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Items: 1 to 50 of 99

1.

Improved hepatic MRP2/ABCC2 transport activity in LPS-induced cholestasis by aquaporin-1 gene transfer.

Marrone J, Tocchetti GN, Danielli M, Mottino AD, Marinelli RA.

Biochimie. 2019 Oct;165:179-182. doi: 10.1016/j.biochi.2019.07.027. Epub 2019 Aug 1.

PMID:
31377196
2.

Reversion of down-regulation of intestinal multidrug resistance-associated protein 2 in fructose-fed rats by geraniol and vitamin C: Potential role of inflammatory response and oxidative stress.

Zecchinati F, Barranco MM, Arana MR, Tocchetti GN, Domínguez CJ, Perdomo VG, Ruiz ML, Mottino AD, García F, Villanueva SSM.

J Nutr Biochem. 2019 Jun;68:7-15. doi: 10.1016/j.jnutbio.2019.03.002. Epub 2019 Mar 19.

PMID:
31005848
3.

Inhibition of multidrug resistance-associated protein 2 (MRP2) activity by the contraceptive nomegestrol acetate in HepG2 and Caco-2 cells.

Tocchetti GN, Domínguez CJ, Zecchinati F, Arana MR, Ruiz ML, Villanueva SSM, Mottino AD, Weiss J, Rigalli JP.

Eur J Pharm Sci. 2018 Sep 15;122:205-213. doi: 10.1016/j.ejps.2018.07.017. Epub 2018 Jul 6.

PMID:
29981893
4.

Biphasic modulation of cAMP levels by the contraceptive nomegestrol acetate. Impact on P-glycoprotein expression and activity in hepatic cells.

Tocchetti GN, Domínguez CJ, Zecchinati F, Arana MR, Ruiz ML, Villanueva SSM, Weiss J, Mottino AD, Rigalli JP.

Biochem Pharmacol. 2018 Aug;154:118-126. doi: 10.1016/j.bcp.2018.04.023. Epub 2018 Apr 21.

PMID:
29684377
5.

Inhibition of sirtuins 1 and 2 impairs cell survival and migration and modulates the expression of P-glycoprotein and MRP3 in hepatocellular carcinoma cell lines.

Ceballos MP, Decándido G, Quiroga AD, Comanzo CG, Livore VI, Lorenzetti F, Lambertucci F, Chazarreta-Cifre L, Banchio C, Alvarez ML, Mottino AD, Carrillo MC.

Toxicol Lett. 2018 Jun 1;289:63-74. doi: 10.1016/j.toxlet.2018.03.011. Epub 2018 Mar 12.

PMID:
29545174
6.

Acute regulation of multidrug resistance-associated protein 2 localization and activity by cAMP and estradiol-17β-D-glucuronide in rat intestine and Caco-2 cells.

Tocchetti GN, Arias A, Arana MR, Rigalli JP, Domínguez CJ, Zecchinati F, Ruiz ML, Villanueva SSM, Mottino AD.

Arch Toxicol. 2018 Feb;92(2):777-788. doi: 10.1007/s00204-017-2092-9. Epub 2017 Oct 20.

PMID:
29052767
7.

Glucagon-like peptide 2 prevents down-regulation of intestinal multidrug resistance-associated protein 2 and P-glycoprotein in endotoxemic rats.

Arana MR, Tocchetti GN, Zecchinati F, Londero AS, Dominguez C, Perdomo V, Rigalli JP, Villanueva SSM, Mottino AD.

Toxicology. 2017 Sep 1;390:22-31. doi: 10.1016/j.tox.2017.08.007. Epub 2017 Aug 23.

PMID:
28842383
8.

Intestinal multidrug resistance-associated protein 2 is down-regulated in fructose-fed rats.

Londero AS, Arana MR, Perdomo VG, Tocchetti GN, Zecchinati F, Ghanem CI, Ruiz ML, Rigalli JP, Mottino AD, García F, Villanueva SSM.

J Nutr Biochem. 2017 Feb;40:178-186. doi: 10.1016/j.jnutbio.2016.11.002. Epub 2016 Nov 9.

PMID:
27915161
9.

