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Items: 23


Overexpression of Fgfr2c causes craniofacial bone hypoplasia and ameliorates craniosynostosis in the Crouzon mouse.

Lee KKL, Peskett E, Quinn CM, Aiello R, Adeeva L, Moulding DA, Stanier P, Pauws E.

Dis Model Mech. 2018 Nov 9;11(11). pii: dmm035311. doi: 10.1242/dmm.035311.


Somatic mutations and progressive monosomy modify SAMD9-related phenotypes in humans.

Buonocore F, Kühnen P, Suntharalingham JP, Del Valle I, Digweed M, Stachelscheid H, Khajavi N, Didi M, Brady AF, Blankenstein O, Procter AM, Dimitri P, Wales JKH, Ghirri P, Knöbl D, Strahm B, Erlacher M, Wlodarski MW, Chen W, Kokai GK, Anderson G, Morrogh D, Moulding DA, McKee SA, Niemeyer CM, Grüters A, Achermann JC.

J Clin Invest. 2017 May 1;127(5):1700-1713. doi: 10.1172/JCI91913. Epub 2017 Mar 27.


Actin cytoskeletal defects in immunodeficiency.

Moulding DA, Record J, Malinova D, Thrasher AJ.

Immunol Rev. 2013 Nov;256(1):282-99. doi: 10.1111/imr.12114. Review. Erratum in: Immunol Rev. 2016 May;271(1):293.


The cytoplasm of living cells behaves as a poroelastic material.

Moeendarbary E, Valon L, Fritzsche M, Harris AR, Moulding DA, Thrasher AJ, Stride E, Mahadevan L, Charras GT.

Nat Mater. 2013 Mar;12(3):253-61. doi: 10.1038/nmat3517. Epub 2013 Jan 6.


Excess F-actin mechanically impedes mitosis leading to cytokinesis failure in X-linked neutropenia by exceeding Aurora B kinase error correction capacity.

Moulding DA, Moeendarbary E, Valon L, Record J, Charras GT, Thrasher AJ.

Blood. 2012 Nov 1;120(18):3803-11. doi: 10.1182/blood-2012-03-419663. Epub 2012 Sep 12.


A congenital activating mutant of WASp causes altered plasma membrane topography and adhesion under flow in lymphocytes.

Burns SO, Killock DJ, Moulding DA, Metelo J, Nunes J, Taylor RR, Forge A, Thrasher AJ, Ivetic A.

Blood. 2010 Jul 1;115(26):5355-65. doi: 10.1182/blood-2009-08-236174. Epub 2010 Mar 30.


Phosphorylation of WASp is a key regulator of activity and stability in vivo.

Blundell MP, Bouma G, Metelo J, Worth A, Calle Y, Cowell LA, Westerberg LS, Moulding DA, Mirando S, Kinnon C, Cory GO, Jones GE, Snapper SB, Burns SO, Thrasher AJ.

Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15738-43. doi: 10.1073/pnas.0904346106. Epub 2009 Sep 1.


Unregulated actin polymerization by WASp causes defects of mitosis and cytokinesis in X-linked neutropenia.

Moulding DA, Blundell MP, Spiller DG, White MR, Cory GO, Calle Y, Kempski H, Sinclair J, Ancliff PJ, Kinnon C, Jones GE, Thrasher AJ.

J Exp Med. 2007 Sep 3;204(9):2213-24. Epub 2007 Aug 27.


Sodium salicylate promotes neutrophil apoptosis by stimulating caspase-dependent turnover of Mcl-1.

Derouet M, Thomas L, Moulding DA, Akgul C, Cross A, Moots RJ, Edwards SW.

J Immunol. 2006 Jan 15;176(2):957-65.


Continuous MLL-ENL expression is necessary to establish a "Hox Code" and maintain immortalization of hematopoietic progenitor cells.

Horton SJ, Grier DG, McGonigle GJ, Thompson A, Morrow M, De Silva I, Moulding DA, Kioussis D, Lappin TR, Brady HJ, Williams O.

Cancer Res. 2005 Oct 15;65(20):9245-52.


Alternative splicing of Bcl-2-related genes: functional consequences and potential therapeutic applications.

Akgul C, Moulding DA, Edwards SW.

Cell Mol Life Sci. 2004 Sep;61(17):2189-99. Review.


Regulation of neutrophil apoptosis.

Edwards SW, Moulding DA, Derouet M, Moots RJ.

Chem Immunol Allergy. 2003;83:204-24. Review. No abstract available.


The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis.

Fossati G, Moulding DA, Spiller DG, Moots RJ, White MR, Edwards SW.

J Immunol. 2003 Feb 15;170(4):1964-72.


BCL-2 family expression in human neutrophils during delayed and accelerated apoptosis.

Moulding DA, Akgul C, Derouet M, White MR, Edwards SW.

J Leukoc Biol. 2001 Nov;70(5):783-92.


Molecular control of neutrophil apoptosis.

Akgul C, Moulding DA, Edwards SW.

FEBS Lett. 2001 Jan 5;487(3):318-22. Review.


Apoptosis is rapidly triggered by antisense depletion of MCL-1 in differentiating U937 cells.

Moulding DA, Giles RV, Spiller DG, White MR, Tidd DM, Edwards SW.

Blood. 2000 Sep 1;96(5):1756-63.


In vivo localisation and stability of human Mcl-1 using green fluorescent protein (GFP) fusion proteins.

Akgul C, Moulding DA, White MR, Edwards SW.

FEBS Lett. 2000 Jul 28;478(1-2):72-6.


Effects of staphylococcal enterotoxins on human neutrophil functions and apoptosis.

Moulding DA, Walter C, Hart CA, Edwards SW.

Infect Immun. 1999 May;67(5):2312-8.


In vitro effects of GM-CSF on mature peripheral blood neutrophils.

Fossati G, Mazzucchelli I, Gritti D, Ricevuti G, Edwards SW, Moulding DA, Rossi ML.

Int J Mol Med. 1998 Jun;1(6):943-51.


Mcl-1 expression in human neutrophils: regulation by cytokines and correlation with cell survival.

Moulding DA, Quayle JA, Hart CA, Edwards SW.

Blood. 1998 Oct 1;92(7):2495-502.


Modulation of neutrophil apoptosis by pharmacological agents.

Moulding DA, Hart CA, Edwards SW.

Biochem Soc Trans. 1996 Aug;24(3):492S. No abstract available.


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