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Items: 19


T cells bearing a chimeric antigen receptor against prostate-specific membrane antigen mediate vascular disruption and result in tumor regression.

Santoro SP, Kim S, Motz GT, Alatzoglou D, Li C, Irving M, Powell DJ Jr, Coukos G.

Cancer Immunol Res. 2015 Jan;3(1):68-84. doi: 10.1158/2326-6066.CIR-14-0192. Epub 2014 Oct 30.


T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy.

Melero I, Rouzaut A, Motz GT, Coukos G.

Cancer Discov. 2014 May;4(5):522-6. doi: 10.1158/2159-8290.CD-13-0985.


Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors.

Motz GT, Santoro SP, Wang LP, Garrabrant T, Lastra RR, Hagemann IS, Lal P, Feldman MD, Benencia F, Coukos G.

Nat Med. 2014 Jun;20(6):607-15. doi: 10.1038/nm.3541. Epub 2014 May 4.


Deciphering and reversing tumor immune suppression.

Motz GT, Coukos G.

Immunity. 2013 Jul 25;39(1):61-73. doi: 10.1016/j.immuni.2013.07.005. Review.


A dendritic cell vaccine pulsed with autologous hypochlorous acid-oxidized ovarian cancer lysate primes effective broad antitumor immunity: from bench to bedside.

Chiang CL, Kandalaft LE, Tanyi J, Hagemann AR, Motz GT, Svoronos N, Montone K, Mantia-Smaldone GM, Smith L, Nisenbaum HL, Levine BL, Kalos M, Czerniecki BJ, Torigian DA, Powell DJ Jr, Mick R, Coukos G.

Clin Cancer Res. 2013 Sep 1;19(17):4801-15. doi: 10.1158/1078-0432.CCR-13-1185. Epub 2013 Jul 9.


T-regulatory cells: key players in tumor immune escape and angiogenesis.

Facciabene A, Motz GT, Coukos G.

Cancer Res. 2012 May 1;72(9):2162-71. doi: 10.1158/0008-5472.CAN-11-3687. Review.


NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease.

Wortham BW, Eppert BL, Motz GT, Flury JL, Orozco-Levi M, Hoebe K, Panos RJ, Maxfield M, Glasser SW, Senft AP, Raulet DH, Borchers MT.

J Immunol. 2012 May 1;188(9):4468-75. doi: 10.4049/jimmunol.1102643. Epub 2012 Mar 30.


The parallel lives of angiogenesis and immunosuppression: cancer and other tales.

Motz GT, Coukos G.

Nat Rev Immunol. 2011 Sep 23;11(10):702-11. doi: 10.1038/nri3064.


Tumor immune surveillance and ovarian cancer: lessons on immune mediated tumor rejection or tolerance.

Kandalaft LE, Motz GT, Duraiswamy J, Coukos G.

Cancer Metastasis Rev. 2011 Mar;30(1):141-51. doi: 10.1007/s10555-011-9289-9. Review.


Angiogenesis and the tumor vasculature as antitumor immune modulators: the role of vascular endothelial growth factor and endothelin.

Kandalaft LE, Motz GT, Busch J, Coukos G.

Curr Top Microbiol Immunol. 2011;344:129-48. doi: 10.1007/82_2010_95. Review.


Chronic cigarette smoke exposure primes NK cell activation in a mouse model of chronic obstructive pulmonary disease.

Motz GT, Eppert BL, Wortham BW, Amos-Kroohs RM, Flury JL, Wesselkamper SC, Borchers MT.

J Immunol. 2010 Apr 15;184(8):4460-9. doi: 10.4049/jimmunol.0903654. Epub 2010 Mar 12.


CCR7 deficiency leads to leukocyte activation and increased clearance in response to pulmonary Pseudomonas aeruginosa infection.

Eppert BL, Motz GT, Wortham BW, Flury JL, Borchers MT.

Infect Immun. 2010 May;78(5):2099-107. doi: 10.1128/IAI.00962-09. Epub 2010 Feb 22.


Chronic cigarette smoke exposure generates pathogenic T cells capable of driving COPD-like disease in Rag2-/- mice.

Motz GT, Eppert BL, Wesselkamper SC, Flury JL, Borchers MT.

Am J Respir Crit Care Med. 2010 Jun 1;181(11):1223-33. doi: 10.1164/rccm.200910-1485OC. Epub 2010 Feb 4.


Sustained CTL activation by murine pulmonary epithelial cells promotes the development of COPD-like disease.

Borchers MT, Wesselkamper SC, Curull V, Ramirez-Sarmiento A, Sánchez-Font A, Garcia-Aymerich J, Coronell C, Lloreta J, Agusti AG, Gea J, Howington JA, Reed MF, Starnes SL, Harris NL, Vitucci M, Eppert BL, Motz GT, Fogel K, McGraw DW, Tichelaar JW, Orozco-Levi M.

J Clin Invest. 2009 Mar;119(3):636-49. doi: 10.1172/JCI34462. Epub 2009 Feb 9.


Persistence of lung CD8 T cell oligoclonal expansions upon smoking cessation in a mouse model of cigarette smoke-induced emphysema.

Motz GT, Eppert BL, Sun G, Wesselkamper SC, Linke MJ, Deka R, Borchers MT.

J Immunol. 2008 Dec 1;181(11):8036-43.


NKG2D is critical for NK cell activation in host defense against Pseudomonas aeruginosa respiratory infection.

Wesselkamper SC, Eppert BL, Motz GT, Lau GW, Hassett DJ, Borchers MT.

J Immunol. 2008 Oct 15;181(8):5481-9.


Nonredundant functions of alphabeta and gammadelta T cells in acrolein-induced pulmonary pathology.

Borchers MT, Wesselkamper SC, Eppert BL, Motz GT, Sartor MA, Tomlinson CR, Medvedovic M, Tichelaar JW.

Toxicol Sci. 2008 Sep;105(1):188-99. doi: 10.1093/toxsci/kfn106. Epub 2008 May 29.


Heme oxygenase-1 induction by NRF2 requires inactivation of the transcriptional repressor BACH1.

Reichard JF, Motz GT, Puga A.

Nucleic Acids Res. 2007;35(21):7074-86. Epub 2007 Oct 16.

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