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Items: 1 to 50 of 57

1.

The discovery and maturation of peptide biologics targeting the small G protein Cdc42: a bioblockade for Ras-driven signalling.

Tetley GJN, Murphy NP, Bonetto S, Ivanova-Berndt G, Revell J, Mott HR, Cooley RN, Owen D.

J Biol Chem. 2020 Jan 20. pii: jbc.RA119.010077. doi: 10.1074/jbc.RA119.010077. [Epub ahead of print]

2.

NMR resonance assignments for the active and inactive conformations of the small G protein RalA.

Shafiq A, Campbell LJ, Owen D, Mott HR.

Biomol NMR Assign. 2020 Jan 8. doi: 10.1007/s12104-019-09925-7. [Epub ahead of print]

PMID:
31916136
3.

Allostery and dynamics in small G proteins.

Mott HR, Owen D.

Biochem Soc Trans. 2018 Oct 19;46(5):1333-1343. doi: 10.1042/BST20170569. Epub 2018 Oct 8. Review.

PMID:
30301845
4.

CRIB effector disorder: exquisite function from chaos.

Owen D, Mott HR.

Biochem Soc Trans. 2018 Oct 19;46(5):1289-1302. doi: 10.1042/BST20170570. Epub 2018 Aug 28. Review.

PMID:
30154092
5.

Bond swapping from a charge cloud allows flexible coordination of upstream signals through WASP: Multiple regulatory roles for the WASP basic region.

Tetley GJN, Szeto A, Fountain AJ, Mott HR, Owen D.

J Biol Chem. 2018 Sep 28;293(39):15136-15151. doi: 10.1074/jbc.RA118.003290. Epub 2018 Aug 13.

6.

Bioblockades join the assault on small G protein signalling.

Mott HR, Owen D.

Semin Cancer Biol. 2019 Feb;54:149-161. doi: 10.1016/j.semcancer.2018.01.001. Epub 2018 Jan 4. Review.

PMID:
29307570
7.

Genomic Subtypes of Non-invasive Bladder Cancer with Distinct Metabolic Profile and Female Gender Bias in KDM6A Mutation Frequency.

Hurst CD, Alder O, Platt FM, Droop A, Stead LF, Burns JE, Burghel GJ, Jain S, Klimczak LJ, Lindsay H, Roulson JA, Taylor CF, Thygesen H, Cameron AJ, Ridley AJ, Mott HR, Gordenin DA, Knowles MA.

Cancer Cell. 2017 Nov 13;32(5):701-715.e7. doi: 10.1016/j.ccell.2017.08.005.

8.

Structural basis for the shielding function of the dynamic trypanosome variant surface glycoprotein coat.

Bartossek T, Jones NG, Schäfer C, Cvitković M, Glogger M, Mott HR, Kuper J, Brennich M, Carrington M, Smith AS, Fenz S, Kisker C, Engstler M.

Nat Microbiol. 2017 Nov;2(11):1523-1532. doi: 10.1038/s41564-017-0013-6. Epub 2017 Sep 11.

PMID:
28894098
9.

A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK.

Tetley GJN, Mott HR, Cooley RN, Owen D.

J Biol Chem. 2017 Jul 7;292(27):11361-11373. doi: 10.1074/jbc.M117.789883. Epub 2017 May 24.

10.

Cdc42 in actin dynamics: An ordered pathway governed by complex equilibria and directional effector handover.

Watson JR, Owen D, Mott HR.

Small GTPases. 2017 Oct 2;8(4):237-244. doi: 10.1080/21541248.2016.1215657. Epub 2016 Aug 11. Review.

11.

Inhibition of Ral GTPases Using a Stapled Peptide Approach.

Thomas JC, Cooper JM, Clayton NS, Wang C, White MA, Abell C, Owen D, Mott HR.

J Biol Chem. 2016 Aug 26;291(35):18310-25. doi: 10.1074/jbc.M116.720243. Epub 2016 Jun 22.

12.

Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES.

Watson JR, Fox HM, Nietlispach D, Gallop JL, Owen D, Mott HR.

J Biol Chem. 2016 Jun 24;291(26):13875-90. doi: 10.1074/jbc.M116.724294. Epub 2016 Apr 22.

13.

Erratum to: 1H, 13C and 15N resonance assignments of the Cdc42-binding domain of TOCA1.

