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A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies.

Tang Y, Lenzini PA, Pop-Busui R, Ray PR, Campbell H, Perkins BA, Callaghan B, Wagner MJ, Motsinger-Reif AA, Buse JB, Price TJ, Mychaleckyj JC, Cresci S, Shah H, Doria A.

Diabetes. 2019 Aug;68(8):1649-1662. doi: 10.2337/db19-0109. Epub 2019 May 24.


Identifying individual risk rare variants using protein structure guided local tests (POINT).

Marceau West R, Lu W, Rotroff DM, Kuenemann MA, Chang SM, Wu MC, Wagner MJ, Buse JB, Motsinger-Reif AA, Fourches D, Tzeng JY.

PLoS Comput Biol. 2019 Feb 19;15(2):e1006722. doi: 10.1371/journal.pcbi.1006722. eCollection 2019 Feb.


The influence of Neanderthal alleles on cytotoxic response.

Akhtari FS, Havener TM, Fukudo M, Jack JR, McLeod HL, Wiltshire T, Motsinger-Reif AA.

PeerJ. 2018 Oct 23;6:e5691. doi: 10.7717/peerj.5691. eCollection 2018.


Genetic Tools for Coronary Risk Assessment in Type 2 Diabetes: A Cohort Study From the ACCORD Clinical Trial.

Morieri ML, Gao H, Pigeyre M, Shah HS, Sjaarda J, Mendonca C, Hastings T, Buranasupkajorn P, Motsinger-Reif AA, Rotroff DM, Sigal RJ, Marcovina SM, Kraft P, Buse JB, Wagner MJ, Gerstein HC, Mychaleckyj JC, Parè G, Doria A.

Diabetes Care. 2018 Nov;41(11):2404-2413. doi: 10.2337/dc18-0709. Epub 2018 Sep 27.


Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate.

Kaddurah-Daouk R, Hankemeier T, Scholl EH, Baillie R, Harms A, Stage C, Dalhoff KP, Jűrgens G, Taboureau O, Nzabonimpa GS, Motsinger-Reif AA, Thomsen R, Linnet K, Rasmussen HB; INDICES Consortium; Pharmacometabolomics Research Network.

CPT Pharmacometrics Syst Pharmacol. 2018 Aug;7(8):525-533. doi: 10.1002/psp4.12309.


Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes.

Rotroff DM, Yee SW, Zhou K, Marvel SW, Shah HS, Jack JR, Havener TM, Hedderson MM, Kubo M, Herman MA, Gao H, Mychaleckyi JC, McLeod HL, Doria A, Giacomini KM, Pearson ER, Wagner MJ, Buse JB, Motsinger-Reif AA; MetGen Investigators; ACCORD/ACCORDion Investigators.

Diabetes. 2018 Jul;67(7):1428-1440. doi: 10.2337/db17-1164. Epub 2018 Apr 12.


Pharmacogenetic Analysis of the Model-Based Pharmacokinetics of Five Anti-HIV Drugs: How Does This Influence the Effect of Aging?

Chen J, Akhtari FS, Wagner MJ, Suzuki O, Wiltshire T, Motsinger-Reif AA, Dumond JB.

Clin Transl Sci. 2018 Mar;11(2):226-236. doi: 10.1111/cts.12525. Epub 2017 Dec 3.


Gene expression and linkage analysis implicate CBLB as a mediator of rituximab resistance.

Jack J, Small GW, Brown CC, Havener TM, McLeod HL, Motsinger-Reif AA, Richards KL.

Pharmacogenomics J. 2018 May 22;18(3):467-473. doi: 10.1038/tpj.2017.41. Epub 2017 Dec 5.


Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD.

Shah HS, Morieri ML, Marcovina SM, Sigal RJ, Gerstein HC, Wagner MJ, Motsinger-Reif AA, Buse JB, Kraft P, Mychaleckyj JC, Doria A.

Diabetes Care. 2018 Feb;41(2):348-355. doi: 10.2337/dc17-1638. Epub 2017 Nov 28.


