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The Development of a Vaccine Against Meningococcus B Using Reverse Vaccinology.

Masignani V, Pizza M, Moxon ER.

Front Immunol. 2019 Apr 16;10:751. doi: 10.3389/fimmu.2019.00751. eCollection 2019. Review.


Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia.

Ercoli G, Fernandes VE, Chung WY, Wanford JJ, Thomson S, Bayliss CD, Straatman K, Crocker PR, Dennison A, Martinez-Pomares L, Andrew PW, Moxon ER, Oggioni MR.

Nat Microbiol. 2018 May;3(5):600-610. doi: 10.1038/s41564-018-0147-1. Epub 2018 Apr 16.


Genomic Surveillance of 4CMenB Vaccine Antigenic Variants among Disease-Causing Neisseria meningitidis Isolates, United Kingdom, 2010-2016.

Rodrigues CMC, Lucidarme J, Borrow R, Smith A, Cameron JC, Moxon ER, Maiden MCJ.

Emerg Infect Dis. 2018 Apr;24(4):673-682. doi: 10.3201/eid2404.171480.


In-silico prediction and deep-DNA sequencing validation indicate phase variation in 115 Neisseria meningitidis genes.

Siena E, D'Aurizio R, Riley D, Tettelin H, Guidotti S, Torricelli G, Moxon ER, Medini D.

BMC Genomics. 2016 Oct 28;17(1):843.


Distribution of Bexsero® Antigen Sequence Types (BASTs) in invasive meningococcal disease isolates: Implications for immunisation.

Brehony C, Rodrigues CMC, Borrow R, Smith A, Cunney R, Moxon ER, Maiden MCJ.

Vaccine. 2016 Sep 7;34(39):4690-4697. doi: 10.1016/j.vaccine.2016.08.015. Epub 2016 Aug 9.


Crystal Structure of a Complex of Surfactant Protein D (SP-D) and Haemophilus influenzae Lipopolysaccharide Reveals Shielding of Core Structures in SP-D-Resistant Strains.

Clark HW, Mackay RM, Deadman ME, Hood DW, Madsen J, Moxon ER, Townsend JP, Reid KBM, Ahmed A, Shaw AJ, Greenhough TJ, Shrive AK.

Infect Immun. 2016 Apr 22;84(5):1585-1592. doi: 10.1128/IAI.01239-15. Print 2016 May.


Adjuvant effects elicited by novel oligosaccharide variants of detoxified meningococcal lipopolysaccharides on Neisseria meningitidis recombinant PorA protein: a comparison in mice.

Mehta OH, Norheim G, Hoe JC, Rollier CS, Nagaputra JC, Makepeace K, Saleem M, Chan H, Ferguson DJ, Jones C, Sadarangani M, Hood DW, Feavers I, Derrick JP, Pollard AJ, Moxon ER.

PLoS One. 2014 Dec 29;9(12):e115713. doi: 10.1371/journal.pone.0115713. eCollection 2014.


No evidence for political manipulation regarding the new group B meningococcus vaccine.

Moxon ER, Black S.

BMJ. 2014 May 8;348:g2929. doi: 10.1136/bmj.g2929. No abstract available.


Genome sequencing of disease and carriage isolates of nontypeable Haemophilus influenzae identifies discrete population structure.

De Chiara M, Hood D, Muzzi A, Pickard DJ, Perkins T, Pizza M, Dougan G, Rappuoli R, Moxon ER, Soriani M, Donati C.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):5439-44. doi: 10.1073/pnas.1403353111. Epub 2014 Mar 25.


The role of host and microbial factors in the pathogenesis of pneumococcal bacteraemia arising from a single bacterial cell bottleneck.

Gerlini A, Colomba L, Furi L, Braccini T, Manso AS, Pammolli A, Wang B, Vivi A, Tassini M, van Rooijen N, Pozzi G, Ricci S, Andrew PW, Koedel U, Moxon ER, Oggioni MR.

PLoS Pathog. 2014 Mar 20;10(3):e1004026. doi: 10.1371/journal.ppat.1004026. eCollection 2014 Mar.


Neisseria meningitidis native outer membrane vesicles containing different lipopolysaccharide glycoforms as adjuvants for meningococcal and nonmeningococcal antigens.

Nagaputra JC, Rollier CS, Sadarangani M, Hoe JC, Mehta OH, Norheim G, Saleem M, Chan H, Derrick JP, Feavers I, Pollard AJ, Moxon ER.

Clin Vaccine Immunol. 2014 Feb;21(2):234-42. doi: 10.1128/CVI.00561-13. Epub 2013 Dec 18.


