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Items: 45


Mitochondrial fusion is required for regulation of mitochondrial DNA replication.

Silva Ramos E, Motori E, Brüser C, Kühl I, Yeroslaviz A, Ruzzenente B, Kauppila JHK, Busch JD, Hultenby K, Habermann BH, Jakobs S, Larsson NG, Mourier A.

PLoS Genet. 2019 Jun 6;15(6):e1008085. doi: 10.1371/journal.pgen.1008085. eCollection 2019 Jun.


Human COX7A2L Regulates Complex III Biogenesis and Promotes Supercomplex Organization Remodeling without Affecting Mitochondrial Bioenergetics.

Lobo-Jarne T, Nývltová E, Pérez-Pérez R, Timón-Gómez A, Molinié T, Choi A, Mourier A, Fontanesi F, Ugalde C, Barrientos A.

Cell Rep. 2018 Nov 13;25(7):1786-1799.e4. doi: 10.1016/j.celrep.2018.10.058.


Glycerol supports growth of the Trypanosoma brucei bloodstream forms in the absence of glucose: Analysis of metabolic adaptations on glycerol-rich conditions.

Pineda E, Thonnus M, Mazet M, Mourier A, Cahoreau E, Kulyk H, Dupuy JW, Biran M, Masante C, Allmann S, Rivière L, Rotureau B, Portais JC, Bringaud F.

PLoS Pathog. 2018 Nov 1;14(11):e1007412. doi: 10.1371/journal.ppat.1007412. eCollection 2018 Nov.


Dietary methionine deficiency affects oxidative status, mitochondrial integrity and mitophagy in the liver of rainbow trout (Oncorhynchus mykiss).

Séité S, Mourier A, Camougrand N, Salin B, Figueiredo-Silva AC, Fontagné-Dicharry S, Panserat S, Seiliez I.

Sci Rep. 2018 Jul 5;8(1):10151. doi: 10.1038/s41598-018-28559-8.


Base-excision repair deficiency alone or combined with increased oxidative stress does not increase mtDNA point mutations in mice.

Kauppila JHK, Bonekamp NA, Mourier A, Isokallio MA, Just A, Kauppila TES, Stewart JB, Larsson NG.

Nucleic Acids Res. 2018 Jul 27;46(13):6642-6669. doi: 10.1093/nar/gky456.


A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency.

Simard ML, Mourier A, Greaves LC, Taylor RW, Stewart JB.

J Pathol. 2018 Jul;245(3):311-323. doi: 10.1002/path.5084. Epub 2018 May 14.


Transcriptomic and proteomic landscape of mitochondrial dysfunction reveals secondary coenzyme Q deficiency in mammals.

Kühl I, Miranda M, Atanassov I, Kuznetsova I, Hinze Y, Mourier A, Filipovska A, Larsson NG.

Elife. 2017 Nov 14;6. pii: e30952. doi: 10.7554/eLife.30952.


Changes of mitochondrial ultrastructure and function during ageing in mice and Drosophila.

Brandt T, Mourier A, Tain LS, Partridge L, Larsson NG, Kühlbrandt W.

Elife. 2017 Jul 12;6. pii: e24662. doi: 10.7554/eLife.24662.


CLUH regulates mitochondrial metabolism by controlling translation and decay of target mRNAs.

Schatton D, Pla-Martin D, Marx MC, Hansen H, Mourier A, Nemazanyy I, Pessia A, Zentis P, Corona T, Kondylis V, Barth E, Schauss AC, Velagapudi V, Rugarli EI.

J Cell Biol. 2017 Mar 6;216(3):675-693. doi: 10.1083/jcb.201607019. Epub 2017 Feb 10.


A Phenotype-Driven Approach to Generate Mouse Models with Pathogenic mtDNA Mutations Causing Mitochondrial Disease.

Kauppila JHK, Baines HL, Bratic A, Simard ML, Freyer C, Mourier A, Stamp C, Filograna R, Larsson NG, Greaves LC, Stewart JB.

Cell Rep. 2016 Sep 13;16(11):2980-2990. doi: 10.1016/j.celrep.2016.08.037.


COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation.

Pérez-Pérez R, Lobo-Jarne T, Milenkovic D, Mourier A, Bratic A, García-Bartolomé A, Fernández-Vizarra E, Cadenas S, Delmiro A, García-Consuegra I, Arenas J, Martín MA, Larsson NG, Ugalde C.

