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Items: 32

1.

Phosphorylated CRMP2 Regulates Spinal Nociceptive Neurotransmission.

Yu J, Moutal A, Dorame A, Bellampalli SS, Chefdeville A, Kanazawa I, Pham NYN, Park KD, Weimer JM, Khanna R.

Mol Neurobiol. 2018 Dec 18. doi: 10.1007/s12035-018-1445-6. [Epub ahead of print]

PMID:
30565051
2.

(-)-Hardwickiic acid and Hautriwaic acid induce antinociception via blockade of tetrodotoxin-sensitive voltage-dependent sodium channels.

Cai S, Bellampalli SS, Yu J, Li W, Ji Y, Wijeratne EMK, Dorame A, Luo S, Shan Z, Khanna M, Moutal A, Streicher JM, Gunatilaka AAL, Khanna R.

ACS Chem Neurosci. 2018 Dec 7. doi: 10.1021/acschemneuro.8b00617. [Epub ahead of print]

PMID:
30525440
3.

A light-gated potassium channel for sustained neuronal inhibition.

Alberio L, Locarno A, Saponaro A, Romano E, Bercier V, Albadri S, Simeoni F, Moleri S, Pelucchi S, Porro A, Marcello E, Barsotti N, Kukovetz K, Boender AJ, Contestabile A, Luo S, Moutal A, Ji Y, Romani G, Beltrame M, Del Bene F, Di Luca M, Khanna R, Colecraft HM, Pasqualetti M, Thiel G, Tonini R, Moroni A.

Nat Methods. 2018 Nov;15(11):969-976. doi: 10.1038/s41592-018-0186-9. Epub 2018 Oct 30.

PMID:
30377377
4.

High Fidelity Cryopreservation and Recovery of Primary Rodent Cortical Neurons.

Parker SS, Moutal A, Cai S, Chandrasekaran S, Roman MR, Koshy AA, Khanna R, Zinsmaier KE, Mouneimne G.

eNeuro. 2018 Sep 27;5(5). pii: ENEURO.0135-18.2018. doi: 10.1523/ENEURO.0135-18.2018. eCollection 2018 Sep-Oct.

5.

Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels.

Bellampalli SS, Ji Y, Moutal A, Cai S, Wijeratne EMK, Gandini MA, Yu J, Chefdeville A, Dorame A, Chew LA, Madura CL, Luo S, Molnar G, Khanna M, Streicher JM, Zamponi GW, Gunatilaka AAL, Khanna R.

Pain. 2019 Jan;160(1):117-135. doi: 10.1097/j.pain.0000000000001385.

PMID:
30169422
6.

A Chemical Biology Approach to Model Pontocerebellar Hypoplasia Type 1B (PCH1B).

François-Moutal L, Jahanbakhsh S, Nelson ADL, Ray D, Scott DD, Hennefarth MR, Moutal A, Perez-Miller S, Ambrose AJ, Al-Shamari A, Coursodon P, Meechoovet B, Reiman R, Lyons E, Beilstein M, Chapman E, Morris QD, Van Keuren-Jensen K, Hughes TR, Khanna R, Koehler C, Jen J, Gokhale V, Khanna M.

ACS Chem Biol. 2018 Oct 19;13(10):3000-3010. doi: 10.1021/acschembio.8b00745. Epub 2018 Sep 6.

PMID:
30141626
7.

A porcine model of neurofibromatosis type 1 that mimics the human disease.

White KA, Swier VJ, Cain JT, Kohlmeyer JL, Meyerholz DK, Tanas MR, Uthoff J, Hammond E, Li H, Rohret FA, Goeken A, Chan CH, Leidinger MR, Umesalma S, Wallace MR, Dodd RD, Panzer K, Tang AH, Darbro BW, Moutal A, Cai S, Li W, Bellampalli SS, Khanna R, Rogers CS, Sieren JC, Quelle DE, Weimer JM.

JCI Insight. 2018 Jun 21;3(12). pii: 120402. doi: 10.1172/jci.insight.120402. [Epub ahead of print]

8.

Inhibition of the Ubc9 E2 SUMO-conjugating enzyme-CRMP2 interaction decreases NaV1.7 currents and reverses experimental neuropathic pain.

François-Moutal L, Dustrude ET, Wang Y, Brustovetsky T, Dorame A, Ju W, Moutal A, Perez-Miller S, Brustovetsky N, Gokhale V, Khanna M, Khanna R.

Pain. 2018 Oct;159(10):2115-2127. doi: 10.1097/j.pain.0000000000001294.

PMID:
29847471
9.

CRMP2-Neurofibromin Interface Drives NF1-related Pain.

Moutal A, Sun L, Yang X, Li W, Cai S, Luo S, Khanna R.

