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Items: 32


Reversible and long-term immobilization in a hydrogel-microbead matrix for high-resolution imaging of Caenorhabditis elegans and other small organisms.

Dong L, Cornaglia M, Krishnamani G, Zhang J, Mouchiroud L, Lehnert T, Auwerx J, Gijs MAM.

PLoS One. 2018 Mar 6;13(3):e0193989. doi: 10.1371/journal.pone.0193989. eCollection 2018.


Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity.

Sorrentino V, Romani M, Mouchiroud L, Beck JS, Zhang H, D'Amico D, Moullan N, Potenza F, Schmid AW, Rietsch S, Counts SE, Auwerx J.

Nature. 2017 Dec 14;552(7684):187-193. doi: 10.1038/nature25143. Epub 2017 Dec 6.


A multiscale study of the role of dynamin in the regulation of glucose uptake.

Trouillon R, Letizia MC, Menzies KJ, Mouchiroud L, Auwerx J, Schoonjans K, Gijs MAM.

Integr Biol (Camb). 2017 Oct 16;9(10):810-819. doi: 10.1039/c7ib00015d.


Label-free three-dimensional imaging of Caenorhabditis elegans with visible optical coherence microscopy.

Coquoz S, Marchand PJ, Bouwens A, Mouchiroud L, Sorrentino V, Szlag D, Auwerx J, Lasser T.

PLoS One. 2017 Jul 20;12(7):e0181676. doi: 10.1371/journal.pone.0181676. eCollection 2017.


Deguelin exerts potent nematocidal activity via the mitochondrial respiratory chain.

Preston S, Korhonen PK, Mouchiroud L, Cornaglia M, McGee SL, Young ND, Davis RA, Crawford S, Nowell C, Ansell BRE, Fisher GM, Andrews KT, Chang BCH, Gijs MAM, Sternberg PW, Auwerx J, Baell J, Hofmann A, Jabbar A, Gasser RB.

FASEB J. 2017 Oct;31(10):4515-4532. doi: 10.1096/fj.201700288R. Epub 2017 Jul 7.


A homozygous missense mutation in ERAL1, encoding a mitochondrial rRNA chaperone, causes Perrault syndrome.

Chatzispyrou IA, Alders M, Guerrero-Castillo S, Zapata Perez R, Haagmans MA, Mouchiroud L, Koster J, Ofman R, Baas F, Waterham HR, Spelbrink JN, Auwerx J, Mannens MM, Houtkooper RH, Plomp AS.

Hum Mol Genet. 2017 Jul 1;26(13):2541-2550. doi: 10.1093/hmg/ddx152.


NAD+ repletion improves muscle function in muscular dystrophy and counters global PARylation.

Ryu D, Zhang H, Ropelle ER, Sorrentino V, Mázala DA, Mouchiroud L, Marshall PL, Campbell MD, Ali AS, Knowels GM, Bellemin S, Iyer SR, Wang X, Gariani K, Sauve AA, Cantó C, Conley KE, Walter L, Lovering RM, Chin ER, Jasmin BJ, Marcinek DJ, Menzies KJ, Auwerx J.

Sci Transl Med. 2016 Oct 19;8(361):361ra139.


The Movement Tracker: A Flexible System for Automated Movement Analysis in Invertebrate Model Organisms.

Mouchiroud L, Sorrentino V, Williams EG, Cornaglia M, Frochaux MV, Lin T, Nicolet-Dit-Félix AA, Krishnamani G, Ouhmad T, Gijs MA, Deplancke B, Auwerx J.

Curr Protoc Neurosci. 2016 Oct 3;77:8.37.1-8.37.21. doi: 10.1002/cpns.17.


Track C. Biomedical Instrumentation & Micro and Nano Systems.

Cornaglia M, Mouchiroud L, Krishnamani G, Marette A, Narasimhan S, Jovaisaite V, Sorrentino V, Lehnert T, Auwerx J, Gijs MA.

Biomed Tech (Berl). 2016 Sep 1;61(s1):24-29. doi: 10.1515/bmt-2016-5002. No abstract available.


A screening-based platform for the assessment of cellular respiration in Caenorhabditis elegans.

Koopman M, Michels H, Dancy BM, Kamble R, Mouchiroud L, Auwerx J, Nollen EA, Houtkooper RH.

