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Items: 1 to 50 of 64

1.

Anti-HIV-1 antibodies trigger non-lytic complement deposition on infected cells.

Dufloo J, Guivel-Benhassine F, Buchrieser J, Lorin V, Grzelak L, Dupouy E, Mestrallet G, Bourdic K, Lambotte O, Mouquet H, Bruel T, Schwartz O.

EMBO Rep. 2019 Dec 12:e49351. doi: 10.15252/embr.201949351. [Epub ahead of print]

PMID:
31833228
2.

TLR9 signalling in HCV-associated atypical memory B cells triggers Th1 and rheumatoid factor autoantibody responses.

Comarmond C, Lorin V, Marques C, Maciejewski-Duval A, Joher N, Planchais C, Touzot M, Biard L, Hieu T, Quiniou V, Desbois AC, Rosenzwajg M, Klatzmann D, Cacoub P, Mouquet H, Saadoun D.

J Hepatol. 2019 Nov;71(5):908-919. doi: 10.1016/j.jhep.2019.06.029. Epub 2019 Jul 4.

PMID:
31279905
3.

HIV-1 Envelope Recognition by Polyreactive and Cross-Reactive Intestinal B Cells.

Planchais C, Kök A, Kanyavuz A, Lorin V, Bruel T, Guivel-Benhassine F, Rollenske T, Prigent J, Hieu T, Prazuck T, Lefrou L, Wardemann H, Schwartz O, Dimitrov JD, Hocqueloux L, Mouquet H.

Cell Rep. 2019 Apr 9;27(2):572-585.e7. doi: 10.1016/j.celrep.2019.03.032.

4.

A human immune system mouse model with robust lymph node development.

Li Y, Masse-Ranson G, Garcia Z, Bruel T, Kök A, Strick-Marchand H, Jouvion G, Serafini N, Lim AI, Dusseaux M, Hieu T, Bourgade F, Toubert A, Finke D, Schwartz O, Bousso P, Mouquet H, Di Santo JP.

Nat Methods. 2018 Aug;15(8):623-630. doi: 10.1038/s41592-018-0071-6. Epub 2018 Jul 31.

PMID:
30065364
5.

Conformational Plasticity in Broadly Neutralizing HIV-1 Antibodies Triggers Polyreactivity.

Prigent J, Jarossay A, Planchais C, Eden C, Dufloo J, Kök A, Lorin V, Vratskikh O, Couderc T, Bruel T, Schwartz O, Seaman MS, Ohlenschläger O, Dimitrov JD, Mouquet H.

Cell Rep. 2018 May 29;23(9):2568-2581. doi: 10.1016/j.celrep.2018.04.101.

6.

Early Antiretroviral Therapy Preserves Functional Follicular Helper T and HIV-Specific B Cells in the Gut Mucosa of HIV-1-Infected Individuals.

Planchais C, Hocqueloux L, Ibanez C, Gallien S, Copie C, Surenaud M, Kök A, Lorin V, Fusaro M, Delfau-Larue MH, Lefrou L, Prazuck T, Lévy M, Seddiki N, Lelièvre JD, Mouquet H, Lévy Y, Hüe S.

J Immunol. 2018 May 15;200(10):3519-3529. doi: 10.4049/jimmunol.1701615. Epub 2018 Apr 9.

7.

Humanized mouse models to study pathophysiology and treatment of HIV infection.

Masse-Ranson G, Mouquet H, Di Santo JP.

Curr Opin HIV AIDS. 2018 Mar;13(2):143-151. doi: 10.1097/COH.0000000000000440. Review.

PMID:
29194124
8.

Genetically Intact but Functionally Impaired HIV-1 Env Glycoproteins in the T-Cell Reservoir.

de Verneuil A, Migraine J, Mammano F, Molina JM, Gallien S, Mouquet H, Hance AJ, Clavel F, Dutrieux J.

J Virol. 2018 Jan 30;92(4). pii: e01684-17. doi: 10.1128/JVI.01684-17. Print 2018 Feb 15.

9.

Impact of Antigen Density on the Binding Mechanism of IgG Antibodies.

Hadzhieva M, Pashov AD, Kaveri S, Lacroix-Desmazes S, Mouquet H, Dimitrov JD.

Sci Rep. 2017 Jun 19;7(1):3767. doi: 10.1038/s41598-017-03942-z.

10.

What Are the Primary Limitations in B-Cell Affinity Maturation, and How Much Affinity Maturation Can We Drive with Vaccination? Lessons from the Antibody Response to HIV-1.