Neuroscience. 2018 Jun 15;381:79-90. doi: 10.1016/j.neuroscience.2018.04.002. Epub 2018 Apr 12.

PMID:
29655575
10.

Restoration of Kv7 Channel-Mediated Inhibition Reduces Cued-Reinstatement of Cocaine Seeking.

Parrilla-Carrero J, Buchta WC, Goswamee P, Culver O, McKendrick G, Harlan B, Moutal A, Penrod R, Lauer A, Ramakrishnan V, Khanna R, Kalivas P, Riegel AC.

J Neurosci. 2018 Apr 25;38(17):4212-4229. doi: 10.1523/JNEUROSCI.2767-17.2018. Epub 2018 Apr 10.

11.

Unconventional Signaling by Extracellular CRMP2: Possible Role as an Atypical Neurotransmitter?

Moutal A, Khanna R.

Neuroscience. 2018 Apr 15;376:224-226. doi: 10.1016/j.neuroscience.2018.02.025. No abstract available.

PMID:
29555038
12.

Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5.

Naudet N, Moutal A, Vu HN, Chounlamountri N, Watrin C, Cavagna S, Malleval C, Benetollo C, Bardel C, Dronne MA, Honnorat J, Meissirel C, Besançon R.

Cell Mol Life Sci. 2018 Jan;75(1):67-79. doi: 10.1007/s00018-017-2634-6. Epub 2017 Sep 1.

PMID:
28864883
13.

CRMP2 is necessary for Neurofibromatosis type 1 related pain.

Moutal A, Cai S, Luo S, Voisin R, Khanna R.

Channels (Austin). 2018 Jan 1;12(1):47-50. doi: 10.1080/19336950.2017.1370524.

14.

CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide.

Moutal A, Yang X, Li W, Gilbraith KB, Luo S, Cai S, François-Moutal L, Chew LA, Yeon SK, Bellampalli SS, Qu C, Xie JY, Ibrahim MM, Khanna M, Park KD, Porreca F, Khanna R.

Pain. 2017 Dec;158(12):2301-2319. doi: 10.1097/j.pain.0000000000001002.

PMID:
28809766
15.

Dissecting the role of the CRMP2-neurofibromin complex on pain behaviors.

Moutal A, Wang Y, Yang X, Ji Y, Luo S, Dorame A, Bellampalli SS, Chew LA, Cai S, Dustrude ET, Keener JE, Marty MT, Vanderah TW, Khanna R.

Pain. 2017 Nov;158(11):2203-2221. doi: 10.1097/j.pain.0000000000001026.

PMID:
28767512
16.

CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation.

Moutal A, Villa LS, Yeon SK, Householder KT, Park KD, Sirianni RW, Khanna R.

Mol Neurobiol. 2018 May;55(5):4403-4416. doi: 10.1007/s12035-017-0653-9. Epub 2017 Jun 28.

PMID:
28660485
17.

Blocking CRMP2 SUMOylation reverses neuropathic pain.

Moutal A, Dustrude ET, Largent-Milnes TM, Vanderah TW, Khanna M, Khanna R.

Mol Psychiatry. 2018 Nov;23(11):2119-2121. doi: 10.1038/mp.2017.117. No abstract available.

18.

Genetic and pharmacological antagonism of NK1 receptor prevents opiate abuse potential.

Sandweiss AJ, McIntosh MI, Moutal A, Davidson-Knapp R, Hu J, Giri AK, Yamamoto T, Hruby VJ, Khanna R, Largent-Milnes TM, Vanderah TW.

Mol Psychiatry. 2018 Aug;23(8):1745-1755. doi: 10.1038/mp.2017.102. Epub 2017 May 9.

19.

Targeting a Potassium Channel/Syntaxin Interaction Ameliorates Cell Death in Ischemic Stroke.

Yeh CY, Bulas AM, Moutal A, Saloman JL, Hartnett KA, Anderson CT, Tzounopoulos T, Sun D, Khanna R, Aizenman E.

J Neurosci. 2017 Jun 7;37(23):5648-5658. doi: 10.1523/JNEUROSCI.3811-16.2017. Epub 2017 May 8.

20.

A single structurally conserved SUMOylation site in CRMP2 controls NaV1.7 function.

Dustrude ET, Perez-Miller S, François-Moutal L, Moutal A, Khanna M, Khanna R.

Channels (Austin). 2017 Jul 4;11(4):316-328. doi: 10.1080/19336950.2017.1299838. Epub 2017 Feb 28.

21.

Homology-guided mutational analysis reveals the functional requirements for antinociceptive specificity of collapsin response mediator protein 2-derived peptides.