A novel branching pattern in the lipopolysaccharide expressed by non-typeable Haemophilus influenzae strain 1232.

Vitiazeva V, Li J, Hood DW, Moxon ER, Schweda EK.

Carbohydr Res. 2013 Aug 30;378:114-22. doi: 10.1016/j.carres.2013.03.011. Epub 2013 Mar 22.


Broad conditions favor the evolution of phase-variable loci.

Palmer ME, Lipsitch M, Moxon ER, Bayliss CD.

mBio. 2013 Jan 8;4(1):e00430-12. doi: 10.1128/mBio.00430-12.


Investigations into genome diversity of Haemophilus influenzae using whole genome sequencing of clinical isolates and laboratory transformants.

Power PM, Bentley SD, Parkhill J, Moxon ER, Hood DW.

BMC Microbiol. 2012 Nov 23;12:273. doi: 10.1186/1471-2180-12-273.


Development of a vaccine against serogroup B has been the main scientific challenge. Preface.

Rappuoli R, Pizza M, Black S, Moxon ER.

Vaccine. 2012 May 30;30 Suppl 2:B1-2. doi: 10.1016/j.vaccine.2012.02.006. No abstract available.


Inactivation of Haemophilus influenzae lipopolysaccharide biosynthesis genes interferes with outer membrane localization of the hap autotransporter.

Spahich NA, Hood DW, Moxon ER, St Geme JW 3rd.

J Bacteriol. 2012 Apr;194(7):1815-22. doi: 10.1128/JB.06316-11. Epub 2012 Jan 27.


The challenge of post-implementation surveillance for novel meningococcal vaccines.

Snape MD, Medini D, Halperin SA, DeTora L, Drori J, Moxon ER.

Vaccine. 2012 May 30;30 Suppl 2:B67-72. doi: 10.1016/j.vaccine.2011.12.126. Epub 2012 Jan 9. Review.


The next decade of vaccines: societal and scientific challenges.

Moxon ER, Siegrist CA.

Lancet. 2011 Jul 23;378(9788):348-59. doi: 10.1016/S0140-6736(11)60407-8. Epub 2011 Jun 12.


A call to action for the new decade of vaccines.

Moxon ER, Das P, Greenwood B, Heymann DL, Horton R, Levine OS, Plotkin S, Nossal G.

Lancet. 2011 Jul 23;378(9788):298-302. doi: 10.1016/S0140-6736(11)60766-6. Epub 2011 Jun 12. No abstract available.


Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination.

Budroni S, Siena E, Dunning Hotopp JC, Seib KL, Serruto D, Nofroni C, Comanducci M, Riley DR, Daugherty SC, Angiuoli SV, Covacci A, Pizza M, Rappuoli R, Moxon ER, Tettelin H, Medini D.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4494-9. doi: 10.1073/pnas.1019751108. Epub 2011 Feb 28.


Darwin, microbes and evolution by natural selection.

Moxon ER.

Adv Exp Med Biol. 2011;697:77-86. doi: 10.1007/978-1-4419-7185-2_6.


Structure and dynamics of the pan-genome of Streptococcus pneumoniae and closely related species.

Donati C, Hiller NL, Tettelin H, Muzzi A, Croucher NJ, Angiuoli SV, Oggioni M, Dunning Hotopp JC, Hu FZ, Riley DR, Covacci A, Mitchell TJ, Bentley SD, Kilian M, Ehrlich GD, Rappuoli R, Moxon ER, Masignani V.

Genome Biol. 2010;11(10):R107. doi: 10.1186/gb-2010-11-10-r107. Epub 2010 Oct 29. Erratum in: Genome Biol. 2011;12(10):140.


Qualitative and quantitative assessment of meningococcal antigens to evaluate the potential strain coverage of protein-based vaccines.

Donnelly J, Medini D, Boccadifuoco G, Biolchi A, Ward J, Frasch C, Moxon ER, Stella M, Comanducci M, Bambini S, Muzzi A, Andrews W, Chen J, Santos G, Santini L, Boucher P, Serruto D, Pizza M, Rappuoli R, Giuliani MM.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19490-5. doi: 10.1073/pnas.1013758107. Epub 2010 Oct 20.


Investigating the candidacy of LPS-based glycoconjugates to prevent invasive meningococcal disease: immunology of glycoconjugates with high carbohydrate loading.

Cox AD, St Michael F, Neelamegan D, Lacelle S, Cairns CM, Giuliani MM, Biolchi A, Hoe JC, Moxon ER, Richards JC.

Glycoconj J. 2010 Oct;27(7-9):643-8. doi: 10.1007/s10719-010-9309-y. Epub 2010 Oct 5.


