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Items: 22

1.

Inhibition of the protein kinase MK-2 protects podocytes from nephrotic syndrome-related injury.

Pengal R, Guess AJ, Agrawal S, Manley J, Ransom RF, Mourey RJ, Benndorf R, Smoyer WE.

Am J Physiol Renal Physiol. 2011 Sep;301(3):F509-19. doi: 10.1152/ajprenal.00661.2010. Epub 2011 May 25.

2.

Acute lymphoid and gastrointestinal toxicity induced by selective p38alpha map kinase and map kinase-activated protein kinase-2 (MK2) inhibitors in the dog.

Morris DL, O'Neil SP, Devraj RV, Portanova JP, Gilles RW, Gross CJ, Curtiss SW, Komocsar WJ, Garner DS, Happa FA, Kraus LJ, Nikula KJ, Monahan JB, Selness SR, Galluppi GR, Shevlin KM, Kramer JA, Walker JK, Messing DM, Anderson DR, Mourey RJ, Whiteley LO, Daniels JS, Yang JZ, Rowlands PC, Alden CL, Davis JW 2nd, Sagartz JE.

Toxicol Pathol. 2010 Jun;38(4):606-18. doi: 10.1177/0192623310367807. Epub 2010 May 6.

PMID:
20448081
3.

A benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor alpha production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation.

Mourey RJ, Burnette BL, Brustkern SJ, Daniels JS, Hirsch JL, Hood WF, Meyers MJ, Mnich SJ, Pierce BS, Saabye MJ, Schindler JF, South SA, Webb EG, Zhang J, Anderson DR.

J Pharmacol Exp Ther. 2010 Jun;333(3):797-807. doi: 10.1124/jpet.110.166173. Epub 2010 Mar 17.

PMID:
20237073
4.

Biochemical, cellular, and anti-inflammatory properties of a potent, selective, orally bioavailable benzamide inhibitor of Rho kinase activity.

Rajagopalan LE, Davies MS, Kahn LE, Kornmeier CM, Shimada H, Steiner TA, Zweifel BS, Wendling JM, Payne MA, Loeffler RF, Case BL, Norton MB, Parikh MD, Nemirovskiy OV, Mourey RJ, Masferrer JL, Misko TP, Kolodziej SA.

J Pharmacol Exp Ther. 2010 Jun;333(3):707-16. doi: 10.1124/jpet.110.166033. Epub 2010 Mar 12.

PMID:
20228155
5.

Benzothiophene inhibitors of MK2. Part 1: structure-activity relationships, assessments of selectivity and cellular potency.

Anderson DR, Meyers MJ, Kurumbail RG, Caspers N, Poda GI, Long SA, Pierce BS, Mahoney MW, Mourey RJ.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4878-81. doi: 10.1016/j.bmcl.2009.02.015. Epub 2009 Feb 8.

PMID:
19616945
6.

Benzothiophene inhibitors of MK2. Part 2: improvements in kinase selectivity and cell potency.

Anderson DR, Meyers MJ, Kurumbail RG, Caspers N, Poda GI, Long SA, Pierce BS, Mahoney MW, Mourey RJ, Parikh MD.

Bioorg Med Chem Lett. 2009 Aug 15;19(16):4882-4. doi: 10.1016/j.bmcl.2009.02.017. Epub 2009 Feb 8.

PMID:
19616942
7.

Aqueous versus non-aqueous salt delivery strategies to enhance oral bioavailability of a mitogen-activated protein kinase-activated protein kinase (MK-2) inhibitor in rats.

Chiang PC, South SA, Daniels JS, Anderson DR, Wene SP, Albin LA, Mourey RJ, Selbo JG.

J Pharm Sci. 2009 Jan;98(1):248-56. doi: 10.1002/jps.21425.

PMID:
18449936
8.

Synthesis, crystal structure, and activity of pyrazole-based inhibitors of p38 kinase.

Graneto MJ, Kurumbail RG, Vazquez ML, Shieh HS, Pawlitz JL, Williams JM, Stallings WC, Geng L, Naraian AS, Koszyk FJ, Stealey MA, Xu XD, Weier RM, Hanson GJ, Mourey RJ, Compton RP, Mnich SJ, Anderson GD, Monahan JB, Devraj R.

