019 Jun 11.

3.

IL-15 in autoimmunity and cancer: O-tu-b or not O-tu-b?

Moynagh PN.

Nat Immunol. 2019 Jul;20(7):780-782. doi: 10.1038/s41590-019-0424-z. No abstract available.

PMID:
31182806
4.

Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses.

O'Brien A, Loftus RM, Pisarska MM, Tobin LM, Bergin R, Wood NAW, Foley C, Mat A, Tinley FC, Bannan C, Sommerville G, Veerapen N, Besra GS, Sinclair LV, Moynagh PN, Lynch L, Finlay DK, O'Shea D, Hogan AE.

J Immunol. 2019 Jun 15;202(12):3404-3411. doi: 10.4049/jimmunol.1801600. Epub 2019 May 10.

PMID:
31076528
5.

The E3 ubiquitin ligase Pellino2 mediates priming of the NLRP3 inflammasome.

Humphries F, Bergin R, Jackson R, Delagic N, Wang B, Yang S, Dubois AV, Ingram RJ, Moynagh PN.

Nat Commun. 2018 Apr 19;9(1):1560. doi: 10.1038/s41467-018-03669-z.

6.

MyD88 is an essential component of retinoic acid-induced differentiation in human pluripotent embryonal carcinoma cells.

Sulaiman G, Cooke A, Ffrench B, Gasch C, Abdullai OA, O'Connor K, Elbaruni S, Blackshields G, Spillane C, Keegan H, McEneaney V, Knittel R, Rogers A, Jeffery IB, Doyle B, Bates M, d'Adhemar C, Lee MY, Campbell EL, Moynagh PN, Higgins DG, O'Toole S, O'Neill L, O'Leary JJ, Gallagher MF.

Cell Death Differ. 2017 Nov;24(11):1975-1986. doi: 10.1038/cdd.2017.124. Epub 2017 Sep 8.

7.

Regulatory T cells promote myelin regeneration in the central nervous system.

Dombrowski Y, O'Hagan T, Dittmer M, Penalva R, Mayoral SR, Bankhead P, Fleville S, Eleftheriadis G, Zhao C, Naughton M, Hassan R, Moffat J, Falconer J, Boyd A, Hamilton P, Allen IV, Kissenpfennig A, Moynagh PN, Evergren E, Perbal B, Williams AC, Ingram RJ, Chan JR, Franklin RJM, Fitzgerald DC.

Nat Neurosci. 2017 May;20(5):674-680. doi: 10.1038/nn.4528. Epub 2017 Mar 13.

8.

NF-κB signalling is involved in immune-modulation, but not basal functioning, of the mouse suprachiasmatic circadian clock.

O'Keeffe SM, Beynon AL, Davies JS, Moynagh PN, Coogan AN.

Eur J Neurosci. 2017 Apr;45(8):1111-1123. doi: 10.1111/ejn.13553. Epub 2017 Mar 23.

PMID:
28245070
9.

Differential modulation of Helicobacter pylori lipopolysaccharide-mediated TLR2 signaling by individual Pellino proteins.

Smith SM, Freeley M, Moynagh PN, Kelleher DP.

Helicobacter. 2017 Feb;22(1). doi: 10.1111/hel.12325. Epub 2016 Jun 15.

PMID:
27302665
10.

The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.

Downer EJ, Clifford E, Amu S, Fallon PG, Moynagh PN.

J Biol Chem. 2016 Jan 22;291(4):1604. doi: 10.1074/jbc.A112.371757. No abstract available.

11.

Functional conservation of an ancestral Pellino protein in helminth species.

Cluxton CD, Caffrey BE, Kinsella GK, Moynagh PN, Fares MA, Fallon PG.

Sci Rep. 2015 Jun 29;5:11687. doi: 10.1038/srep11687.

12.

Molecular and physiological roles of Pellino E3 ubiquitin ligases in immunity.

Humphries F, Moynagh PN.

Immunol Rev. 2015 Jul;266(1):93-108. doi: 10.1111/imr.12306. Review.

PMID:
26085209
13.

Orphan receptor IL-17RD regulates Toll-like receptor signalling via SEFIR/TIR interactions.

Mellett M, Atzei P, Bergin R, Horgan A, Floss T, Wurst W, Callanan JJ, Moynagh PN.

Nat Commun. 2015 Mar 26;6:6669. doi: 10.1038/ncomms7669.

PMID:
25808990
14.

The E3 ubiquitin ligase Pellino3 protects against obesity-induced inflammation and insulin resistance.

Yang S, Wang B, Humphries F, Hogan AE, O'Shea D, Moynagh PN.

Immunity. 2014 Dec 18;41(6):973-87. doi: 10.1016/j.immuni.2014.11.013. Epub 2014 Nov 29.

15.

RIP kinases: key decision makers in cell death and innate immunity.

Humphries F, Yang S, Wang B, Moynagh PN.

Cell Death Differ. 2015 Feb;22(2):225-36. doi: 10.1038/cdd.2014.126. Epub 2014 Aug 22. Review.

16.