Modulation of expression and activity of intestinal multidrug resistance-associated protein 2 by xenobiotics.

Tocchetti GN, Rigalli JP, Arana MR, Villanueva SSM, Mottino AD.

Toxicol Appl Pharmacol. 2016 Jul 15;303:45-57. doi: 10.1016/j.taap.2016.05.002. Epub 2016 May 4. Review.

PMID:
27155371
10.

Physiological and pathophysiological factors affecting the expression and activity of the drug transporter MRP2 in intestine. Impact on its function as membrane barrier.

Arana MR, Tocchetti GN, Rigalli JP, Mottino AD, Villanueva SS.

Pharmacol Res. 2016 Jul;109:32-44. doi: 10.1016/j.phrs.2016.04.014. Epub 2016 Apr 22. Review.

PMID:
27109321
11.

Modulation of Expression and Activity of ABC Transporters by the Phytoestrogen Genistein. Impact on Drug Disposition.

Rigalli JP, Ciriaci N, Mottino AD, Catania VA, Ruiz ML.

Curr Med Chem. 2016;23(13):1370-89. Review.

PMID:
27048380
12.

Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity.

Ghanem CI, Pérez MJ, Manautou JE, Mottino AD.

Pharmacol Res. 2016 Jul;109:119-31. doi: 10.1016/j.phrs.2016.02.020. Epub 2016 Feb 26. Review.

13.

Coordinated induction of GST and MRP2 by cAMP in Caco-2 cells: Role of protein kinase A signaling pathway and toxicological relevance.

Arana MR, Tocchetti GN, Domizi P, Arias A, Rigalli JP, Ruiz ML, Luquita MG, Banchio C, Mottino AD, Villanueva SSM.

Toxicol Appl Pharmacol. 2015 Sep 1;287(2):178-190. doi: 10.1016/j.taap.2015.06.003. Epub 2015 Jun 3.

PMID:
26049102
14.

Regulation of multidrug resistance proteins by genistein in a hepatocarcinoma cell line: impact on sorafenib cytotoxicity.

Rigalli JP, Ciriaci N, Arias A, Ceballos MP, Villanueva SS, Luquita MG, Mottino AD, Ghanem CI, Catania VA, Ruiz ML.

PLoS One. 2015 Mar 17;10(3):e0119502. doi: 10.1371/journal.pone.0119502. eCollection 2015.

15.

Regulation of expression and activity of multidrug resistance proteins MRP2 and MDR1 by estrogenic compounds in Caco-2 cells. Role in prevention of xenobiotic-induced cytotoxicity.

Arias A, Rigalli JP, Villanueva SS, Ruiz ML, Luquita MG, Perdomo VG, Vore M, Catania VA, Mottino AD.

Toxicology. 2014 Jun 5;320:46-55. doi: 10.1016/j.tox.2014.03.007. Epub 2014 Mar 28.

PMID:
24685904
16.

Physiological concentrations of unconjugated bilirubin prevent oxidative stress-induced hepatocanalicular dysfunction and cholestasis.

Basiglio CL, Toledo FD, Boaglio AC, Arriaga SM, Ochoa JE, Sánchez Pozzi EJ, Mottino AD, Roma MG.

Arch Toxicol. 2014 Feb;88(2):501-14. doi: 10.1007/s00204-013-1143-0. Epub 2013 Dec 4.

PMID:
24306262
17.

Hormonal regulation of hepatic drug biotransformation and transport systems.

Ruiz ML, Mottino AD, Catania VA, Vore M.

Compr Physiol. 2013 Oct;3(4):1721-40. doi: 10.1002/cphy.c130018. Review.

PMID:
24265243
18.

Acetaminophen inhibits intestinal p-glycoprotein transport activity.

Novak A, Carpini GD, Ruiz ML, Luquita MG, Rubio MC, Mottino AD, Ghanem CI.

J Pharm Sci. 2013 Oct;102(10):3830-7. doi: 10.1002/jps.23673. Epub 2013 Jul 29.

PMID:
23897240
19.

Estrogen receptor-α mediates human multidrug resistance associated protein 3 induction by 17α-ethynylestradiol. Role of activator protein-1.

