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Items: 39


Assessment of endothelial damage and cardiac injury in a mouse model mimicking thrombotic thrombocytopenic purpura.

Le Besnerais M, Favre J, Denis CV, Mulder P, Martinet J, Nicol L, Levesque H, Veyradier A, Kopić A, Motto DG, Coppo P, Richard V, Benhamou Y.

J Thromb Haemost. 2016 Oct;14(10):1917-1930. doi: 10.1111/jth.13439. Epub 2016 Sep 28.


ADAMTS13 autoantibodies cloned from patients with acquired thrombotic thrombocytopenic purpura: 2. Pathogenicity in an animal model.

Ostertag EM, Bdeir K, Kacir S, Thiboutot M, Gulendran G, Yunk L, Hayes VM, Motto DG, Poncz M, Zheng XL, Cines DB, Siegel DL.

Transfusion. 2016 Jul;56(7):1775-85. doi: 10.1111/trf.13583. Epub 2016 Apr 4.


Diagnostic approach to von Willebrand disease.

Ng C, Motto DG, Di Paola J.

Blood. 2015 Mar 26;125(13):2029-37. doi: 10.1182/blood-2014-08-528398. Epub 2015 Feb 23. Review. No abstract available.


Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis.

Dayal S, Wilson KM, Motto DG, Miller FJ Jr, Chauhan AK, Lentz SR.

Circulation. 2013 Mar 26;127(12):1308-16. doi: 10.1161/CIRCULATIONAHA.112.000966. Epub 2013 Feb 20.


Red blood cells mediate the onset of thrombosis in the ferric chloride murine model.

Barr JD, Chauhan AK, Schaeffer GV, Hansen JK, Motto DG.

Blood. 2013 May 2;121(18):3733-41. doi: 10.1182/blood-2012-11-468983. Epub 2013 Jan 23.


Manganese superoxide dismutase depletion in murine hematopoietic stem cells perturbs iron homeostasis, globin switching, and epigenetic control in erythrocyte precursor cells.

Case AJ, Madsen JM, Motto DG, Meyerholz DK, Domann FE.

Free Radic Biol Med. 2013 Mar;56:17-27. doi: 10.1016/j.freeradbiomed.2012.11.018. Epub 2012 Dec 5.


ADAMTS13 deficiency exacerbates VWF-dependent acute myocardial ischemia/reperfusion injury in mice.

Gandhi C, Motto DG, Jensen M, Lentz SR, Chauhan AK.

Blood. 2012 Dec 20;120(26):5224-30. doi: 10.1182/blood-2012-06-440255. Epub 2012 Sep 14.


ADAMTS13 reduces VWF-mediated acute inflammation following focal cerebral ischemia in mice.

Khan MM, Motto DG, Lentz SR, Chauhan AK.

J Thromb Haemost. 2012 Aug;10(8):1665-71. doi: 10.1111/j.1538-7836.2012.04822.x.


Alternatively-spliced extra domain A of fibronectin promotes acute inflammation and brain injury after cerebral ischemia in mice.

Khan MM, Gandhi C, Chauhan N, Stevens JW, Motto DG, Lentz SR, Chauhan AK.

Stroke. 2012 May;43(5):1376-82. doi: 10.1161/STROKEAHA.111.635516. Epub 2012 Feb 23.


The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-associated hemolytic uremic syndrome in humans and mice.

Petruzziello-Pellegrini TN, Yuen DA, Page AV, Patel S, Soltyk AM, Matouk CC, Wong DK, Turgeon PJ, Fish JE, Ho JJ, Steer BM, Khajoee V, Tigdi J, Lee WL, Motto DG, Advani A, Gilbert RE, Karumanchi SA, Robinson LA, Tarr PI, Liles WC, Brunton JL, Marsden PA.

J Clin Invest. 2012 Feb;122(2):759-76. doi: 10.1172/JCI57313. Epub 2012 Jan 9.


Blood group O and black race are independent risk factors for thrombotic thrombocytopenic purpura associated with severe ADAMTS13 deficiency.

Terrell DR, Motto DG, Kremer Hovinga JA, Lämmle B, George JN, Vesely SK.

Transfusion. 2011 Oct;51(10):2237-43. doi: 10.1111/j.1537-2995.2011.03125.x. Epub 2011 Apr 6.


Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice.

Huang J, Motto DG, Bundle DR, Sadler JE.

Blood. 2010 Nov 4;116(18):3653-9. doi: 10.1182/blood-2010-02-271957. Epub 2010 Jul 19.


von Willebrand factor is a major determinant of ADAMTS-13 decrease during mouse sepsis induced by cecum ligation and puncture.

Lerolle N, Dunois-Lardé C, Badirou I, Motto DG, Hill G, Bruneval P, Diehl JL, Denis CV, Baruch D.

J Thromb Haemost. 2009 May;7(5):843-50. doi: 10.1111/j.1538-7836.2009.03313.x. Epub 2009 Jan 31.


Correction of ADAMTS13 deficiency by in utero gene transfer of lentiviral vector encoding ADAMTS13 genes.

Niiya M, Endo M, Shang D, Zoltick PW, Muvarak NE, Cao W, Jin SY, Skipwith CG, Motto DG, Flake AW, Zheng XL.

Mol Ther. 2009 Jan;17(1):34-41. doi: 10.1038/mt.2008.223. Epub 2008 Oct 28.


The combined roles of ADAMTS13 and VWF in murine models of TTP, endotoxemia, and thrombosis.

Chauhan AK, Walsh MT, Zhu G, Ginsburg D, Wagner DD, Motto DG.