Watson JR, Nietlispach D, Owen D, Mott HR.

Biomol NMR Assign. 2016 Oct;10(2):413-414. No abstract available.

14.

(1)H, (13)C and (15)N resonance assignments of the Cdc42-binding domain of TOCA1.

Watson JR, Nietlispach D, Owen D, Mott HR.

Biomol NMR Assign. 2016 Oct;10(2):407-11. doi: 10.1007/s12104-016-9677-8. Epub 2016 Mar 18. Erratum in: Biomol NMR Assign. 2016 Oct;10(2):413-4.

15.

Structures of Ras superfamily effector complexes: What have we learnt in two decades?

Mott HR, Owen D.

Crit Rev Biochem Mol Biol. 2015 Mar-Apr;50(2):85-133. doi: 10.3109/10409238.2014.999191. Epub 2015 Apr 1. Review.

PMID:
25830673
16.

Thermodynamic mapping of effector protein interfaces with RalA and RalB.

Campbell LJ, Peppa M, Crabtree MD, Shafiq A, McGough NF, Mott HR, Owen D.

Biochemistry. 2015 Feb 17;54(6):1380-9. doi: 10.1021/bi501530u. Epub 2015 Feb 5.

PMID:
25621740
17.

Integral membrane protein structure determination using pseudocontact shifts.

Crick DJ, Wang JX, Graham B, Swarbrick JD, Mott HR, Nietlispach D.

J Biomol NMR. 2015 Apr;61(3-4):197-207. doi: 10.1007/s10858-015-9899-6. Epub 2015 Jan 22.

18.

Structure and function of RLIP76 (RalBP1): an intersection point between Ras and Rho signalling.

Mott HR, Owen D.

Biochem Soc Trans. 2014 Feb;42(1):52-8. doi: 10.1042/BST20130231.

PMID:
24450627
19.

The structure of the RLIP76 RhoGAP-Ral binding domain dyad: fixed position of the domains leads to dual engagement of small G proteins at the membrane.

Rajasekar KV, Campbell LJ, Nietlispach D, Owen D, Mott HR.

Structure. 2013 Dec 3;21(12):2131-42. doi: 10.1016/j.str.2013.09.007. Epub 2013 Oct 24.

20.

Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB.

Hutchinson CL, Lowe PN, McLaughlin SH, Mott HR, Owen D.

Biochemistry. 2013 Nov 12;52(45):7999-8011. doi: 10.1021/bi401216w. Epub 2013 Oct 31.

PMID:
24128008
21.

Atomic structure and hierarchical assembly of a cross-β amyloid fibril.

Fitzpatrick AW, Debelouchina GT, Bayro MJ, Clare DK, Caporini MA, Bajaj VS, Jaroniec CP, Wang L, Ladizhansky V, Müller SA, MacPhee CE, Waudby CA, Mott HR, De Simone A, Knowles TP, Saibil HR, Vendruscolo M, Orlova EV, Griffin RG, Dobson CM.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5468-73. doi: 10.1073/pnas.1219476110. Epub 2013 Mar 19.

22.

1H, 13C and 15N resonance assignments of the GTPase-activating (GAP) and Ral binding domains (GBD) of RLIP76 (RalBP1).

Rajasekar KV, Campbell LJ, Nietlispach D, Owen D, Mott HR.

Biomol NMR Assign. 2012 Oct;6(2):119-22. doi: 10.1007/s12104-011-9337-y. Epub 2011 Sep 14.

PMID:
21915608
23.

RLIP76 (RalBP1): The first piece of the structural puzzle.

Mott HR, Owen D.

Small GTPases. 2010 Nov;1(3):157-160.

24.

Mutational analysis reveals a single binding interface between RhoA and its effector, PRK1.

Hutchinson CL, Lowe PN, McLaughlin SH, Mott HR, Owen D.

Biochemistry. 2011 Apr 12;50(14):2860-9. doi: 10.1021/bi200039u. Epub 2011 Mar 16.

PMID:
21351730
25.

The RalB-RLIP76 complex reveals a novel mode of ral-effector interaction.

Fenwick RB, Campbell LJ, Rajasekar K, Prasannan S, Nietlispach D, Camonis J, Owen D, Mott HR.

Structure. 2010 Aug 11;18(8):985-95. doi: 10.1016/j.str.2010.05.013.

26.

