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A modified flow cytometry method for objective estimation of human CD4+ regulatory T cells (CD4+ Tregs) in peripheral blood, via CD4/CD25/CD45RO/FoxP3 labeling.

Petsiou A, Paschou SA, Vartholomatos G, Chatzigianni K, Kolaitis N, Giotaki E, Bondinas GP, Moustakas AK, Karamoutsios A, Zervou E, Tigas S, Tsatsoulis A, Papadopoulos GK.

Cytometry B Clin Cytom. 2019 Sep 30. doi: 10.1002/cyto.b.21841. [Epub ahead of print]


The TGFB2-AS1 lncRNA Regulates TGF-β Signaling by Modulating Corepressor Activity.

Papoutsoglou P, Tsubakihara Y, Caja L, Morén A, Pallis P, Ameur A, Heldin CH, Moustakas A.

Cell Rep. 2019 Sep 17;28(12):3182-3198.e11. doi: 10.1016/j.celrep.2019.08.028.


Discriminative T cell recognition of cross-reactive islet-antigens is associated with HLA-DQ8 transdimer-mediated autoimmune diabetes.

Chow IT, Gates TJ, Papadopoulos GK, Moustakas AK, Kolawole EM, Notturno RJ, McGinty JW, Torres-Chinn N, James EA, Greenbaum C, Nepom GT, Evavold BD, Kwok WW.

Sci Adv. 2019 Aug 21;5(8):eaaw9336. doi: 10.1126/sciadv.aaw9336. eCollection 2019 Aug.


Severe presentation of antibody-negative, postinfectious steroid-responsive encephalitis and atonic bladder after herpes simplex encephalitis.

Mrad L, Moustakas A, Fuino R, Waheed W.

BMJ Case Rep. 2019 Jul 22;12(7). pii: e230005. doi: 10.1136/bcr-2019-230005.


Emulsifiers from Partially Composted Olive Waste.

Koliastasi A, Kompothekra V, Giotis C, Moustakas AK, Skotti EP, Gerakis A, Kalogianni E, Ritzoulis C.

Foods. 2019 Jul 20;8(7). pii: E271. doi: 10.3390/foods8070271.


Eleven Amino Acids of HLA-DRB1 and Fifteen Amino Acids of HLA-DRB3, 4, and 5 Include Potentially Causal Residues Responsible for the Risk of Childhood Type 1 Diabetes.

Zhao LP, Papadopoulos GK, Kwok WW, Xu B, Kong M, Moustakas AK, Bondinas GP, Carlsson A, Elding-Larsson H, Ludvigsson J, Marcus C, Persson M, Samuelsson U, Wang R, Pyo CW, Nelson WC, Geraghty DE, Lernmark Å.

Diabetes. 2019 Aug;68(8):1692-1704. doi: 10.2337/db19-0273. Epub 2019 May 24.


LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation.

Morén A, Bellomo C, Tsubakihara Y, Kardassis D, Mikulits W, Heldin CH, Moustakas A.

Oncogenesis. 2019 May 16;8(6):36. doi: 10.1038/s41389-019-0140-4.


TANK-binding kinase 1 is a mediator of platelet-induced EMT in mammary carcinoma cells.

Zhang Y, Unnithan RVM, Hamidi A, Caja L, Saupe F, Moustakas A, Cedervall J, Olsson AK.

FASEB J. 2019 Jul;33(7):7822-7832. doi: 10.1096/fj.201801936RRR. Epub 2019 Mar 26.


Transforming growth factor β (TGFβ) induces NUAK kinase expression to fine-tune its signaling output.

Kolliopoulos C, Raja E, Razmara M, Heldin P, Heldin CH, Moustakas A, van der Heide LP.

J Biol Chem. 2019 Mar 15;294(11):4119-4136. doi: 10.1074/jbc.RA118.004984. Epub 2019 Jan 8.


Epithelial-Mesenchymal Transition and Metastasis under the Control of Transforming Growth Factor β.

Tsubakihara Y, Moustakas A.

Int J Mol Sci. 2018 Nov 20;19(11). pii: E3672. doi: 10.3390/ijms19113672. Review.


Upregulated BMP-Smad signaling activity in the glucuronyl C5-epimerase knock out MEF cells.

Batool T, Fang J, Jansson V, Zhao H, Gallant C, Moustakas A, Li JP.

Cell Signal. 2019 Feb;54:122-129. doi: 10.1016/j.cellsig.2018.11.010. Epub 2018 Nov 17.