Targeted metabolomics and medication classification data from participants in the ADNI1 cohort.

St John-Williams L, Blach C, Toledo JB, Rotroff DM, Kim S, Klavins K, Baillie R, Han X, Mahmoudiandehkordi S, Jack J, Massaro TJ, Lucas JE, Louie G, Motsinger-Reif AA, Risacher SL; Alzheimer’s Disease Neuroimaging Initiative; Alzheimer’s Disease Metabolomics Consortium, Saykin AJ, Kastenmüller G, Arnold M, Koal T, Moseley MA, Mangravite LM, Peters MA, Tenenbaum JD, Thompson JW, Kaddurah-Daouk R.

Sci Data. 2017 Oct 17;4:170140. doi: 10.1038/sdata.2017.140.


Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes.

Rotroff DM, Pijut SS, Marvel SW, Jack JR, Havener TM, Pujol A, Schluter A, Graf GA, Ginsberg HN, Shah HS, Gao H, Morieri ML, Doria A, Mychaleckyi JC, McLeod HL, Buse JB, Wagner MJ, Motsinger-Reif AA; ACCORD/ACCORDion Investigators.

Clin Pharmacol Ther. 2018 Apr;103(4):712-721. doi: 10.1002/cpt.798. Epub 2017 Nov 3.


The Effect of Heart Disease on Anesthetic Complications During Routine Dental Procedures in Dogs.

Carter JE, Motsinger-Reif AA, Krug WV, Keene BW.

J Am Anim Hosp Assoc. 2017 Jul/Aug;53(4):206-213. doi: 10.5326/JAAHA-MS-6512. Epub 2017 May 23.


Common and rare genetic markers of lipid variation in subjects with type 2 diabetes from the ACCORD clinical trial.

Marvel SW, Rotroff DM, Wagner MJ, Buse JB, Havener TM, McLeod HL, Motsinger-Reif AA; The ACCORD/ACCORDion Investigators.

PeerJ. 2017 May 2;5:e3187. doi: 10.7717/peerj.3187. eCollection 2017.


An Introduction to Terminology and Methodology of Chemical Synergy-Perspectives from Across Disciplines.

Roell KR, Reif DM, Motsinger-Reif AA.

Front Pharmacol. 2017 Apr 20;8:158. doi: 10.3389/fphar.2017.00158. eCollection 2017. Review.


Incorporating Concomitant Medications into Genome-Wide Analyses for the Study of Complex Disease and Drug Response.

Graham HT, Rotroff DM, Marvel SW, Buse JB, Havener TM, Wilson AG, Wagner MJ, Motsinger-Reif AA; ACCORD/ACCORDion Investigators.

Front Genet. 2016 Aug 17;7:138. eCollection 2016.


Embracing Integrative Multiomics Approaches.

Rotroff DM, Motsinger-Reif AA.

Int J Genomics. 2016;2016:1715985. doi: 10.1155/2016/1715985. Epub 2016 Sep 4. Review.


Genetic Predictors of Cardiovascular Mortality During Intensive Glycemic Control in Type 2 Diabetes: Findings From the ACCORD Clinical Trial.

Shah HS, Gao H, Morieri ML, Skupien J, Marvel S, Paré G, Mannino GC, Buranasupkajorn P, Mendonca C, Hastings T, Marcovina SM, Sigal RJ, Gerstein HC, Wagner MJ, Motsinger-Reif AA, Buse JB, Kraft P, Mychaleckyj JC, Doria A.

Diabetes Care. 2016 Nov;39(11):1915-1924. Epub 2016 Aug 15.


Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin.

