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Items: 28


Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.

McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar A, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J, Tienari P, Corti O, Dunnett SB, Ganley IG, Suomalainen A, Muqit MMK.

Open Biol. 2018 Nov 7;8(11). pii: 180108. doi: 10.1098/rsob.180108.


PKR modulates abnormal brain signaling in experimental obesity.

Taga M, Mouton-Liger F, Sadoune M, Gourmaud S, Norman J, Tible M, Thomasseau S, Paquet C, Nicoll JAR, Boche D, Hugon J.

PLoS One. 2018 May 24;13(5):e0196983. doi: 10.1371/journal.pone.0196983. eCollection 2018.


Parkin deficiency modulates NLRP3 inflammasome activation by attenuating an A20-dependent negative feedback loop.

Mouton-Liger F, Rosazza T, Sepulveda-Diaz J, Ieang A, Hassoun SM, Claire E, Mangone G, Brice A, Michel PP, Corvol JC, Corti O.

Glia. 2018 Apr 17. doi: 10.1002/glia.23337. [Epub ahead of print]


Downregulated apoptosis and autophagy after anti-Aβ immunotherapy in Alzheimer's disease.

Paquet C, Nicoll JA, Love S, Mouton-Liger F, Holmes C, Hugon J, Boche D.

Brain Pathol. 2018 Sep;28(5):603-610. doi: 10.1111/bpa.12567. Epub 2018 Feb 6.


PKR involvement in Alzheimer's disease.

Hugon J, Mouton-Liger F, Dumurgier J, Paquet C.

Alzheimers Res Ther. 2017 Oct 5;9(1):83. doi: 10.1186/s13195-017-0308-0. Review.


PINK1/Parkin-Dependent Mitochondrial Surveillance: From Pleiotropy to Parkinson's Disease.

Mouton-Liger F, Jacoupy M, Corvol JC, Corti O.

Front Mol Neurosci. 2017 May 1;10:120. doi: 10.3389/fnmol.2017.00120. eCollection 2017. Review.


From dysfunctional endoplasmic reticulum-mitochondria coupling to neurodegeneration.

Erpapazoglou Z, Mouton-Liger F, Corti O.

Neurochem Int. 2017 Oct;109:171-183. doi: 10.1016/j.neuint.2017.03.021. Epub 2017 Apr 5. Review.


Dual Kinase Inhibition Affords Extended in vitro Neuroprotection in Amyloid-β Toxicity.

Gourmaud S, Mouton-Liger F, Abadie C, Meurs EF, Paquet C, Hugon J.

J Alzheimers Dis. 2016 Oct 18;54(4):1659-1670.


Primary Progressive Aphasia in the Network of French Alzheimer Plan Memory Centers.

Magnin E, Démonet JF, Wallon D, Dumurgier J, Troussière AC, Jager A, Duron E, Gabelle A, de la Sayette V, Volpe-Gillot L, Tio G, Evain S, Boutoleau-Bretonnière C, Enderle A, Mouton-Liger F, Robert P, Hannequin D, Pasquier F, Hugon J, Paquet C; ePLM collaborators.

J Alzheimers Dis. 2016 Oct 18;54(4):1459-1471.


Utility of CSF biomarkers in psychiatric disorders: a national multicentre prospective study.

Paquet C, Magnin E, Wallon D, Troussière AC, Dumurgier J, Jager A, Bellivier F, Bouaziz-Amar E, Blanc F, Beaufils E, Miguet-Alfonsi C, Quillard M, Schraen S, Pasquier F, Hannequin D, Robert P, Hugon J, Mouton-Liger F; For ePLM network and collaborators.

Alzheimers Res Ther. 2016 Jun 13;8:27. doi: 10.1186/s13195-016-0192-z.


The endoplasmic reticulum-mitochondria interface is perturbed in PARK2 knockout mice and patients with PARK2 mutations.

Gautier CA, Erpapazoglou Z, Mouton-Liger F, Muriel MP, Cormier F, Bigou S, Duffaure S, Girard M, Foret B, Iannielli A, Broccoli V, Dalle C, Bohl D, Michel PP, Corvol JC, Brice A, Corti O.

Hum Mol Genet. 2016 Jul 15;25(14):2972-2984. Epub 2016 May 19.


Neuroinflammation and Aβ accumulation linked to systemic inflammation are decreased by genetic PKR down-regulation.

Carret-Rebillat AS, Pace C, Gourmaud S, Ravasi L, Montagne-Stora S, Longueville S, Tible M, Sudol E, Chang RC, Paquet C, Mouton-Liger F, Hugon J.

Sci Rep. 2015 Feb 17;5:8489. doi: 10.1038/srep08489.


PKR downregulation prevents neurodegeneration and β-amyloid production in a thiamine-deficient model.

Mouton-Liger F, Rebillat AS, Gourmaud S, Paquet C, Leguen A, Dumurgier J, Bernadelli P, Taupin V, Pradier L, Rooney T, Hugon J.

Cell Death Dis. 2015 Jan 15;6:e1594. doi: 10.1038/cddis.2014.552.


Increased levels of cerebrospinal fluid JNK3 associated with amyloid pathology: links to cognitive decline.

Gourmaud S, Paquet C, Dumurgier J, Pace C, Bouras C, Gray F, Laplanche JL, Meurs EF, Mouton-Liger F, Hugon J.

J Psychiatry Neurosci. 2015 May;40(3):151-61.


Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease.