Ruiz ML, Rigalli JP, Arias A, Villanueva SS, Banchio C, Vore M, Mottino AD, Catania VA.

Biochem Pharmacol. 2013 Aug 1;86(3):401-9. doi: 10.1016/j.bcp.2013.05.025. Epub 2013 Jun 6.

PMID:
23747343
20.

Regulation of biotransformation systems and ABC transporters by benznidazole in HepG2 cells: involvement of pregnane X-receptor.

Rigalli JP, Perdomo VG, Luquita MG, Villanueva SS, Arias A, Theile D, Weiss J, Mottino AD, Ruiz ML, Catania VA.

PLoS Negl Trop Dis. 2012;6(12):e1951. doi: 10.1371/journal.pntd.0001951. Epub 2012 Dec 13.

21.

Induction of hepatic multidrug resistance-associated protein 3 by ethynylestradiol is independent of cholestasis and mediated by estrogen receptor.

Ruiz ML, Rigalli JP, Arias A, Villanueva S, Banchio C, Vore M, Mottino AD, Catania VA.

Drug Metab Dispos. 2013 Feb;41(2):275-80. doi: 10.1124/dmd.112.047357. Epub 2012 Oct 17.

22.

Effect of glucagon-like peptide 2 on hepatic, renal, and intestinal disposition of 1-chloro-2,4-dinitrobenzene.

Villanueva SS, Perdomo VG, Ruiz ML, Rigalli JP, Arias A, Luquita MG, Vore M, Catania VA, Mottino AD.

Drug Metab Dispos. 2012 Jul;40(7):1252-8. doi: 10.1124/dmd.111.044339. Epub 2012 Mar 27.

23.

Localization status of hepatocellular transporters in cholestasis.

Crocenzi FA, Zucchetti AE, Boaglio AC, Barosso IR, Sanchez Pozzi EJ, Mottino AD, Roma MG.

Front Biosci (Landmark Ed). 2012 Jan 1;17:1201-18. Review.

PMID:
22201798
24.

Pregnane X receptor mediates the induction of P-glycoprotein by spironolactone in HepG2 cells.

Rigalli JP, Ruiz ML, Perdomo VG, Villanueva SS, Mottino AD, Catania VA.

Toxicology. 2011 Jul 11;285(1-2):18-24. doi: 10.1016/j.tox.2011.03.015. Epub 2011 Apr 1.

PMID:
21459122
25.

Acetaminophen-induced stimulation of MDR1 expression and activity in rat intestine and in LS 174T human intestinal cell line.

Ghanem CI, Arias A, Novak A, Carpini GD, Villanueva S, Blazquez AG, Marin JJ, Mottino AD, Rubio MC.

Biochem Pharmacol. 2011 Jan 15;81(2):244-50. doi: 10.1016/j.bcp.2010.10.006. Epub 2010 Oct 16.

PMID:
20955690
26.

Phosphoinositide 3-kinase/protein kinase B signaling pathway is involved in estradiol 17β-D-glucuronide-induced cholestasis: complementarity with classical protein kinase C.

Boaglio AC, Zucchetti AE, Sánchez Pozzi EJ, Pellegrino JM, Ochoa JE, Mottino AD, Vore M, Crocenzi FA, Roma MG.

Hepatology. 2010 Oct;52(4):1465-76. doi: 10.1002/hep.23846.

PMID:
20815017
27.

Tauroursodeoxycholate counteracts hepatocellular lysis induced by tensioactive bile salts by preventing plasma membrane-micelle transition.

Basiglio CL, Mottino AD, Roma MG.

Chem Biol Interact. 2010 Dec 5;188(3):386-92. doi: 10.1016/j.cbi.2010.08.004. Epub 2010 Aug 24.

PMID:
20797393
28.

Induction of intestinal multidrug resistance-associated protein 2 by glucagon-like Peptide 2 in the rat.

Villanueva SS, Arias A, Ruiz ML, Rigalli JP, Pellegrino JM, Vore M, Catania VA, Mottino AD.

J Pharmacol Exp Ther. 2010 Nov;335(2):332-41. doi: 10.1124/jpet.110.171041. Epub 2010 Aug 18.