Lipopolysaccharide-induced sepsis induces long-lasting affective changes in the mouse.

Anderson ST, Commins S, Moynagh PN, Coogan AN.

Brain Behav Immun. 2015 Jan;43:98-109. doi: 10.1016/j.bbi.2014.07.007. Epub 2014 Jul 22.

PMID:
25063709
17.

Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune responses.

Hanuszkiewicz A, Pittock P, Humphries F, Moll H, Rosales AR, Molinaro A, Moynagh PN, Lajoie GA, Valvano MA.

J Biol Chem. 2014 Jul 4;289(27):19231-44. doi: 10.1074/jbc.M114.562603. Epub 2014 May 19.

18.

Epstein-Barr virus large tegument protein BPLF1 contributes to innate immune evasion through interference with toll-like receptor signaling.

van Gent M, Braem SG, de Jong A, Delagic N, Peeters JG, Boer IG, Moynagh PN, Kremmer E, Wiertz EJ, Ovaa H, Griffin BD, Ressing ME.

PLoS Pathog. 2014 Feb 20;10(2):e1003960. doi: 10.1371/journal.ppat.1003960. eCollection 2014 Feb.

19.

The roles of Pellino E3 ubiquitin ligases in immunity.

Moynagh PN.

Nat Rev Immunol. 2014 Feb;14(2):122-31. doi: 10.1038/nri3599. Epub 2014 Jan 21. Review.

PMID:
24445667
20.

Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-α.

Yang S, Wang B, Tang LS, Siednienko J, Callanan JJ, Moynagh PN.

Nat Commun. 2013;4:2583. doi: 10.1038/ncomms3583.

PMID:
24113711
21.

Pellino3 ubiquitinates RIP2 and mediates Nod2-induced signaling and protective effects in colitis.

Yang S, Wang B, Humphries F, Jackson R, Healy ME, Bergin R, Aviello G, Hall B, McNamara D, Darby T, Quinlan A, Shanahan F, Melgar S, Fallon PG, Moynagh PN.

Nat Immunol. 2013 Sep;14(9):927-36. doi: 10.1038/ni.2669. Epub 2013 Jul 28.

PMID:
23892723
22.

Changes in human dendritic cell number and function in severe obesity may contribute to increased susceptibility to viral infection.

O'Shea D, Corrigan M, Dunne MR, Jackson R, Woods C, Gaoatswe G, Moynagh PN, O'Connell J, Hogan AE.

Int J Obes (Lond). 2013 Nov;37(11):1510-3. doi: 10.1038/ijo.2013.16. Epub 2013 Feb 26.

PMID:
23439322
23.

Long-lasting effects of sepsis on circadian rhythms in the mouse.

O'Callaghan EK, Anderson ST, Moynagh PN, Coogan AN.

PLoS One. 2012;7(10):e47087. doi: 10.1371/journal.pone.0047087. Epub 2012 Oct 11.

24.

Orphan receptor IL-17RD tunes IL-17A signalling and is required for neutrophilia.

Mellett M, Atzei P, Horgan A, Hams E, Floss T, Wurst W, Fallon PG, Moynagh PN.

Nat Commun. 2012;3:1119. doi: 10.1038/ncomms2127.

PMID:
23047677
25.

Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons.

Siednienko J, Jackson R, Mellett M, Delagic N, Yang S, Wang B, Tang LS, Callanan JJ, Mahon BP, Moynagh PN.

Nat Immunol. 2012 Nov;13(11):1055-62. doi: 10.1038/ni.2429. Epub 2012 Oct 7.

PMID:
23042151
26.

The synthetic cannabinoid R(+)WIN55,212-2 augments interferon-β expression via peroxisome proliferator-activated receptor-α.

Downer EJ, Clifford E, Amu S, Fallon PG, Moynagh PN.

J Biol Chem. 2012 Jul 20;287(30):25440-53. doi: 10.1074/jbc.M112.371757. Epub 2012 May 31. Erratum in: J Biol Chem. 2016 Jan 22;291(4):1604.

27.

Nuclear factor κB subunits RelB and cRel negatively regulate Toll-like receptor 3-mediated β-interferon production via induction of transcriptional repressor protein YY1.

Siednienko J, Maratha A, Yang S, Mitkiewicz M, Miggin SM, Moynagh PN.

J Biol Chem. 2011 Dec 30;286(52):44750-63. doi: 10.1074/jbc.M111.250894. Epub 2011 Nov 7.

28.

Peli1 (rel)ieves autoimmunity.

Moynagh PN.

Nat Immunol. 2011 Sep 20;12(10):927-9. doi: 10.1038/ni.2108.

PMID:
21934671
29.

Glucagon-like peptide-1 (GLP-1) and the regulation of human invariant natural killer T cells: lessons from obesity, diabetes and psoriasis.

Hogan AE, Tobin AM, Ahern T, Corrigan MA, Gaoatswe G, Jackson R, O'Reilly V, Lynch L, Doherty DG, Moynagh PN, Kirby B, O'Connell J, O'Shea D.