Victora GD, Mouquet H.

Cold Spring Harb Perspect Biol. 2018 May 1;10(5). pii: a029389. doi: 10.1101/cshperspect.a029389. Review.

PMID:
28630079
11.

HIV-Specific B Cell Frequency Correlates with Neutralization Breadth in Patients Naturally Controlling HIV-Infection.

Rouers A, Klingler J, Su B, Samri A, Laumond G, Even S, Avettand-Fenoel V, Richetta C, Paul N, Boufassa F, Hocqueloux L, Mouquet H, Rouzioux C, Lambotte O, Autran B, Graff-Dubois S, Moog C, Moris A; ANRS CO21 Cohort.

EBioMedicine. 2017 Jul;21:158-169. doi: 10.1016/j.ebiom.2017.05.029. Epub 2017 May 31.

12.

Broadly neutralizing antibodies suppress post-transcytosis HIV-1 infectivity.

Lorin V, Malbec M, Eden C, Bruel T, Porrot F, Seaman MS, Schwartz O, Mouquet H.

Mucosal Immunol. 2017 May;10(3):829. doi: 10.1038/mi.2017.39. No abstract available.

PMID:
28435154
13.

Hunting Down the HIV-1 Reservoir: A Starring Role for Antibodies?

Mouquet H.

Immunity. 2017 Apr 18;46(4):527-529. doi: 10.1016/j.immuni.2017.04.001.

14.

Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity.

Zhivaki D, Lemoine S, Lim A, Morva A, Vidalain PO, Schandene L, Casartelli N, Rameix-Welti MA, Hervé PL, Dériaud E, Beitz B, Ripaux-Lefevre M, Miatello J, Lemercier B, Lorin V, Descamps D, Fix J, Eléouët JF, Riffault S, Schwartz O, Porcheray F, Mascart F, Mouquet H, Zhang X, Tissières P, Lo-Man R.

Immunity. 2017 Feb 21;46(2):301-314. doi: 10.1016/j.immuni.2017.01.010.

15.

Lack of ADCC Breadth of Human Nonneutralizing Anti-HIV-1 Antibodies.

Bruel T, Guivel-Benhassine F, Lorin V, Lortat-Jacob H, Baleux F, Bourdic K, Noël N, Lambotte O, Mouquet H, Schwartz O.

J Virol. 2017 Mar 29;91(8). pii: e02440-16. doi: 10.1128/JVI.02440-16. Print 2017 Apr 15.

16.

Antibody 10-1074 suppresses viremia in HIV-1-infected individuals.

Caskey M, Schoofs T, Gruell H, Settler A, Karagounis T, Kreider EF, Murrell B, Pfeifer N, Nogueira L, Oliveira TY, Learn GH, Cohen YZ, Lehmann C, Gillor D, Shimeliovich I, Unson-O'Brien C, Weiland D, Robles A, Kümmerle T, Wyen C, Levin R, Witmer-Pack M, Eren K, Ignacio C, Kiss S, West AP Jr, Mouquet H, Zingman BS, Gulick RM, Keler T, Bjorkman PJ, Seaman MS, Hahn BH, Fätkenheuer G, Schlesinger SJ, Nussenzweig MC, Klein F.

Nat Med. 2017 Feb;23(2):185-191. doi: 10.1038/nm.4268. Epub 2017 Jan 16.

17.

Broadly neutralizing antibodies suppress post-transcytosis HIV-1 infectivity.

Lorin V, Malbec M, Eden C, Bruel T, Porrot F, Seaman MS, Schwartz O, Mouquet H.

Mucosal Immunol. 2017 May;10(3):814-826. doi: 10.1038/mi.2016.106. Epub 2016 Dec 14.

PMID:
27966557
18.

[Antibodies that kill HIV-1-infected cells].

Bruel T, Mouquet H, Schwartz O.

Med Sci (Paris). 2016 8-9;32(8-9):671-4. doi: 10.1051/medsci/20163208004. Epub 2016 Sep 12. French. No abstract available.

19.

Scarcity of autoreactive human blood IgA+ memory B cells.

Prigent J, Lorin V, Kök A, Hieu T, Bourgeau S, Mouquet H.

Eur J Immunol. 2016 Oct;46(10):2340-2351. doi: 10.1002/eji.201646446. Epub 2016 Aug 25.

20.

Elimination of HIV-1-infected cells by broadly neutralizing antibodies.