Structure determination of the seven-helix transmembrane receptor sensory rhodopsin II by solution NMR spectroscopy.

Gautier A, Mott HR, Bostock MJ, Kirkpatrick JP, Nietlispach D.

Nat Struct Mol Biol. 2010 Jun;17(6):768-74. doi: 10.1038/nsmb.1807. Epub 2010 May 30.

27.

1H, 13C and 15N resonance assignments for Binder of Arl2, BART.

Bailey LK, Campbell LJ, Evetts KA, Littlefield K, Rajendra E, Nietlispach D, Owen D, Mott HR.

Biomol NMR Assign. 2009 Jun;3(1):33-6. doi: 10.1007/s12104-008-9135-3. Epub 2008 Dec 16.

PMID:
19636941
28.

Resonance assignments for the RLIP76 Ral binding domain in its free form and in complex with the small G protein RalB.

Fenwick RB, Prasannan S, Campbell LJ, Evetts KA, Nietlispach D, Owen D, Mott HR.

Biomol NMR Assign. 2008 Dec;2(2):191-4. doi: 10.1007/s12104-008-9118-4. Epub 2008 Oct 7.

PMID:
19636902
29.

1H, 13C and 15N resonance assignments for the active conformation of the small G protein RalB in complex with its effector RLIP76.

Fenwick RB, Prasannan S, Campbell LJ, Evetts KA, Nietlispach D, Owen D, Mott HR.

Biomol NMR Assign. 2008 Dec;2(2):179-82. doi: 10.1007/s12104-008-9115-7. Epub 2008 Oct 19.

PMID:
19636899
30.

Solution structure and dynamics of the small GTPase RalB in its active conformation: significance for effector protein binding.

Fenwick RB, Prasannan S, Campbell LJ, Nietlispach D, Evetts KA, Camonis J, Mott HR, Owen D.

Biochemistry. 2009 Mar 17;48(10):2192-206. doi: 10.1021/bi802129d.

PMID:
19166349
31.

The structure of binder of Arl2 (BART) reveals a novel G protein binding domain: implications for function.

Bailey LK, Campbell LJ, Evetts KA, Littlefield K, Rajendra E, Nietlispach D, Owen D, Mott HR.

J Biol Chem. 2009 Jan 9;284(2):992-9. doi: 10.1074/jbc.M806167200. Epub 2008 Nov 3.

32.

Role of intermolecular forces in defining material properties of protein nanofibrils.

Knowles TP, Fitzpatrick AW, Meehan S, Mott HR, Vendruscolo M, Dobson CM, Welland ME.

Science. 2007 Dec 21;318(5858):1900-3.

33.

The Rac1 polybasic region is required for interaction with its effector PRK1.

Modha R, Campbell LJ, Nietlispach D, Buhecha HR, Owen D, Mott HR.

J Biol Chem. 2008 Jan 18;283(3):1492-500. Epub 2007 Nov 15.

34.

Structure of a glycosylphosphatidylinositol-anchored domain from a trypanosome variant surface glycoprotein.

Jones NG, Nietlispach D, Sharma R, Burke DF, Eyres I, Mues M, Mott HR, Carrington M.

J Biol Chem. 2008 Feb 8;283(6):3584-93. Epub 2007 Nov 14.

35.

Double mutant cycle thermodynamic analysis of the hydrophobic Cdc42-ACK protein-protein interaction.

Elliot-Smith AE, Owen D, Mott HR, Lowe PN.

Biochemistry. 2007 Dec 11;46(49):14087-99. Epub 2007 Nov 14.

PMID:
17999470
36.

The IQGAP1-Rac1 and IQGAP1-Cdc42 interactions: interfaces differ between the complexes.

Owen D, Campbell LJ, Littlefield K, Evetts KA, Li Z, Sacks DB, Lowe PN, Mott HR.

J Biol Chem. 2008 Jan 18;283(3):1692-704. Epub 2007 Nov 5.

37.

1H, 13C and 15N resonance assignments for the small G protein RalB in its active conformation.

Prasannan S, Fenwick RB, Campbell LJ, Evetts KA, Nietlispach D, Owen D, Mott HR.

Biomol NMR Assign. 2007 Jul;1(1):147-9. doi: 10.1007/s12104-007-9040-1. Epub 2007 Jul 25. Erratum in: Biomol NMR Assign. 2007 Dec;1(2):249.

