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Items: 1 to 50 of 257

1.

Nrf2 Suppresses Allergic Lung Inflammation by Attenuating the Type 2 Innate Lymphoid Cell Response.

Nagashima R, Kosai H, Masuo M, Izumiyama K, Noshikawaji T, Morimoto M, Kumaki S, Miyazaki Y, Motohashi H, Yamamoto M, Tanaka N.

J Immunol. 2019 Jan 23. pii: ji1801180. doi: 10.4049/jimmunol.1801180. [Epub ahead of print]

PMID:
30674574
2.

Polysulfide stabilization by tyrosine and hydroxyphenyl-containing derivatives that is important for a reactive sulfur metabolomics analysis.

Hamid HA, Tanaka A, Ida T, Nishimura A, Matsunaga T, Fujii S, Morita M, Sawa T, Fukuto JM, Nagy P, Tsutsumi R, Motohashi H, Ihara H, Akaike T.

Redox Biol. 2019 Feb;21:101096. doi: 10.1016/j.redox.2019.101096. Epub 2019 Jan 2.

3.

Lactate Dehydrogenase C Is Required for the Protein Expression of a Sperm-specific Isoform of Lactate Dehydrogenase A.

Dodo M, Kitamura H, Shima H, Saigusa D, Wati SM, Ota N, Katsuoka F, Chiba H, Okae H, Arima T, Igarashi K, Koseki T, Sekine H, Motohashi H.

J Biochem. 2018 Dec 24. doi: 10.1093/jb/mvy108. [Epub ahead of print]

PMID:
30590713
4.

Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding.

Kanamoto M, Tsuchiya Y, Nakao Y, Suzuki T, Motohashi H, Yamamoto M, Kamata H.

PLoS One. 2018 Nov 30;13(11):e0203978. doi: 10.1371/journal.pone.0203978. eCollection 2018.

5.

Tumors sweeten macrophages with acids.

Sekine H, Yamamoto M, Motohashi H.

Nat Immunol. 2018 Dec;19(12):1281-1283. doi: 10.1038/s41590-018-0258-0. No abstract available.

PMID:
30397351
6.

Nickel-Catalyzed Aromatic Cross-Coupling Difluoromethylation of Grignard Reagents with Difluoroiodomethane.

Motohashi H, Mikami K.

Org Lett. 2018 Sep 7;20(17):5340-5343. doi: 10.1021/acs.orglett.8b02264. Epub 2018 Aug 21.

PMID:
30130118
7.

O-GlcNAcylation Signal Mediates Proteasome Inhibitor Resistance in Cancer Cells by Stabilizing NRF1.

Sekine H, Okazaki K, Kato K, Alam MM, Shima H, Katsuoka F, Tsujita T, Suzuki N, Kobayashi A, Igarashi K, Yamamoto M, Motohashi H.

Mol Cell Biol. 2018 Jun 25. pii: MCB.00252-18. doi: 10.1128/MCB.00252-18. [Epub ahead of print]

8.

Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells.

Fujii S, Sawa T, Motohashi H, Akaike T.

Br J Pharmacol. 2019 Feb;176(4):607-615. doi: 10.1111/bph.14356. Epub 2018 Jun 7. Review.

PMID:
29748969
9.

Transferability and within- and between-laboratory reproducibilities of EpiSensA for predicting skin sensitization potential in vitro: A ring study in three laboratories.

Mizumachi H, Sakuma M, Ikezumi M, Saito K, Takeyoshi M, Imai N, Okutomi H, Umetsu A, Motohashi H, Watanabe M, Miyazawa M.

J Appl Toxicol. 2018 Sep;38(9):1233-1243. doi: 10.1002/jat.3634. Epub 2018 May 3.

PMID:
29722446
10.

The KEAP1-NRF2 System: a Thiol-Based Sensor-Effector Apparatus for Maintaining Redox Homeostasis.

Yamamoto M, Kensler TW, Motohashi H.

Physiol Rev. 2018 Jul 1;98(3):1169-1203. doi: 10.1152/physrev.00023.2017. Review.