Cell Rep. 2016 Aug 30;16(9):2387-98. doi: 10.1016/j.celrep.2016.07.081. Epub 2016 Aug 18.


POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA.

Kühl I, Miranda M, Posse V, Milenkovic D, Mourier A, Siira SJ, Bonekamp NA, Neumann U, Filipovska A, Polosa PL, Gustafsson CM, Larsson NG.

Sci Adv. 2016 Aug 5;2(8):e1600963. doi: 10.1126/sciadv.1600963. eCollection 2016 Aug.


Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly.

Rackham O, Busch JD, Matic S, Siira SJ, Kuznetsova I, Atanassov I, Ermer JA, Shearwood AM, Richman TR, Stewart JB, Mourier A, Milenkovic D, Larsson NG, Filipovska A.

Cell Rep. 2016 Aug 16;16(7):1874-90. doi: 10.1016/j.celrep.2016.07.031. Epub 2016 Aug 4.


Bioenergetic roles of mitochondrial fusion.

Silva Ramos E, Larsson NG, Mourier A.

Biochim Biophys Acta. 2016 Aug;1857(8):1277-1283. doi: 10.1016/j.bbabio.2016.04.002. Epub 2016 Apr 7. Review.


Intra-mitochondrial Methylation Deficiency Due to Mutations in SLC25A26.

Kishita Y, Pajak A, Bolar NA, Marobbio CM, Maffezzini C, Miniero DV, Monné M, Kohda M, Stranneheim H, Murayama K, Naess K, Lesko N, Bruhn H, Mourier A, Wibom R, Nennesmo I, Jespers A, Govaert P, Ohtake A, Van Laer L, Loeys BL, Freyer C, Palmieri F, Wredenberg A, Okazaki Y, Wedell A.

Am J Hum Genet. 2015 Nov 5;97(5):761-8. doi: 10.1016/j.ajhg.2015.09.013. Epub 2015 Oct 29.


SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation.

Lagouge M, Mourier A, Lee HJ, Spåhr H, Wai T, Kukat C, Silva Ramos E, Motori E, Busch JD, Siira S; German Mouse Clinic Consortium, Kremmer E, Filipovska A, Larsson NG.

PLoS Genet. 2015 Aug 6;11(8):e1005423. doi: 10.1371/journal.pgen.1005423. eCollection 2015 Aug.


Rescue of primary ubiquinone deficiency due to a novel COQ7 defect using 2,4-dihydroxybensoic acid.

Freyer C, Stranneheim H, Naess K, Mourier A, Felser A, Maffezzini C, Lesko N, Bruhn H, Engvall M, Wibom R, Barbaro M, Hinze Y, Magnusson M, Andeer R, Zetterström RH, von Döbeln U, Wredenberg A, Wedell A.

J Med Genet. 2015 Nov;52(11):779-83. doi: 10.1136/jmedgenet-2015-102986. Epub 2015 Jun 17.


MICOS coordinates with respiratory complexes and lipids to establish mitochondrial inner membrane architecture.

Friedman JR, Mourier A, Yamada J, McCaffery JM, Nunnari J.

Elife. 2015 Apr 28;4. doi: 10.7554/eLife.07739.


Mitofusin 2 is required to maintain mitochondrial coenzyme Q levels.

Mourier A, Motori E, Brandt T, Lagouge M, Atanassov I, Galinier A, Rappl G, Brodesser S, Hultenby K, Dieterich C, Larsson NG.

J Cell Biol. 2015 Feb 16;208(4):429-42. doi: 10.1083/jcb.201411100.


The respiratory chain supercomplex organization is independent of COX7a2l isoforms.

Mourier A, Matic S, Ruzzenente B, Larsson NG, Milenkovic D.

Cell Metab. 2014 Dec 2;20(6):1069-75. doi: 10.1016/j.cmet.2014.11.005.


Drosophila melanogaster LRPPRC2 is involved in coordination of mitochondrial translation.

Baggio F, Bratic A, Mourier A, Kauppila TE, Tain LS, Kukat C, Habermann B, Partridge L, Larsson NG.

Nucleic Acids Res. 2014 Dec 16;42(22):13920-38. doi: 10.1093/nar/gku1132. Epub 2014 Nov 26.


POLRMT does not transcribe nuclear genes.

Kühl I, Kukat C, Ruzzenente B, Milenkovic D, Mourier A, Miranda M, Koolmeister C, Falkenberg M, Larsson NG.

Nature. 2014 Oct 9;514(7521):E7-11. doi: 10.1038/nature13690. No abstract available.


Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.

Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM, Mauer J, Xu E, Hammerschmidt P, Brönneke HS, Trifunovic A, LoSasso G, Wunderlich FT, Kornfeld JW, Blüher M, Krönke M, Brüning JC.

Cell Metab. 2014 Oct 7;20(4):678-86. doi: 10.1016/j.cmet.2014.08.002.


Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications.

Vernochet C, Damilano F, Mourier A, Bezy O, Mori MA, Smyth G, Rosenzweig A, Larsson NG, Kahn CR.

FASEB J. 2014 Oct;28(10):4408-19. doi: 10.1096/fj.14-253971. Epub 2014 Jul 8.


Loss of UCP2 attenuates mitochondrial dysfunction without altering ROS production and uncoupling activity.

Kukat A, Dogan SA, Edgar D, Mourier A, Jacoby C, Maiti P, Mauer J, Becker C, Senft K, Wibom R, Kudin AP, Hultenby K, Flögel U, Rosenkranz S, Ricquier D, Kunz WS, Trifunovic A.

PLoS Genet. 2014 Jun 19;10(6):e1004385. doi: 10.1371/journal.pgen.1004385. eCollection 2014 Jun.


Loss of LRPPRC causes ATP synthase deficiency.

Mourier A, Ruzzenente B, Brandt T, Kühlbrandt W, Larsson NG.

Hum Mol Genet. 2014 May 15;23(10):2580-92. doi: 10.1093/hmg/ddt652. Epub 2014 Jan 6.


Germline mitochondrial DNA mutations aggravate ageing and can impair brain development.

Ross JM, Stewart JB, Hagström E, Brené S, Mourier A, Coppotelli G, Freyer C, Lagouge M, Hoffer BJ, Olson L, Larsson NG.

Nature. 2013 Sep 19;501(7467):412-5. doi: 10.1038/nature12474. Epub 2013 Aug 21.


MTERF1 binds mtDNA to prevent transcriptional interference at the light-strand promoter but is dispensable for rRNA gene transcription regulation.

Terzioglu M, Ruzzenente B, Harmel J, Mourier A, Jemt E, López MD, Kukat C, Stewart JB, Wibom R, Meharg C, Habermann B, Falkenberg M, Gustafsson CM, Park CB, Larsson NG.

Cell Metab. 2013 Apr 2;17(4):618-26. doi: 10.1016/j.cmet.2013.03.006.


Succinate dehydrogenase upregulation destabilize complex I and limits the lifespan of gas-1 mutant.

Pujol C, Bratic-Hench I, Sumakovic M, Hench J, Mourier A, Baumann L, Pavlenko V, Trifunovic A.

PLoS One. 2013;8(3):e59493. doi: 10.1371/journal.pone.0059493. Epub 2013 Mar 28.


MTERF3 regulates mitochondrial ribosome biogenesis in invertebrates and mammals.

Wredenberg A, Lagouge M, Bratic A, Metodiev MD, Spåhr H, Mourier A, Freyer C, Ruzzenente B, Tain L, Grönke S, Baggio F, Kukat C, Kremmer E, Wibom R, Polosa PL, Habermann B, Partridge L, Park CB, Larsson NG.

PLoS Genet. 2013;9(1):e1003178. doi: 10.1371/journal.pgen.1003178. Epub 2013 Jan 3.


Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance.

Vernochet C, Mourier A, Bezy O, Macotela Y, Boucher J, Rardin MJ, An D, Lee KY, Ilkayeva OR, Zingaretti CM, Emanuelli B, Smyth G, Cinti S, Newgard CB, Gibson BW, Larsson NG, Kahn CR.

Cell Metab. 2012 Dec 5;16(6):765-76. doi: 10.1016/j.cmet.2012.10.016. Epub 2012 Nov 15.


Variation in germline mtDNA heteroplasmy is determined prenatally but modified during subsequent transmission.

Freyer C, Cree LM, Mourier A, Stewart JB, Koolmeister C, Milenkovic D, Wai T, Floros VI, Hagström E, Chatzidaki EE, Wiesner RJ, Samuels DC, Larsson NG, Chinnery PF.

Nat Genet. 2012 Nov;44(11):1282-5. doi: 10.1038/ng.2427. Epub 2012 Oct 7.


Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons.

Lee S, Sterky FH, Mourier A, Terzioglu M, Cullheim S, Olson L, Larsson NG.