DRB4*01:01 Has a Distinct Motif and Presents a Proinsulin Epitope That Is Recognized in Subjects with Type 1 Diabetes.

James EA, Gillette L, Durinovic-Bello I, Speake C, Bondinas GP, Moustakas AK, Greenbaum CJ, Papadopoulos GK, Kwok WW.

J Immunol. 2018 Dec 15;201(12):3524-3533. doi: 10.4049/jimmunol.1800723. Epub 2018 Nov 19.


Data-driven competitive facilitative tree interactions and their implications on nature-based solutions.

Moustakas A, Daliakopoulos IN, Benton TG.

Sci Total Environ. 2019 Feb 15;651(Pt 2):2269-2280. doi: 10.1016/j.scitotenv.2018.09.349. Epub 2018 Sep 29.


Has2 natural antisense RNA and Hmga2 promote Has2 expression during TGFβ-induced EMT in breast cancer.

Kolliopoulos C, Lin CY, Heldin CH, Moustakas A, Heldin P.

Matrix Biol. 2019 Jul;80:29-45. doi: 10.1016/j.matbio.2018.09.002. Epub 2018 Sep 5.


Abrupt events and population synchrony in the dynamics of Bovine Tuberculosis.

Moustakas A, Evans MR, Daliakopoulos IN, Markonis Y.

Nat Commun. 2018 Jul 19;9(1):2821. doi: 10.1038/s41467-018-04915-0.


Serglycin promotes breast cancer cell aggressiveness: Induction of epithelial to mesenchymal transition, proteolytic activity and IL-8 signaling.

Bouris P, Manou D, Sopaki-Valalaki A, Kolokotroni A, Moustakas A, Kapoor A, Iozzo RV, Karamanos NK, Theocharis AD.

Matrix Biol. 2018 Dec;74:35-51. doi: 10.1016/j.matbio.2018.05.011. Epub 2018 May 26.


Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells.

Maturi V, Enroth S, Heldin CH, Moustakas A.

J Cell Physiol. 2018 Oct;233(10):7113-7127. doi: 10.1002/jcp.26634. Epub 2018 May 10.


Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells.

Maturi V, Morén A, Enroth S, Heldin CH, Moustakas A.

Mol Oncol. 2018 Jun;12(7):1153-1174. doi: 10.1002/1878-0261.12317. Epub 2018 May 21.


TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer.

Caja L, Dituri F, Mancarella S, Caballero-Diaz D, Moustakas A, Giannelli G, Fabregat I.

Int J Mol Sci. 2018 Apr 26;19(5). pii: E1294. doi: 10.3390/ijms19051294. Review.


Systemic and specific effects of antihypertensive and lipid-lowering medication on plasma protein biomarkers for cardiovascular diseases.

Enroth S, Maturi V, Berggrund M, Enroth SB, Moustakas A, Johansson Å, Gyllensten U.

Sci Rep. 2018 Apr 3;8(1):5531. doi: 10.1038/s41598-018-23860-y.


The protein kinase SIK downregulates the polarity protein Par3.

Vanlandewijck M, Dadras MS, Lomnytska M, Mahzabin T, Lee Miller M, Busch C, Brunak S, Heldin CH, Moustakas A.

Oncotarget. 2017 Dec 31;9(5):5716-5735. doi: 10.18632/oncotarget.23788. eCollection 2018 Jan 19.


Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells.

Caja L, Tzavlaki K, Dadras MS, Tan EJ, Hatem G, Maturi NP, Morén A, Wik L, Watanabe Y, Savary K, Kamali-Moghaddan M, Uhrbom L, Heldin CH, Moustakas A.

Oncogene. 2018 May;37(19):2515-2531. doi: 10.1038/s41388-018-0136-0. Epub 2018 Feb 16.


Sampling alien species inside and outside protected areas: Does it matter?

Moustakas A, Voutsela A, Katsanevakis S.

Sci Total Environ. 2018 Jun 1;625:194-198. doi: 10.1016/j.scitotenv.2017.12.198. Epub 2017 Dec 27.


Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma.

Bellomo C, Caja L, Fabregat I, Mikulits W, Kardassis D, Heldin CH, Moustakas A.

Cell Death Differ. 2018 May;25(5):885-903. doi: 10.1038/s41418-017-0021-3. Epub 2017 Dec 11.


Mechanistic Insights into Autoinhibition of the Oncogenic Chromatin Remodeler ALC1.

Lehmann LC, Hewitt G, Aibara S, Leitner A, Marklund E, Maslen SL, Maturi V, Chen Y, van der Spoel D, Skehel JM, Moustakas A, Boulton SJ, Deindl S.