PMID:
29717933
11.

Hyperactivation of Nrf2 leads to hypoplasia of bone in vivo.

Yoshida E, Suzuki T, Morita M, Taguchi K, Tsuchida K, Motohashi H, Doita M, Yamamoto M.

Genes Cells. 2018 May;23(5):386-392. doi: 10.1111/gtc.12579. Epub 2018 Mar 15.

12.

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth.

Morita M, Sato T, Nomura M, Sakamoto Y, Inoue Y, Tanaka R, Ito S, Kurosawa K, Yamaguchi K, Sugiura Y, Takizaki H, Yamashita Y, Katakura R, Sato I, Kawai M, Okada Y, Watanabe H, Kondoh G, Matsumoto S, Kishimoto A, Obata M, Matsumoto M, Fukuhara T, Motohashi H, Suematsu M, Komatsu M, Nakayama KI, Watanabe T, Soga T, Shima H, Maemondo M, Tanuma N.

Cancer Cell. 2018 Mar 12;33(3):355-367.e7. doi: 10.1016/j.ccell.2018.02.004.

PMID:
29533781
13.

NRF2 addiction in cancer cells.

Kitamura H, Motohashi H.

Cancer Sci. 2018 Apr;109(4):900-911. doi: 10.1111/cas.13537. Epub 2018 Mar 10. Review.

14.

Gut Microbiota-Derived Short Chain Fatty Acids Induce Circadian Clock Entrainment in Mouse Peripheral Tissue.

Tahara Y, Yamazaki M, Sukigara H, Motohashi H, Sasaki H, Miyakawa H, Haraguchi A, Ikeda Y, Fukuda S, Shibata S.

Sci Rep. 2018 Jan 23;8(1):1395. doi: 10.1038/s41598-018-19836-7.

15.

Night eating model shows time-specific depression-like behavior in the forced swimming test.

Haraguchi A, Fukuzawa M, Iwami S, Nishimura Y, Motohashi H, Tahara Y, Shibata S.

Sci Rep. 2018 Jan 18;8(1):1081. doi: 10.1038/s41598-018-19433-8.

16.

Nucleomethylin deficiency impairs embryonic erythropoiesis.

Murakami S, Suzuki T, Yokoyama W, Yagi S, Matsumura K, Nakajima Y, Harigae H, Fukamizu A, Motohashi H.

J Biochem. 2018 May 1;163(5):413-423. doi: 10.1093/jb/mvx086.

PMID:
29244083
17.

Prediction of Apparent Oral Clearance of Small-Molecule Inhibitors in Pediatric Patients.

Kimura Y, Chisaki Y, Saki T, Matsumura C, Motohashi H, Onoue M, Yano Y.

J Pharm Sci. 2018 Mar;107(3):949-956. doi: 10.1016/j.xphs.2017.11.001. Epub 2017 Nov 10.

PMID:
29133236
18.

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics.

Akaike T, Ida T, Wei FY, Nishida M, Kumagai Y, Alam MM, Ihara H, Sawa T, Matsunaga T, Kasamatsu S, Nishimura A, Morita M, Tomizawa K, Nishimura A, Watanabe S, Inaba K, Shima H, Tanuma N, Jung M, Fujii S, Watanabe Y, Ohmuraya M, Nagy P, Feelisch M, Fukuto JM, Motohashi H.

Nat Commun. 2017 Oct 27;8(1):1177. doi: 10.1038/s41467-017-01311-y.

19.

Generation of transgenic marmosets using a tetracyclin-inducible transgene expression system as a neurodegenerative disease model.

Tomioka I, Nogami N, Nakatani T, Owari K, Fujita N, Motohashi H, Takayama O, Takae K, Nagai Y, Seki K.

Biol Reprod. 2017 Nov 1;97(5):772-780. doi: 10.1093/biolre/iox129.

PMID:
29045563
20.

Low-Dose Irradiation Promotes Persistent Oxidative Stress and Decreases Self-Renewal in Hematopoietic Stem Cells.

