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Items: 33

1.

MicroRNA-382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells.

Dahlmans D, Houzelle A, Andreux P, Wang X, Jörgensen JA, Moullan N, Daemen S, Kersten S, Auwerx J, Hoeks J.

J Cell Physiol. 2019 May;234(5):6601-6610. doi: 10.1002/jcp.27401. Epub 2018 Nov 11.

2.

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.

Sorrentino V, Romani M, Mouchiroud L, Beck JS, Zhang H, D'Amico D, Moullan N, Potenza F, Schmid AW, Rietsch S, Counts SE, Auwerx J.

Nature. 2017 Dec 14;552(7684):187-193. doi: 10.1038/nature25143. Epub 2017 Dec 6.

3.

Parkin functionally interacts with PGC-1α to preserve mitochondria and protect dopaminergic neurons.

Zheng L, Bernard-Marissal N, Moullan N, D'Amico D, Auwerx J, Moore DJ, Knott G, Aebischer P, Schneider BL.

Hum Mol Genet. 2017 Feb 1;26(3):582-598. doi: 10.1093/hmg/ddw418.

PMID:
28053050
4.

Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.

Ryu D, Mouchiroud L, Andreux PA, Katsyuba E, Moullan N, Nicolet-Dit-Félix AA, Williams EG, Jha P, Lo Sasso G, Huzard D, Aebischer P, Sandi C, Rinsch C, Auwerx J.

Nat Med. 2016 Aug;22(8):879-88. doi: 10.1038/nm.4132. Epub 2016 Jul 11.

PMID:
27400265
5.

LRH-1-dependent programming of mitochondrial glutamine processing drives liver cancer.

Xu P, Oosterveer MH, Stein S, Demagny H, Ryu D, Moullan N, Wang X, Can E, Zamboni N, Comment A, Auwerx J, Schoonjans K.

Genes Dev. 2016 Jun 1;30(11):1255-60. doi: 10.1101/gad.277483.116.

6.

Eliciting the mitochondrial unfolded protein response by nicotinamide adenine dinucleotide repletion reverses fatty liver disease in mice.

Gariani K, Menzies KJ, Ryu D, Wegner CJ, Wang X, Ropelle ER, Moullan N, Zhang H, Perino A, Lemos V, Kim B, Park YK, Piersigilli A, Pham TX, Yang Y, Ku CS, Koo SI, Fomitchova A, Cantó C, Schoonjans K, Sauve AA, Lee JY, Auwerx J.

Hepatology. 2016 Apr;63(4):1190-204. doi: 10.1002/hep.28245. Epub 2015 Dec 16.

7.

Loss of the RNA polymerase III repressor MAF1 confers obesity resistance.

Bonhoure N, Byrnes A, Moir RD, Hodroj W, Preitner F, Praz V, Marcelin G, Chua SC Jr, Martinez-Lopez N, Singh R, Moullan N, Auwerx J, Willemin G, Shah H, Hartil K, Vaitheesvaran B, Kurland I, Hernandez N, Willis IM.

Genes Dev. 2015 May 1;29(9):934-47. doi: 10.1101/gad.258350.115.

8.

Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research.

Moullan N, Mouchiroud L, Wang X, Ryu D, Williams EG, Mottis A, Jovaisaite V, Frochaux MV, Quiros PM, Deplancke B, Houtkooper RH, Auwerx J.

Cell Rep. 2015 Mar 17;10(10):1681-1691. doi: 10.1016/j.celrep.2015.02.034. Epub 2015 Mar 12.

9.

Evidence for a direct effect of the NAD+ precursor acipimox on muscle mitochondrial function in humans.

van de Weijer T, Phielix E, Bilet L, Williams EG, Ropelle ER, Bierwagen A, Livingstone R, Nowotny P, Sparks LM, Paglialunga S, Szendroedi J, Havekes B, Moullan N, Pirinen E, Hwang JH, Schrauwen-Hinderling VB, Hesselink MK, Auwerx J, Roden M, Schrauwen P.

Diabetes. 2015 Apr;64(4):1193-201. doi: 10.2337/db14-0667. Epub 2014 Oct 28.

10.

A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans.

Andreux PA, Mouchiroud L, Wang X, Jovaisaite V, Mottis A, Bichet S, Moullan N, Houtkooper RH, Auwerx J.

Sci Rep. 2014 Jun 13;4:5285. doi: 10.1038/srep05285.