Moutal A, Li W, Wang Y, Ju W, Luo S, Cai S, François-Moutal L, Perez-Miller S, Hu J, Dustrude ET, Vanderah TW, Gokhale V, Khanna M, Khanna R.

Br J Pharmacol. 2018 Jun;175(12):2244-2260. doi: 10.1111/bph.13737. Epub 2017 Mar 17.

22.

Long-lasting antinociceptive effects of green light in acute and chronic pain in rats.

Ibrahim MM, Patwardhan A, Gilbraith KB, Moutal A, Yang X, Chew LA, Largent-Milnes T, Malan TP, Vanderah TW, Porreca F, Khanna R.

Pain. 2017 Feb;158(2):347-360. doi: 10.1097/j.pain.0000000000000767.

23.

Hierarchical CRMP2 posttranslational modifications control NaV1.7 function.

Dustrude ET, Moutal A, Yang X, Wang Y, Khanna M, Khanna R.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8443-E8452. doi: 10.1073/pnas.1610531113. Epub 2016 Dec 8.

24.

Efficacy of (S)-Lacosamide in preclinical models of cephalic pain.

Moutal A, Eyde N, Telemi E, Park KD, Xie JY, Dodick DW, Porreca F, Khanna R.

Pain Rep. 2016 Jun;1(1). pii: e565.

25.

Sustained relief of ongoing experimental neuropathic pain by a CRMP2 peptide aptamer with low abuse potential.

Xie JY, Chew LA, Yang X, Wang Y, Qu C, Wang Y, Federici LM, Fitz SD, Ripsch MS, Due MR, Moutal A, Khanna M, White FA, Vanderah TW, Johnson PL, Porreca F, Khanna R.

Pain. 2016 Sep;157(9):2124-40. doi: 10.1097/j.pain.0000000000000628.

26.

Sensitization of Ion Channels Contributes to Central and Peripheral Dysfunction in Neurofibromatosis Type 1.

Moutal A, Dustrude ET, Khanna R.

Mol Neurobiol. 2017 Jul;54(5):3342-3349. doi: 10.1007/s12035-016-9907-1. Epub 2016 May 11. Review.

PMID:
27167129
27.

(S)-lacosamide inhibition of CRMP2 phosphorylation reduces postoperative and neuropathic pain behaviors through distinct classes of sensory neurons identified by constellation pharmacology.

Moutal A, Chew LA, Yang X, Wang Y, Yeon SK, Telemi E, Meroueh S, Park KD, Shrinivasan R, Gilbraith KB, Qu C, Xie JY, Patwardhan A, Vanderah TW, Khanna M, Porreca F, Khanna R.

Pain. 2016 Jul;157(7):1448-63. doi: 10.1097/j.pain.0000000000000555.

28.

CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling.

Moutal A, Honnorat J, Massoma P, Désormeaux P, Bertrand C, Malleval C, Watrin C, Chounlamountri N, Mayeur ME, Besançon R, Naudet N, Magadoux L, Khanna R, Ducray F, Meyronet D, Thomasset N.

Cancer Res. 2015 Sep 1;75(17):3519-28. doi: 10.1158/0008-5472.CAN-14-0631. Epub 2015 Jun 29.

29.

(S)-Lacosamide Binding to Collapsin Response Mediator Protein 2 (CRMP2) Regulates CaV2.2 Activity by Subverting Its Phosphorylation by Cdk5.

Moutal A, François-Moutal L, Perez-Miller S, Cottier K, Chew LA, Yeon SK, Dai J, Park KD, Khanna M, Khanna R.

Mol Neurobiol. 2016 Apr;53(3):1959-1976. doi: 10.1007/s12035-015-9141-2. Epub 2015 Apr 7.

PMID:
25846820
30.

A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors.

François-Moutal L, Wang Y, Moutal A, Cottier KE, Melemedjian OK, Yang X, Wang Y, Ju W, Largent-Milnes TM, Khanna M, Vanderah TW, Khanna R.

Pain. 2015 Jul;156(7):1247-64. doi: 10.1097/j.pain.0000000000000147.

31.

Differential neuroprotective potential of CRMP2 peptide aptamers conjugated to cationic, hydrophobic, and amphipathic cell penetrating peptides.

Moutal A, François-Moutal L, Brittain JM, Khanna M, Khanna R.

Front Cell Neurosci. 2015 Jan 26;8:471. doi: 10.3389/fncel.2014.00471. eCollection 2014.

32.

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth.

Wilson SM, Moutal A, Melemedjian OK, Wang Y, Ju W, François-Moutal L, Khanna M, Khanna R.

Front Cell Neurosci. 2014 Jul 24;8:196. doi: 10.3389/fncel.2014.00196. eCollection 2014.

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