PMID:
20719938
29.

Complement activation and disease: protective effects of hyperbilirubinaemia.

Basiglio CL, Arriaga SM, Pelusa F, Almará AM, Kapitulnik J, Mottino AD.

Clin Sci (Lond). 2009 Oct 12;118(2):99-113. doi: 10.1042/CS20080540. Review.

PMID:
19807696
30.

Induction of intestinal multidrug resistance-associated protein 2 (Mrp2) by spironolactone in rats.

Ruiz ML, Villanueva SS, Luquita MG, Pellegrino JM, Rigalli JP, Arias A, Sánchez Pozzi EJ, Mottino AD, Catania VA.

Eur J Pharmacol. 2009 Nov 25;623(1-3):103-6. doi: 10.1016/j.ejphar.2009.09.014. Epub 2009 Sep 17.

PMID:
19766108
31.

Effect of repeated administration with subtoxic doses of acetaminophen to rats on enterohepatic recirculation of a subsequent toxic dose.

Ghanem CI, Ruiz ML, Villanueva SS, Luquita M, Llesuy S, Catania VA, Bengochea LA, Mottino AD.

Biochem Pharmacol. 2009 May 15;77(10):1621-8. doi: 10.1016/j.bcp.2009.02.006. Epub 2009 Feb 23.

PMID:
19426699
32.

Regulation of expression and activity of rat intestinal multidrug resistance-associated protein 2 by cholestatic estrogens.

Arias A, Villanueva SS, Ruiz ML, Luquita MG, Veggi LM, Pellegrino JM, Vore M, Catania VA, Mottino AD.

Drug Metab Dispos. 2009 Jun;37(6):1277-85. doi: 10.1124/dmd.108.025643. Epub 2009 Mar 19.

PMID:
19299525
33.

Unconjugated bilirubin inhibits C1 esterase activity.

Arriaga SM, Basiglio CL, Mottino AD, Almará AM.

Clin Biochem. 2009 Jun;42(9):919-21. doi: 10.1016/j.clinbiochem.2008.12.015. Epub 2009 Jan 3.

PMID:
19150444
34.

Differential effects of silymarin and its active component silibinin on plasma membrane stability and hepatocellular lysis.

Basiglio CL, Sánchez Pozzi EJ, Mottino AD, Roma MG.

Chem Biol Interact. 2009 May 15;179(2-3):297-303. doi: 10.1016/j.cbi.2008.12.008. Epub 2008 Dec 24.

PMID:
19135039
35.

Hepatic drug transporters and nuclear receptors: regulation by therapeutic agents.

Mottino AD, Catania VA.

World J Gastroenterol. 2008 Dec 14;14(46):7068-74. Review.

36.

Dynamic localization of hepatocellular transporters in health and disease.

Roma MG, Crocenzi FA, Mottino AD.

World J Gastroenterol. 2008 Nov 28;14(44):6786-801. Review.

37.

Ca(2+)-dependent protein kinase C isoforms are critical to estradiol 17beta-D-glucuronide-induced cholestasis in the rat.

Crocenzi FA, Sánchez Pozzi EJ, Ruiz ML, Zucchetti AE, Roma MG, Mottino AD, Vore M.

Hepatology. 2008 Dec;48(6):1885-95. doi: 10.1002/hep.22532.

38.

Dapsone induces oxidative stress and impairs antioxidant defenses in rat liver.

Veggi LM, Pretto L, Ochoa EJ, Catania VA, Luquita MG, Taborda DR, Sánchez Pozzi EJ, Ikushiro S, Coleman MD, Roma MG, Mottino AD.

Life Sci. 2008 Aug 1;83(5-6):155-63. doi: 10.1016/j.lfs.2008.05.016. Epub 2008 Jun 18.

PMID:
18602405
39.

Hepatic synthesis and urinary elimination of acetaminophen glucuronide are exacerbated in bile duct-ligated rats.

Villanueva SS, Ruiz ML, Ghanem CI, Luquita MG, Catania VA, Mottino AD.

Drug Metab Dispos. 2008 Mar;36(3):475-80. Epub 2007 Dec 20.