Zhou K, Yee SW, Seiser EL, van Leeuwen N, Tavendale R, Bennett AJ, Groves CJ, Coleman RL, van der Heijden AA, Beulens JW, de Keyser CE, Zaharenko L, Rotroff DM, Out M, Jablonski KA, Chen L, Javorský M, Židzik J, Levin AM, Williams LK, Dujic T, Semiz S, Kubo M, Chien HC, Maeda S, Witte JS, Wu L, Tkáč I, Kooy A, van Schaik RHN, Stehouwer CDA, Logie L; MetGen Investigators; DPP Investigators; ACCORD Investigators, Sutherland C, Klovins J, Pirags V, Hofman A, Stricker BH, Motsinger-Reif AA, Wagner MJ, Innocenti F, 't Hart LM, Holman RR, McCarthy MI, Hedderson MM, Palmer CNA, Florez JC, Giacomini KM, Pearson ER.

Nat Genet. 2016 Sep;48(9):1055-1059. doi: 10.1038/ng.3632. Epub 2016 Aug 8.


Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans.

Rotroff DM, Oki NO, Liang X, Yee SW, Stocker SL, Corum DG, Meisner M, Fiehn O, Motsinger-Reif AA, Giacomini KM, Kaddurah-Daouk R.

Front Pharmacol. 2016 Jun 14;7:135. doi: 10.3389/fphar.2016.00135. eCollection 2016.


A comparison of DMET Plus microarray and genome-wide technologies by assessing population substructure.

Jackson JN, Long KM, He Y, Motsinger-Reif AA, McLeod HL, Jack J.

Pharmacogenet Genomics. 2016 Apr;26(4):147-153. doi: 10.1097/FPC.0000000000000200.


Relative Quantification and Higher-Order Modeling of the Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples.

Hecht ES, Scholl EH, Walker SH, Taylor AD, Cliby WA, Motsinger-Reif AA, Muddiman DC.

J Proteome Res. 2015 Oct 2;14(10):4394-401. doi: 10.1021/acs.jproteome.5b00703. Epub 2015 Sep 14.


Evaluating the role of admixture in cancer therapy via in vitro drug response and multivariate genome-wide associations.

Jack J, Havener TM, McLeod HL, Motsinger-Reif AA, Foster M.

Pharmacogenomics. 2015;16(13):1451-63. doi: 10.2217/PGS.15.85. Epub 2015 Aug 28.


Accuracy of SNPs to predict risk of HLA alleles associated with drug-induced hypersensitivity events across racial groups.

He Y, Hoskins JM, Clark S, Campbell NH, Wagner K, Motsinger-Reif AA, McLeod HL.

Pharmacogenomics. 2015 Jul;16(8):817-24. doi: 10.2217/pgs.15.41. Epub 2015 Jun 17.


Canine urothelial carcinoma: genomically aberrant and comparatively relevant.

Shapiro SG, Raghunath S, Williams C, Motsinger-Reif AA, Cullen JM, Liu T, Albertson D, Ruvolo M, Bergstrom Lucas A, Jin J, Knapp DW, Schiffman JD, Breen M.

Chromosome Res. 2015 Jun;23(2):311-31. doi: 10.1007/s10577-015-9471-y. Epub 2015 Mar 18.


An investigation of gene-gene interactions in dose-response studies with Bayesian nonparametrics.

Beam AL, Motsinger-Reif AA, Doyle J.

BioData Min. 2015 Feb 6;8:6. doi: 10.1186/s13040-015-0039-3. eCollection 2015.


Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study.

Abdo N, Xia M, Brown CC, Kosyk O, Huang R, Sakamuru S, Zhou YH, Jack JR, Gallins P, Xia K, Li Y, Chiu WA, Motsinger-Reif AA, Austin CP, Tice RR, Rusyn I, Wright FA.

Environ Health Perspect. 2015 May;123(5):458-66. doi: 10.1289/ehp.1408775. Epub 2015 Jan 13.


Single-nucleotide polymorphism data support the general unrelatedness of the males in the agricultural health study.

Jack JR, Motsinger-Reif AA, Koutros S, Alavanja MC, Beane Freeman LE, Hoppin JA.