Blood. 2008 Apr 1;111(7):3452-7. Epub 2007 Dec 14.


Thrombotic thrombocytopenic purpura in humans and mice.

Desch KC, Motto DG.

Arterioscler Thromb Vasc Biol. 2007 Sep;27(9):1901-8. Epub 2007 May 24. Review.


Systemic antithrombotic effects of ADAMTS13.

Chauhan AK, Motto DG, Lamb CB, Bergmeier W, Dockal M, Plaimauer B, Scheiflinger F, Ginsburg D, Wagner DD.

J Exp Med. 2006 Mar 20;203(3):767-76. Epub 2006 Mar 13.


Coagulation and metastasis--an unexpected role for von Willebrand factor.

Shavit JA, Motto DG.

J Thromb Haemost. 2006 Mar;4(3):517-8. No abstract available.


Shigatoxin triggers thrombotic thrombocytopenic purpura in genetically susceptible ADAMTS13-deficient mice.

Motto DG, Chauhan AK, Zhu G, Homeister J, Lamb CB, Desch KC, Zhang W, Tsai HM, Wagner DD, Ginsburg D.

J Clin Invest. 2005 Oct;115(10):2752-61.


Cloning, expression and functional characterization of the full-length murine ADAMTS13.

Bruno K, Völkel D, Plaimauer B, Antoine G, Pable S, Motto DG, Lemmerhirt HL, Dorner F, Zimmermann K, Scheiflinger F.

J Thromb Haemost. 2005 May;3(5):1064-73.


ADAMTS13 turns 3.

Levy GG, Motto DG, Ginsburg D.

Blood. 2005 Jul 1;106(1):11-7. Epub 2005 Mar 17. Review.


Contribution of Drosophila DEG/ENaC genes to salt taste.

Liu L, Leonard AS, Motto DG, Feller MA, Price MP, Johnson WA, Welsh MJ.

Neuron. 2003 Jul 3;39(1):133-46.


Rituximab for refractory childhood autoimmune hemolytic anemia.

Motto DG, Williams JA, Boxer LA.

Isr Med Assoc J. 2002 Nov;4(11):1006-8.


A novel chromosomal inversion at 11q23 in infant acute myeloid leukemia fuses MLL to CALM, a gene that encodes a clathrin assembly protein.

Wechsler DS, Engstrom LD, Alexander BM, Motto DG, Roulston D.

Genes Chromosomes Cancer. 2003 Jan;36(1):26-36.


Ripped pocket and pickpocket, novel Drosophila DEG/ENaC subunits expressed in early development and in mechanosensory neurons.

Adams CM, Anderson MG, Motto DG, Price MP, Johnson WA, Welsh MJ.

J Cell Biol. 1998 Jan 12;140(1):143-52.


Three domains of SLP-76 are required for its optimal function in a T cell line.

Musci MA, Motto DG, Ross SE, Fang N, Koretzky GA.

J Immunol. 1997 Aug 15;159(4):1639-47.


Molecular cloning of SLAP-130, an SLP-76-associated substrate of the T cell antigen receptor-stimulated protein tyrosine kinases.

Musci MA, Hendricks-Taylor LR, Motto DG, Paskind M, Kamens J, Turck CW, Koretzky GA.

J Biol Chem. 1997 May 2;272(18):11674-7.


SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells.

Hendricks-Taylor LR, Motto DG, Zhang J, Siraganian RP, Koretzky GA.

J Biol Chem. 1997 Jan 10;272(2):1363-7.


Tyrosines 113, 128, and 145 of SLP-76 are required for optimal augmentation of NFAT promoter activity.

Fang N, Motto DG, Ross SE, Koretzky GA.

J Immunol. 1996 Nov 1;157(9):3769-73. Review.


Polymorphism in and localization of the gene LCP2 (SLP-76) to chromosome 5q33.1-qter.

Sunden SL, Carr LL, Clements JL, Motto DG, Koretzky GA.

Genomics. 1996 Jul 1;35(1):269-70. No abstract available.


Vav and SLP-76 interact and functionally cooperate in IL-2 gene activation.

Wu J, Motto DG, Koretzky GA, Weiss A.

Immunity. 1996 Jun;4(6):593-602.


Epidermal growth factor receptor targeting prevents uncoupling of the Grb2-SOS complex.

Holt KH, Waters SB, Okada S, Yamauchi K, Decker SJ, Saltiel AR, Motto DG, Koretzky GA, Pessin JE.

J Biol Chem. 1996 Apr 5;271(14):8300-6.


Implication of the GRB2-associated phosphoprotein SLP-76 in T cell receptor-mediated interleukin 2 production.

Motto DG, Ross SE, Wu J, Hendricks-Taylor LR, Koretzky GA.

J Exp Med. 1996 Apr 1;183(4):1937-43.


Molecular cloning of SLP-76, a 76-kDa tyrosine phosphoprotein associated with Grb2 in T cells.

Jackman JK, Motto DG, Sun Q, Tanemoto M, Turck CW, Peltz GA, Koretzky GA, Findell PR.

J Biol Chem. 1995 Mar 31;270(13):7029-32.


In vivo association of Grb2 with pp116, a substrate of the T cell antigen receptor-activated protein tyrosine kinase.

Motto DG, Ross SE, Jackman JK, Sun Q, Olson AL, Findell PR, Koretzky GA.

J Biol Chem. 1994 Aug 26;269(34):21608-13.


Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45.

Hovis RR, Donovan JA, Musci MA, Motto DG, Goldman FD, Ross SE, Koretzky GA.

Science. 1993 Apr 23;260(5107):544-6.


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