Mol Cell. 2017 Dec 7;68(5):847-859.e7. doi: 10.1016/j.molcel.2017.10.017.


Molecular basis for increased susceptibility of Indigenous North Americans to seropositive rheumatoid arthritis.

Scally SW, Law SC, Ting YT, Heemst JV, Sokolove J, Deutsch AJ, Bridie Clemens E, Moustakas AK, Papadopoulos GK, van der Woude D, Smolik I, Hitchon CA, Robinson DB, Ferucci ED, Bernstein CN, Meng X, Anaparti V, Huizinga T, Kedzierska K, Reid HH, Raychaudhuri S, Toes RE, Rossjohn J, El-Gabalawy H, Thomas R.

Ann Rheum Dis. 2017 Nov;76(11):1915-1923. doi: 10.1136/annrheumdis-2017-211300. Epub 2017 Aug 11.


Epithelial-mesenchymal transition in cancer.

Moustakas A, de Herreros AG.

Mol Oncol. 2017 Jul;11(7):715-717. doi: 10.1002/1878-0261.12094. No abstract available.


TGF-β Family Signaling in Ductal Differentiation and Branching Morphogenesis.

Kahata K, Maturi V, Moustakas A.

Cold Spring Harb Perspect Biol. 2018 Mar 1;10(3). pii: a031997. doi: 10.1101/cshperspect.a031997. Review.


Overexpression of heparanase attenuated TGF-β-stimulated signaling in tumor cells.

Batool T, Fang J, Barash U, Moustakas A, Vlodavsky I, Li JP.

FEBS Open Bio. 2017 Feb 11;7(3):405-413. doi: 10.1002/2211-5463.12190. eCollection 2017 Mar.


TGF-β Family Signaling in Epithelial Differentiation and Epithelial-Mesenchymal Transition.

Kahata K, Dadras MS, Moustakas A.

Cold Spring Harb Perspect Biol. 2018 Jan 2;10(1). pii: a022194. doi: 10.1101/cshperspect.a022194. Review.


Somatic Ephrin Receptor Mutations Are Associated with Metastasis in Primary Colorectal Cancer.

Mathot L, Kundu S, Ljungström V, Svedlund J, Moens L, Adlerteg T, Falk-Sörqvist E, Rendo V, Bellomo C, Mayrhofer M, Cortina C, Sundström M, Micke P, Botling J, Isaksson A, Moustakas A, Batlle E, Birgisson H, Glimelius B, Nilsson M, Sjöblom T.

Cancer Res. 2017 Apr 1;77(7):1730-1740. doi: 10.1158/0008-5472.CAN-16-1921. Epub 2017 Jan 20.


Modified niche optima and breadths explain the historical contingency of bacterial community responses to eutrophication in coastal sediments.

Fodelianakis S, Moustakas A, Papageorgiou N, Manoli O, Tsikopoulou I, Michoud G, Daffonchio D, Karakassis I, Ladoukakis ED.

Mol Ecol. 2017 Apr;26(7):2006-2018. doi: 10.1111/mec.13842. Epub 2016 Oct 7.


Ras and TGF-β signaling enhance cancer progression by promoting the ΔNp63 transcriptional program.

Vasilaki E, Morikawa M, Koinuma D, Mizutani A, Hirano Y, Ehata S, Sundqvist A, Kawasaki N, Cedervall J, Olsson AK, Aburatani H, Moustakas A, Miyazono K, Heldin CH.

Sci Signal. 2016 Aug 23;9(442):ra84. doi: 10.1126/scisignal.aag3232.


Transforming growth factor β as regulator of cancer stemness and metastasis.

Bellomo C, Caja L, Moustakas A.

Br J Cancer. 2016 Sep 27;115(7):761-9. doi: 10.1038/bjc.2016.255. Epub 2016 Aug 18. Review.


Signaling Receptors for TGF-β Family Members.

Heldin CH, Moustakas A.

Cold Spring Harb Perspect Biol. 2016 Aug 1;8(8). pii: a022053. doi: 10.1101/cshperspect.a022053. Review.


Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation.

Carthy JM, Stöter M, Bellomo C, Vanlandewijck M, Heldin A, Morén A, Kardassis D, Gahman TC, Shiau AK, Bickle M, Zerial M, Heldin CH, Moustakas A.

Sci Rep. 2016 Jul 19;6:29868. doi: 10.1038/srep29868.