Bruel T, Guivel-Benhassine F, Amraoui S, Malbec M, Richard L, Bourdic K, Donahue DA, Lorin V, Casartelli N, Noël N, Lambotte O, Mouquet H, Schwartz O.

Nat Commun. 2016 Mar 3;7:10844. doi: 10.1038/ncomms10844.

21.

V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1.

Morgand M, Bouvin-Pley M, Plantier JC, Moreau A, Alessandri E, Simon F, Pace CS, Pancera M, Ho DD, Poignard P, Bjorkman PJ, Mouquet H, Nussenzweig MC, Kwong PD, Baty D, Chames P, Braibant M, Barin F.

J Acquir Immune Defic Syndr. 2016 Mar 1;71(3):237-45. doi: 10.1097/QAI.0000000000000854.

22.

Tailored immunogens for rationally designed antibody-based HIV-1 vaccines.

Mouquet H.

Trends Immunol. 2015 Aug;36(8):437-9. doi: 10.1016/j.it.2015.07.001. Epub 2015 Jul 11.

PMID:
26169255
23.

Efficient generation of human IgA monoclonal antibodies.

Lorin V, Mouquet H.

J Immunol Methods. 2015 Jul;422:102-10. doi: 10.1016/j.jim.2015.04.010. Epub 2015 Apr 22.

PMID:
25910833
24.

Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas.

Barbian HJ, Decker JM, Bibollet-Ruche F, Galimidi RP, West AP Jr, Learn GH, Parrish NF, Iyer SS, Li Y, Pace CS, Song R, Huang Y, Denny TN, Mouquet H, Martin L, Acharya P, Zhang B, Kwong PD, Mascola JR, Verrips CT, Strokappe NM, Rutten L, McCoy LE, Weiss RA, Brown CS, Jackson R, Silvestri G, Connors M, Burton DR, Shaw GM, Nussenzweig MC, Bjorkman PJ, Ho DD, Farzan M, Hahn BH.

MBio. 2015 Apr 21;6(2). pii: e00296-15. doi: 10.1128/mBio.00296-15.

25.

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges.

Gardner MR, Kattenhorn LM, Kondur HR, von Schaewen M, Dorfman T, Chiang JJ, Haworth KG, Decker JM, Alpert MD, Bailey CC, Neale ES Jr, Fellinger CH, Joshi VR, Fuchs SP, Martinez-Navio JM, Quinlan BD, Yao AY, Mouquet H, Gorman J, Zhang B, Poignard P, Nussenzweig MC, Burton DR, Kwong PD, Piatak M Jr, Lifson JD, Gao G, Desrosiers RC, Evans DT, Hahn BH, Ploss A, Cannon PM, Seaman MS, Farzan M.

Nature. 2015 Mar 5;519(7541):87-91. doi: 10.1038/nature14264. Epub 2015 Feb 18.

26.

Amplification of highly mutated human Ig lambda light chains from an HIV-1 infected patient.

Freund NT, Scheid JF, Mouquet H, Nussenzweig MC.

J Immunol Methods. 2015 Mar;418:61-5. doi: 10.1016/j.jim.2015.01.011. Epub 2015 Feb 7.

PMID:
25667013
27.

HIV antibodies. Antigen modification regulates competition of broad and narrow neutralizing HIV antibodies.

McGuire AT, Dreyer AM, Carbonetti S, Lippy A, Glenn J, Scheid JF, Mouquet H, Stamatatos L.

Science. 2014 Dec 12;346(6215):1380-1383. doi: 10.1126/science.1259206.

28.

Antibody B cell responses in HIV-1 infection.

Mouquet H.

Trends Immunol. 2014 Nov;35(11):549-61. doi: 10.1016/j.it.2014.08.007. Epub 2014 Sep 16. Review.

PMID:
25240985
29.

Drift of the HIV-1 envelope glycoprotein gp120 toward increased neutralization resistance over the course of the epidemic: a comprehensive study using the most potent and broadly neutralizing monoclonal antibodies.

Bouvin-Pley M, Morgand M, Meyer L, Goujard C, Moreau A, Mouquet H, Nussenzweig M, Pace C, Ho D, Bjorkman PJ, Baty D, Chames P, Pancera M, Kwong PD, Poignard P, Barin F, Braibant M.

J Virol. 2014 Dec;88(23):13910-7. doi: 10.1128/JVI.02083-14. Epub 2014 Sep 17.

30.

Passive transfer of modest titers of potent and broadly neutralizing anti-HIV monoclonal antibodies block SHIV infection in macaques.