Rodrigues-Moreira S, Moreno SG, Ghinatti G, Lewandowski D, Hoffschir F, Ferri F, Gallouet AS, Gay D, Motohashi H, Yamamoto M, Joiner MC, Gault N, Romeo PH.

Cell Rep. 2017 Sep 26;20(13):3199-3211. doi: 10.1016/j.celrep.2017.09.013.

21.

Prolyl isomerase Pin1 promotes proplatelet formation of megakaryocytes via tau.

Shimizu T, Uchida C, Shimizu R, Motohashi H, Uchida T.

Biochem Biophys Res Commun. 2017 Nov 18;493(2):946-951. doi: 10.1016/j.bbrc.2017.09.115. Epub 2017 Sep 21.

PMID:
28943044
22.

FANTOM5 CAGE profiles of human and mouse samples.

Noguchi S, Arakawa T, Fukuda S, Furuno M, Hasegawa A, Hori F, Ishikawa-Kato S, Kaida K, Kaiho A, Kanamori-Katayama M, Kawashima T, Kojima M, Kubosaki A, Manabe RI, Murata M, Nagao-Sato S, Nakazato K, Ninomiya N, Nishiyori-Sueki H, Noma S, Saijyo E, Saka A, Sakai M, Simon C, Suzuki N, Tagami M, Watanabe S, Yoshida S, Arner P, Axton RA, Babina M, Baillie JK, Barnett TC, Beckhouse AG, Blumenthal A, Bodega B, Bonetti A, Briggs J, Brombacher F, Carlisle AJ, Clevers HC, Davis CA, Detmar M, Dohi T, Edge ASB, Edinger M, Ehrlund A, Ekwall K, Endoh M, Enomoto H, Eslami A, Fagiolini M, Fairbairn L, Farach-Carson MC, Faulkner GJ, Ferrai C, Fisher ME, Forrester LM, Fujita R, Furusawa JI, Geijtenbeek TB, Gingeras T, Goldowitz D, Guhl S, Guler R, Gustincich S, Ha TJ, Hamaguchi M, Hara M, Hasegawa Y, Herlyn M, Heutink P, Hitchens KJ, Hume DA, Ikawa T, Ishizu Y, Kai C, Kawamoto H, Kawamura YI, Kempfle JS, Kenna TJ, Kere J, Khachigian LM, Kitamura T, Klein S, Klinken SP, Knox AJ, Kojima S, Koseki H, Koyasu S, Lee W, Lennartsson A, Mackay-Sim A, Mejhert N, Mizuno Y, Morikawa H, Morimoto M, Moro K, Morris KJ, Motohashi H, Mummery CL, Nakachi Y, Nakahara F, Nakamura T, Nakamura Y, Nozaki T, Ogishima S, Ohkura N, Ohno H, Ohshima M, Okada-Hatakeyama M, Okazaki Y, Orlando V, Ovchinnikov DA, Passier R, Patrikakis M, Pombo A, Pradhan-Bhatt S, Qin XY, Rehli M, Rizzu P, Roy S, Sajantila A, Sakaguchi S, Sato H, Satoh H, Savvi S, Saxena A, Schmidl C, Schneider C, Schulze-Tanzil GG, Schwegmann A, Sheng G, Shin JW, Sugiyama D, Sugiyama T, Summers KM, Takahashi N, Takai J, Tanaka H, Tatsukawa H, Tomoiu A, Toyoda H, van de Wetering M, van den Berg LM, Verardo R, Vijayan D, Wells CA, Winteringham LN, Wolvetang E, Yamaguchi Y, Yamamoto M, Yanagi-Mizuochi C, Yoneda M, Yonekura Y, Zhang PG, Zucchelli S, Abugessaisa I, Arner E, Harshbarger J, Kondo A, Lassmann T, Lizio M, Sahin S, Sengstag T, Severin J, Shimoji H, Suzuki M, Suzuki H, Kawai J, Kondo N, Itoh M, Daub CO, Kasukawa T, Kawaji H, Carninci P, Forrest ARR, Hayashizaki Y.

Sci Data. 2017 Aug 29;4:170112. doi: 10.1038/sdata.2017.112.