Nat Protoc. 2016 Oct;11(10):1798-816. doi: 10.1038/nprot.2016.106. Epub 2016 Sep 1.


Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents.

Ryu D, Mouchiroud L, Andreux PA, Katsyuba E, Moullan N, Nicolet-Dit-Félix AA, Williams EG, Jha P, Lo Sasso G, Huzard D, Aebischer P, Sandi C, Rinsch C, Auwerx J.

Nat Med. 2016 Aug;22(8):879-88. doi: 10.1038/nm.4132. Epub 2016 Jul 11.


Two Conserved Histone Demethylases Regulate Mitochondrial Stress-Induced Longevity.

Merkwirth C, Jovaisaite V, Durieux J, Matilainen O, Jordan SD, Quiros PM, Steffen KK, Williams EG, Mouchiroud L, Tronnes SU, Murillo V, Wolff SC, Shaw RJ, Auwerx J, Dillin A.

Cell. 2016 May 19;165(5):1209-1223. doi: 10.1016/j.cell.2016.04.012. Epub 2016 Apr 28.


Automated longitudinal monitoring of in vivo protein aggregation in neurodegenerative disease C. elegans models.

Cornaglia M, Krishnamani G, Mouchiroud L, Sorrentino V, Lehnert T, Auwerx J, Gijs MA.

Mol Neurodegener. 2016 Feb 9;11:17. doi: 10.1186/s13024-016-0083-6.


Tetracycline antibiotics impair mitochondrial function and its experimental use confounds research.

Chatzispyrou IA, Held NM, Mouchiroud L, Auwerx J, Houtkooper RH.

Cancer Res. 2015 Nov 1;75(21):4446-9. doi: 10.1158/0008-5472.CAN-15-1626. Epub 2015 Oct 16. Review.


Type 5 adenylyl cyclase disruption leads to enhanced exercise performance.

Vatner DE, Yan L, Lai L, Yuan C, Mouchiroud L, Pachon RE, Zhang J, Dillinger JG, Houtkooper RH, Auwerx J, Vatner SF.

Aging Cell. 2015 Dec;14(6):1075-84. doi: 10.1111/acel.12401. Epub 2015 Oct 1.


An automated microfluidic platform for C. elegans embryo arraying, phenotyping, and long-term live imaging.

Cornaglia M, Mouchiroud L, Marette A, Narasimhan S, Lehnert T, Jovaisaite V, Auwerx J, Gijs MA.

Sci Rep. 2015 May 7;5:10192. doi: 10.1038/srep10192.


Tetracyclines Disturb Mitochondrial Function across Eukaryotic Models: A Call for Caution in Biomedical Research.

Moullan N, Mouchiroud L, Wang X, Ryu D, Williams EG, Mottis A, Jovaisaite V, Frochaux MV, Quiros PM, Deplancke B, Houtkooper RH, Auwerx J.

Cell Rep. 2015 Mar 10. pii: S2211-1247(15)00180-1. doi: 10.1016/j.celrep.2015.02.034. [Epub ahead of print]


An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement.

Williams EG, Mouchiroud L, Frochaux M, Pandey A, Andreux PA, Deplancke B, Auwerx J.

PLoS Genet. 2014 Sep 25;10(9):e1004673. doi: 10.1371/journal.pgen.1004673. eCollection 2014 Sep.


Loss of Sirt1 function improves intestinal anti-bacterial defense and protects from colitis-induced colorectal cancer.

Lo Sasso G, Ryu D, Mouchiroud L, Fernando SC, Anderson CL, Katsyuba E, Piersigilli A, Hottiger MO, Schoonjans K, Auwerx J.

PLoS One. 2014 Jul 11;9(7):e102495. doi: 10.1371/journal.pone.0102495. eCollection 2014.


A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans.

Andreux PA, Mouchiroud L, Wang X, Jovaisaite V, Mottis A, Bichet S, Moullan N, Houtkooper RH, Auwerx J.

Sci Rep. 2014 Jun 13;4:5285. doi: 10.1038/srep05285.


Metabolomics analysis uncovers that dietary restriction buffers metabolic changes associated with aging in Caenorhabditis elegans.

Pontoizeau C, Mouchiroud L, Molin L, Mergoud-Dit-Lamarche A, Dallière N, Toulhoat P, Elena-Herrmann B, Solari F.