Shingai M, Donau OK, Plishka RJ, Buckler-White A, Mascola JR, Nabel GJ, Nason MC, Montefiori D, Moldt B, Poignard P, Diskin R, Bjorkman PJ, Eckhaus MA, Klein F, Mouquet H, Cetrulo Lorenzi JC, Gazumyan A, Burton DR, Nussenzweig MC, Martin MA, Nishimura Y.

J Exp Med. 2014 Sep 22;211(10):2061-74. doi: 10.1084/jem.20132494. Epub 2014 Aug 25.

31.

[HIV-1 cell-to-cell transmission and broadly neutralizing antibodies].

Malbec M, Mouquet H, Schwartz O.

Med Sci (Paris). 2014 May;30(5):508-10. doi: 10.1051/medsci/20143005011. Epub 2014 Jun 13. French. No abstract available.

32.

Broadly neutralizing antibodies that inhibit HIV-1 cell to cell transmission.

Malbec M, Porrot F, Rua R, Horwitz J, Klein F, Halper-Stromberg A, Scheid JF, Eden C, Mouquet H, Nussenzweig MC, Schwartz O.

J Exp Med. 2013 Dec 16;210(13):2813-21. doi: 10.1084/jem.20131244. Epub 2013 Nov 25.

33.

Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia.

Shingai M, Nishimura Y, Klein F, Mouquet H, Donau OK, Plishka R, Buckler-White A, Seaman M, Piatak M Jr, Lifson JD, Dimitrov DS, Nussenzweig MC, Martin MA.

Nature. 2013 Nov 14;503(7475):277-80. doi: 10.1038/nature12746. Epub 2013 Oct 30.

34.

HIV-1 suppression and durable control by combining single broadly neutralizing antibodies and antiretroviral drugs in humanized mice.

Horwitz JA, Halper-Stromberg A, Mouquet H, Gitlin AD, Tretiakova A, Eisenreich TR, Malbec M, Gravemann S, Billerbeck E, Dorner M, Büning H, Schwartz O, Knops E, Kaiser R, Seaman MS, Wilson JM, Rice CM, Ploss A, Bjorkman PJ, Klein F, Nussenzweig MC.

Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16538-43. doi: 10.1073/pnas.1315295110. Epub 2013 Sep 16.

35.

Antibodies in HIV-1 vaccine development and therapy.

Klein F, Mouquet H, Dosenovic P, Scheid JF, Scharf L, Nussenzweig MC.

Science. 2013 Sep 13;341(6151):1199-204. doi: 10.1126/science.1241144. Review.

36.

HIV: Roadmaps to a vaccine.

Mouquet H, Nussenzweig MC.

Nature. 2013 Apr 25;496(7446):441-2. doi: 10.1038/nature12091. Epub 2013 Apr 3. No abstract available.

PMID:
23552894
37.

Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization.

Klein F, Diskin R, Scheid JF, Gaebler C, Mouquet H, Georgiev IS, Pancera M, Zhou T, Incesu RB, Fu BZ, Gnanapragasam PN, Oliveira TY, Seaman MS, Kwong PD, Bjorkman PJ, Nussenzweig MC.

Cell. 2013 Mar 28;153(1):126-38. doi: 10.1016/j.cell.2013.03.018.

38.

Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies.

Mouquet H, Scharf L, Euler Z, Liu Y, Eden C, Scheid JF, Halper-Stromberg A, Gnanapragasam PN, Spencer DI, Seaman MS, Schuitemaker H, Feizi T, Nussenzweig MC, Bjorkman PJ.

Proc Natl Acad Sci U S A. 2012 Nov 20;109(47):E3268-77. doi: 10.1073/pnas.1217207109. Epub 2012 Oct 30.

39.

HIV therapy by a combination of broadly neutralizing antibodies in humanized mice.

Klein F, Halper-Stromberg A, Horwitz JA, Gruell H, Scheid JF, Bournazos S, Mouquet H, Spatz LA, Diskin R, Abadir A, Zang T, Dorner M, Billerbeck E, Labitt RN, Gaebler C, Marcovecchio P, Incesu RB, Eisenreich TR, Bieniasz PD, Seaman MS, Bjorkman PJ, Ravetch JV, Ploss A, Nussenzweig MC.

Nature. 2012 Dec 6;492(7427):118-22. doi: 10.1038/nature11604. Epub 2012 Oct 24.

40.

Broad neutralization by a combination of antibodies recognizing the CD4 binding site and a new conformational epitope on the HIV-1 envelope protein.