PMID:
19636851
38.

Specificity determinants on Cdc42 for binding its effector protein ACK.

Elliot-Smith AE, Mott HR, Lowe PN, Laue ED, Owen D.

Biochemistry. 2005 Sep 20;44(37):12373-83.

PMID:
16156650
39.

Structural analysis of the SH3 domain of beta-PIX and its interaction with alpha-p21 activated kinase (PAK).

Mott HR, Nietlispach D, Evetts KA, Owen D.

Biochemistry. 2005 Aug 23;44(33):10977-83.

PMID:
16101281
40.

Fluorescence properties of green fluorescent protein FRET pairs concatenated with the small G protein, Rac, and its interacting domain of the kinase, p21-activated kinase.

Collinson AD, Bligh SW, Graham DL, Mott HR, Chalk PA, Korniotis N, Lowe PN.

Assay Drug Dev Technol. 2004 Dec;2(6):659-73.

PMID:
15674024
41.

Structure of the C-terminal domain from Trypanosoma brucei variant surface glycoprotein MITat1.2.

Chattopadhyay A, Jones NG, Nietlispach D, Nielsen PR, Voorheis HP, Mott HR, Carrington M.

J Biol Chem. 2005 Feb 25;280(8):7228-35. Epub 2004 Nov 22.

42.

Structure determination of protein complexes by NMR.

Nietlispach D, Mott HR, Stott KM, Nielsen PR, Thiru A, Laue ED.

Methods Mol Biol. 2004;278:255-88.

PMID:
15318000
43.

Structural basis of HP1/PXVXL motif peptide interactions and HP1 localisation to heterochromatin.

Thiru A, Nietlispach D, Mott HR, Okuwaki M, Lyon D, Nielsen PR, Hirshberg M, Verreault A, Murzina NV, Laue ED.

EMBO J. 2004 Feb 11;23(3):489-99. Epub 2004 Feb 5.

44.

Structure of the sterile alpha motif (SAM) domain of the Saccharomyces cerevisiae mitogen-activated protein kinase pathway-modulating protein STE50 and analysis of its interaction with the STE11 SAM.

Grimshaw SJ, Mott HR, Stott KM, Nielsen PR, Evetts KA, Hopkins LJ, Nietlispach D, Owen D.

J Biol Chem. 2004 Jan 16;279(3):2192-201. Epub 2003 Oct 22. Erratum in: J Biol Chem. 2004 Mar 5;279(10):9672.

45.

Molecular dissection of the interaction between the small G proteins Rac1 and RhoA and protein kinase C-related kinase 1 (PRK1).

Owen D, Lowe PN, Nietlispach D, Brosnan CE, Chirgadze DY, Parker PJ, Blundell TL, Mott HR.

J Biol Chem. 2003 Dec 12;278(50):50578-87. Epub 2003 Sep 26.

46.

Structure of the GTPase-binding domain of Sec5 and elucidation of its Ral binding site.

Mott HR, Nietlispach D, Hopkins LJ, Mirey G, Camonis JH, Owen D.

J Biol Chem. 2003 May 9;278(19):17053-9. Epub 2003 Mar 6.

47.

Structure of the HP1 chromodomain bound to histone H3 methylated at lysine 9.

Nielsen PR, Nietlispach D, Mott HR, Callaghan J, Bannister A, Kouzarides T, Murzin AG, Murzina NV, Laue ED.

Nature. 2002 Mar 7;416(6876):103-7. Epub 2002 Feb 20.

PMID:
11882902
48.

Structure of Cdc42 bound to the GTPase binding domain of PAK.

Morreale A, Venkatesan M, Mott HR, Owen D, Nietlispach D, Lowe PN, Laue ED.

Nat Struct Biol. 2000 May;7(5):384-8.

PMID:
10802735
49.

Residues in Cdc42 that specify binding to individual CRIB effector proteins.

Owen D, Mott HR, Laue ED, Lowe PN.

Biochemistry. 2000 Feb 15;39(6):1243-50.

PMID:
10684602
50.

Structure of the small G protein Cdc42 bound to the GTPase-binding domain of ACK.

Mott HR, Owen D, Nietlispach D, Lowe PN, Manser E, Lim L, Laue ED.

Nature. 1999 May 27;399(6734):384-8.

PMID:
10360579

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