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Human gut bacteria contain acquired interbacterial defence systems.

Ross BD, Verster AJ, Radey MC, Schmidtke DT, Pope CE, Hoffman LR, Hajjar AM, Peterson SB, Borenstein E, Mougous JD.

Nature. 2019 Nov;575(7781):224-228. doi: 10.1038/s41586-019-1708-z. Epub 2019 Oct 30.


Structure of the type VI secretion system TssK-TssF-TssG baseplate subcomplex revealed by cryo-electron microscopy.

Park YJ, Lacourse KD, Cambillau C, DiMaio F, Mougous JD, Veesler D.

Nat Commun. 2018 Dec 19;9(1):5385. doi: 10.1038/s41467-018-07796-5.


Bifunctional Immunity Proteins Protect Bacteria against FtsZ-Targeting ADP-Ribosylating Toxins.

Ting SY, Bosch DE, Mangiameli SM, Radey MC, Huang S, Park YJ, Kelly KA, Filip SK, Goo YA, Eng JK, Allaire M, Veesler D, Wiggins PA, Peterson SB, Mougous JD.

Cell. 2018 Nov 15;175(5):1380-1392.e14. doi: 10.1016/j.cell.2018.09.037. Epub 2018 Oct 18.


Mechanism of loading and translocation of type VI secretion system effector Tse6.

Quentin D, Ahmad S, Shanthamoorthy P, Mougous JD, Whitney JC, Raunser S.

Nat Microbiol. 2018 Oct;3(10):1142-1152. doi: 10.1038/s41564-018-0238-z. Epub 2018 Sep 3.


A Phosphatidylinositol 3-Kinase Effector Alters Phagosomal Maturation to Promote Intracellular Growth of Francisella.

Ledvina HE, Kelly KA, Eshraghi A, Plemel RL, Peterson SB, Lee B, Steele S, Adler M, Kawula TH, Merz AJ, Skerrett SJ, Celli J, Mougous JD.

Cell Host Microbe. 2018 Aug 8;24(2):285-295.e8. doi: 10.1016/j.chom.2018.07.003. Epub 2018 Jul 26.


Ixodes scapularis does not harbor a stable midgut microbiome.

Ross BD, Hayes B, Radey MC, Lee X, Josek T, Bjork J, Neitzel D, Paskewitz S, Chou S, Mougous JD.

ISME J. 2018 Nov;12(11):2596-2607. doi: 10.1038/s41396-018-0161-6. Epub 2018 Jun 26.


Conditional toxicity and synergy drive diversity among antibacterial effectors.

LaCourse KD, Peterson SB, Kulasekara HD, Radey MC, Kim J, Mougous JD.

Nat Microbiol. 2018 Apr;3(4):440-446. doi: 10.1038/s41564-018-0113-y. Epub 2018 Feb 19.


The Landscape of Type VI Secretion across Human Gut Microbiomes Reveals Its Role in Community Composition.

Verster AJ, Ross BD, Radey MC, Bao Y, Goodman AL, Mougous JD, Borenstein E.

Cell Host Microbe. 2017 Sep 13;22(3):411-419.e4. doi: 10.1016/j.chom.2017.08.010.


A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria.

Whitney JC, Peterson SB, Kim J, Pazos M, Verster AJ, Radey MC, Kulasekara HD, Ching MQ, Bullen NP, Bryant D, Goo YA, Surette MG, Borenstein E, Vollmer W, Mougous JD.

Elife. 2017 Jul 11;6. pii: e26938. doi: 10.7554/eLife.26938.


From Striking Out to Striking Gold: Discovering that Type VI Secretion Targets Bacteria.

Hood RD, Peterson SB, Mougous JD.

Cell Host Microbe. 2017 Mar 8;21(3):286-289. doi: 10.1016/j.chom.2017.02.001.


Secreted Effectors Encoded within and outside of the Francisella Pathogenicity Island Promote Intramacrophage Growth.

Eshraghi A, Kim J, Walls AC, Ledvina HE, Miller CN, Ramsey KM, Whitney JC, Radey MC, Peterson SB, Ruhland BR, Tran BQ, Goo YA, Goodlett DR, Dove SL, Celli J, Veesler D, Mougous JD.

Cell Host Microbe. 2016 Nov 9;20(5):573-583. doi: 10.1016/j.chom.2016.10.008.


Human symbionts inject and neutralize antibacterial toxins to persist in the gut.

Wexler AG, Bao Y, Whitney JC, Bobay LM, Xavier JB, Schofield WB, Barry NA, Russell AB, Tran BQ, Goo YA, Goodlett DR, Ochman H, Mougous JD, Goodman AL.