Klein F, Gaebler C, Mouquet H, Sather DN, Lehmann C, Scheid JF, Kraft Z, Liu Y, Pietzsch J, Hurley A, Poignard P, Feizi T, Morris L, Walker BD, Fätkenheuer G, Seaman MS, Stamatatos L, Nussenzweig MC.

J Exp Med. 2012 Jul 30;209(8):1469-79. doi: 10.1084/jem.20120423. Epub 2012 Jul 23.

41.

Dll4-Notch signaling in Flt3-independent dendritic cell development and autoimmunity in mice.

Billiard F, Lobry C, Darrasse-Jèze G, Waite J, Liu X, Mouquet H, DaNave A, Tait M, Idoyaga J, Leboeuf M, Kyratsous CA, Burton J, Kalter J, Klinakis A, Zhang W, Thurston G, Merad M, Steinman RM, Murphy AJ, Yancopoulos GD, Aifantis I, Skokos D.

J Exp Med. 2012 May 7;209(5):1011-28. doi: 10.1084/jem.20111615. Epub 2012 Apr 30.

42.

Enhanced HIV-1 neutralization by antibody heteroligation.

Mouquet H, Warncke M, Scheid JF, Seaman MS, Nussenzweig MC.

Proc Natl Acad Sci U S A. 2012 Jan 17;109(3):875-80. doi: 10.1073/pnas.1120059109. Epub 2012 Jan 4.

43.

Polyreactive antibodies in adaptive immune responses to viruses.

Mouquet H, Nussenzweig MC.

Cell Mol Life Sci. 2012 May;69(9):1435-45. doi: 10.1007/s00018-011-0872-6. Epub 2011 Nov 2. Review.

PMID:
22045557
44.

Differential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells.

Scheid JF, Mouquet H, Kofer J, Yurasov S, Nussenzweig MC, Wardemann H.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18044-8. doi: 10.1073/pnas.1113395108. Epub 2011 Oct 24.

45.

Memory B cell antibodies to HIV-1 gp140 cloned from individuals infected with clade A and B viruses.

Mouquet H, Klein F, Scheid JF, Warncke M, Pietzsch J, Oliveira TY, Velinzon K, Seaman MS, Nussenzweig MC.

PLoS One. 2011;6(9):e24078. doi: 10.1371/journal.pone.0024078. Epub 2011 Sep 8.

46.

Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding.

Scheid JF, Mouquet H, Ueberheide B, Diskin R, Klein F, Oliveira TY, Pietzsch J, Fenyo D, Abadir A, Velinzon K, Hurley A, Myung S, Boulad F, Poignard P, Burton DR, Pereyra F, Ho DD, Walker BD, Seaman MS, Bjorkman PJ, Chait BT, Nussenzweig MC.

Science. 2011 Sep 16;333(6049):1633-7. doi: 10.1126/science.1207227. Epub 2011 Jul 14.

47.

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation.

Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, Artyomov MN, Pietzsch J, Connors M, Pereyra F, Walker BD, Ho DD, Wilson PC, Seaman MS, Eisen HN, Chakraborty AK, Hope TJ, Ravetch JV, Wardemann H, Nussenzweig MC.

Nature. 2010 Sep 30;467(7315):591-5. doi: 10.1038/nature09385.

48.

Human anti-HIV-neutralizing antibodies frequently target a conserved epitope essential for viral fitness.

Pietzsch J, Scheid JF, Mouquet H, Klein F, Seaman MS, Jankovic M, Corti D, Lanzavecchia A, Nussenzweig MC.

J Exp Med. 2010 Aug 30;207(9):1995-2002. doi: 10.1084/jem.20101176. Epub 2010 Aug 2.

49.

Anti-gp41 antibodies cloned from HIV-infected patients with broadly neutralizing serologic activity.

Pietzsch J, Scheid JF, Mouquet H, Seaman MS, Broder CC, Nussenzweig MC.

J Virol. 2010 May;84(10):5032-42. doi: 10.1128/JVI.00154-10. Epub 2010 Mar 10.

50.

Feedback control of regulatory T cell homeostasis by dendritic cells in vivo.

Darrasse-Jèze G, Deroubaix S, Mouquet H, Victora GD, Eisenreich T, Yao KH, Masilamani RF, Dustin ML, Rudensky A, Liu K, Nussenzweig MC.

J Exp Med. 2009 Aug 31;206(9):1853-62. doi: 10.1084/jem.20090746. Epub 2009 Aug 10.

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