Hum Mol Genet. 2012 Nov 15;21(22):4827-35. doi: 10.1093/hmg/dds352. Epub 2012 Aug 21.


A tissue-specific approach to the analysis of metabolic changes in Caenorhabditis elegans.

Hench J, Bratić Hench I, Pujol C, Ipsen S, Brodesser S, Mourier A, Tolnay M, Frank S, Trifunović A.

PLoS One. 2011;6(12):e28417. doi: 10.1371/journal.pone.0028417. Epub 2011 Dec 5.


The bicoid stability factor controls polyadenylation and expression of specific mitochondrial mRNAs in Drosophila melanogaster.

Bratic A, Wredenberg A, Grönke S, Stewart JB, Mourier A, Ruzzenente B, Kukat C, Wibom R, Habermann B, Partridge L, Larsson NG.

PLoS Genet. 2011 Oct;7(10):e1002324. doi: 10.1371/journal.pgen.1002324. Epub 2011 Oct 13.


Tracing the trail of protons through complex I of the mitochondrial respiratory chain.

Mourier A, Larsson NG.

PLoS Biol. 2011 Aug;9(8):e1001129. doi: 10.1371/journal.pbio.1001129. Epub 2011 Aug 23.


Electron competition process in respiratory chain: regulatory mechanisms and physiological functions.

Rigoulet M, Mourier A, Galinier A, Casteilla L, Devin A.

Biochim Biophys Acta. 2010 Jun-Jul;1797(6-7):671-7. doi: 10.1016/j.bbabio.2010.01.030. Epub 2010 Feb 1.


Active proton leak in mitochondria: a new way to regulate substrate oxidation.

Mourier A, Devin A, Rigoulet M.

Biochim Biophys Acta. 2010 Feb;1797(2):255-61. doi: 10.1016/j.bbabio.2009.10.011. Epub 2009 Nov 6.


Kinetic activation of yeast mitochondrial D-lactate dehydrogenase by carboxylic acids.

Mourier A, Vallortigara J, Yoboue ED, Rigoulet M, Devin A.

Biochim Biophys Acta. 2008 Oct;1777(10):1283-8. doi: 10.1016/j.bbabio.2008.06.007. Epub 2008 Jun 20.


Mitochondrial adaptations to steatohepatitis induced by a methionine- and choline-deficient diet.

Romestaing C, Piquet MA, Letexier D, Rey B, Mourier A, Servais S, Belouze M, Rouleau V, Dautresme M, Ollivier I, Favier R, Rigoulet M, Duchamp C, Sibille B.

Am J Physiol Endocrinol Metab. 2008 Jan;294(1):E110-9. Epub 2007 Nov 6.


A randomised phase II multicentre trial of irinotecan (CPT-11) using four different schedules in patients with metastatic colorectal cancer.

Schoemaker NE, Kuppens IE, Moiseyenko V, Glimelius B, Kjaer M, Starkhammer H, Richel DJ, Smaaland R, Bertelsen K, Poulsen JP, Voznyi E, Norum J, Fennelly D, Tveit KM, Garin A, Gruia G, Mourier A, Sibaud D, Lefebvre P, Beijnen JH, Schellens JH, ten Bokkel Huinink WW.

Br J Cancer. 2004 Oct 18;91(8):1434-41.


Evaluation of abdominal fat distribution in noninsulin-dependent diabetes mellitus: relationship to insulin resistance.

Gautier JF, Mourier A, de Kerviler E, Tarentola A, Bigard AX, Villette JM, Guezennec CY, Cathelineau G.

J Clin Endocrinol Metab. 1998 Apr;83(4):1306-11.


Mobilization of visceral adipose tissue related to the improvement in insulin sensitivity in response to physical training in NIDDM. Effects of branched-chain amino acid supplements.

Mourier A, Gautier JF, De Kerviler E, Bigard AX, Villette JM, Garnier JP, Duvallet A, Guezennec CY, Cathelineau G.

Diabetes Care. 1997 Mar;20(3):385-91.


Combined effects of caloric restriction and branched-chain amino acid supplementation on body composition and exercise performance in elite wrestlers.

Mourier A, Bigard AX, de Kerviler E, Roger B, Legrand H, Guezennec CY.

Int J Sports Med. 1997 Jan;18(1):47-55.


[342 children admitted to a pediatric clinic for acute abdomen].

Hvorslev V, Klebak S, Mourier A.

Ugeskr Laeger. 1983 Jan 3;145(1):19-21. Danish. No abstract available.


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