11.

Super-resolution biological microscopy using virtual imaging by a microsphere nanoscope.

Yang H, Moullan N, Auwerx J, Gijs MA.

Small. 2014 May 14;10(9):1712-8. No abstract available.

PMID:
24914446
12.

Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle.

Pirinen E, Cantó C, Jo YS, Morato L, Zhang H, Menzies KJ, Williams EG, Mouchiroud L, Moullan N, Hagberg C, Li W, Timmers S, Imhof R, Verbeek J, Pujol A, van Loon B, Viscomi C, Zeviani M, Schrauwen P, Sauve AA, Schoonjans K, Auwerx J.

Cell Metab. 2014 Jun 3;19(6):1034-41. doi: 10.1016/j.cmet.2014.04.002. Epub 2014 May 8.

13.

Metabolic characterization of a Sirt5 deficient mouse model.

Yu J, Sadhukhan S, Noriega LG, Moullan N, He B, Weiss RS, Lin H, Schoonjans K, Auwerx J.

Sci Rep. 2013 Sep 30;3:2806. doi: 10.1038/srep02806.

14.

The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.

Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Cantó C, Mottis A, Jo YS, Viswanathan M, Schoonjans K, Guarente L, Auwerx J.

Cell. 2013 Jul 18;154(2):430-41. doi: 10.1016/j.cell.2013.06.016.

15.

Mitonuclear protein imbalance as a conserved longevity mechanism.

Houtkooper RH, Mouchiroud L, Ryu D, Moullan N, Katsyuba E, Knott G, Williams RW, Auwerx J.

Nature. 2013 May 23;497(7450):451-7. doi: 10.1038/nature12188.

16.

LRH-1-dependent glucose sensing determines intermediary metabolism in liver.

Oosterveer MH, Mataki C, Yamamoto H, Harach T, Moullan N, van Dijk TH, Ayuso E, Bosch F, Postic C, Groen AK, Auwerx J, Schoonjans K.

J Clin Invest. 2012 Aug;122(8):2817-26. doi: 10.1172/JCI62368. Epub 2012 Jul 9.

17.

Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis.

Fernandez-Marcos PJ, Jeninga EH, Canto C, Harach T, de Boer VC, Andreux P, Moullan N, Pirinen E, Yamamoto H, Houten SM, Schoonjans K, Auwerx J.

Sci Rep. 2012;2:425. doi: 10.1038/srep00425. Epub 2012 May 28.

18.

Activation of peroxisome proliferator-activated receptor beta/delta inhibits lipopolysaccharide-induced cytokine production in adipocytes by lowering nuclear factor-kappaB activity via extracellular signal-related kinase 1/2.

Rodríguez-Calvo R, Serrano L, Coll T, Moullan N, Sánchez RM, Merlos M, Palomer X, Laguna JC, Michalik L, Wahli W, Vázquez-Carrera M.

Diabetes. 2008 Aug;57(8):2149-57. doi: 10.2337/db08-0176. Epub 2008 Apr 28.

19.

Inherited predisposition of lung cancer: a hierarchical modeling approach to DNA repair and cell cycle control pathways.

Hung RJ, Baragatti M, Thomas D, McKay J, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Chabrier A, Moullan N, Canzian F, Hall J, Boffetta P, Brennan P.

Cancer Epidemiol Biomarkers Prev. 2007 Dec;16(12):2736-44.

20.

Folate-related genes and the risk of tobacco-related cancers in Central Europe.

Hung RJ, Hashibe M, McKay J, Gaborieau V, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates I, Foretova L, Janout V, Bencko V, Chabrier A, Moullan N, Canzian F, Hall J, Boffetta P, Brennan P.

Carcinogenesis. 2007 Jun;28(6):1334-40. Epub 2007 Mar 26.

PMID:
17389614
21.

The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract.

Hall J, Hashibe M, Boffetta P, Gaborieau V, Moullan N, Chabrier A, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Mates D, Janout V, Fabiánová E, Holcatova I, Hung RJ, McKay J, Canzian F, Brennan P.

Carcinogenesis. 2007 Mar;28(3):665-71. Epub 2006 Oct 13.

PMID:
17040931
22.

Sequence variants in cell cycle control pathway, X-ray exposure, and lung cancer risk: a multicenter case-control study in Central Europe.