23.

Tumor Proteins D52 and D54 Have Opposite Effects on the Terminal Differentiation of Chondrocytes.

Ito C, Mukudai Y, Itose M, Kato K, Motohashi H, Shimane T, Kondo S, Shirota T.

Biomed Res Int. 2017;2017:6014278. doi: 10.1155/2017/6014278. Epub 2017 Jul 17.

24.

Polyporus and Bupleuri radix effectively alter peripheral circadian clock phase acutely in male mice.

Motohashi H, Sukigara H, Tahara Y, Saito K, Yamazaki M, Shiraishi T, Kikuchi Y, Haraguchi A, Shibata S.

Nutr Res. 2017 Jul;43:16-24. doi: 10.1016/j.nutres.2017.05.001. Epub 2017 May 18.

PMID:
28739049
25.

Age-related circadian disorganization caused by sympathetic dysfunction in peripheral clock regulation.

Tahara Y, Takatsu Y, Shiraishi T, Kikuchi Y, Yamazaki M, Motohashi H, Muto A, Sasaki H, Haraguchi A, Kuriki D, Nakamura TJ, Shibata S.

NPJ Aging Mech Dis. 2017 Jan 5;3:16030. doi: 10.1038/npjamd.2016.30. eCollection 2017.

26.

IL-11 contribution to tumorigenesis in an NRF2 addiction cancer model.

Kitamura H, Onodera Y, Murakami S, Suzuki T, Motohashi H.

Oncogene. 2017 Nov 9;36(45):6315-6324. doi: 10.1038/onc.2017.236. Epub 2017 Jul 17.

PMID:
28714957
27.

NRF2 Activation Impairs Quiescence and Bone Marrow Reconstitution Capacity of Hematopoietic Stem Cells.

Murakami S, Suzuki T, Harigae H, Romeo PH, Yamamoto M, Motohashi H.

Mol Cell Biol. 2017 Sep 12;37(19). pii: e00086-17. doi: 10.1128/MCB.00086-17. Print 2017 Oct 1.

28.

Live, full-term mouse pups from oocytes grown and matured in vitro with serum substitutes.

Motohashi HH, Taniguchi R, Sakamoto J, Sankai T, Kada H.

Reprod Biol. 2017 Jun;17(2):180-184. doi: 10.1016/j.repbio.2017.05.004. Epub 2017 May 13.

PMID:
28511995
29.

Systemic Activation of NRF2 Alleviates Lethal Autoimmune Inflammation in Scurfy Mice.

Suzuki T, Murakami S, Biswal SS, Sakaguchi S, Harigae H, Yamamoto M, Motohashi H.

Mol Cell Biol. 2017 Jul 14;37(15). pii: e00063-17. doi: 10.1128/MCB.00063-17. Print 2017 Aug 1.

30.

Transgenic Monkey Model of the Polyglutamine Diseases Recapitulating Progressive Neurological Symptoms.

Tomioka I, Ishibashi H, Minakawa EN, Motohashi HH, Takayama O, Saito Y, Popiel HA, Puentes S, Owari K, Nakatani T, Nogami N, Yamamoto K, Noguchi S, Yonekawa T, Tanaka Y, Fujita N, Suzuki H, Kikuchi H, Aizawa S, Nagano S, Yamada D, Nishino I, Ichinohe N, Wada K, Kohsaka S, Nagai Y, Seki K.

eNeuro. 2017 Mar 28;4(2). pii: ENEURO.0250-16.2017. doi: 10.1523/ENEURO.0250-16.2017. eCollection 2017 Mar-Apr.

31.

Opposite effects of tumor protein D (TPD) 52 and TPD54 on oral squamous cell carcinoma cells.

Kato K, Mukudai Y, Motohashi H, Ito C, Kamoshida S, Shimane T, Kondo S, Shirota T.

Int J Oncol. 2017 May;50(5):1634-1646. doi: 10.3892/ijo.2017.3929. Epub 2017 Mar 23.

PMID:
28339026
32.

Glucocorticoid receptor signaling represses the antioxidant response by inhibiting histone acetylation mediated by the transcriptional activator NRF2.