Long-term complications and risk of other serious infections following invasive Haemophilus influenzae serotype b disease in vaccinated children.

Ladhani S, Heath PT, Aibara RJ, Ramsay ME, Slack MPE, Hibberd ML, Pollard AJ, Moxon ER, Booy R.

Vaccine. 2010 Mar 2;28(10):2195-2200. doi: 10.1016/j.vaccine.2009.12.057. Epub 2010 Jan 5.


Bacterial variation, virulence and vaccines.

Moxon ER.

Microbiology. 2009 Apr;155(Pt 4):997-1003. doi: 10.1099/mic.0.024877-0.


Lex2B, a phase-variable glycosyltransferase, adds either a glucose or a galactose to Haemophilus influenzae lipopolysaccharide.

Deadman ME, Hermant P, Engskog M, Makepeace K, Moxon ER, Schweda EK, Hood DW.

Infect Immun. 2009 Jun;77(6):2376-84. doi: 10.1128/IAI.01446-08. Epub 2009 Mar 16.


The macrophage scavenger receptor A is host-protective in experimental meningococcal septicaemia.

Plüddemann A, Hoe JC, Makepeace K, Moxon ER, Gordon S.

PLoS Pathog. 2009 Feb;5(2):e1000297. doi: 10.1371/journal.ppat.1000297. Epub 2009 Feb 13.


Simple sequence repeats in Haemophilus influenzae.

Power PM, Sweetman WA, Gallacher NJ, Woodhall MR, Kumar GA, Moxon ER, Hood DW.

Infect Genet Evol. 2009 Mar;9(2):216-28. doi: 10.1016/j.meegid.2008.11.006. Epub 2008 Nov 28.


Naturally-occurring human serum antibodies to inner core lipopolysaccharide epitopes of Neisseria meningitidis protect against invasive meningococcal disease caused by isolates displaying homologous inner core structures.

Jäkel A, Plested JS, Hoe JC, Makepeace K, Gidney MA, Lacelle S, St Michael F, Cox AD, Richards JC, Moxon ER.

Vaccine. 2008 Dec 2;26(51):6655-63. doi: 10.1016/j.vaccine.2008.09.041.


Anti-polyribosylribitol phosphate antibody concentrations and avidities in children since the start of Haemophilus influenzae type b immunization of infants in the United Kingdom.

Kelly DF, Moxon ER, Yu LM, Pollard AJ.

Clin Vaccine Immunol. 2009 Feb;16(2):246-52. doi: 10.1128/CVI.00023-08. Epub 2008 Sep 10.


Neisseria meningitidis escape from the bactericidal activity of a monoclonal antibody is mediated by phase variation of lgtG and enhanced by a mutator phenotype.

Bayliss CD, Hoe JC, Makepeace K, Martin P, Hood DW, Moxon ER.

Infect Immun. 2008 Nov;76(11):5038-48. doi: 10.1128/IAI.00395-08. Epub 2008 Aug 11.


Identification of a novel structural motif in the lipopolysaccharide of the galE/galK double mutant of Haemophilus influenzae strain Eagan.

Masoud H, Uhrin D, Moxon ER, Richards JC.

Carbohydr Res. 2008 Nov 3;343(16):2763-70. doi: 10.1016/j.carres.2008.04.027. Epub 2008 Apr 29.


Structural analysis of the lipopolysaccharide from nontypeable Haemophilus influenzae strain R2846.

Lundström SL, Li J, Deadman ME, Hood DW, Moxon ER, Schweda EK.

Biochemistry. 2008 Jun 3;47(22):6025-38. doi: 10.1021/bi702510b. Epub 2008 May 8.


Application of capillary electrophoresis mass spectrometry and liquid chromatography multiple-step tandem electrospray mass spectrometry to profile glycoform expression during Haemophilus influenzae pathogenesis in the chinchilla model of experimental otitis media.

Lundström SL, Li J, Månsson M, Figueira M, Leroy M, Goldstein R, Hood DW, Moxon ER, Richards JC, Schweda EK.

Infect Immun. 2008 Jul;76(7):3255-67. doi: 10.1128/IAI.01710-07. Epub 2008 May 5.


Structural elucidation of the major Hex4 lipopolysaccharide glycoform from the lgtC mutant of Haemophilus influenzae strain Eagan.

Masoud H, Moxon ER, Richards JC.

Carbohydr Res. 2008 Jul 7;343(9):1424-34. doi: 10.1016/j.carres.2008.04.002. Epub 2008 Apr 7.


Characterization of intact lipopolysaccharides from the Haemophilus influenzae strain RM 118 using electrophoresis-assisted open-tubular liquid chromatography-mass spectrometry.