Proc Natl Acad Sci U S A. 2016 Mar 29;113(13):3639-44. doi: 10.1073/pnas.1525637113. Epub 2016 Mar 8.


An interbacterial NAD(P)(+) glycohydrolase toxin requires elongation factor Tu for delivery to target cells.

Whitney JC, Quentin D, Sawai S, LeRoux M, Harding BN, Ledvina HE, Tran BQ, Robinson H, Goo YA, Goodlett DR, Raunser S, Mougous JD.

Cell. 2015 Oct 22;163(3):607-19. doi: 10.1016/j.cell.2015.09.027. Epub 2015 Oct 8.


Bacterial danger sensing.

LeRoux M, Peterson SB, Mougous JD.

J Mol Biol. 2015 Nov 20;427(23):3744-53. doi: 10.1016/j.jmb.2015.09.018. Epub 2015 Oct 3. Review.


A self-lysis pathway that enhances the virulence of a pathogenic bacterium.

McFarland KA, Dolben EL, LeRoux M, Kambara TK, Ramsey KM, Kirkpatrick RL, Mougous JD, Hogan DA, Dove SL.

Proc Natl Acad Sci U S A. 2015 Jul 7;112(27):8433-8. doi: 10.1073/pnas.1506299112. Epub 2015 Jun 22.


Kin cell lysis is a danger signal that activates antibacterial pathways of Pseudomonas aeruginosa.

LeRoux M, Kirkpatrick RL, Montauti EI, Tran BQ, Peterson SB, Harding BN, Whitney JC, Russell AB, Traxler B, Goo YA, Goodlett DR, Wiggins PA, Mougous JD.

Elife. 2015 Feb 2;4. doi: 10.7554/eLife.05701.


Transferred interbacterial antagonism genes augment eukaryotic innate immune function.

Chou S, Daugherty MD, Peterson SB, Biboy J, Yang Y, Jutras BL, Fritz-Laylin LK, Ferrin MA, Harding BN, Jacobs-Wagner C, Yang XF, Vollmer W, Malik HS, Mougous JD.

Nature. 2015 Feb 5;518(7537):98-101. doi: 10.1038/nature13965. Epub 2014 Nov 24.


A type VI secretion-related pathway in Bacteroidetes mediates interbacterial antagonism.

Russell AB, Wexler AG, Harding BN, Whitney JC, Bohn AJ, Goo YA, Tran BQ, Barry NA, Zheng H, Peterson SB, Chou S, Gonen T, Goodlett DR, Goodman AL, Mougous JD.

Cell Host Microbe. 2014 Aug 13;16(2):227-236. doi: 10.1016/j.chom.2014.07.007. Epub 2014 Jul 25.


Genetically distinct pathways guide effector export through the type VI secretion system.

Whitney JC, Beck CM, Goo YA, Russell AB, Harding BN, De Leon JA, Cunningham DA, Tran BQ, Low DA, Goodlett DR, Hayes CS, Mougous JD.

Mol Microbiol. 2014 May;92(3):529-42. doi: 10.1111/mmi.12571. Epub 2014 Mar 28.


VgrG-5 is a Burkholderia type VI secretion system-exported protein required for multinucleated giant cell formation and virulence.

Schwarz S, Singh P, Robertson JD, LeRoux M, Skerrett SJ, Goodlett DR, West TE, Mougous JD.

Infect Immun. 2014 Apr;82(4):1445-52. doi: 10.1128/IAI.01368-13. Epub 2014 Jan 22.


Type VI secretion system effectors: poisons with a purpose.

Russell AB, Peterson SB, Mougous JD.

Nat Rev Microbiol. 2014 Feb;12(2):137-48. doi: 10.1038/nrmicro3185. Epub 2014 Jan 2. Review.


Haemolysin coregulated protein is an exported receptor and chaperone of type VI secretion substrates.

Silverman JM, Agnello DM, Zheng H, Andrews BT, Li M, Catalano CE, Gonen T, Mougous JD.

Mol Cell. 2013 Sep 12;51(5):584-93. doi: 10.1016/j.molcel.2013.07.025. Epub 2013 Aug 15.


Identification, structure, and function of a novel type VI secretion peptidoglycan glycoside hydrolase effector-immunity pair.

Whitney JC, Chou S, Russell AB, Biboy J, Gardiner TE, Ferrin MA, Brittnacher M, Vollmer W, Mougous JD.

J Biol Chem. 2013 Sep 13;288(37):26616-24. doi: 10.1074/jbc.M113.488320. Epub 2013 Jul 22.