J Proteome Res. 2014 Jun 6;13(6):2910-9. doi: 10.1021/pr5000686. Epub 2014 May 22.


Pharmacological Inhibition of poly(ADP-ribose) polymerases improves fitness and mitochondrial function in skeletal muscle.

Pirinen E, Cantó C, Jo YS, Morato L, Zhang H, Menzies KJ, Williams EG, Mouchiroud L, Moullan N, Hagberg C, Li W, Timmers S, Imhof R, Verbeek J, Pujol A, van Loon B, Viscomi C, Zeviani M, Schrauwen P, Sauve AA, Schoonjans K, Auwerx J.

Cell Metab. 2014 Jun 3;19(6):1034-41. doi: 10.1016/j.cmet.2014.04.002. Epub 2014 May 8.


Transcriptional coregulators: fine-tuning metabolism.

Mouchiroud L, Eichner LJ, Shaw RJ, Auwerx J.

Cell Metab. 2014 Jul 1;20(1):26-40. doi: 10.1016/j.cmet.2014.03.027. Epub 2014 May 1. Review.


The mitochondrial unfolded protein response, a conserved stress response pathway with implications in health and disease.

Jovaisaite V, Mouchiroud L, Auwerx J.

J Exp Biol. 2014 Jan 1;217(Pt 1):137-43. doi: 10.1242/jeb.090738. Review.


The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling.

Mouchiroud L, Houtkooper RH, Moullan N, Katsyuba E, Ryu D, Cantó C, Mottis A, Jo YS, Viswanathan M, Schoonjans K, Guarente L, Auwerx J.

Cell. 2013 Jul 18;154(2):430-41. doi: 10.1016/j.cell.2013.06.016.


NAD⁺ metabolism: a therapeutic target for age-related metabolic disease.

Mouchiroud L, Houtkooper RH, Auwerx J.

Crit Rev Biochem Mol Biol. 2013 Jul-Aug;48(4):397-408. doi: 10.3109/10409238.2013.789479. Epub 2013 Jun 6. Review.


Mitonuclear protein imbalance as a conserved longevity mechanism.

Houtkooper RH, Mouchiroud L, Ryu D, Moullan N, Katsyuba E, Knott G, Williams RW, Auwerx J.

Nature. 2013 May 23;497(7450):451-7. doi: 10.1038/nature12188.


Emerging roles of the corepressors NCoR1 and SMRT in homeostasis.

Mottis A, Mouchiroud L, Auwerx J.

Genes Dev. 2013 Apr 15;27(8):819-35. doi: 10.1101/gad.214023.113. Review.


NCoR1 is a conserved physiological modulator of muscle mass and oxidative function.

Yamamoto H, Williams EG, Mouchiroud L, Cantó C, Fan W, Downes M, Héligon C, Barish GD, Desvergne B, Evans RM, Schoonjans K, Auwerx J.

Cell. 2011 Nov 11;147(4):827-39. doi: 10.1016/j.cell.2011.10.017.


Pyruvate imbalance mediates metabolic reprogramming and mimics lifespan extension by dietary restriction in Caenorhabditis elegans.

Mouchiroud L, Molin L, Kasturi P, Triba MN, Dumas ME, Wilson MC, Halestrap AP, Roussel D, Masse I, Dallière N, Ségalat L, Billaud M, Solari F.

Aging Cell. 2011 Feb;10(1):39-54. doi: 10.1111/j.1474-9726.2010.00640.x. Epub 2010 Nov 15.


Life span extension by resveratrol, rapamycin, and metformin: The promise of dietary restriction mimetics for an healthy aging.

Mouchiroud L, Molin L, Dallière N, Solari F.

Biofactors. 2010 Sep-Oct;36(5):377-82. doi: 10.1002/biof.127. Review.


A novel role for the SMG-1 kinase in lifespan and oxidative stress resistance in Caenorhabditis elegans.

Masse I, Molin L, Mouchiroud L, Vanhems P, Palladino F, Billaud M, Solari F.

PLoS One. 2008 Oct 6;3(10):e3354. doi: 10.1371/journal.pone.0003354. Erratum in: PLoS ONE. 2009;4(1). doi: 10.1371/annotation/8b010ad6-34d5-45fc-9bc2-c82a7370ebc7.

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