Hung RJ, Boffetta P, Canzian F, Moullan N, Szeszenia-Dabrowska N, Zaridze D, Lissowska J, Rudnai P, Fabianova E, Mates D, Foretova L, Janout V, Bencko V, Chabrier A, Landi S, Gemignani F, Hall J, Brennan P.

Cancer Res. 2006 Aug 15;66(16):8280-6.

23.

The XRCC1 -77T->C variant: haplotypes, breast cancer risk, response to radiotherapy and the cellular response to DNA damage.

Brem R, Cox DG, Chapot B, Moullan N, Romestaing P, Gérard JP, Pisani P, Hall J.

Carcinogenesis. 2006 Dec;27(12):2469-74. Epub 2006 Jul 8.

PMID:
16829685
24.

Evidence for an important role of alcohol- and aldehyde-metabolizing genes in cancers of the upper aerodigestive tract.

Hashibe M, Boffetta P, Zaridze D, Shangina O, Szeszenia-Dabrowska N, Mates D, Janout V, Fabiánová E, Bencko V, Moullan N, Chabrier A, Hung R, Hall J, Canzian F, Brennan P.

Cancer Epidemiol Biomarkers Prev. 2006 Apr;15(4):696-703.

25.

Effect of cruciferous vegetables on lung cancer in patients stratified by genetic status: a mendelian randomisation approach.

Brennan P, Hsu CC, Moullan N, Szeszenia-Dabrowska N, Lissowska J, Zaridze D, Rudnai P, Fabianova E, Mates D, Bencko V, Foretova L, Janout V, Gemignani F, Chabrier A, Hall J, Hung RJ, Boffetta P, Canzian F.

Lancet. 2005 Oct 29-Nov 4;366(9496):1558-60.

PMID:
16257343
26.

ATM polymorphisms as risk factors for prostate cancer development.

Angèle S, Falconer A, Edwards SM, Dörk T, Bremer M, Moullan N, Chapot B, Muir K, Houlston R, Norman AR, Bullock S, Hope Q, Meitz J, Dearnaley D, Dowe A, Southgate C, Ardern-Jones A, Easton DF, Eeles RA, Hall J.

Br J Cancer. 2004 Aug 16;91(4):783-7.

27.

Functional consequences of ATM sequence variants for chromosomal radiosensitivity.

Gutiérrez-Enríquez S, Fernet M, Dörk T, Bremer M, Lauge A, Stoppa-Lyonnet D, Moullan N, Angèle S, Hall J.

Genes Chromosomes Cancer. 2004 Jun;40(2):109-19.

PMID:
15101044
28.

Cellular responses to ionising radiation of AT heterozygotes: differences between missense and truncating mutation carriers.

Fernet M, Moullan N, Lauge A, Stoppa-Lyonnet D, Hall J.

Br J Cancer. 2004 Feb 23;90(4):866-73.

29.

ATM haplotypes and cellular response to DNA damage: association with breast cancer risk and clinical radiosensitivity.

Angèle S, Romestaing P, Moullan N, Vuillaume M, Chapot B, Friesen M, Jongmans W, Cox DG, Pisani P, Gérard JP, Hall J.

Cancer Res. 2003 Dec 15;63(24):8717-25.

30.

Polymorphisms in the DNA repair gene XRCC1, breast cancer risk, and response to radiotherapy.

Moullan N, Cox DG, Angèle S, Romestaing P, Gérard JP, Hall J.

Cancer Epidemiol Biomarkers Prev. 2003 Nov;12(11 Pt 1):1168-74.

31.

A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA.

Gemignani F, Moreno V, Landi S, Moullan N, Chabrier A, Gutiérrez-Enríquez S, Hall J, Guino E, Peinado MA, Capella G, Canzian F.

Oncogene. 2004 Mar 11;23(10):1954-6.

PMID:
14647431
32.

Idiopathic and radiation-induced ocular telangiectasia: the involvement of the ATM gene.

Mauget-Faÿsse M, Vuillaume M, Quaranta M, Moullan N, Angèle S, Friesen MD, Hall J.

Invest Ophthalmol Vis Sci. 2003 Aug;44(8):3257-62.

PMID:
12882767
33.

Phenotypic cellular characterization of an ataxia telangiectasia patient carrying a causal homozygous missense mutation.

Angèle S, Laugé A, Fernet M, Moullan N, Beauvais P, Couturier J, Stoppa-Lyonnet D, Hall J.

Hum Mutat. 2003 Feb;21(2):169-70.

PMID:
12552566

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