Paquet C, Amin J, Mouton-Liger F, Nasser M, Love S, Gray F, Pickering RM, Nicoll JA, Holmes C, Hugon J, Boche D.

J Pathol. 2015 Apr;235(5):721-30. doi: 10.1002/path.4491. Epub 2015 Jan 7.


The screening of Alzheimer's patients with CSF biomarkers, modulates the distribution of APOE genotype: impact on clinical trials.

Dumurgier J, Laplanche JL, Mouton-Liger F, Lapalus P, Indart S, Prévot M, Peoc'h K, Hugon J, Paquet C.

J Neurol. 2014 Jun;261(6):1187-95. doi: 10.1007/s00415-014-7335-6. Epub 2014 Apr 12.


Who needs cerebrospinal biomarkers? A national survey in clinical practice.

Troussière AC, Wallon D, Mouton-Liger F, Yatimi R, Robert P, Hugon J, Hannequin D, Pasquier F, Paquet C.

J Alzheimers Dis. 2014;40(4):857-61. doi: 10.3233/JAD-132672.


Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome.

Mouton-Liger F, Sahún I, Collin T, Lopes Pereira P, Masini D, Thomas S, Paly E, Luilier S, Même S, Jouhault Q, Bennaï S, Beloeil JC, Bizot JC, Hérault Y, Dierssen M, Créau N.

Neurobiol Dis. 2014 Mar;63:92-106. doi: 10.1016/j.nbd.2013.11.016. Epub 2013 Nov 28.


Impact of cerebro-spinal fluid biomarkers of Alzheimer's disease in clinical practice: a multicentric study.

Mouton-Liger F, Wallon D, Troussière AC, Yatimi R, Dumurgier J, Magnin E, de la Sayette V, Duron E, Philippi N, Beaufils E, Gabelle A, Croisile B, Robert P, Pasquier F, Hannequin D, Hugon J, Paquet C.

J Neurol. 2014 Jan;261(1):144-51. doi: 10.1007/s00415-013-7160-3. Epub 2013 Oct 27.


Cerebrospinal fluid PKR level predicts cognitive decline in Alzheimer's disease.

Dumurgier J, Mouton-Liger F, Lapalus P, Prevot M, Laplanche JL, Hugon J, Paquet C; Groupe d’Investigation du Liquide Cephalorachidien (GIL) Study Network.

PLoS One. 2013;8(1):e53587. doi: 10.1371/journal.pone.0053587. Epub 2013 Jan 8.


Oxidative stress increases BACE1 protein levels through activation of the PKR-eIF2α pathway.

Mouton-Liger F, Paquet C, Dumurgier J, Bouras C, Pradier L, Gray F, Hugon J.

Biochim Biophys Acta. 2012 Jun;1822(6):885-96. doi: 10.1016/j.bbadis.2012.01.009. Epub 2012 Jan 28.


Increased cerebrospinal fluid levels of double-stranded RNA-dependant protein kinase in Alzheimer's disease.

Mouton-Liger F, Paquet C, Dumurgier J, Lapalus P, Gray F, Laplanche JL, Hugon J; Groupe d'Investigation du Liquide Céphalorachidien Study Network.

Biol Psychiatry. 2012 May 1;71(9):829-35. doi: 10.1016/j.biopsych.2011.11.031. Epub 2012 Jan 26.


CSF Aβ₁₋₄₂ levels and glucose metabolism in Alzheimer's disease.

Dumurgier J, Paquet C, Peoc'h K, Lapalus P, Mouton-Liger F, Benisty S, Chasseigneaux S, Chabriat H, Hugon J.

J Alzheimers Dis. 2011;27(4):845-51. doi: 10.3233/JAD-2011-111007.


The PKR activator PACT is induced by Aβ: involvement in Alzheimer's disease.

Paquet C, Mouton-Liger F, Meurs EF, Mazot P, Bouras C, Pradier L, Gray F, Hugon J.

Brain Pathol. 2012 Mar;22(2):219-29. doi: 10.1111/j.1750-3639.2011.00520.x. Epub 2011 Sep 16.


Modulation of oxidative stress and tau phosphorylation by the mTOR activator phosphatidic acid in SH-SY5Y cells.

Taga M, Mouton-Liger F, Paquet C, Hugon J.

FEBS Lett. 2011 Jun 23;585(12):1801-6. doi: 10.1016/j.febslet.2011.04.022. Epub 2011 Apr 15.


PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome.

Mouton-Liger F, Thomas S, Rattenbach R, Magnol L, Larigaldie V, Ledru A, Herault Y, Verney C, Créau N.

J Comp Neurol. 2011 Oct 1;519(14):2779-802. doi: 10.1002/cne.22651. Erratum in: J Comp Neurol. 2011 Dec 1;519(17):3597.


Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.

Bose A, Mouton-Liger F, Paquet C, Mazot P, Vigny M, Gray F, Hugon J.

Brain Pathol. 2011 Mar;21(2):189-200. doi: 10.1111/j.1750-3639.2010.00437.x. Epub 2010 Oct 3.


Inverse association between CSF Aβ 42 levels and years of education in mild form of Alzheimer's disease: the cognitive reserve theory.

Dumurgier J, Paquet C, Benisty S, Kiffel C, Lidy C, Mouton-Liger F, Chabriat H, Laplanche JL, Hugon J.

Neurobiol Dis. 2010 Nov;40(2):456-9. doi: 10.1016/j.nbd.2010.07.007. Epub 2010 Jul 22.


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