Cancer Epidemiol Biomarkers Prev. 2014 Oct;23(10):2192-5. doi: 10.1158/1055-9965.EPI-14-0276. Epub 2014 Jul 21.


An adaptive permutation approach for genome-wide association study: evaluation and recommendations for use.

Che R, Jack JR, Motsinger-Reif AA, Brown CC.

BioData Min. 2014 Jun 14;7:9. doi: 10.1186/1756-0381-7-9. eCollection 2014.


Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics.

Hariani GD, Lam ET, Havener T, Kwok PY, McLeod HL, Wagner MJ, Motsinger-Reif AA.

BMC Res Notes. 2014 Jun 12;7:360. doi: 10.1186/1756-0500-7-360. Erratum in: BMC Res Notes. 2014;7:652. Lam, Ernest J [corrected to Lam, Ernest T].


Evaluation of thromboelastography for prediction of clinical bleeding in thrombocytopenic dogs after total body irradiation and hematopoietic cell transplantation.

Bucknoff MC, Hanel RM, Marks SL, Motsinger-Reif AA, Suter SE.

Am J Vet Res. 2014 May;75(5):425-32. doi: 10.2460/ajvr.75.5.425.


Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013.

Gonzalez LM, Fogle CA, Baker WT, Hughes FE, Law JM, Motsinger-Reif AA, Blikslager AT.

Equine Vet J. 2015 May;47(3):279-84. doi: 10.1111/evj.12273. Epub 2014 May 29.


Genetic heterogeneity beyond CYP2C8*3 does not explain differential sensitivity to paclitaxel-induced neuropathy.

Hertz DL, Roy S, Jack J, Motsinger-Reif AA, Drobish A, Clark LS, Carey LA, Dees EC, McLeod HL.

Breast Cancer Res Treat. 2014 May;145(1):245-54. doi: 10.1007/s10549-014-2910-1. Epub 2014 Apr 6.


Alfaxalone anesthesia in bullfrogs (Lithobates catesbeiana) by injection or immersion.

Posner LP, Bailey KM, Richardson EY, Motsinger-Reif AA, Harms CA.

J Zoo Wildl Med. 2013 Dec;44(4):965-71.


Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines.

Brown CC, Havener TM, Medina MW, Jack JR, Krauss RM, McLeod HL, Motsinger-Reif AA.

Pharmacogenomics. 2014 Feb;15(2):137-46. doi: 10.2217/pgs.13.213.


Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine.

Rotroff DM, Thomas R, Breen M, Motsinger-Reif AA.

Pharmacogenomics. 2013 Dec;14(16):1929-31. doi: 10.2217/pgs.13.178. No abstract available.


Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging.

Motsinger-Reif AA, Zhu H, Kling MA, Matson W, Sharma S, Fiehn O, Reif DM, Appleby DH, Doraiswamy PM, Trojanowski JQ, Kaddurah-Daouk R, Arnold SE.

Acta Neuropathol Commun. 2013 Jun 27;1:28. doi: 10.1186/2051-5960-1-28.


Association of dilated cardiomyopathy with the striatin mutation genotype in boxer dogs.

Meurs KM, Stern JA, Sisson DD, Kittleson MD, Cunningham SM, Ames MK, Atkins CE, DeFrancesco T, Hodge TE, Keene BW, Reina Doreste Y, Leuthy M, Motsinger-Reif AA, Tou SP.

J Vet Intern Med. 2013 Nov-Dec;27(6):1437-40. doi: 10.1111/jvim.12163. Epub 2013 Aug 28.


Cumulative genetic risk predicts platinum/taxane-induced neurotoxicity.

McWhinney-Glass S, Winham SJ, Hertz DL, Yen Revollo J, Paul J, He Y, Brown R, Motsinger-Reif AA, McLeod HL; Scottish Gynaecological Clinical Trials Group.

Clin Cancer Res. 2013 Oct 15;19(20):5769-76. doi: 10.1158/1078-0432.CCR-13-0774. Epub 2013 Aug 20.