Mechanisms of TGFβ-Induced Epithelial-Mesenchymal Transition.

Moustakas A, Heldin CH.

J Clin Med. 2016 Jun 29;5(7). pii: E63. doi: 10.3390/jcm5070063. Review.


Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation.

Watanabe Y, Papoutsoglou P, Maturi V, Tsubakihara Y, Hottiger MO, Heldin CH, Moustakas A.

J Biol Chem. 2016 Jun 10;291(24):12706-23. doi: 10.1074/jbc.M116.729699. Epub 2016 Apr 21.


Single Chain Antibodies as Tools to Study transforming growth factor-β-Regulated SMAD Proteins in Proximity Ligation-Based Pharmacological Screens.

Blokzijl A, Zieba A, Hust M, Schirrmann T, Helmsing S, Grannas K, Hertz E, Moren A, Chen L, Söderberg O, Moustakas A, Dübel S, Landegren U.

Mol Cell Proteomics. 2016 Jun;15(6):1848-56. doi: 10.1074/mcp.M115.055756. Epub 2016 Feb 29.


In vitro and ex vivo vanadium antitumor activity in (TGF-β)-induced EMT. Synergistic activity with carboplatin and correlation with tumor metastasis in cancer patients.

Petanidis S, Kioseoglou E, Domvri K, Zarogoulidis P, Carthy JM, Anestakis D, Moustakas A, Salifoglou A.

Int J Biochem Cell Biol. 2016 May;74:121-34. doi: 10.1016/j.biocel.2016.02.015. Epub 2016 Feb 23.


The rationale for targeting TGF-β in chronic liver diseases.

Giannelli G, Mikulits W, Dooley S, Fabregat I, Moustakas A, ten Dijke P, Portincasa P, Winter P, Janssen R, Leporatti S, Herrera B, Sanchez A.

Eur J Clin Invest. 2016 Apr;46(4):349-61. doi: 10.1111/eci.12596. Epub 2016 Mar 12. Review.


The protein kinase LKB1 negatively regulates bone morphogenetic protein receptor signaling.

Raja E, Tzavlaki K, Vuilleumier R, Edlund K, Kahata K, Zieba A, Morén A, Watanabe Y, Voytyuk I, Botling J, Söderberg O, Micke P, Pyrowolakis G, Heldin CH, Moustakas A.

Oncotarget. 2016 Jan 12;7(2):1120-43. doi: 10.18632/oncotarget.6683.


Mechanisms of action of bone morphogenetic proteins in cancer.

Davis H, Raja E, Miyazono K, Tsubakihara Y, Moustakas A.

Cytokine Growth Factor Rev. 2016 Feb;27:81-92. doi: 10.1016/j.cytogfr.2015.11.009. Epub 2015 Nov 24. Review.


A phase II trial of enzastaurin (LY317615) in combination with bevacizumab in adults with recurrent malignant gliomas.

Odia Y, Iwamoto FM, Moustakas A, Fraum TJ, Salgado CA, Li A, Kreisl TN, Sul J, Butman JA, Fine HA.

J Neurooncol. 2016 Mar;127(1):127-35. doi: 10.1007/s11060-015-2020-x. Epub 2015 Dec 7.


Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β.

Valcourt U, Carthy J, Okita Y, Alcaraz L, Kato M, Thuault S, Bartholin L, Moustakas A.

Methods Mol Biol. 2016;1344:147-81. doi: 10.1007/978-1-4939-2966-5_9.


Commercially Available Preparations of Recombinant Wnt3a Contain Non-Wnt Related Activities Which May Activate TGF-β Signaling.

Carthy JM, Engström U, Heldin CH, Moustakas A.

J Cell Biochem. 2016 Apr;117(4):938-45. doi: 10.1002/jcb.25378. Epub 2015 Sep 22.


MEG3 long noncoding RNA regulates the TGF-β pathway genes through formation of RNA-DNA triplex structures.

Mondal T, Subhash S, Vaid R, Enroth S, Uday S, Reinius B, Mitra S, Mohammed A, James AR, Hoberg E, Moustakas A, Gyllensten U, Jones SJ, Gustafsson CM, Sims AH, Westerlund F, Gorab E, Kanduri C.

Nat Commun. 2015 Jul 24;6:7743. doi: 10.1038/ncomms8743.


Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.

Carthy JM, Sundqvist A, Heldin A, van Dam H, Kletsas D, Heldin CH, Moustakas A.

J Cell Physiol. 2015 Dec;230(12):3084-92. doi: 10.1002/jcp.25049.


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