Diabetologia. 2011 Nov;54(11):2745-54. doi: 10.1007/s00125-011-2232-3. Epub 2011 Jul 9.

30.

Nitric oxide affects IL-6 expression in human peripheral blood mononuclear cells involving cGMP-dependent modulation of NF-κB activity.

Siednienko J, Nowak J, Moynagh PN, Gorczyca WA.

Cytokine. 2011 Jun;54(3):282-8. doi: 10.1016/j.cyto.2011.02.015. Epub 2011 Mar 16.

PMID:
21414799
31.

Mal mediates TLR-induced activation of CREB and expression of IL-10.

Mellett M, Atzei P, Jackson R, O'Neill LA, Moynagh PN.

J Immunol. 2011 Apr 15;186(8):4925-35. doi: 10.4049/jimmunol.1002739. Epub 2011 Mar 11.

32.

A poxviral homolog of the Pellino protein inhibits Toll and Toll-like receptor signalling.

Griffin BD, Mellett M, Campos-Torres A, Kinsella GK, Wang B, Moynagh PN.

Eur J Immunol. 2011 Mar;41(3):798-812. doi: 10.1002/eji.201040774. Epub 2011 Feb 2. No abstract available.

33.

Identification of the synthetic cannabinoid R(+)WIN55,212-2 as a novel regulator of IFN regulatory factor 3 activation and IFN-beta expression: relevance to therapeutic effects in models of multiple sclerosis.

Downer EJ, Clifford E, Gran B, Nel HJ, Fallon PG, Moynagh PN.

J Biol Chem. 2011 Mar 25;286(12):10316-28. doi: 10.1074/jbc.M110.188599. Epub 2011 Jan 18.

34.

Cactin targets the MHC class III protein IkappaB-like (IkappaBL) and inhibits NF-kappaB and interferon-regulatory factor signaling pathways.

Atzei P, Gargan S, Curran N, Moynagh PN.

J Biol Chem. 2010 Nov 19;285(47):36804-17. doi: 10.1074/jbc.M110.139113. Epub 2010 Sep 9.

35.

Characterisation of expression patterns and functional role of Cactin in early zebrafish development.

Atzei P, Yang F, Collery R, Kennedy BN, Moynagh PN.

Gene Expr Patterns. 2010 Jun;10(4-5):199-206. doi: 10.1016/j.gep.2010.03.003. Epub 2010 Mar 27.

PMID:
20348034
36.

The Pellino family: IRAK E3 ligases with emerging roles in innate immune signalling.

Moynagh PN.

Trends Immunol. 2009 Jan;30(1):33-42. doi: 10.1016/j.it.2008.10.001. Epub 2008 Nov 18. Review.

PMID:
19022706
37.

NF-kappaB activity in distinct neural subtypes of the rat hippocampus: Influence of time and GABA antagonism in acute slice preparations.

Sheridan GK, Pickering M, Twomey C, Moynagh PN, O'Connor JJ, Murphy KJ.

Learn Mem. 2007 Aug 3;14(8):525-32. Print 2007 Aug.

39.

Temporal change in gene expression in the rat dentate gyrus following passive avoidance learning.

O'Sullivan NC, McGettigan PA, Sheridan GK, Pickering M, Conboy L, O'Connor JJ, Moynagh PN, Higgins DG, Regan CM, Murphy KJ.

J Neurochem. 2007 May;101(4):1085-98. Epub 2007 Feb 9.

40.

Evidence for a role for the group I metabotropic glutamate receptor in the inhibitory effect of tumor necrosis factor-alpha on long-term potentiation.

Cumiskey D, Butler MP, Moynagh PN, O'connor JJ.

Brain Res. 2007 Mar 9;1136(1):13-9. Epub 2007 Jan 2.

PMID:
17198691
41.

The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling.

Carty M, Goodbody R, Schröder M, Stack J, Moynagh PN, Bowie AG.

Nat Immunol. 2006 Oct;7(10):1074-81. Epub 2006 Sep 10.

PMID:
16964262
42.
43.
44.

The NF-kappaB pathway.

Moynagh PN.

J Cell Sci. 2005 Oct 15;118(Pt 20):4589-92. Review. No abstract available.

45.
46.

The synthetic cannabinoid R(+)WIN 55,212-2 inhibits the interleukin-1 signaling pathway in human astrocytes in a cannabinoid receptor-independent manner.

Curran NM, Griffin BD, O'Toole D, Brady KJ, Fitzgerald SN, Moynagh PN.

J Biol Chem. 2005 Oct 28;280(43):35797-806. Epub 2005 Aug 16.

47.

TLR signalling and activation of IRFs: revisiting old friends from the NF-kappaB pathway.

Moynagh PN.

Trends Immunol. 2005 Sep;26(9):469-76. Review.

PMID:
16006187
48.

Pellino3 is a novel upstream regulator of p38 MAPK and activates CREB in a p38-dependent manner.

Butler MP, Hanly JA, Moynagh PN.

J Biol Chem. 2005 Jul 29;280(30):27759-68. Epub 2005 May 25.

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