Diverse type VI secretion phospholipases are functionally plastic antibacterial effectors.

Russell AB, LeRoux M, Hathazi K, Agnello DM, Ishikawa T, Wiggins PA, Wai SN, Mougous JD.

Nature. 2013 Apr 25;496(7446):508-12. doi: 10.1038/nature12074. Epub 2013 Apr 3.


Quantitative single-cell characterization of bacterial interactions reveals type VI secretion is a double-edged sword.

LeRoux M, De Leon JA, Kuwada NJ, Russell AB, Pinto-Santini D, Hood RD, Agnello DM, Robertson SM, Wiggins PA, Mougous JD.

Proc Natl Acad Sci U S A. 2012 Nov 27;109(48):19804-9. doi: 10.1073/pnas.1213963109. Epub 2012 Nov 12.


Structure of a peptidoglycan amidase effector targeted to Gram-negative bacteria by the type VI secretion system.

Chou S, Bui NK, Russell AB, Lexa KW, Gardiner TE, LeRoux M, Vollmer W, Mougous JD.

Cell Rep. 2012 Jun 28;1(6):656-64. doi: 10.1016/j.celrep.2012.05.016. Epub 2012 May 31.


An ABC transporter and an outer membrane lipoprotein participate in posttranslational activation of type VI secretion in Pseudomonas aeruginosa.

Casabona MG, Silverman JM, Sall KM, Boyer F, Couté Y, Poirel J, Grunwald D, Mougous JD, Elsen S, Attree I.

Environ Microbiol. 2013 Feb;15(2):471-86. doi: 10.1111/j.1462-2920.2012.02816.x. Epub 2012 Jul 6.


Structure and regulation of the type VI secretion system.

Silverman JM, Brunet YR, Cascales E, Mougous JD.

Annu Rev Microbiol. 2012;66:453-72. doi: 10.1146/annurev-micro-121809-151619. Epub 2012 Jun 28. Review.


A widespread bacterial type VI secretion effector superfamily identified using a heuristic approach.

Russell AB, Singh P, Brittnacher M, Bui NK, Hood RD, Carl MA, Agnello DM, Schwarz S, Goodlett DR, Vollmer W, Mougous JD.

Cell Host Microbe. 2012 May 17;11(5):538-49. doi: 10.1016/j.chom.2012.04.007.


Structural basis for type VI secretion effector recognition by a cognate immunity protein.

Li M, Le Trong I, Carl MA, Larson ET, Chou S, De Leon JA, Dove SL, Stenkamp RE, Mougous JD.

PLoS Pathog. 2012;8(4):e1002613. doi: 10.1371/journal.ppat.1002613. Epub 2012 Apr 12.


Separate inputs modulate phosphorylation-dependent and -independent type VI secretion activation.

Silverman JM, Austin LS, Hsu F, Hicks KG, Hood RD, Mougous JD.

Mol Microbiol. 2011 Dec;82(5):1277-90. doi: 10.1111/j.1365-2958.2011.07889.x. Epub 2011 Nov 4.


Type VI secretion delivers bacteriolytic effectors to target cells.

Russell AB, Hood RD, Bui NK, LeRoux M, Vollmer W, Mougous JD.

Nature. 2011 Jul 20;475(7356):343-7. doi: 10.1038/nature10244.


What is type VI secretion doing in all those bugs?

Schwarz S, Hood RD, Mougous JD.

Trends Microbiol. 2010 Dec;18(12):531-7. doi: 10.1016/j.tim.2010.09.001. Epub 2010 Oct 18.


Burkholderia type VI secretion systems have distinct roles in eukaryotic and bacterial cell interactions.

Schwarz S, West TE, Boyer F, Chiang WC, Carl MA, Hood RD, Rohmer L, Tolker-Nielsen T, Skerrett SJ, Mougous JD.

PLoS Pathog. 2010 Aug 26;6(8):e1001068. doi: 10.1371/journal.ppat.1001068.


A type VI secretion system of Pseudomonas aeruginosa targets a toxin to bacteria.

Hood RD, Singh P, Hsu F, Güvener T, Carl MA, Trinidad RR, Silverman JM, Ohlson BB, Hicks KG, Plemel RL, Li M, Schwarz S, Wang WY, Merz AJ, Goodlett DR, Mougous JD.

Cell Host Microbe. 2010 Jan 21;7(1):25-37. doi: 10.1016/j.chom.2009.12.007.


A minimalist substrate for enzymatic peptide and protein conjugation.

Wollack JW, Silverman JM, Petzold CJ, Mougous JD, Distefano MD.

Chembiochem. 2009 Dec 14;10(18):2934-43. doi: 10.1002/cbic.200900566.