Dzieciatkowska M, Schweda EK, Moxon ER, Richards JC, Li J.

Electrophoresis. 2008 May;29(10):2171-81. doi: 10.1002/elps.200700762.


School-aged children: a reservoir for continued circulation of Haemophilus influenzae type b in the United Kingdom.

Oh SY, Griffiths D, John T, Lee YC, Yu LM, McCarthy N, Heath PT, Crook D, Ramsay M, Moxon ER, Pollard AJ.

J Infect Dis. 2008 May 1;197(9):1275-81. doi: 10.1086/586716. Erratum in: J Infect Dis. 2011 Jul;204(1):176.


Structural elucidation of lipopolysaccharide core oligosaccharides from lic1 and lic1/lic2 mutants of Haemophilus influenzae type b strain Eagan.

Masoud H, Moxon ER, Richards JC.

Can J Microbiol. 2008 Apr;54(4):281-90. doi: 10.1139/w08-009.


Haemophilus influenzae biofilms: hypothesis or fact?

Moxon ER, Sweetman WA, Deadman ME, Ferguson DJ, Hood DW.

Trends Microbiol. 2008 Mar;16(3):95-100. doi: 10.1016/j.tim.2007.12.005. Epub 2008 Feb 14. Review.


RecJ, ExoI and RecG are required for genome maintenance but not for generation of genetic diversity by repeat-mediated phase variation in Haemophilus influenzae.

Kumar GA, Woodhall MR, Hood DW, Moxon ER, Bayliss CD.

Mutat Res. 2008 Apr 2;640(1-2):46-53. doi: 10.1016/j.mrfmmm.2007.12.002. Epub 2007 Dec 23.


Duplicate copies of lic1 direct the addition of multiple phosphocholine residues in the lipopolysaccharide of Haemophilus influenzae.

Fox KL, Li J, Schweda EK, Vitiazeva V, Makepeace K, Jennings MP, Moxon ER, Hood DW.

Infect Immun. 2008 Feb;76(2):588-600. Epub 2007 Nov 5.


Novel globoside-like oligosaccharide expression patterns in nontypeable Haemophilus influenzae lipopolysaccharide.

Lundström SL, Twelkmeyer B, Sagemark MK, Li J, Richards JC, Hood DW, Moxon ER, Schweda EK.

FEBS J. 2007 Sep;274(18):4886-903. Epub 2007 Aug 24.


Expression and structural diversity of the lipopolysaccharide of Haemophilus influenzae: implication in virulence.

Schweda EK, Richards JC, Hood DW, Moxon ER.

Int J Med Microbiol. 2007 Sep;297(5):297-306. Epub 2007 Apr 23. Review.


A randomized study comparing the safety and immunogenicity of a conjugate vaccine combination containing meningococcal group C and pneumococcal capsular polysaccharide--CRM197 with a meningococcal group C conjugate vaccine in healthy infants: challenge phase.

Riddell A, Buttery JP, McVernon J, Chantler T, Lane L, Bowen-Morris J, Diggle L, Morris R, Lockhart S, Pollard AJ, Cartwright K, Moxon ER.

Vaccine. 2007 May 10;25(19):3906-12. Epub 2007 Feb 7.


Structural characterization of sialylated glycoforms of H. influenzae by electrospray mass spectrometry: fragmentation of protonated and sodiated O-deacylated lipopolysaccharides.

Li J, Dzieciatkowska M, Hood DW, Cox AD, Schweda EK, Moxon ER, Richards JC.

Rapid Commun Mass Spectrom. 2007;21(6):952-60.


The role familiarity with science and medicine plays in parents' decision making about enrolling a child in vaccine research.

Chantler TE, Lees A, Moxon ER, Mant D, Pollard AJ, Fiztpatrick R.

Qual Health Res. 2007 Mar;17(3):311-22.


Role of complement in defense of the middle ear revealed by restoring the virulence of nontypeable Haemophilus influenzae siaB mutants.

Figueira MA, Ram S, Goldstein R, Hood DW, Moxon ER, Pelton SI.

Infect Immun. 2007 Jan;75(1):325-33. Epub 2006 Nov 6.


Serogroup C meningococcal glycoconjugate vaccine in adolescents: persistence of bactericidal antibodies and kinetics of the immune response to a booster vaccine more than 3 years after immunization.

Snape MD, Kelly DF, Salt P, Green S, Snowden C, Diggle L, Borkowski A, Yu LM, Moxon ER, Pollard AJ.

Clin Infect Dis. 2006 Dec 1;43(11):1387-94. Epub 2006 Oct 31.


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