Prevalence of onychectomy in cats presented for veterinary care near Raleigh, NC and educational attitudes toward the procedure.

Lockhart LE, Motsinger-Reif AA, Simpson WM, Posner LP.

Vet Anaesth Analg. 2014 Jan;41(1):48-53. doi: 10.1111/vaa.12077. Epub 2013 Jul 25.


Evaluation of genetic risk score models in the presence of interaction and linkage disequilibrium.

Che R, Motsinger-Reif AA.

Front Genet. 2013 Jul 23;4:138. doi: 10.3389/fgene.2013.00138. eCollection 2013.


Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL.

Richards KL, Motsinger-Reif AA, Chen HW, Fedoriw Y, Fan C, Nielsen DM, Small GW, Thomas R, Smith C, Dave SS, Perou CM, Breen M, Borst LB, Suter SE.

Cancer Res. 2013 Aug 15;73(16):5029-39. doi: 10.1158/0008-5472.CAN-12-3546. Epub 2013 Jun 19.


Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas.

Guo L, Tsai SQ, Hardison NE, James AH, Motsinger-Reif AA, Thames B, Stone EA, Deng C, Piedrahita JA.

Placenta. 2013 Jul;34(7):599-605. doi: 10.1016/j.placenta.2013.04.007. Epub 2013 Apr 30.


Alterations in metabolic pathways and networks in Alzheimer's disease.

Kaddurah-Daouk R, Zhu H, Sharma S, Bogdanov M, Rozen SG, Matson W, Oki NO, Motsinger-Reif AA, Churchill E, Lei Z, Appleby D, Kling MA, Trojanowski JQ, Doraiswamy PM, Arnold SE; Pharmacometabolomics Research Network.

Transl Psychiatry. 2013 Apr 9;3:e244. doi: 10.1038/tp.2013.18.


CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel.

Hertz DL, Roy S, Motsinger-Reif AA, Drobish A, Clark LS, McLeod HL, Carey LA, Dees EC.

Ann Oncol. 2013 Jun;24(6):1472-8. doi: 10.1093/annonc/mdt018. Epub 2013 Feb 14.


Differences in X-chromosome transcriptional activity and cholesterol metabolism between placentae from swine breeds from Asian and Western origins.

Bischoff SR, Tsai SQ, Hardison NE, Motsinger-Reif AA, Freking BA, Nonneman DJ, Rohrer GA, Piedrahita JA.

PLoS One. 2013;8(1):e55345. doi: 10.1371/journal.pone.0055345. Epub 2013 Jan 31.


Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction.

Dai H, Charnigo RJ, Becker ML, Leeder JS, Motsinger-Reif AA.

BioData Min. 2013 Jan 8;6(1):1. doi: 10.1186/1756-0381-6-1.


Twice-daily application of HIV microbicides alter the vaginal microbiota.

Ravel J, Gajer P, Fu L, Mauck CK, Koenig SS, Sakamoto J, Motsinger-Reif AA, Doncel GF, Zeichner SL.

MBio. 2012 Dec 18;3(6). pii: e00370-12. doi: 10.1128/mBio.00370-12.


Multivariate methods and software for association mapping in dose-response genome-wide association studies.

Brown CC, Havener TM, Medina MW, Krauss RM, McLeod HL, Motsinger-Reif AA.

BioData Min. 2012 Dec 12;5(1):21. doi: 10.1186/1756-0381-5-21.


Comparison of venous sampling methods for thromboelastography in clinically normal dogs.

Walker JM, Hanel RM, Hansen BD, Motsinger-Reif AA.

Am J Vet Res. 2012 Dec;73(12):1864-70. doi: 10.2460/ajvr.73.12.1864.


A comparison of internal model validation methods for multifactor dimensionality reduction in the case of genetic heterogeneity.

Gory JJ, Sweeney HC, Reif DM, Motsinger-Reif AA.

BMC Res Notes. 2012 Nov 5;5:623. doi: 10.1186/1756-0500-5-623.

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