The complete genome of Teredinibacter turnerae T7901: an intracellular endosymbiont of marine wood-boring bivalves (shipworms).

Yang JC, Madupu R, Durkin AS, Ekborg NA, Pedamallu CS, Hostetler JB, Radune D, Toms BS, Henrissat B, Coutinho PM, Schwarz S, Field L, Trindade-Silva AE, Soares CA, Elshahawi S, Hanora A, Schmidt EW, Haygood MG, Posfai J, Benner J, Madinger C, Nove J, Anton B, Chaudhary K, Foster J, Holman A, Kumar S, Lessard PA, Luyten YA, Slatko B, Wood N, Wu B, Teplitski M, Mougous JD, Ward N, Eisen JA, Badger JH, Distel DL.

PLoS One. 2009 Jul 1;4(7):e6085. doi: 10.1371/journal.pone.0006085.


TagR promotes PpkA-catalysed type VI secretion activation in Pseudomonas aeruginosa.

Hsu F, Schwarz S, Mougous JD.

Mol Microbiol. 2009 Jun;72(5):1111-25. doi: 10.1111/j.1365-2958.2009.06701.x. Epub 2009 Apr 21.


In vitro self-assembly of tailorable nanotubes from a simple protein building block.

Ballister ER, Lai AH, Zuckermann RN, Cheng Y, Mougous JD.

Proc Natl Acad Sci U S A. 2008 Mar 11;105(10):3733-8. doi: 10.1073/pnas.0712247105. Epub 2008 Feb 29.


Threonine phosphorylation post-translationally regulates protein secretion in Pseudomonas aeruginosa.

Mougous JD, Gifford CA, Ramsdell TL, Mekalanos JJ.

Nat Cell Biol. 2007 Jul;9(7):797-803. Epub 2007 Jun 10.


Vaccine efficacy of an attenuated but persistent Mycobacterium tuberculosis cysH mutant.

Senaratne RH, Mougous JD, Reader JR, Williams SJ, Zhang T, Bertozzi CR, Riley LW.

J Med Microbiol. 2007 Apr;56(Pt 4):454-8.


Lipidomics reveals control of Mycobacterium tuberculosis virulence lipids via metabolic coupling.

Jain M, Petzold CJ, Schelle MW, Leavell MD, Mougous JD, Bertozzi CR, Leary JA, Cox JS.

Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5133-8. Epub 2007 Mar 8.


A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus.

Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordoñez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ.

Science. 2006 Jun 9;312(5779):1526-30.


5'-Adenosinephosphosulphate reductase (CysH) protects Mycobacterium tuberculosis against free radicals during chronic infection phase in mice.

Senaratne RH, De Silva AD, Williams SJ, Mougous JD, Reader JR, Zhang T, Chan S, Sidders B, Lee DH, Chan J, Bertozzi CR, Riley LW.

Mol Microbiol. 2006 Mar;59(6):1744-53.


A sulfated metabolite produced by stf3 negatively regulates the virulence of Mycobacterium tuberculosis.

Mougous JD, Senaratne RH, Petzold CJ, Jain M, Lee DH, Schelle MW, Leavell MD, Cox JS, Leary JA, Riley LW, Bertozzi CR.

Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4258-63. Epub 2006 Mar 6.


Molecular basis for G protein control of the prokaryotic ATP sulfurylase.

Mougous JD, Lee DH, Hubbard SC, Schelle MW, Vocadlo DJ, Berger JM, Bertozzi CR.

Mol Cell. 2006 Jan 6;21(1):109-22.


Kinetic measurements and mechanism determination of Stf0 sulfotransferase using mass spectrometry.

Pi N, Hoang MB, Gao H, Mougous JD, Bertozzi CR, Leary JA.

Anal Biochem. 2005 Jun 1;341(1):94-104.


Identification, function and structure of the mycobacterial sulfotransferase that initiates sulfolipid-1 biosynthesis.

Mougous JD, Petzold CJ, Senaratne RH, Lee DH, Akey DL, Lin FL, Munchel SE, Pratt MR, Riley LW, Leary JA, Berger JM, Bertozzi CR.

Nat Struct Mol Biol. 2004 Aug;11(8):721-9. Epub 2004 Jul 18.


Trehalose is required for growth of Mycobacterium smegmatis.

Woodruff PJ, Carlson BL, Siridechadilok B, Pratt MR, Senaratne RH, Mougous JD, Riley LW, Williams SJ, Bertozzi CR.

J Biol Chem. 2004 Jul 9;279(28):28835-43. Epub 2004 Apr 21.


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