J Med Chem. 2007 Nov 15;50(23):5712-9. Epub 2007 Oct 19.

PMID:
17948975
9.

Pyrrolopyridine inhibitors of mitogen-activated protein kinase-activated protein kinase 2 (MK-2).

Anderson DR, Meyers MJ, Vernier WF, Mahoney MW, Kurumbail RG, Caspers N, Poda GI, Schindler JF, Reitz DB, Mourey RJ.

J Med Chem. 2007 May 31;50(11):2647-54. Epub 2007 May 5.

PMID:
17480064
10.

Examination of the kinetic mechanism of mitogen-activated protein kinase activated protein kinase-2.

Schindler JF, Godbey A, Hood WF, Bolten SL, Broadus RM, Kasten TP, Cassely AJ, Hirsch JL, Merwood MA, Nagy MA, Fok KF, Saabye MJ, Morgan HM, Compton RP, Mourey RJ, Wittwer AJ, Monahan JB.

Biochim Biophys Acta. 2002 Jul 29;1598(1-2):88-97.

PMID:
12147348
11.

Purification and kinetic characterization of the mitogen-activated protein kinase phosphatase rVH6.

Wiland AM, Denu JM, Mourey RJ, Dixon JE.

J Biol Chem. 1996 Dec 27;271(52):33486-92.

12.

A novel cytoplasmic dual specificity protein tyrosine phosphatase implicated in muscle and neuronal differentiation.

Mourey RJ, Vega QC, Campbell JS, Wenderoth MP, Hauschka SD, Krebs EG, Dixon JE.

J Biol Chem. 1996 Feb 16;271(7):3795-802.

13.

Identification of a hormonally regulated protein tyrosine phosphatase associated with bone and testicular differentiation.

Mauro LJ, Olmsted EA, Skrobacz BM, Mourey RJ, Davis AR, Dixon JE.

J Biol Chem. 1994 Dec 2;269(48):30659-67.

14.

Protein tyrosine phosphatases: characterization of extracellular and intracellular domains.

Mourey RJ, Dixon JE.

Curr Opin Genet Dev. 1994 Feb;4(1):31-9. Review.

15.

Inositol 1,4,5-trisphosphate receptors: immunohistochemical localization to discrete areas of rat central nervous system.

Sharp AH, Dawson TM, Ross CA, Fotuhi M, Mourey RJ, Snyder SH.

Neuroscience. 1993 Apr;53(4):927-42.

PMID:
8389431
16.

Inositol 1,4,5-trisphosphate receptors: labeling the inositol 1,4,5-trisphosphate binding site with photoaffinity ligands.

Mourey RJ, Estevez VA, Marecek JF, Barrow RK, Prestwich GD, Snyder SH.

Biochemistry. 1993 Feb 23;32(7):1719-26.

PMID:
8382518
17.

[3H]noscapine binding sites in brain: relationship to indoleamines and the phosphoinositide and adenylyl cyclase messenger systems.

Mourey RJ, Dawson TM, Barrow RK, Enna AE, Snyder SH.

Mol Pharmacol. 1992 Oct;42(4):619-26.

PMID:
1331753
18.

Photoaffinity labeling and characterization of isolated inositol 1,3,4,5-tetrakisphosphate- and inositol hexakisphosphate-binding proteins.

Theibert AB, Estevez VA, Mourey RJ, Marecek JF, Barrow RK, Prestwich GD, Snyder SH.

J Biol Chem. 1992 May 5;267(13):9071-9.

19.

Purification and characterization of the inositol 1,4,5- trisphosphate receptor protein from rat vas deferens.

Mourey RJ, Verma A, Supattapone S, Snyder SH.

Biochem J. 1990 Dec 1;272(2):383-9.

20.

In vitro antibacterial activity and interactions with beta-lactamases and penicillin-binding proteins of the new monocarbam antibiotic U-78608.

Zurenko GE, Truesdell SE, Yagi BH, Mourey RJ, Laborde AL.

Antimicrob Agents Chemother. 1990 May;34(5):884-8.

21.

A simple, sensitive, and specific radioreceptor assay for inositol 1,4,5-trisphosphate in biological tissues.

Bredt DS, Mourey RJ, Snyder SH.

Biochem Biophys Res Commun. 1989 Mar 31;159(3):976-82.

PMID:
2539157
22.

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