Alam MM, Okazaki K, Nguyen LTT, Ota N, Kitamura H, Murakami S, Shima H, Igarashi K, Sekine H, Motohashi H.

J Biol Chem. 2017 May 5;292(18):7519-7530. doi: 10.1074/jbc.M116.773960. Epub 2017 Mar 17.

33.

Tumor protein D52 expression is post-transcriptionally regulated by T-cell intercellular antigen (TIA) 1 and TIA-related protein via mRNA stability.

Motohashi H, Mukudai Y, Ito C, Kato K, Shimane T, Kondo S, Shirota T.

Biochem J. 2017 May 4;474(10):1669-1687. doi: 10.1042/BCJ20160942.

PMID:
28298474
34.

Redox regulation of electrophilic signaling by reactive persulfides in cardiac cells.

Nishida M, Nishimura A, Matsunaga T, Motohashi H, Kasamatsu S, Akaike T.

Free Radic Biol Med. 2017 Aug;109:132-140. doi: 10.1016/j.freeradbiomed.2017.01.024. Epub 2017 Jan 18. Review.

PMID:
28109891
35.

Protein polysulfidation-dependent persulfide dioxygenase activity of ethylmalonic encephalopathy protein 1.

Jung M, Kasamatsu S, Matsunaga T, Akashi S, Ono K, Nishimura A, Morita M, Abdul Hamid H, Fujii S, Kitamura H, Sawa T, Ida T, Motohashi H, Akaike T.

Biochem Biophys Res Commun. 2016 Nov 11;480(2):180-186. doi: 10.1016/j.bbrc.2016.10.022. Epub 2016 Oct 11.

PMID:
27742479
36.

Recent advances in elucidating KEAP1-NRF2 functions in hematopoietic/immune cells and leukemic cells.

Murakami S, Motohashi H.

Rinsho Ketsueki. 2016;57(10):1860-1868. Japanese.

PMID:
27725581
37.

Redox-dependent Regulation of Gluconeogenesis by a Novel Mechanism Mediated by a Peroxidatic Cysteine of Peroxiredoxin.

Irokawa H, Tachibana T, Watanabe T, Matsuyama Y, Motohashi H, Ogasawara A, Iwai K, Naganuma A, Kuge S.

Sci Rep. 2016 Sep 16;6:33536. doi: 10.1038/srep33536.

38.

Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery.

Saigusa D, Okamura Y, Motoike IN, Katoh Y, Kurosawa Y, Saijyo R, Koshiba S, Yasuda J, Motohashi H, Sugawara J, Tanabe O, Kinoshita K, Yamamoto M.

PLoS One. 2016 Aug 31;11(8):e0160555. doi: 10.1371/journal.pone.0160555. eCollection 2016.

39.

The structural origin of metabolic quantitative diversity.

Koshiba S, Motoike I, Kojima K, Hasegawa T, Shirota M, Saito T, Saigusa D, Danjoh I, Katsuoka F, Ogishima S, Kawai Y, Yamaguchi-Kabata Y, Sakurai M, Hirano S, Nakata J, Motohashi H, Hozawa A, Kuriyama S, Minegishi N, Nagasaki M, Takai-Igarashi T, Fuse N, Kiyomoto H, Sugawara J, Suzuki Y, Kure S, Yaegashi N, Tanabe O, Kinoshita K, Yasuda J, Yamamoto M.

Sci Rep. 2016 Aug 16;6:31463. doi: 10.1038/srep31463.

40.

CD271 regulates the proliferation and motility of hypopharyngeal cancer cells.

Mochizuki M, Tamai K, Imai T, Sugawara S, Ogama N, Nakamura M, Matsuura K, Yamaguchi K, Satoh K, Sato I, Motohashi H, Sugamura K, Tanaka N.

Sci Rep. 2016 Jul 29;6:30707. doi: 10.1038/srep30707.

41.

p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming.

Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, Hirose Y, Nagahashi M, Iso T, Fukutomi T, Ohishi M, Endo K, Uemura T, Nishito Y, Okuda S, Obata M, Kouno T, Imamura R, Tada Y, Obata R, Yasuda D, Takahashi K, Fujimura T, Pi J, Lee MS, Ueno T, Ohe T, Mashino T, Wakai T, Kojima H, Okabe T, Nagano T, Motohashi H, Waguri S, Soga T, Yamamoto M, Tanaka K, Komatsu M.

Nat Commun. 2016 Jun 27;7:12030. doi: 10.1038/ncomms12030.

42.

Methanol and Butanol Extracts of Paeonia lutea Leaves Repress Metastasis of Squamous Cell Carcinoma.

Mukudai Y, Zhang M, Shiogama S, Kondo S, Ito C, Motohashi H, Kato K, Fujii M, Shintani S, Shigemori H, Yazawa K, Shirota T.

Evid Based Complement Alternat Med. 2016;2016:6087213. doi: 10.1155/2016/6087213. Epub 2016 May 17.

43.

Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription.

Kobayashi EH, Suzuki T, Funayama R, Nagashima T, Hayashi M, Sekine H, Tanaka N, Moriguchi T, Motohashi H, Nakayama K, Yamamoto M.

Nat Commun. 2016 May 23;7:11624. doi: 10.1038/ncomms11624.

44.

Telaprevir-Induced Renal Adverse Events in Japanese Patients Reported in the PMDA Adverse Drug Reactions Reporting Database.

Ichida A, Motohashi H, Kitano A, Takayama A, Inui KI, Yano Y.

Ther Innov Regul Sci. 2016 May;50(3):355-360. doi: 10.1177/2168479015618694.

PMID:
30227075
45.

Redox signaling regulated by an electrophilic cyclic nucleotide and reactive cysteine persulfides.

Fujii S, Sawa T, Nishida M, Ihara H, Ida T, Motohashi H, Akaike T.

Arch Biochem Biophys. 2016 Apr 1;595:140-6. doi: 10.1016/j.abb.2015.11.008. Review.

PMID:
27095231
46.

Redox signaling regulated by electrophiles and reactive sulfur species.

Nishida M, Kumagai Y, Ihara H, Fujii S, Motohashi H, Akaike T.

J Clin Biochem Nutr. 2016 Mar;58(2):91-8. doi: 10.3164/jcbn.15-111. Epub 2016 Feb 17. Review.

47.

Significant effect of age on docetaxel pharmacokinetics in Japanese female breast cancer patients by using the population modeling approach.

Onoue H, Yano I, Tanaka A, Itohara K, Hanai A, Ishiguro H, Motohashi H, Masuda S, Matsubara K.

Eur J Clin Pharmacol. 2016 Jun;72(6):703-10. doi: 10.1007/s00228-016-2031-3. Epub 2016 Feb 23.

PMID:
26905999
48.

Cryopreservation of ovaries from neonatal marmoset monkeys.

Motohashi HH, Ishibashi H.

Exp Anim. 2016 Jul 29;65(3):189-96. doi: 10.1538/expanim.15-0097. Epub 2016 Feb 15.

49.

NRF2 Is a Key Target for Prevention of Noise-Induced Hearing Loss by Reducing Oxidative Damage of Cochlea.

Honkura Y, Matsuo H, Murakami S, Sakiyama M, Mizutari K, Shiotani A, Yamamoto M, Morita I, Shinomiya N, Kawase T, Katori Y, Motohashi H.

Sci Rep. 2016 Jan 18;6:19329. doi: 10.1038/srep19329.

50.

The Transcription Factor Bach2 Is Phosphorylated at Multiple Sites in Murine B Cells but a Single Site Prevents Its Nuclear Localization.

Ando R, Shima H, Tamahara T, Sato Y, Watanabe-Matsui M, Kato H, Sax N, Motohashi H, Taguchi K, Yamamoto M, Nio M, Maeda T, Ochiai K, Muto A, Igarashi K.

J Biol Chem. 2016 Jan 22;291(4):1826-40. doi: 10.1074/jbc.M115.661702. Epub 2015 Nov 30.

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