PMID:
18096675
40.

Upregulation of multidrug resistance-associated protein 3 by acetaminophen may help to increase its own clearance.

Ghanem CI, Mottino AD.

Clin Pharmacol Ther. 2008 Apr;83(4):527; author reply 528. No abstract available.

PMID:
18043697
41.

Beneficial effect of spironolactone administration on ethynylestradiol-induced cholestasis in the rat: involvement of up-regulation of multidrug resistance-associated protein 2.

Ruiz ML, Villanueva SS, Luquita MG, Ikushiro S, Mottino AD, Catania VA.

Drug Metab Dispos. 2007 Nov;35(11):2060-6. Epub 2007 Aug 8.

PMID:
17686906
42.

Disruption of function and localization of tight junctional structures and Mrp2 in sustained estradiol-17beta-D-glucuronide-induced cholestasis.

Mottino AD, Hoffman T, Crocenzi FA, Sánchez Pozzi EJ, Roma MG, Vore M.

Am J Physiol Gastrointest Liver Physiol. 2007 Jul;293(1):G391-402. Epub 2007 Apr 26.

43.

Protective role of unconjugated bilirubin on complement-mediated hepatocytolysis.

Basiglio CL, Arriaga SM, Pelusa HF, Almará AM, Roma MG, Mottino AD.

Biochim Biophys Acta. 2007 Jul;1770(7):1003-10. Epub 2007 Mar 19.

PMID:
17442495
44.

Induction of rat intestinal P-glycoprotein by spironolactone and its effect on absorption of orally administered digoxin.

Ghanem CI, Gómez PC, Arana MC, Perassolo M, Delli Carpini G, Luquita MG, Veggi LM, Catania VA, Bengochea LA, Mottino AD.

J Pharmacol Exp Ther. 2006 Sep;318(3):1146-52. Epub 2006 Jun 1.

PMID:
16740618
45.

Hepatic and extrahepatic synthesis and disposition of dinitrophenyl-S-glutathione in bile duct-ligated rats.

Villanueva SS, Ruiz ML, Soroka CJ, Cai SY, Luquita MG, Torres AM, Sánchez Pozzi EJ, Pellegrino JM, Boyer JL, Catania VA, Mottino AD.

Drug Metab Dispos. 2006 Aug;34(8):1301-9. Epub 2006 May 5.

PMID:
16679389
46.

Galactosamine prevents ethinylestradiol-induced cholestasis.

Crocenzi FA, Pellegrino JM, Catania VA, Luquita MG, Roma MG, Mottino AD, Pozzi EJ.

Drug Metab Dispos. 2006 Jun;34(6):993-7. Epub 2006 Mar 22.

PMID:
16554370
47.

Ethynylestradiol increases expression and activity of rat liver MRP3.

Ruiz ML, Villanueva SS, Luquita MG, Vore M, Mottino AD, Catania VA.

Drug Metab Dispos. 2006 Jun;34(6):1030-4. Epub 2006 Mar 22.

PMID:
16554369
48.

Canalicular membrane localization of hepatocyte aquaporin-8 is preserved in estradiol-17beta-D-glucuronide-induced cholestasis.

Mottino AD, Carreras FI, Gradilone SA, Marinelli RA, Vore M.

J Hepatol. 2006 Jan;44(1):232-3. Epub 2005 Sep 23. No abstract available.

PMID:
16274833
49.

Shift from biliary to urinary elimination of acetaminophen-glucuronide in acetaminophen-pretreated rats.

Ghanem CI, Ruiz ML, Villanueva SS, Luquita MG, Catania VA, Jones B, Bengochea LA, Vore M, Mottino AD.

J Pharmacol Exp Ther. 2005 Dec;315(3):987-95. Epub 2005 Aug 18.

PMID:
16109740
50.

Dapsone impairs the bile salt-independent fraction of bile flow in rats: Possible involvement of its N-hydroxylated metabolite.

Veggi LM, Crocenzi FA, Roma MG, Mottino AD.

Toxicology. 2005 Jul 1;211(1-2):97-106. Epub 2005 Apr 7.

PMID:
15863252

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