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Items: 16


CBP/p300 Drives the Differentiation of Regulatory T Cells through Transcriptional and Non-Transcriptional Mechanisms.

Castillo J, Wu E, Lowe C, Srinivasan S, McCord R, Wagle MC, Jayakar S, Edick MG, Eastham-Anderson J, Liu B, Hutchinson KE, Jones W, Stokes MP, Tarighat SS, Holcomb T, Glibicky A, Romero FA, Magnuson S, Huang SA, Plaks V, Giltnane JM, Lackner MR, Mounir Z.

Cancer Res. 2019 Aug 1;79(15):3916-3927. doi: 10.1158/0008-5472.CAN-18-3622. Epub 2019 Jun 10.


Transcriptomic analysis of hepatocellular carcinoma reveals molecular features of disease progression and tumor immune biology.

Okrah K, Tarighat S, Liu B, Koeppen H, Wagle MC, Cheng G, Sun C, Dey A, Chang MT, Sumiyoshi T, Mounir Z, Cummings C, Hampton G, Amler L, Fridlyand J, Hegde PS, Turley SJ, Lackner MR, Huang SM.

NPJ Precis Oncol. 2018 Nov 15;2:25. doi: 10.1038/s41698-018-0068-8. eCollection 2018.


A transcriptional MAPK Pathway Activity Score (MPAS) is a clinically relevant biomarker in multiple cancer types.

Wagle MC, Kirouac D, Klijn C, Liu B, Mahajan S, Junttila M, Moffat J, Merchant M, Huw L, Wongchenko M, Okrah K, Srinivasan S, Mounir Z, Sumiyoshi T, Haverty PM, Yauch RL, Yan Y, Kabbarah O, Hampton G, Amler L, Ramanujan S, Lackner MR, Huang SA.

NPJ Precis Oncol. 2018 Mar 7;2(1):7. doi: 10.1038/s41698-018-0051-4. eCollection 2018.


Oxidative stress and histopathological changes induced by methylthiophanate, a systemic fungicide, in blood, liver and kidney of adult rats.

Ibtissem BA, Hajer BS, Ahmed H, Awatef E, Choumous K, Ons B, Mounir ZK, Najiba Z.

Afr Health Sci. 2017 Mar;17(1):154-163. doi: 10.4314/ahs.v17i1.20.


ERG signaling in prostate cancer is driven through PRMT5-dependent methylation of the Androgen Receptor.

Mounir Z, Korn JM, Westerling T, Lin F, Kirby CA, Schirle M, McAllister G, Hoffman G, Ramadan N, Hartung A, Feng Y, Kipp DR, Quinn C, Fodor M, Baird J, Schoumacher M, Meyer R, Deeds J, Buchwalter G, Stams T, Keen N, Sellers WR, Brown M, Pagliarini RA.

Elife. 2016 May 16;5. pii: e13964. doi: 10.7554/eLife.13964.


mTORC2 Balances AKT Activation and eIF2α Serine 51 Phosphorylation to Promote Survival under Stress.

Tenkerian C, Krishnamoorthy J, Mounir Z, Kazimierczak U, Khoutorsky A, Staschke KA, Kristof AS, Wang S, Hatzoglou M, Koromilas AE.

Mol Cancer Res. 2015 Oct;13(10):1377-88. doi: 10.1158/1541-7786.MCR-15-0184-T. Epub 2015 Jun 30.


TMPRSS2:ERG blocks neuroendocrine and luminal cell differentiation to maintain prostate cancer proliferation.

Mounir Z, Lin F, Lin VG, Korn JM, Yu Y, Valdez R, Aina OH, Buchwalter G, Jaffe AB, Korpal M, Zhu P, Brown M, Cardiff RD, Rocnik JL, Yang Y, Pagliarini R.

Oncogene. 2015 Jul;34(29):3815-25. doi: 10.1038/onc.2014.308. Epub 2014 Sep 29.


Scorpion peptides: potential use for new drug development.

Hmed B, Serria HT, Mounir ZK.

J Toxicol. 2013;2013:958797. doi: 10.1155/2013/958797. Epub 2013 Jun 15.


Control of oncogenesis by eIF2α phosphorylation: implications in PTEN and PI3K-Akt signaling and tumor treatment.

Koromilas AE, Mounir Z.

Future Oncol. 2013 Jul;9(7):1005-15. doi: 10.2217/fon.13.49. Review.


Akt determines cell fate through inhibition of the PERK-eIF2α phosphorylation pathway.

Mounir Z, Krishnamoorthy JL, Wang S, Papadopoulou B, Campbell S, Muller WJ, Hatzoglou M, Koromilas AE.

Sci Signal. 2011 Sep 27;4(192):ra62. doi: 10.1126/scisignal.2001630.


Uncovering the PKR pathway's potential for treatment of tumors.

Mounir Z, Koromilas AE.

Future Oncol. 2010 May;6(5):643-5. doi: 10.2217/fon.10.45. Review. No abstract available.


Tumor suppression by PTEN requires the activation of the PKR-eIF2alpha phosphorylation pathway.

Mounir Z, Krishnamoorthy JL, Robertson GP, Scheuner D, Kaufman RJ, Georgescu MM, Koromilas AE.

Sci Signal. 2009 Dec 22;2(102):ra85. doi: 10.1126/scisignal.2000389.


The eIF2alpha kinases inhibit vesicular stomatitis virus replication independently of eIF2alpha phosphorylation.

Krishnamoorthy J, Mounir Z, Raven JF, Koromilas AE.

Cell Cycle. 2008 Aug;7(15):2346-51. Epub 2008 May 21.


PKR and PKR-like endoplasmic reticulum kinase induce the proteasome-dependent degradation of cyclin D1 via a mechanism requiring eukaryotic initiation factor 2alpha phosphorylation.

Raven JF, Baltzis D, Wang S, Mounir Z, Papadakis AI, Gao HQ, Koromilas AE.

J Biol Chem. 2008 Feb 8;283(6):3097-108. Epub 2007 Dec 6.


A novel function of eIF2alpha kinases as inducers of the phosphoinositide-3 kinase signaling pathway.

Kazemi S, Mounir Z, Baltzis D, Raven JF, Wang S, Krishnamoorthy JL, Pluquet O, Pelletier J, Koromilas AE.

Mol Biol Cell. 2007 Sep;18(9):3635-44. Epub 2007 Jun 27.


Expression of the subgenomic hepatitis C virus replicon alters iron homeostasis in Huh7 cells.

Fillebeen C, Muckenthaler M, Andriopoulos B, Bisaillon M, Mounir Z, Hentze MW, Koromilas AE, Pantopoulos K.

J Hepatol. 2007 Jul;47(1):12-22. Epub 2007 Mar 2.


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